Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
gorilla, western |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
orangutan, Bornean |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
hamster, Chinese |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanco P |
Year: |
2001 |
Journal: |
Genomics |
Title: |
A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. |
Volume: |
74 |
Issue: |
1 |
Pages: |
1-11 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3614462 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3616217 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
RT-PCR E13.5 brain |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3614462 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616217 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
RT-PCR P0 brain |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615038 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3616660 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
RT-PCR E13.5 brain |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615038 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616660 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
RT-PCR P0 brain |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1665821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1697427 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716827 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753627 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression in precortical tissue. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617174 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615806 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3617174 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKee AE |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. |
Volume: |
5 |
|
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Kazak L |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
Alternative translation initiation augments the human mitochondrial proteome. |
Volume: |
41 |
Issue: |
4 |
Pages: |
2354-69 |
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Publication |
First Author: |
Féral C |
Year: |
2001 |
Journal: |
Nucleic Acids Res |
Title: |
Human testis expresses a specific poly(A)-binding protein. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1872-83 |
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•
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Publication |
First Author: |
Mangus DA |
Year: |
2003 |
Journal: |
Genome Biol |
Title: |
Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. |
Volume: |
4 |
Issue: |
7 |
Pages: |
223 |
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Publication |
First Author: |
Deo RC |
Year: |
1999 |
Journal: |
Cell |
Title: |
Recognition of polyadenylate RNA by the poly(A)-binding protein. |
Volume: |
98 |
Issue: |
6 |
Pages: |
835-45 |
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Publication |
First Author: |
Sladic RT |
Year: |
2004 |
Journal: |
Eur J Biochem |
Title: |
Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4. |
Volume: |
271 |
Issue: |
2 |
Pages: |
450-7 |
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Publication |
First Author: |
Kini HK |
Year: |
2016 |
Journal: |
RNA |
Title: |
Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs. |
Volume: |
22 |
Issue: |
1 |
Pages: |
61-74 |
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Publication |
First Author: |
Burgess HM |
Year: |
2011 |
Journal: |
J Cell Sci |
Title: |
Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. |
Volume: |
124 |
Issue: |
Pt 19 |
Pages: |
3344-55 |
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Publication |
First Author: |
Kessler SH |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
RNA recognition motif 2 of yeast Pab1p is required for its functional interaction with eukaryotic translation initiation factor 4G. |
Volume: |
18 |
Issue: |
1 |
Pages: |
51-7 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif 2 (RRM2) of type I poly(A)-binding proteins (PABPs).Poly(A)-binding proteins (PABPs) are highly conserved proteins that bind to the poly(A) tail present at the 3' ends of most eukaryotic mRNAs []. These highly conserved proteins are found only in eukaryotes; single-celled eukaryotes each have a single PABP, whereas humans have five and Arabidopis has eight. In humans, three lineages of PABP proteins are observed: cytoplasmic PABPs (PABPC1, PABPC3, and iPABP); nuclear PABP (PABPN1); and X-linked PABP (PABPC5) []. The mammalian PABPs contain four RNA recognition motifs (RRMs). RRM 1 and 2 are primarily responsible for the high-affinity binding to homopolymeric adenosines, while RRMs 3 and 4 can bind to nonhomopolymeric AU sequences []. Proteins containing this motif include:Polyadenylate-binding protein 1 (PABP-1 or PABPC1): PABP-1 is the major cytoplasmic PABP isoform in adult mouse somatic cells. It is able to bindsimultaneously to the cap-binding complex subunit eIF4G and to the poly(A) tail. Therefore, it has been suggested to play a role in altering the structure and/or function of the translation termination complex. It may have additional functions within the eukaryotic mRNA transcriptome. PABP-1 possesses an A-rich sequence in its 5'-UTR and allows binding of PABP and blockage of translation of its own mRNA []. Polyadenylate-binding protein 3 (PABP-3 or PABPC3): PABP-3 is a testis-specific poly(A)-binding protein specifically expressed in round spermatids. It is mainly found in mammalian and may play an important role in the testis-specific regulation of mRNA homeostasis. PABP-3 shows significant sequence similarity to PABP-1. However, it binds to poly(A) with a lower affinity than PABP-1. Dislike PABP-1, PABP-3 lacks the A-rich sequence in its 5'-UTR []. Polyadenylate-binding protein 4 (PABP-4 or APP-1 or iPABP): PABP-4 is an inducible poly(A)-binding protein (iPABP) that is primarily localized to the cytoplasm. It shows significant sequence similarity to PABP-1 as well. The RNA binding properties of PABP-1 and PABP-4 appear to be identical []. Polyadenylate-binding protein 5 (PABP-5 or PABPC5):PABP-5 is encoded by PABPC5 gene within the X-specific subinterval, and expressed in fetal brain and in a range of adult tissues in mammals, such as ovary and testis. It may play an important role in germ cell development []. Moreover, unlike other PABPs, PABP-5 contains only four RRMs, but lacks both the linker region and the CTD. Polyadenylate-binding protein 1-like (PABP-1-like or PABPC1L): orthologue of PABP-1.Polyadenylate-binding protein 1-like 2 (PABPC1L2 or RBM32): orthologue of PABP-1. Polyadenylate-binding protein 4-like (PABP-4-like or PABPC4L): orthologue of PABP-5. Polyadenylate-binding protein, cytoplasmic and nuclear (PABP or ACBP-67): PABP is a conserved poly(A) binding protein containing poly(A) tails that can be attached to the 3'-ends of mRNAs. The yeast PABP, also known as Pab1, and its homologues may play important roles in the initiation of translation and in mRNA decay []. Like vertebrate PABP-1, Pab1 contains four RRMs, a linker region, and a proline-rich CTD as well. The first two RRMs are mainly responsible for specific binding to poly(A). The proline-rich region may be involved in protein-protein interactions. The association of RRM2 of yeast Pab1 with eIF4G is a prerequisite for the poly(A) tail to stimulate the translation of mRNA in vitro []. Polyadenylate-binding protein Pes4 and Mip6. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
172
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
true |
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•
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Publication |
First Author: |
Anderson JT |
Year: |
1993 |
Journal: |
Mol Cell Biol |
Title: |
PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae. |
Volume: |
13 |
Issue: |
10 |
Pages: |
6102-13 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
381
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
370
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
636
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
607
 |
Fragment?: |
false |
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
660
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
615
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
631
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
590
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
644
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
603
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
636
 |
Fragment?: |
false |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
636
 |
Fragment?: |
false |
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•
•
•
•
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