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Search results 1 to 100 out of 842 for Pak1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
5058 | PAK1
Type: gene
Organism: human
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Gene
533729 | PAK1
Type: gene
Organism: cattle
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Gene
419083 | PAK1
Type: gene
Organism: chicken
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Gene
373103 | pak1
Type: gene
Organism: zebrafish
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Gene
698585 | PAK1
Type: gene
Organism: macaque, rhesus
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Gene
100135731 | pak1
Type: gene
Organism: frog, western clawed
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Gene
29431 | Pak1
Type: gene
Organism: rat
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Gene
607885 | PAK1
Type: gene
Organism: dog, domestic
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Gene
451439 | PAK1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1339975 | Pak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
55003 | PAK1IP1
Type: gene
Organism: human
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Publication
26304465 | J:317257
First Author: Dammann K
Year: 2015
Journal: Cancer Prev Res (Phila)
Title: PAK1 promotes intestinal tumor initiation.
Volume: 8
Issue: 11
Pages: 1093-101
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Publication
16331248 | J:108776
First Author: Wang RA
Year: 2006
Journal: Oncogene
Title: PAK1 hyperactivation is sufficient for mammary gland tumor formation.
Volume: 25
Issue: 20
Pages: 2931-6
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Publication
11604394 | J:73513
First Author: Rashid T
Year: 2001
Journal: J Biol Chem
Title: Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology.
Volume: 276
Issue: 52
Pages: 49043-52
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Publication
26036343 | J:233928
First Author: Dammann K
Year: 2015
Journal: Biochim Biophys Acta
Title: PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.
Volume: 1853
Issue: 10 Pt A
Pages: 2349-60
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Publication
26555075 | J:244016
First Author: Sosa-García B
Year: 2015
Journal: PLoS One
Title: The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts.
Volume: 10
Issue: 11
Pages: e0142406
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Protein
G3BKE5
Organism: Mus musculus/domesticus
Length: 14  
Fragment?: true
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Publication
23576562 | J:198342
First Author: Arias-Romero LE
Year: 2013
Journal: Cancer Res
Title: Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.
Volume: 73
Issue: 12
Pages: 3671-82
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Publication
25074413 | J:215913
First Author: Zhou W
Year: 2014
Journal: J Pathol
Title: PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.
Volume: 234
Issue: 4
Pages: 502-13
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Publication
15684429 | J:98481
First Author: Alberts AS
Year: 2005
Journal: J Biol Chem
Title: PAK1 negatively regulates the activity of the Rho exchange factor NET1.
Volume: 280
Issue: 13
Pages: 12152-61
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Publication
22082674 | J:193804
First Author: Liu W
Year: 2011
Journal: Circulation
Title: Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Volume: 124
Issue: 24
Pages: 2702-15
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Publication
26043730 | J:225713
 
First Author: Pan X
Year: 2015
Journal: Mol Brain
Title: PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.
Volume: 8
Pages: 36
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Publication
18768391 | J:142439
First Author: McDaniel AS
Year: 2008
Journal: Blood
Title: Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.
Volume: 112
Issue: 12
Pages: 4646-54
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Publication
30891040 | J:294417
 
First Author: Dios-Esponera A
Year: 2019
Journal: Front Immunol
Title: Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.
Volume: 10
Pages: 370
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Publication
35222279 | J:321609
 
First Author: Merz KE
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Volume: 13
Pages: 821849
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Publication
26025676 | J:233929
First Author: Pinto VI
Year: 2015
Journal: Biochim Biophys Acta
Title: PAK1 is involved in sensing the orientation of collagen stiffness gradients in mouse fibroblasts.
Volume: 1853
Issue: 10 Pt A
Pages: 2526-38
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Publication
32427988 | J:290526
First Author: Okumura K
Year: 2020
Journal: Oncogene
Title: Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis.
Volume: 39
Issue: 24
Pages: 4756-4769
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Publication
22815483 | J:190406
First Author: Combeau G
Year: 2012
Journal: J Biol Chem
Title: The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Volume: 287
Issue: 36
Pages: 30084-96
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Publication
12213441 | J:79013
First Author: Hayashi K
Year: 2002
Journal: Mol Cell Neurosci
Title: Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.
Volume: 20
Issue: 4
Pages: 579-94
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Publication
25456130 | J:218754
First Author: Chatterjee A
Year: 2014
Journal: Cell Rep
Title: Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.
Volume: 9
Issue: 4
Pages: 1333-48
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Publication
12950086 | J:85489
First Author: Zhong JL
Year: 2003
Journal: Dev Dyn
Title: Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent.
Volume: 228
Issue: 1
Pages: 121-7
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Publication
31857154 | J:283658
 
First Author: Wang K
Year: 2020
Journal: Cancer Lett
Title: Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1.
Volume: 472
Pages: 8-18
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191013
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Pak1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191013
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Pak1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191013
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Pak1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191013
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Pak1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191013
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Pak1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191013
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Pak1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6180013
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191013
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Pak1
Detected: true
Specimen Num: 7
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Publication
31391572 | J:297723
First Author: Rajah A
Year: 2019
Journal: Sci Rep
Title: Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
Volume: 9
Issue: 1
Pages: 11430
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Publication
18515095 | J:140789
First Author: He H
Year: 2008
Journal: Biochim Biophys Acta
Title: PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.
Volume: 1783
Issue: 10
Pages: 1943-54
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Publication
33181191 | J:322058
 
First Author: Ahn M
Year: 2021
Journal: Metabolism
Title: A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis.
Volume: 115
Pages: 154431
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Publication
25446075 | J:220289
First Author: Ijuin T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain.
Volume: 456
Issue: 1
Pages: 41-6
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Publication
34075397 | J:308853
     
First Author: Hawley E
Year: 2021
Journal: Hum Mol Genet
Title: PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
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Gene
361232 | Pak1ip1
Type: gene
Organism: rat
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Gene
478719 | PAK1IP1
Type: gene
Organism: dog, domestic
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Gene
463143 | PAK1IP1
Type: gene
Organism: chimpanzee
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Gene
505125 | PAK1IP1
Type: gene
Organism: cattle
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Gene
420850 | PAK1IP1
Type: gene
Organism: chicken
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Gene
336470 | pak1ip1
Type: gene
Organism: zebrafish
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Gene
697856 | PAK1IP1
Type: gene
Organism: macaque, rhesus
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Gene
549808 | pak1ip1
Type: gene
Organism: frog, western clawed
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Gene
103691737 | Cripak
Type: gene
Organism: rat
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Publication
17429073 | J:127464
First Author: Stockton R
Year: 2007
Journal: Mol Biol Cell
Title: Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.
Volume: 18
Issue: 6
Pages: 2346-55
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Strain
MGI:5451052 | B6;129P2-Adcyap1r1<tm1Dgen>/H
Attribute String: mutant stock, targeted mutation
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Publication
26493375 | J:225712
 
First Author: Shan LL
Year: 2015
Journal: Sci Rep
Title: Light exposure before learning improves memory consolidation at night.
Volume: 5
Pages: 15578
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Publication
35240107 | J:323200
     
First Author: Okumura K
Year: 2022
Journal: J Invest Dermatol
Title: Functional Polymorphism in Pak1-3' Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation.
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Publication
18644395 | J:225714
First Author: Asrar S
Year: 2009
Journal: Neuropharmacology
Title: Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1).
Volume: 56
Issue: 1
Pages: 73-80
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Publication
17687038 | J:123684
First Author: Jacobs T
Year: 2007
Journal: J Neurosci
Title: Localized activation of p21-activated kinase controls neuronal polarity and morphology.
Volume: 27
Issue: 32
Pages: 8604-15
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Publication
22983922 | J:192901
First Author: Chow HY
Year: 2012
Journal: Cancer Res
Title: p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.
Volume: 72
Issue: 22
Pages: 5966-75
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Publication
26464331 | J:259616
First Author: Davis RT 3rd
Year: 2015
Journal: Cardiovasc Res
Title: Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling.
Volume: 108
Issue: 3
Pages: 335-47
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Publication
23183186 | J:194205
First Author: Chiang YA
Year: 2013
Journal: Endocrinology
Title: P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice.
Volume: 154
Issue: 1
Pages: 77-88
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Publication
21969371 | J:178151
First Author: Wang Z
Year: 2011
Journal: J Biol Chem
Title: Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.
Volume: 286
Issue: 48
Pages: 41359-67
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Publication
24684301 | J:212414
First Author: Chiang YT
Year: 2014
Journal: Endocrinology
Title: Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.
Volume: 155
Issue: 6
Pages: 2122-32
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Publication
25379771 | J:225315
First Author: Elsherif L
Year: 2014
Journal: PLoS One
Title: Potential compensation among group I PAK members in hindlimb ischemia and wound healing.
Volume: 9
Issue: 11
Pages: e112239
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Publication
22900031 | J:189933
First Author: Hoover WC
Year: 2012
Journal: PLoS One
Title: Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.
Volume: 7
Issue: 8
Pages: e42601
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Publication
12732616 | J:83342
First Author: Wang RA
Year: 2003
Journal: J Cell Biol
Title: Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.
Volume: 161
Issue: 3
Pages: 583-92
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Publication
24368667 | J:211477
First Author: Chiang YT
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: p21-Activated protein kinases and their emerging roles in glucose homeostasis.
Volume: 306
Issue: 7
Pages: E707-22
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Publication
25199455 | J:217907
First Author: Tunduguru R
Year: 2014
Journal: Biochem Pharmacol
Title: Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.
Volume: 92
Issue: 2
Pages: 380-8
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Publication
28109008 | J:241303
First Author: Yeo D
Year: 2017
Journal: Int J Cancer
Title: Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer.
Volume: 140
Issue: 9
Pages: 2101-2111
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Publication
22824149 | J:318090
 
First Author: Jhaveri KA
Year: 2012
Journal: BMC Cardiovasc Disord
Title: The role of p21-activated kinase in the initiation of atherosclerosis.
Volume: 12
Pages: 55
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Publication
25242307 | J:219424
First Author: Molosh AI
Year: 2014
Journal: Nat Neurosci
Title: Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
Volume: 17
Issue: 11
Pages: 1583-90
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Publication
25215948 | J:230193
First Author: Zhang W
Year: 2015
Journal: Cell Death Differ
Title: Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway.
Volume: 22
Issue: 2
Pages: 287-97
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Publication
27296803 | J:234293
   
First Author: Xia S
Year: 2016
Journal: Elife
Title: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.
Volume: 5
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Publication
18065495 | J:132047
First Author: Luo S
Year: 2008
Journal: Hum Mol Genet
Title: p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity.
Volume: 17
Issue: 6
Pages: 895-905
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Publication
19435845 | J:150010
First Author: Van den Broeke C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.
Volume: 106
Issue: 21
Pages: 8707-12
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Publication
26104863 | J:223014
 
First Author: Singh NK
Year: 2015
Journal: Nat Commun
Title: Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Volume: 6
Pages: 7450
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Publication
27394663 | J:237058
First Author: Ahn M
Year: 2016
Journal: Diabetologia
Title: The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets.
Volume: 59
Issue: 10
Pages: 2145-55
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Publication
23306081 | J:195082
First Author: Huynh N
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.
Volume: 304
Issue: 6
Pages: G561-7
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Publication
19124833 | J:145444
First Author: Allen JD
Year: 2009
Journal: Blood
Title: p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Volume: 113
Issue: 12
Pages: 2695-705
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Publication
23019370 | J:190318
First Author: Goh KY
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression.
Volume: 109
Issue: 39
Pages: 15853-8
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Publication
22669945 | J:188847
First Author: Nie J
Year: 2012
Journal: J Biol Chem
Title: Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
Volume: 287
Issue: 31
Pages: 26435-44
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Publication
21115725 | J:169422
First Author: Huang W
Year: 2011
Journal: Mol Cell Biol
Title: p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.
Volume: 31
Issue: 3
Pages: 388-403
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Publication
23303955 | J:193907
First Author: Li S
Year: 2013
Journal: J Neurosci
Title: The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).
Volume: 33
Issue: 2
Pages: 790-803
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Publication
20400510 | J:164552
First Author: Deguchi A
Year: 2010
Journal: J Biol Chem
Title: LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.
Volume: 285
Issue: 24
Pages: 18283-90
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Publication
26857814 | J:246814
First Author: Kumar R
Year: 2016
Journal: J Cell Sci
Title: A new role for cofilin in retinal neovascularization.
Volume: 129
Issue: 6
Pages: 1234-49
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Publication
14580336 | J:86235
First Author: Kissil JL
Year: 2003
Journal: Mol Cell
Title: Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.
Volume: 12
Issue: 4
Pages: 841-9
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Publication
12165471 | J:78399
First Author: Luo ZG
Year: 2002
Journal: Neuron
Title: Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.
Volume: 35
Issue: 3
Pages: 489-505
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Publication
27920252 | J:240318
 
First Author: Joseph GA
Year: 2017
Journal: Mol Cell Biol
Title: Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.
Volume: 37
Issue: 4
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Publication
28629331 | J:273566
First Author: Huynh N
Year: 2017
Journal: BMC Cancer
Title: Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.
Volume: 17
Issue: 1
Pages: 431
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Publication
22037191 | J:181574
First Author: Monasky MM
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation.
Volume: 302
Issue: 1
Pages: H224-30
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Publication
28408623 | J:243667
First Author: Chang JK
Year: 2017
Journal: J Biol Chem
Title: Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Volume: 292
Issue: 23
Pages: 9523-9539
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Publication
12374744 | J:79577
First Author: Wang RA
Year: 2002
Journal: EMBO J
Title: P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
Volume: 21
Issue: 20
Pages: 5437-47
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Publication
15814684 | J:98167
First Author: Carstanjen D
Year: 2005
Journal: J Immunol
Title: Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways.
Volume: 174
Issue: 8
Pages: 4613-20
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Publication
23038262 | J:327838
First Author: Sánchez-Solana B
Year: 2012
Journal: J Biol Chem
Title: p21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor.
Volume: 287
Issue: 47
Pages: 39291-302
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Publication
15800193 | J:98630
First Author: Zhang H
Year: 2005
Journal: J Neurosci
Title: A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
Volume: 25
Issue: 13
Pages: 3379-88
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Publication
19819308 | J:158222
First Author: Demyanenko GP
Year: 2010
Journal: Neuroscience
Title: CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.
Volume: 165
Issue: 1
Pages: 107-15
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Publication
18940914 | J:145781
First Author: Smith SD
Year: 2008
Journal: J Cell Sci
Title: PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.
Volume: 121
Issue: Pt 22
Pages: 3729-36
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Publication
17012749 | J:117620
First Author: Zhou GL
Year: 2006
Journal: J Biol Chem
Title: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
Volume: 281
Issue: 47
Pages: 36443-53
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Publication
24141051 | J:215732
 
First Author: Podkowa M
Year: 2013
Journal: Mol Cell Neurosci
Title: p21-Activated kinase (PAK) is required for Bone Morphogenetic Protein (BMP)-induced dendritogenesis in cortical neurons.
Volume: 57
Pages: 83-92
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