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Search results 1 to 100 out of 224 for Pak2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rabbit, European
Protein Domain
Type: Family
Description: PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis []. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response []. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1 []. PAK2 belongs to the group I PAKs.Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Coniglio SJ
Year: 2008
Journal: Mol Cell Biol
Title: Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.
Volume: 28
Issue: 12
Pages: 4162-72
Publication
First Author: Bokoch GM
Year: 1998
Journal: Cell Death Differ
Title: Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?
Volume: 5
Issue: 8
Pages: 637-45
Publication  
First Author: Roig J
Year: 2001
Journal: Vitam Horm
Title: Cytostatic p21 G protein-activated protein kinase gamma-PAK.
Volume: 62
Pages: 167-98
Publication
First Author: Jaffer ZM
Year: 2002
Journal: Int J Biochem Cell Biol
Title: p21-activated kinases: three more join the Pak.
Volume: 34
Issue: 7
Pages: 713-7
Publication
First Author: Kosoff RE
Year: 2015
Journal: Blood
Title: Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.
Volume: 125
Issue: 19
Pages: 2995-3005
Publication
First Author: Wang Y
Year: 2018
Journal: Cell Rep
Title: PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior.
Volume: 24
Issue: 8
Pages: 2029-2041
Protein
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
Publication
First Author: Zeng Y
Year: 2015
Journal: Stem Cells
Title: Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Volume: 33
Issue: 5
Pages: 1630-41
Publication
First Author: Luo S
Year: 2009
Journal: J Cell Sci
Title: Huntingtin promotes cell survival by preventing Pak2 cleavage.
Volume: 122
Issue: Pt 6
Pages: 875-85
Publication
First Author: Lee JS
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Pak2 kinase promotes cellular senescence and organismal aging.
Volume: 116
Issue: 27
Pages: 13311-13319
Publication
First Author: Binder P
Year: 2019
Journal: Circ Res
Title: Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response.
Volume: 124
Issue: 5
Pages: 696-711
Publication  
First Author: Phee H
Year: 2014
Journal: Elife
Title: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.
Volume: 3
Pages: e02270
Publication
First Author: O'Hagan KL
Year: 2015
Journal: J Immunol
Title: Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Volume: 195
Issue: 4
Pages: 1564-77
Publication
First Author: Kosoff R
Year: 2013
Journal: J Biol Chem
Title: Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.
Volume: 288
Issue: 2
Pages: 974-83
Publication
First Author: O'Hagan KL
Year: 2017
Journal: Sci Rep
Title: Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.
Volume: 7
Issue: 1
Pages: 17097
Publication  
First Author: Binder P
Year: 2022
Journal: Front Cardiovasc Med
Title: Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart.
Volume: 9
Pages: 851419
Publication  
First Author: Varshney P
Year: 2016
Journal: Mol Cell Endocrinol
Title: P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells.
Volume: 429
Pages: 50-61
Publication
First Author: Kurakin AV
Year: 2003
Journal: J Biol Chem
Title: Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.
Volume: 278
Issue: 36
Pages: 34102-9
Publication
First Author: Sementino E
Year: 2022
Journal: Mol Cancer Res
Title: Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Volume: 20
Issue: 5
Pages: 699-711
Publication
First Author: Van den Broeke C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.
Volume: 106
Issue: 21
Pages: 8707-12
Publication
First Author: Vincent P
Year: 2006
Journal: J Biol Chem
Title: Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.
Volume: 281
Issue: 11
Pages: 6940-54
Publication
First Author: Kathania M
Year: 2022
Journal: Cell Rep
Title: Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation.
Volume: 40
Issue: 11
Pages: 111345
Publication
First Author: Choi J
Year: 2018
Journal: Immunology
Title: P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells.
Volume: 154
Issue: 2
Pages: 309-321
Publication
First Author: Reddy PN
Year: 2016
Journal: Blood
Title: p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix.
Volume: 127
Issue: 16
Pages: 1967-75
Publication
First Author: Hu S
Year: 2019
Journal: Exp Mol Med
Title: MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2.
Volume: 51
Issue: 10
Pages: 1-13
Publication
First Author: Orton KC
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Volume: 279
Issue: 37
Pages: 38649-57
Publication
First Author: Dorrance AM
Year: 2013
Journal: Blood
Title: The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.
Volume: 121
Issue: 13
Pages: 2474-82
Publication      
First Author: Hawley E
Year: 2021
Journal: Hum Mol Genet
Title: PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
Publication  
First Author: Joseph GA
Year: 2017
Journal: Mol Cell Biol
Title: Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.
Volume: 37
Issue: 4
Publication
First Author: Chang JK
Year: 2017
Journal: J Biol Chem
Title: Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Volume: 292
Issue: 23
Pages: 9523-9539
Publication
First Author: Radu M
Year: 2015
Journal: Mol Cell Biol
Title: p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.
Volume: 35
Issue: 23
Pages: 3990-4005
Publication
First Author: Joseph GA
Year: 2019
Journal: Skelet Muscle
Title: Late-onset megaconial myopathy in mice lacking group I Paks.
Volume: 9
Issue: 1
Pages: 5
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
Strain
Attribute String: targeted mutation, mutant stock
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kaur N
Year: 2022
Journal: iScience
Title: Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy.
Volume: 25
Issue: 3
Pages: 103973
Publication
First Author: Marlin JW
Year: 2011
Journal: Mamm Genome
Title: Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34.
Volume: 22
Issue: 5-6
Pages: 306-17
Publication
First Author: Marler KJ
Year: 2005
Journal: Mol Cell Biol
Title: Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK.
Volume: 25
Issue: 12
Pages: 5226-41
GXD Expression      
Probe: MGI:3843161
Assay Type: Western blot
Annotation Date: 2009-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3843168
Age: postnatal week 8
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3843161
Assay Type: Western blot
Annotation Date: 2009-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3843168
Age: postnatal week 8
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3843161
Assay Type: Western blot
Annotation Date: 2009-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3843168
Age: postnatal week 8
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4457048
Assay Type: Western blot
Annotation Date: 2010-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:4457149
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4457048
Assay Type: Western blot
Annotation Date: 2010-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:4457149
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4457048
Assay Type: Western blot
Annotation Date: 2010-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Stage: TS25
Assay Id: MGI:4457149
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4457048
Assay Type: Western blot
Annotation Date: 2010-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:4457149
Age: postnatal day 12
Specimen Label: P12
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2010-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836643
Age: embryonic day 18.5
Specimen Label: Dhcr7 +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2010-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836643
Age: embryonic day 18.5
Specimen Label: Dhcr7 delta/delta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4836641
Assay Type: Western blot
Annotation Date: 2010-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836646
Age: embryonic day 18.5
Specimen Label: Dhcr7 +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4836641
Assay Type: Western blot
Annotation Date: 2010-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836646
Age: embryonic day 18.5
Specimen Label: Dhcr7 delta/delta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2010-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836888
Age: embryonic day 18.5
Specimen Label: Sc5d +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2010-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836888
Age: embryonic day 18.5
Specimen Label: Sc5d -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4836641
Assay Type: Western blot
Annotation Date: 2010-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836892
Age: embryonic day 18.5
Specimen Label: Sc5d +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4836641
Assay Type: Western blot
Annotation Date: 2010-10-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4836892
Age: embryonic day 18.5
Specimen Label: Sc5d -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5086225
Assay Type: Western blot
Annotation Date: 2011-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5086226
Age: embryonic day 9.5
Specimen Label: W/R
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5086225
Assay Type: Western blot
Annotation Date: 2011-08-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5086226
Age: embryonic day 9.5
Specimen Label: W/W
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5086225
Assay Type: Western blot
Annotation Date: 2011-08-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5086226
Age: embryonic day 9.5
Specimen Label: R?R
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6728117
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728123
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: S490P/NHEJ
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4836639
Assay Type: Western blot
Annotation Date: 2021-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278928
Stage: TS28
Assay Id: MGI:6728125
Age: postnatal week 8
Image: 2
Specimen Label: wt
Detected: true
Specimen Num: 6