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Search results 1 to 100 out of 136 for Pan2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
9924 | PAN2
Type: gene
Organism: human
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Gene
100145682 | pan2
Type: gene
Organism: frog, western clawed
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Gene
408200 | Pan2
Type: gene
Organism: rat
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Gene
474404 | PAN2
Type: gene
Organism: dog, domestic
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Gene
538820 | PAN2
Type: gene
Organism: cattle
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Gene
101057768 | PAN2
Type: gene
Organism: chimpanzee
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Gene
429172 | PAN2
Type: gene
Organism: chicken
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Gene
792831 | pan2
Type: gene
Organism: zebrafish
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Gene
712478 | PAN2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030843 | PAN2
Type: Family
Description: Pan2 is a catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. Pan2 is involved in the initial stage of deadenylation of mRNA, which is required for poly(A) tail shortening []. Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment tomRNA targets [].
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Protein Coding Gene
MGI:1918984 | Pan2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8550599 | -
First Author: Boeck R
Year: 1996
Journal: J Biol Chem
Title: The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.
Volume: 271
Issue: 1
Pages: 432-8
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Publication
24880343 | -
First Author: Jonas S
Year: 2014
Journal: Nat Struct Mol Biol
Title: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.
Volume: 21
Issue: 7
Pages: 599-608
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Publication
24872509 | -
First Author: Wolf J
Year: 2014
Journal: EMBO J
Title: Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.
Volume: 33
Issue: 14
Pages: 1514-26
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Protein
Q8BGF7
Organism: Mus musculus/domesticus
Length: 1200  
Fragment?: false
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Publication
16284618 | -
First Author: Yamashita A
Year: 2005
Journal: Nat Struct Mol Biol
Title: Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover.
Volume: 12
Issue: 12
Pages: 1054-63
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Publication
11283721 | -
First Author: Wilusz CJ
Year: 2001
Journal: Nat Rev Mol Cell Biol
Title: The cap-to-tail guide to mRNA turnover.
Volume: 2
Issue: 4
Pages: 237-46
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Protein Coding Gene
MGP_CAROLIEiJ_G0015930 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017833 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017797 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017719 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018292 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031154 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016755 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6393669
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:6393690
Age: postnatal adult
Image: S1
Specimen Label: GV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6393669
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6393690
Age: postnatal adult
Image: S1
Specimen Label: MII 16h
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6393669
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:6393690
Age: embryonic day 0.5
Image: S1
Specimen Label: Zygote
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6393669
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:6393690
Age: embryonic day 1.5
Image: S1
Specimen Label: 2-cell
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6393669
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:6393690
Age: embryonic day 2.0
Image: S1
Specimen Label: 4-cell
Detected: true
Specimen Num: 5
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Publication
18625844 | J:139263
First Author: Zheng D
Year: 2008
Journal: J Cell Biol
Title: Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.
Volume: 182
Issue: 1
Pages: 89-101
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Publication
31777931 | J:285122
First Author: Sha QQ
Year: 2020
Journal: Nucleic Acids Res
Title: Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.
Volume: 48
Issue: 2
Pages: 879-894
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Protein
Q9ERI6
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Gene
100036851 | pan2.L
Type: gene
Organism: frog, African clawed
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Gene
444430 | pan2.S
Type: gene
Organism: frog, African clawed
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UniProt Feature
UniProt Feature
Begin: 1
Description: PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Type: chain
End: 1200
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Protein
Q8BGF7-2
Organism: Mus musculus/domesticus
Length: 1191  
Fragment?: false
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Protein
Q8BGF7-3
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: false
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Protein
Q8BGF7-4
Organism: Mus musculus/domesticus
Length: 1166  
Fragment?: false
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Allele
Pan2<+> | MGI:3049817
   
Name: PAN2 poly(A) specific ribonuclease subunit; wild type
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Allele
Pan2<Gt(RRM126)Byg> | MGI:4130097
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap RRM126, BayGenomics
Allele Type: Gene trapped
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Allele
Pan2<Gt(OST142315)Lex> | MGI:4202610
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap OST142315, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pan2<Gt(OST354958)Lex> | MGI:4291877
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap OST354958, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pan2<Gt(OST378834)Lex> | MGI:4300166
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap OST378834, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pan2<m1Anu> | MGI:5563441
 
Name: PAN2 poly(A) specific ribonuclease subunit; mutation 1, Australian National University
Allele Type: Chemically induced (ENU)
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Allele
Pan2<Gt(XT0188)Wtsi> | MGI:3867175
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap XT0188, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Pan2<Gt(PST18019)Mfgc> | MGI:3901770
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap PST18019, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pan2<Gt(PST25182)Mfgc> | MGI:3904662
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap PST25182, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pan2<Gt(IST12491A11)Tigm> | MGI:4071844
 
Name: PAN2 poly(A) specific ribonuclease subunit; gene trap IST12491A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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