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Search results 1 to 100 out of 122 for Pan3

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
255967 | PAN3
Type: gene
Organism: human
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Gene
550055 | pan3
Type: gene
Organism: frog, western clawed
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Gene
360760 | Pan3
Type: gene
Organism: rat
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Gene
486024 | PAN3
Type: gene
Organism: dog, domestic
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Gene
736229 | PAN3
Type: gene
Organism: chimpanzee
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Gene
418926 | PAN3
Type: gene
Organism: chicken
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Gene
100126012 | pan3
Type: gene
Organism: zebrafish
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Gene
519743 | PAN3
Type: gene
Organism: cattle
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Gene
711494 | PAN3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030844 | PAN3
Type: Family
Description: Pan3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. It contains a PABP-interacting motif 2 (PAM2) that binds to the C-terminal domain of polyA binding proteins (PABPs) []. It recruits the Pan2-Pan3 complex to mRNA through the Pan3-PABP interaction [].Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment to mRNA targets [].
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Protein Coding Gene
MGI:1919837 | Pan3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0J9YV55
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
H3BJ17
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Protein
Q5U221
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
H3BKF3
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
H3BJA8
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
H3BLB9
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Protein
H3BJH6
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
Q640Q5
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Publication
24880343 | -
First Author: Jonas S
Year: 2014
Journal: Nat Struct Mol Biol
Title: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.
Volume: 21
Issue: 7
Pages: 599-608
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Publication
24872509 | -
First Author: Wolf J
Year: 2014
Journal: EMBO J
Title: Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.
Volume: 33
Issue: 14
Pages: 1514-26
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Publication
17595167 | -
First Author: Siddiqui N
Year: 2007
Journal: J Biol Chem
Title: Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
Volume: 282
Issue: 34
Pages: 25067-75
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Gene
100288730 | PAN3-AS1
Type: gene
Organism: human
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Publication
8550599 | -
First Author: Boeck R
Year: 1996
Journal: J Biol Chem
Title: The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.
Volume: 271
Issue: 1
Pages: 432-8
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Publication
16284618 | -
First Author: Yamashita A
Year: 2005
Journal: Nat Struct Mol Biol
Title: Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover.
Volume: 12
Issue: 12
Pages: 1054-63
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Publication
11283721 | -
First Author: Wilusz CJ
Year: 2001
Journal: Nat Rev Mol Cell Biol
Title: The cap-to-tail guide to mRNA turnover.
Volume: 2
Issue: 4
Pages: 237-46
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Protein Coding Gene
MGP_CAROLIEiJ_G0028040 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030372 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919837 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029488 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030198 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029202 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024606 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029038 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
18625844 | J:139263
First Author: Zheng D
Year: 2008
Journal: J Cell Biol
Title: Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.
Volume: 182
Issue: 1
Pages: 89-101
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Publication
26178733 | J:316183
 
First Author: Cai Y
Year: 2015
Journal: BMC Pulm Med
Title: Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
Volume: 15
Pages: 72
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Publication
23932717 | -
First Author: Christie M
Year: 2013
Journal: Mol Cell
Title: Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.
Volume: 51
Issue: 3
Pages: 360-73
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Protein Domain
IPR041332 | Pan3_PK
Type: Domain
Description: This is a pseudokinase (PK) domain found in PAB-dependent poly(A)-specific ribonuclease subunit PAN3. PAN3 proteins contain three prominent regions: an unstructured N-terminal region (N-term), a central PK domain, and a highly conserved C-terminal domain (C-term). The PAN3 PK domain has retained its ATP binding capacity, and this function is required for mRNA degradation in vivo. Analysis of Pan3 amino acids sequences show that, despite of retaining the general structural characteristics of protein kinases, the PK domain has substitutions in all the conserved motifs that are critical for kinase activity, such as in the catalytic VAIK and HRD motifs and in the Mg2+ binding DFG motif. However, the PAN3 PK domain has been shown to bind ATP. Furthermore, similar to other kinases, the ATP-binding site is located in the cleft between the N- and C-lobes of the kinase fold, however, the ATP-binding pocket is wider than that of typical kinases [].
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UniProt Feature
UniProt Feature
Begin: 1
Description: PAN2-PAN3 deadenylation complex subunit Pan3
Type: chain
End: 837
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Gene
100190773 | pan3.S
Type: gene
Organism: frog, African clawed
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Gene
108708701 | pan3.L
Type: gene
Organism: frog, African clawed
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Protein
Q640Q5-2
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Protein
H3BL68
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
H3BKQ1
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Allele
Pan3<+> | MGI:3620223
 
Name: PAN3 poly(A) specific ribonuclease subunit; wild type
Allele Type: Not Specified
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Allele
Pan3<Gt(BGB533)Byg> | MGI:3858872
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap BGB533, BayGenomics
Allele Type: Gene trapped
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Allele
Pan3<Gt(YHB182)Byg> | MGI:3870095
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap YHB182, BayGenomics
Allele Type: Gene trapped
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Allele
Pan3<Gt(CSH548)Byg> | MGI:3878546
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap CSH548, BayGenomics
Allele Type: Gene trapped
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Allele
Pan3<Gt(CSI758)Byg> | MGI:3880221
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap CSI758, BayGenomics
Allele Type: Gene trapped
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Allele
Pan3<Gt(XG307)Byg> | MGI:4125683
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap XG307, BayGenomics
Allele Type: Gene trapped
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Allele
Pan3<Gt(OST65480)Lex> | MGI:4170553
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap OST65480, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pan3<Gt(OST348431)Lex> | MGI:4289298
 
Name: PAN3 poly(A) specific ribonuclease subunit; gene trap OST348431, Lexicon Genetics
Allele Type: Gene trapped
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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