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Search results 1 to 100 out of 1057 for Parp1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
142 | PARP1
Type: gene
Organism: human
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Gene
100490557 | parp1
Type: gene
Organism: frog, western clawed
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Gene
25591 | Parp1
Type: gene
Organism: rat
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Gene
457785 | PARP1
Type: gene
Organism: chimpanzee
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Gene
490385 | PARP1
Type: gene
Organism: dog, domestic
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Gene
286764 | PARP1
Type: gene
Organism: cattle
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Gene
396199 | PARP1
Type: gene
Organism: chicken
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Gene
560788 | parp1
Type: gene
Organism: zebrafish
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Gene
698806 | PARP1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1340806 | Parp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
55010 | PARPBP
Type: gene
Organism: human
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Publication
39056235 | J:361044
 
First Author: Karpova Y
Year: 2024
Journal: G3 (Bethesda)
Title: Adaptive genetic mechanisms in mammalian Parp1 locus.
Volume: 14
Issue: 9
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GXD Expression
GXD Expression
     
Probe: MGI:7577459
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-29
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:2917722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7577465
Age: embryonic day 14.5
Specimen Label: 3C PARP1 Control
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7577459
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-29
Strength: Weak
Sex: Male
Emaps: EMAPS:2918122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7577465
Age: embryonic day 14.5
Specimen Label: 3C PARP1 Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7577459
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-29
Strength: Present
Sex: Male
Emaps: EMAPS:2918122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7577465
Age: embryonic day 14.5
Note: No difference in percentage of apoptotic cells in either epithelial or mesenchymal compartments.
Specimen Label: 3C PARP1 ARcKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7577459
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-29
Strength: Trace
Sex: Male
Emaps: EMAPS:2917722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7577465
Age: embryonic day 14.5
Note: No difference in percentage of apoptotic cells in either epithelial or mesenchymal compartments.
Specimen Label: 3C PARP1 ARcKO
Detected: true
Specimen Num: 2
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Publication
38481797 | J:346121
First Author: Shu J
Year: 2024
Journal: Int J Biol Sci
Title: PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation.
Volume: 20
Issue: 5
Pages: 1602-1616
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GXD Expression
GXD Expression
Probe: MGI:5762883
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7781731
Age: postnatal day 0
Image: 2A PARP1 KO
Note: Expression illustrates a thinner layer in this mutant.
Specimen Label: 2A PARP1 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5762883
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7781731
Age: postnatal day 0
Image: 2E PARP1 KO
Note: Expression illustrates a thinner layer in this mutant.
Specimen Label: 2E PARP1 KO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3526687
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7781768
Age: postnatal day 5
Image: 4E PARP1 KO
Note: This mutant has an increased number of Cajal-Retzius cells.
Specimen Label: 4E PARP1 KO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5447971
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7781729
Age: postnatal day 0
Image: 2A PARP1 KO
Note: Expression illustrates a thinner layer in this mutant.
Specimen Label: 2A PARP1 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3526687
Assay Type: Immunohistochemistry
Annotation Date: 2024-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7781768
Age: embryonic day 15.5
Image: 4A PARP1 KO
Note: This mutant has an increased number of Cajal-Retzius cells along the marginal zone and a reduction in marginal zone thickness.
Specimen Label: 4A PARP1 KO
Detected: true
Specimen Num: 2
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Publication
37676769 | J:341198
First Author: Desingu PA
Year: 2023
Journal: Cell Rep
Title: PARP1 inhibition protects mice against Japanese encephalitis virus infection.
Volume: 42
Issue: 9
Pages: 113103
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Publication
28002403 | J:241443
First Author: Hoch NC
Year: 2017
Journal: Nature
Title: XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Volume: 541
Issue: 7635
Pages: 87-91
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Publication
16436506 | J:112470
First Author: Gomez M
Year: 2006
Journal: Mol Biol Cell
Title: PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
Volume: 17
Issue: 4
Pages: 1686-96
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Publication
34798058 | J:325961
First Author: Zada D
Year: 2021
Journal: Mol Cell
Title: Parp1 promotes sleep, which enhances DNA repair in neurons.
Volume: 81
Issue: 24
Pages: 4979-4993.e7
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Publication
18093987 | J:161913
First Author: von Lukowicz T
Year: 2008
Journal: Cardiovasc Res
Title: PARP1 is required for adhesion molecule expression in atherogenesis.
Volume: 78
Issue: 1
Pages: 158-66
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Publication
20660013 | J:173824
First Author: Claybon A
Year: 2010
Journal: Nucleic Acids Res
Title: PARP1 suppresses homologous recombination events in mice in vivo.
Volume: 38
Issue: 21
Pages: 7538-45
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Publication
30830864 | J:291285
 
First Author: Mashimo M
Year: 2019
Journal: JCI Insight
Title: PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.
Volume: 4
Issue: 4
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Publication
38932202 | J:360568
 
First Author: Mire MM
Year: 2024
Journal: Viruses
Title: Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology.
Volume: 16
Issue: 6
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Publication
32221289 | J:287174
First Author: Zuo H
Year: 2020
Journal: Nat Commun
Title: Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.
Volume: 11
Issue: 1
Pages: 1578
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Publication
21124852 | J:167317
First Author: Sahaboglu A
Year: 2010
Journal: PLoS One
Title: PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
Volume: 5
Issue: 11
Pages: e15495
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Publication
29748565 | J:263720
First Author: Pettitt SJ
Year: 2018
Journal: Nat Commun
Title: Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Volume: 9
Issue: 1
Pages: 1849
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Publication
42139290 | J:386347
First Author: Jhaldiyal A
Year: 2026
Journal: Proc Natl Acad Sci U S A
Title: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer's disease model.
Volume: 123
Issue: 20
Pages: e2525028123
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Publication
34364219 | J:317149
 
First Author: Wang ZY
Year: 2021
Journal: Redox Biol
Title: PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice.
Volume: 46
Pages: 102084
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Publication
38071218 | J:343730
First Author: Krug S
Year: 2023
Journal: Nat Commun
Title: Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide.
Volume: 14
Issue: 1
Pages: 8161
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Publication
37487079 | J:340904
First Author: Shao Z
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Volume: 120
Issue: 31
Pages: e2301972120
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Publication
35460603 | J:325965
First Author: Wang F
Year: 2022
Journal: Mol Cell
Title: Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
Volume: 82
Issue: 11
Pages: 2032-2049.e7
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Publication
29898385 | J:270938
First Author: Sullivan-Reed K
Year: 2018
Journal: Cell Rep
Title: Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.
Volume: 23
Issue: 11
Pages: 3127-3136
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Publication
28272405 | J:244771
 
First Author: Ke Y
Year: 2017
Journal: Nat Commun
Title: PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.
Volume: 8
Pages: 14632
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Publication
22902501 | J:187148
First Author: Doege CA
Year: 2012
Journal: Nature
Title: Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.
Volume: 488
Issue: 7413
Pages: 652-5
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Publication
19364882 | J:148503
First Author: Robert I
Year: 2009
Journal: J Exp Med
Title: Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
Volume: 206
Issue: 5
Pages: 1047-56
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Publication
26986624 | J:253544
First Author: Shang F
Year: 2016
Journal: PLoS One
Title: Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
Volume: 11
Issue: 3
Pages: e0151845
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Publication
22464733 | J:188026
First Author: Erener S
Year: 2012
Journal: Mol Cell
Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-?B target genes.
Volume: 46
Issue: 2
Pages: 200-11
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Publication
19531481 | J:153457
First Author: Gao F
Year: 2009
Journal: J Biol Chem
Title: PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.
Volume: 284
Issue: 33
Pages: 22263-22273
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Publication
27662363 | J:380306
First Author: Yu C
Year: 2016
Journal: Cell Death Differ
Title: FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Volume: 23
Issue: 11
Pages: 1873-1885
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Publication
35393951 | J:378815
 
First Author: Li L
Year: 2022
Journal: JCI Insight
Title: Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXR?-mediated ABCA1 expression.
Volume: 7
Issue: 7
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Publication
22614020 | J:197234
First Author: Rybanska I
Year: 2013
Journal: Oncogene
Title: PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.
Volume: 32
Issue: 14
Pages: 1761-71
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Publication
17318223 | J:139260
First Author: Wang X
Year: 2007
Journal: Cell Death Differ
Title: Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Volume: 14
Issue: 5
Pages: 924-31
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Publication
28751718 | J:247687
First Author: Knittel G
Year: 2017
Journal: Nat Commun
Title: Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia.
Volume: 8
Issue: 1
Pages: 153
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Publication
19262751 | J:147377
First Author: Zampieri M
Year: 2009
Journal: PLoS One
Title: Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.
Volume: 4
Issue: 3
Pages: e4717
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Publication
27041572 | J:235982
First Author: Na TY
Year: 2016
Journal: Oncogene
Title: Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma.
Volume: 35
Issue: 41
Pages: 5435-5445
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Publication
32139900 | J:382223
First Author: Zhang N
Year: 2020
Journal: Cell Death Differ
Title: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Volume: 27
Issue: 9
Pages: 2605-2619
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Publication
21228215 | J:173720
First Author: Meyer-Ficca ML
Year: 2011
Journal: Biol Reprod
Title: Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.
Volume: 84
Issue: 5
Pages: 900-9
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Publication
27373144 | J:320547
 
First Author: Ghosh R
Year: 2016
Journal: DNA Repair (Amst)
Title: Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.
Volume: 45
Pages: 56-62
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Publication
21187397 | J:169700
First Author: Goldberg MS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Volume: 108
Issue: 2
Pages: 745-50
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Publication
28977496 | J:249307
First Author: Schuhwerk H
Year: 2017
Journal: Nucleic Acids Res
Title: Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
Volume: 45
Issue: 19
Pages: 11174-11192
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Publication
21762709 | J:175069
First Author: Pacchierotti F
Year: 2011
Journal: Mutat Res
Title: In vivo repair of DNA damage induced by X-rays in the early stages of mouse fertilization, and the influence of maternal PARP1 ablation.
Volume: 714
Issue: 1-2
Pages: 44-52
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Publication
25378300 | J:218220
First Author: Szczesny B
Year: 2014
Journal: Nucleic Acids Res
Title: Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.
Volume: 42
Issue: 21
Pages: 13161-73
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HT Experiment
GSE248429 | PARP1 knockout mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27568560 | J:239021
First Author: Van Meter M
Year: 2016
Journal: Cell Rep
Title: JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.
Volume: 16
Issue: 10
Pages: 2641-2650
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GXD Expression
GXD Expression
Probe: MGI:5812130
Assay Type: Immunohistochemistry
Annotation Date: 2016-12-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160398
Pattern: Single cells
Stage: TS08
Assay Id: MGI:5812131
Age: embryonic day 5.5
Image: 3B Cdh1-/-
Note: There were more than five cleaved Parp1 cells in 7/7 embryos.
Specimen Label: 3B Cdh1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5812130
Assay Type: Immunohistochemistry
Annotation Date: 2025-11-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:8260929
Age: embryonic day 14.5
Image: S5C
Note: There was no correlation of Parp1 staining with GFP reporter high or low levels.
Specimen Label: S5C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5812130
Assay Type: Immunohistochemistry
Annotation Date: 2025-11-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:8260929
Age: embryonic day 18.5
Image: S5F
Note: There was no correlation of Parp1 staining with GFP reporter high or low levels.
Specimen Label: S5F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5812130
Assay Type: Immunohistochemistry
Annotation Date: 2016-12-15
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:160398
Pattern: Single cells
Stage: TS08
Assay Id: MGI:5812131
Age: embryonic day 5.5
Image: 3B Control
Note: There were no cleaved Parp1 cells in 16/20 embryos and 1 or 2 cleaved Parp cells in 4/20 embryos (shown).
Specimen Label: 3B Control
Detected: true
Specimen Num: 1
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Gene
452182 | PARPBP
Type: gene
Organism: chimpanzee
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Gene
612196 | PARPBP
Type: gene
Organism: dog, domestic
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Gene
615510 | PARPBP
Type: gene
Organism: cattle
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Gene
100310874 | Parpbp
Type: gene
Organism: rat
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Gene
418092 | PARPBP
Type: gene
Organism: chicken
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Gene
678635 | parpbp
Type: gene
Organism: zebrafish
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Gene
696907 | PARPBP
Type: gene
Organism: macaque, rhesus
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Gene
733805 | parpbp
Type: gene
Organism: frog, western clawed
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Gene
734977 | parpbp.L
Type: gene
Organism: frog, African clawed
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Protein Coding Gene
MGI:1922567 | Parpbp
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20561897 | J:344640
First Author: Mangerich A
Year: 2010
Journal: Mech Ageing Dev
Title: Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
Volume: 131
Issue: 6
Pages: 389-404
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Publication
30819402 | J:291729
First Author: Ju C
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Poly(ADP-ribose) Polymerase-1 is required for hepatocyte proliferation and liver regeneration in mice.
Volume: 511
Issue: 3
Pages: 531-535
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Publication
20515923 | J:161818
First Author: Altmeyer M
Year: 2010
Journal: Infect Immun
Title: Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation.
Volume: 78
Issue: 8
Pages: 3420-31
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Publication
29284668 | J:258234
First Author: Azad GK
Year: 2018
Journal: J Cell Biol
Title: PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation.
Volume: 217
Issue: 2
Pages: 473-481
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Publication
22121211 | J:197737
First Author: Hieb AR
Year: 2012
Journal: Nucleic Acids Res
Title: Fluorescence strategies for high-throughput quantification of protein interactions.
Volume: 40
Issue: 5
Pages: e33
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Publication
21680843 | J:173531
First Author: Mao Z
Year: 2011
Journal: Science
Title: SIRT6 promotes DNA repair under stress by activating PARP1.
Volume: 332
Issue: 6036
Pages: 1443-6
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Publication
19034683 | J:147608
First Author: Mangerich A
Year: 2009
Journal: Transgenic Res
Title: A caveat in mouse genetic engineering: ectopic gene targeting in ES cells by bidirectional extension of the homology arms of a gene replacement vector carrying human PARP-1.
Volume: 18
Issue: 2
Pages: 261-79
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Publication
23268447 | J:200220
First Author: Liu C
Year: 2013
Journal: Nucleic Acids Res
Title: CHFR is important for the first wave of ubiquitination at DNA damage sites.
Volume: 41
Issue: 3
Pages: 1698-710
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Publication
28032120 | J:255945
 
First Author: Wang X
Year: 2016
Journal: eNeuro
Title: Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.
Volume: 3
Issue: 6
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Publication
26598704 | J:228126
First Author: Brochier C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration.
Volume: 112
Issue: 49
Pages: 15220-5
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Publication
37165001 | J:335559
First Author: Hiroki H
Year: 2023
Journal: Sci Rep
Title: Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells.
Volume: 13
Issue: 1
Pages: 7588
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Publication
18242645 | J:133514
First Author: Louro H
Year: 2008
Journal: Mutat Res
Title: Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.
Volume: 640
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