Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The clustered protocadherin (Pcdh) family is the largest subgroup of the cadherin superfamily. In mammals, the clustered Pcdh family consists of three gene clusters: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma (Pcdhg) []. The genomic organisation of the human protocadherin gene clusters is remarkably similar to that of immunoglobulin and T-cell receptor genes. The extracellular and transmembrane domains of each protocadherin protein are encoded by an unusually large "variable"region exon, while the intracellular domains are encoded by three small "constant"region exons located downstream from a tandem array of variable region exons [, ]. The clustered Pcdh proteins are predominantly expressed in the brain []. Pcdh cluster genes may contribute to specifying the identity and diversity of individual neurons [].Pcdhs-alpha are involved in axonal coalescence of olfactory sensory neurons []and visual acuity in mice []. The Pcdh-alpha gene cluster contains 14 members in mouse. This entry represents protocadherin alpha-C2. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Q |
Year: |
2001 |
Journal: |
Genome Res |
Title: |
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. |
Volume: |
11 |
Issue: |
3 |
Pages: |
389-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Q |
Year: |
1999 |
Journal: |
Cell |
Title: |
A striking organization of a large family of human neural cadherin-like cell adhesion genes. |
Volume: |
97 |
Issue: |
6 |
Pages: |
779-90 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1006
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yagi T |
Year: |
2008 |
Journal: |
Dev Growth Differ |
Title: |
Clustered protocadherin family. |
Volume: |
50 Suppl 1 |
|
Pages: |
S131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirano K |
Year: |
2012 |
Journal: |
Front Mol Neurosci |
Title: |
Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. |
Volume: |
5 |
|
Pages: |
90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa S |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. |
Volume: |
38 |
Issue: |
1 |
Pages: |
66-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meguro R |
Year: |
2015 |
Journal: |
J Neurochem |
Title: |
Impaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice. |
Volume: |
133 |
Issue: |
1 |
Pages: |
66-72 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gallerani N |
Year: |
2020 |
Journal: |
Cereb Cortex Commun |
Title: |
Loss of Clustered Protocadherin Diversity Alters the Spatial Distribution of Cortical Interneurons in Mice. |
Volume: |
1 |
Issue: |
1 |
Pages: |
tgaa089 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789313 |
Assay Type: |
Western blot |
Annotation Date: |
2016-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5789343 |
Age: |
postnatal day 21 |
Image: |
2 |
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789313 |
Assay Type: |
Western blot |
Annotation Date: |
2016-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5789343 |
Age: |
postnatal day 21 |
Image: |
2 |
|
Specimen Label: |
+/deltaA |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789313 |
Assay Type: |
Western blot |
Annotation Date: |
2016-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5789343 |
Age: |
postnatal day 21 |
Image: |
2 |
|
Specimen Label: |
deltaA/deltaA |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789313 |
Assay Type: |
Western blot |
Annotation Date: |
2016-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5789343 |
Age: |
postnatal day 21 |
Image: |
2 |
|
Specimen Label: |
+/deltaCR |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5789313 |
Assay Type: |
Western blot |
Annotation Date: |
2016-08-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5789343 |
Age: |
postnatal day 21 |
Image: |
2 |
|
Specimen Label: |
deltaCR/deltaCR |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7489707 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:7489730 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7489707 |
Assay Type: |
RT-PCR |
Annotation Date: |
2023-06-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:7489730 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Dnmt3b-KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7711026 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7711220 |
Age: |
embryonic day 14.0 |
Image: |
1 |
|
Specimen Label: |
control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7711026 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7711220 |
Age: |
embryonic day 14.0 |
Image: |
1 |
|
Specimen Label: |
CtcfNesCre |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7712159 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7712931 |
Age: |
postnatal day 30 |
Image: |
1 |
|
Specimen Label: |
Pcdhc2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katori S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Protocadherin-αC2 is required for diffuse projections of serotonergic axons. |
Volume: |
7 |
Issue: |
1 |
Pages: |
15908 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen WV |
Year: |
2017 |
Journal: |
Science |
Title: |
Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. |
Volume: |
356 |
Issue: |
6336 |
Pages: |
406-411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katori S |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas. |
Volume: |
29 |
Issue: |
29 |
Pages: |
9137-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. |
Volume: |
16 |
Issue: |
15 |
Pages: |
1890-905 |
|
•
•
•
•
•
|
Publication |
First Author: |
Esumi S |
Year: |
2005 |
Journal: |
Nat Genet |
Title: |
Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons. |
Volume: |
37 |
Issue: |
2 |
Pages: |
171-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morishita H |
Year: |
2004 |
Journal: |
Neuroreport |
Title: |
CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity. |
Volume: |
15 |
Issue: |
17 |
Pages: |
2595-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu S |
Year: |
2007 |
Journal: |
Nat Genet |
Title: |
Toward simpler and faster genome-wide mutagenesis in mice. |
Volume: |
39 |
Issue: |
7 |
Pages: |
922-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toyoda S |
Year: |
2014 |
Journal: |
Neuron |
Title: |
Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. |
Volume: |
82 |
Issue: |
1 |
Pages: |
94-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan L |
Year: |
2018 |
Journal: |
Elife |
Title: |
Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mancia Leon WR |
Year: |
2020 |
Journal: |
Elife |
Title: |
Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Elbert A |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. |
Volume: |
39 |
Issue: |
1 |
Pages: |
177-192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Norman TA Jr |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. |
Volume: |
14 |
Issue: |
5 |
Pages: |
e0216795 |
|
•
•
•
•
•
|