Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The clustered protocadherin (Pcdh) family is the largest subgroup of the cadherin superfamily. In mammals, the clustered Pcdh family consists of three gene clusters: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma (Pcdhg) []. The genomic organisation of the human protocadherin gene clusters is remarkably similar to that of immunoglobulin and T-cell receptor genes. The extracellular and transmembrane domains of each protocadherin protein are encoded by an unusually large "variable"region exon, while the intracellular domains are encoded by three small "constant"region exons located downstream from a tandem array of variable region exons [, ]. The clustered Pcdh proteins are predominantly expressed in the brain []. Pcdh cluster genes may contribute to specifying the identity and diversity of individual neurons [].This entry represents protocadherin beta-2. |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7712084 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7712885 |
Age: |
postnatal day 30 |
Image: |
1 |
|
Specimen Label: |
Pcdhb2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Q |
Year: |
2001 |
Journal: |
Genome Res |
Title: |
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. |
Volume: |
11 |
Issue: |
3 |
Pages: |
389-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Q |
Year: |
1999 |
Journal: |
Cell |
Title: |
A striking organization of a large family of human neural cadherin-like cell adhesion genes. |
Volume: |
97 |
Issue: |
6 |
Pages: |
779-90 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
595
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
799
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
799
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yagi T |
Year: |
2008 |
Journal: |
Dev Growth Differ |
Title: |
Clustered protocadherin family. |
Volume: |
50 Suppl 1 |
|
Pages: |
S131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirano K |
Year: |
2012 |
Journal: |
Front Mol Neurosci |
Title: |
Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. |
Volume: |
5 |
|
Pages: |
90 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7711038 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7711242 |
Age: |
embryonic day 14.0 |
Image: |
1 |
|
Specimen Label: |
control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7711038 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-08-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7711242 |
Age: |
embryonic day 14.0 |
Image: |
1 |
|
Specimen Label: |
CtcfNesCre |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanhalst K |
Year: |
2001 |
Journal: |
FEBS Lett |
Title: |
The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. |
Volume: |
495 |
Issue: |
1-2 |
Pages: |
120-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu L |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. |
Volume: |
7 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa S |
Year: |
2016 |
Journal: |
Front Mol Neurosci |
Title: |
Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. |
Volume: |
9 |
|
Pages: |
155 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mancia Leon WR |
Year: |
2020 |
Journal: |
Elife |
Title: |
Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Elbert A |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. |
Volume: |
39 |
Issue: |
1 |
Pages: |
177-192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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•
•
•
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•
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