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Search results 1 to 100 out of 213 for Pcf11

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
51585 | PCF11
Type: gene
Organism: human
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Gene
361605 | Pcf11
Type: gene
Organism: rat
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Gene
476786 | PCF11
Type: gene
Organism: dog, domestic
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Gene
451458 | PCF11
Type: gene
Organism: chimpanzee
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Gene
510604 | PCF11
Type: gene
Organism: cattle
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Gene
419021 | PCF11
Type: gene
Organism: chicken
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Gene
492341 | pcf11
Type: gene
Organism: zebrafish
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Gene
704490 | PCF11
Type: gene
Organism: macaque, rhesus
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Gene
100170197 | pcf11
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1919579 | Pcf11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A5HLW0
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: true
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Protein
A5HLW1
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: true
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Gene
106736475 | PCF11-AS1
Type: gene
Organism: human
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Protein Coding Gene
MGP_CAROLIEiJ_G0029991 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032487 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919579 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032180 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032332 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032322 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031657 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013211 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031101 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Protein
Q8R2P5
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: true
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Protein
Q99KH9
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: true
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Protein
Q8K0S1
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Protein
Q6PCW0
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: true
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Protein
Q80V88
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
F6UFZ5
Organism: Mus musculus/domesticus
Length: 1476  
Fragment?: true
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Protein
G3X9Z4
Organism: Mus musculus/domesticus
Length: 1553  
Fragment?: false
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Publication
30819644 | -
First Author: Kamieniarz-Gdula K
Year: 2019
Journal: Mol Cell
Title: Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Volume: 74
Issue: 1
Pages: 158-172.e9
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Allele
Pcf11<+> | MGI:3588667
 
Name: PCF11 cleavage and polyadenylation factor subunit; wild type
Allele Type: Not Specified
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Allele
Pcf11<Gt(RRP157)Byg> | MGI:4329192
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap RRP157, BayGenomics
Allele Type: Gene trapped
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Publication
15665873 | -
First Author: Noble CG
Year: 2005
Journal: Nat Struct Mol Biol
Title: Key features of the interaction between Pcf11 CID and RNA polymerase II CTD.
Volume: 12
Issue: 2
Pages: 144-51
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Allele
Pcf11<Gt(OST207987)Lex> | MGI:4232584
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap OST207987, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pcf11<Gt(OST267717)Lex> | MGI:4257527
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap OST267717, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pcf11<Gt(OST375724)Lex> | MGI:4298806
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap OST375724, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pcf11<Gt(OST456677)Lex> | MGI:4324048
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap OST456677, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Pcf11<Gt(PST5967)Mfgc> | MGI:4342461
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap PST5967, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Pcf11<Gt(EUCE0015g09)Hmgu> | MGI:4392679
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap EUCE0015g09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Pcf11<tm1a(EUCOMM)Wtsi> | MGI:4461698
Name: PCF11 cleavage and polyadenylation factor subunit; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Pcf11<tm1e(EUCOMM)Wtsi> | MGI:4461768
Name: PCF11 cleavage and polyadenylation factor subunit; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Pcf11<Gt(S13-2G1)Sor> | MGI:4974136
 
Name: PCF11 cleavage and polyadenylation factor subunit; gene trap S13-2G1, Philippe Soriano
Allele Type: Gene trapped
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Publication
21993299 | -
First Author: Ghazy MA
Year: 2012
Journal: Nucleic Acids Res
Title: The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.
Volume: 40
Issue: 3
Pages: 1214-25
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Protein Domain
IPR045154 | PCF11-like
Type: Family
Description: This entry includes Pcf11 and related proteins from animals, fungi and plants.PCF11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [, , ]. It has been reported that PCF11-mediated termination is essential for vertebrate development and its own levels are maintained by an auto-regulatory mechanism involving premature termination of its transcript []. PCF11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [, ].
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Protein Domain
IPR038192 | CSTF_C_sf
Type: Homologous_superfamily
Description: The C-terminal section of cleavage stimulation and termination factor CstF-64 (CSTF2) and its yeast orthologue Rna15 form a discrete structure that is crucial for mRNA 3'-end processing []. This domain interacts with Pcf11 and possibly PC4, thus linking CSTF2 to transcription, transcriptional termination, and cell growth [].
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Publication
17116658 | -
First Author: Qu X
Year: 2007
Journal: J Biol Chem
Title: The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing.
Volume: 282
Issue: 3
Pages: 2101-15
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Publication
12773397 | -
First Author: Dheur S
Year: 2003
Journal: EMBO J
Title: Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation.
Volume: 22
Issue: 11
Pages: 2831-40
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Protein Domain
IPR026896 | CSTF_C
Type: Domain
Description: The C-terminal section of cleavage stimulation and termination factor CstF-64 (CSTF2) and its yeast orthologue Rna15 form a discreet structure that is crucial for mRNA 3'-end processing []. This domain interacts with Pcf11 and possibly PC4, thus linking CSTF2 to transcription, transcriptional termination, and cell growth [].Proteins containing this domain also include Pti1 protein from budding yeast. Pti1 is an essential component of CPF (cleavage and polyadenylation factor) involved in 3' end formation of snoRNA and mRNA [].
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Publication
12727883 | -
First Author: Sadowski M
Year: 2003
Journal: EMBO J
Title: Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination.
Volume: 22
Issue: 9
Pages: 2167-77
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Publication
30139799 | -
First Author: Schäfer P
Year: 2018
Journal: RNA
Title: Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.
Volume: 24
Issue: 12
Pages: 1721-1737
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Protein Domain
IPR021605 | CFIA_Pcf11_C
Type: Domain
Description: This entry represents the Clp1-interacting domain of Pcf11, found towards the C-terminal end of these proteins.PCF11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [, , ]. It has been reported that PCF11-mediated termination is essential for vertebrate development and its own levels are maintained by an auto-regulatory mechanism involving premature termination of its transcript []. PCF11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [, ].
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Publication
19887456 | -
First Author: Hockert JA
Year: 2010
Journal: J Biol Chem
Title: The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation.
Volume: 285
Issue: 1
Pages: 695-704
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Protein
Q3TT32
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: true
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Protein
Q3TTQ0
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: true
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Protein
Q69ZY3
Organism: Mus musculus/domesticus
Length: 1641  
Fragment?: true
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Protein
B2RX07
Organism: Mus musculus/domesticus
Length: 1553  
Fragment?: false
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Protein
A0A338P6R5
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
15241417 | -
First Author: Meinhart A
Year: 2004
Journal: Nature
Title: Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors.
Volume: 430
Issue: 6996
Pages: 223-6
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Protein Domain
IPR006569 | CID_dom
Type: Domain
Description: The C-terminal domain (CTD) of the large subunit of RNA polymerase II is aplatform for mRNA processing factors and links gene transcription to mRNAcapping, splicing and polyadenylation. CTD recognition is dependent on thephosphorylation state of the CTD itself, which varies during the course oftranscription but has also been linked to the isomerization state of the CTD'sproline residues. Several RNA-processing factors recognise the CTD by means ofa conserved CTD-interacting domain (CID). Factors with CID domains include theserine/arginine-rich-like factors SCAF4 and SCAF8, Nrd1 (which is implicatedin polyadenylation-independent RNA 3'-end formation) and Pcf11. Pcf11 is aconserved and essential subunit of the yeast cleavage factor 1A, which isrequired for 3'-RNA processing and transcription termination [, ].The CID domain is a right-handed superhelix of eight α-helices forming acompact domain. The CID fold closely resembles that of VHSdomains and is related to armadillo-repeat proteins , except for the two amino-terminal helices. Amino acid residuesin the hydrophobic core of the domain are highly conserved across CID domains[, ].
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Publication
17151076 | -
First Author: Noble CG
Year: 2007
Journal: Nucleic Acids Res
Title: Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.
Volume: 35
Issue: 1
Pages: 87-99
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Protein
Q9CSU0
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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