Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Procollagen C-endopeptidase enhancer 1 (PCPE1 or PCOLCE) and 2 (PCPE2 or PCOLCE2) are collagen-binding proteins capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases. PCOLCE1 binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahara K |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE). |
Volume: |
269 |
Issue: |
42 |
Pages: |
26280-5 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Riboldi Tunnicliffe G |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
Comparative analysis of the PCOLCE region in Fugu rubripes using a new automated annotation tool. |
Volume: |
11 |
Issue: |
3 |
Pages: |
213-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kessler E |
Year: |
1990 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Procollagen type I C-proteinase enhancer is a naturally occurring connective tissue glycoprotein. |
Volume: |
173 |
Issue: |
1 |
Pages: |
81-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
246
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
493
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
214
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansilvestri Morel P |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression. |
Volume: |
17 |
Issue: |
2 |
Pages: |
e0263828 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scott IC |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. |
Volume: |
55 |
Issue: |
2 |
Pages: |
229-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahara K |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. |
Volume: |
31 |
Issue: |
2 |
Pages: |
253-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bildsoe H |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. |
Volume: |
418 |
Issue: |
1 |
Pages: |
189-203 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Lecain E |
Year: |
1991 |
Journal: |
J Neurochem |
Title: |
Isolation of a novel cDNA corresponding to a transcript expressed in the choroid plexus and leptomeninges. |
Volume: |
56 |
Issue: |
6 |
Pages: |
2133-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steiglitz BM |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues. |
Volume: |
26 |
Issue: |
1 |
Pages: |
238-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu H |
Year: |
2000 |
Journal: |
Genomics |
Title: |
Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. |
Volume: |
66 |
Issue: |
3 |
Pages: |
264-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsiao YT |
Year: |
2024 |
Journal: |
EMBO J |
Title: |
PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. |
Volume: |
43 |
Issue: |
21 |
Pages: |
4846-4869 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
Northern blot |
Annotation Date: |
1999-03-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
|
Stage: |
TS10 |
Assay Id: |
MGI:1331126 |
Age: |
embryonic day 7.0 |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
Northern blot |
Annotation Date: |
1999-03-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603918 |
|
Stage: |
TS18 |
Assay Id: |
MGI:1331126 |
Age: |
embryonic day 11.0 |
|
|
Specimen Label: |
11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
Northern blot |
Annotation Date: |
1999-03-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:1331126 |
Age: |
embryonic day 15.0 |
|
|
Specimen Label: |
15 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
Northern blot |
Annotation Date: |
1999-03-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603925 |
|
Stage: |
TS25 |
Assay Id: |
MGI:1331126 |
Age: |
embryonic day 17.0 |
|
|
Specimen Label: |
17 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721321 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 13.5 |
Image: |
3B |
Note: |
Expressed in the perichondral regions. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
Note: |
Expressed in the perichodrium/periosteum and regions of ossification. Highest expression. |
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1763523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
4 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5824239 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-02-16 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:5824273 |
Age: |
embryonic day 12.5 |
|
Note: |
Expression only found outside of the thymic anlage. |
Specimen Label: |
1D E12.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3596117 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 10.5 |
Image: |
3A |
Note: |
Expressed in most nonneural embryonic mesenchyme. |
Specimen Label: |
3A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3596121 |
Pattern: |
Widespread |
Stage: |
TS21 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 13.5 |
Image: |
3B |
|
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3596123 |
Pattern: |
Widespread |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3819457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:3828714 |
Age: |
embryonic day 7.5 |
|
Note: |
Expression is weak to non-existent. |
Specimen Label: |
E7.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3819457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:3828714 |
Age: |
embryonic day 8.5 |
|
Note: |
Expression is weak to non-existent. |
Specimen Label: |
E8.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842623 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1624721 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 13.5 |
Image: |
3B |
Note: |
Expressed in the submucosal layer. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1624723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
Note: |
Expressed in the submucosal layer. |
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1829023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
Note: |
Expressed in an adjacent site of ossification near Meckels cartilage. |
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3819457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611715 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3828714 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
E9.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3819457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606215 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:3828714 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
E9.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3649317 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 10.5 |
Image: |
3A |
Note: |
Higher expression in the walls of the umbilical vessels. |
Specimen Label: |
3A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:28098 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-09-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5910338 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papke CL |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations. |
Volume: |
24 |
Issue: |
20 |
Pages: |
5867-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hofbauer LC |
Year: |
1996 |
Journal: |
Eur J Endocrinol |
Title: |
Updating the metalloprotease nomenclature: bone morphogenetic protein 1 identified as procollagen C proteinase. |
Volume: |
135 |
Issue: |
1 |
Pages: |
35-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pall GS |
Year: |
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