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Search results 1 to 100 out of 418 for Pdcd1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5133 | PDCD1
Type: gene
Organism: human
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Gene
748796 | PDCD1
Type: gene
Organism: chimpanzee
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Gene
613842 | PDCD1
Type: gene
Organism: cattle
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Gene
424913 | PDCD1
Type: gene
Organism: chicken
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Gene
100135775 | PDCD1
Type: gene
Organism: macaque, rhesus
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Gene
101730727 | pdcd1
Type: gene
Organism: frog, western clawed
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Gene
301626 | Pdcd1
Type: gene
Organism: rat
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Gene
486213 | PDCD1
Type: gene
Organism: dog, domestic
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Protein Domain
IPR042379 | PDCD1
Type: Family
Description: Programmed cell death protein 1 (PDCD1), also known as PD1, is an immune-checkpoint receptor mainly expressed by T cells that negatively regulates immune response []. It interacts with its ligands PD-L1 and PD-L2 to inhibit T cell effector functions in an antigen-specific manner []. The PD1-mediated inhibitory pathway is exploited by some tumours to attenuate anti-tumour immunity and escape destruction by the immune system [].
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Protein Coding Gene
MGI:104879 | Pdcd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q02242
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q544F3
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Publication
21276005 | -
 
First Author: Fife BT
Year: 2011
Journal: Ann N Y Acad Sci
Title: The role of the PD-1 pathway in autoimmunity and peripheral tolerance.
Volume: 1217
Pages: 45-59
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Publication
28951311 | -
 
First Author: Berger KN
Year: 2018
Journal: Gene
Title: PD-1 pathway and its clinical application: A 20year journey after discovery of the complete human PD-1 gene.
Volume: 638
Pages: 20-25
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Publication
34912335 | J:328984
 
First Author: Raghavan S
Year: 2021
Journal: Front Immunol
Title: Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy.
Volume: 12
Pages: 752348
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Publication
37348508 | J:339958
First Author: Zhao J
Year: 2023
Journal: Neuron
Title: PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.
Volume: 111
Issue: 17
Pages: 2709-2726.e9
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Publication
37723306 | J:342227
First Author: Wartewig T
Year: 2023
Journal: Nat Cancer
Title: PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Volume: 4
Issue: 10
Pages: 1508-1525
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Publication
24648472 | J:331331
First Author: Zhang J
Year: 2014
Journal: Int Immunol
Title: PD-1 deletion restores susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice.
Volume: 26
Issue: 7
Pages: 407-15
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Publication
27197661 | J:318389
First Author: Yang L
Year: 2016
Journal: Arch Immunol Ther Exp (Warsz)
Title: Program Death-1 Suppresses Autoimmune Arthritis by Inhibiting Th17 Response.
Volume: 64
Issue: 5
Pages: 417-23
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Publication
33257470 | J:303822
First Author: Wei SC
Year: 2021
Journal: Cancer Discov
Title: A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Volume: 11
Issue: 3
Pages: 614-625
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Publication
32484460 | J:309034
First Author: Wang K
Year: 2020
Journal: J Clin Invest
Title: PD-1 blockade inhibits osteoclast formation and murine bone cancer pain.
Volume: 130
Issue: 7
Pages: 3603-3620
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Publication
29143824 | J:254179
First Author: Wartewig T
Year: 2017
Journal: Nature
Title: PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Volume: 552
Issue: 7683
Pages: 121-125
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Publication
22949674 | J:190150
First Author: Xiao G
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1.
Volume: 109
Issue: 38
Pages: 15419-24
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Publication
31901074 | J:298172
 
First Author: Strauss L
Year: 2020
Journal: Sci Immunol
Title: Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.
Volume: 5
Issue: 43
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Publication
28586108 | J:247111
First Author: Xie MM
Year: 2017
Journal: Eur J Immunol
Title: Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice.
Volume: 47
Issue: 7
Pages: 1136-1141
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Protein Coding Gene
MGP_CAROLIEiJ_G0014470 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016119 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016198 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027706 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015274 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1396582 | J:35861
First Author: Ishida Y
Year: 1992
Journal: EMBO J
Title: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Volume: 11
Issue: 11
Pages: 3887-95
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Publication
9796923 | J:50688
First Author: Nishimura H
Year: 1998
Journal: Int Immunol
Title: Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
Volume: 10
Issue: 10
Pages: 1563-72
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Publication
11209085 | J:66979
First Author: Nishimura H
Year: 2001
Journal: Science
Title: Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
Volume: 291
Issue: 5502
Pages: 319-22
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Publication
28710273 | J:243981
First Author: Zhang Y
Year: 2017
Journal: J Exp Med
Title: PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
Volume: 214
Issue: 9
Pages: 2523-2533
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Publication
37344588 | J:341090
First Author: Damo M
Year: 2023
Journal: Nature
Title: PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens.
Volume: 619
Issue: 7968
Pages: 151-159
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Publication
31358999 | J:324332
First Author: Verma V
Year: 2019
Journal: Nat Immunol
Title: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance.
Volume: 20
Issue: 9
Pages: 1231-1243
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Publication
20113370 | J:166414
First Author: Konkel JE
Year: 2010
Journal: Immunology
Title: PD-1 signalling in CD4(+) T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced tolerance.
Volume: 130
Issue: 1
Pages: 92-102
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Publication
19420358 | J:152278
First Author: Mumprecht S
Year: 2009
Journal: Blood
Title: Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression.
Volume: 114
Issue: 8
Pages: 1528-36
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Publication
22491251 | J:188681
First Author: Tarrio ML
Year: 2012
Journal: J Immunol
Title: PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis.
Volume: 188
Issue: 10
Pages: 4876-84
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Publication
22902234 | J:187367
First Author: Yogev N
Year: 2012
Journal: Immunity
Title: Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells.
Volume: 37
Issue: 2
Pages: 264-75
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Publication
18299579 | J:132764
First Author: Yoshida T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.
Volume: 105
Issue: 9
Pages: 3533-8
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Publication
19261693 | J:148183
First Author: Jiang F
Year: 2009
Journal: Int Immunol
Title: Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
Volume: 21
Issue: 5
Pages: 499-509
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Publication
22459706 | J:183532
First Author: Qiao G
Year: 2012
Journal: Clin Immunol
Title: Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism.
Volume: 143
Issue: 2
Pages: 128-33
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Publication
26034050 | J:224770
First Author: Odorizzi PM
Year: 2015
Journal: J Exp Med
Title: Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.
Volume: 212
Issue: 7
Pages: 1125-37
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Publication
25803808 | J:229622
First Author: Charlton JJ
Year: 2015
Journal: PLoS One
Title: Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines.
Volume: 10
Issue: 3
Pages: e0119200
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Publication
33452107 | J:331279
 
First Author: Kauffman KD
Year: 2021
Journal: Sci Immunol
Title: PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques.
Volume: 6
Issue: 55
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Publication
22144176 | J:187792
First Author: Kaiser AD
Year: 2012
Journal: Eur J Immunol
Title: Reduced tumor-antigen density leads to PD-1/PD-L1-mediated impairment of partially exhausted CD8⁺ T cells.
Volume: 42
Issue: 3
Pages: 662-71
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Publication
25630305 | J:229271
First Author: McAlees JW
Year: 2015
Journal: Eur J Immunol
Title: Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
Volume: 45
Issue: 4
Pages: 1019-29
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Publication
15542030 | J:94511
First Author: Nagahama K
Year: 2004
Journal: Bone
Title: The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis.
Volume: 35
Issue: 5
Pages: 1059-68
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Publication
28096382 | J:240747
First Author: Chamoto K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Volume: 114
Issue: 5
Pages: E761-E770
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Publication
14568931 | J:117980
First Author: Blank C
Year: 2003
Journal: J Immunol
Title: Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells.
Volume: 171
Issue: 9
Pages: 4574-81
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Publication
19182257 | J:154573
First Author: Sugita S
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions.
Volume: 50
Issue: 6
Pages: 2862-70
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Publication
17606980 | J:123925
First Author: Okazaki T
Year: 2007
Journal: Int Immunol
Title: PD-1 and PD-1 ligands: from discovery to clinical application.
Volume: 19
Issue: 7
Pages: 813-24
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Publication
16087865 | J:101146
First Author: Wang J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Volume: 102
Issue: 33
Pages: 11823-8
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Publication
25082151 | J:220123
First Author: Tang L
Year: 2014
Journal: J Leukoc Biol
Title: Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Volume: 96
Issue: 5
Pages: 809-20
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Publication
19332785 | J:147755
First Author: Huang X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.
Volume: 106
Issue: 15
Pages: 6303-8
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Publication
23686498 | J:204836
First Author: Charlton JJ
Year: 2013
Journal: J Immunol
Title: Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.
Volume: 190
Issue: 12
Pages: 6104-14
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Publication
19197390 | J:146479
First Author: Kroner A
Year: 2009
Journal: PLoS One
Title: PD-1 regulates neural damage in oligodendroglia-induced inflammation.
Volume: 4
Issue: 2
Pages: e4405
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Publication
35762356 | J:338115
First Author: Zhu H
Year: 2022
Journal: Circulation
Title: Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis.
Volume: 146
Issue: 4
Pages: 316-335
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Publication
20570856 | J:165890
First Author: Zhou Q
Year: 2010
Journal: Blood
Title: Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.
Volume: 116
Issue: 14
Pages: 2484-93
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Publication
27217330 | J:269062
 
First Author: Horne-Debets JM
Year: 2016
Journal: Sci Rep
Title: Mice lacking Programmed cell death-1 show a role for CD8(+) T cells in long-term immunity against blood-stage malaria.
Volume: 6
Pages: 26210
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Publication
35963284 | J:336078
 
First Author: Gao Y
Year: 2022
Journal: Immunol Lett
Title: Conjugation of human serum albumin and flucloxacillin provokes specific immune response in HLA-B*57:01 transgenic mice.
Volume: 249
Pages: 5-11
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Publication
19959639 | J:164110
First Author: Sugita S
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals.
Volume: 51
Issue: 5
Pages: 2529-36
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Publication
20624978 | J:162565
First Author: Lázár-Molnár E
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.
Volume: 107
Issue: 30
Pages: 13402-7
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Publication
28151427 | J:241069
First Author: Asano T
Year: 2017
Journal: Blood
Title: PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Volume: 129
Issue: 15
Pages: 2186-2197
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Publication
24316071 | J:204141
First Author: Horne-Debets JM
Year: 2013
Journal: Cell Rep
Title: PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.
Volume: 5
Issue: 5
Pages: 1204-13
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Publication
21118907 | J:167224
First Author: Iyoda T
Year: 2010
Journal: Int Immunol
Title: Invariant NKT cell anergy is induced by a strong TCR-mediated signal plus co-stimulation.
Volume: 22
Issue: 11
Pages: 905-13
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Publication
10704469 | J:60919
First Author: Nishimura H
Year: 2000
Journal: J Exp Med
Title: Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.
Volume: 191
Issue: 5
Pages: 891-8
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Publication
21750671 | J:183134
First Author: Chen Y
Year: 2011
Journal: PLoS Pathog
Title: Programmed death (PD)-1-deficient mice are extremely sensitive to murine hepatitis virus strain-3 (MHV-3) infection.
Volume: 7
Issue: 7
Pages: e1001347
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Publication
30693001 | J:284223
 
First Author: Wang J
Year: 2018
Journal: Front Immunol
Title: PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses.
Volume: 9
Pages: 3157
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Publication
21589883 | J:172640
First Author: Tousif S
Year: 2011
Journal: PLoS One
Title: T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection.
Volume: 6
Issue: 5
Pages: e19864
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Publication
24853068 | J:310944
First Author: Yao A
Year: 2014
Journal: Neurotherapeutics
Title: Programmed death 1 deficiency induces the polarization of macrophages/microglia to the M1 phenotype after spinal cord injury in mice.
Volume: 11
Issue: 3
Pages: 636-50
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Publication
19443704 | J:148921
First Author: Kroner A
Year: 2009
Journal: Am J Pathol
Title: Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants.
Volume: 174
Issue: 6
Pages: 2290-9
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Publication
22859605 | J:191307
First Author: Ding ZC
Year: 2012
Journal: Blood
Title: Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.
Volume: 120
Issue: 11
Pages: 2229-39
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Publication
15611321 | J:95689
First Author: Iwai Y
Year: 2005
Journal: Int Immunol
Title: PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Volume: 17
Issue: 2
Pages: 133-44
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Publication
12847136 | J:84458
First Author: Iwai Y
Year: 2003
Journal: J Exp Med
Title: PD-1 inhibits antiviral immunity at the effector phase in the liver.
Volume: 198
Issue: 1
Pages: 39-50
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Publication
32122466 | J:291751
   
First Author: Kumar A
Year: 2020
Journal: Elife
Title: Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy.
Volume: 9
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Publication
35963455 | J:328482
     
First Author: Helou DG
Year: 2022
Journal: J Allergy Clin Immunol
Title: Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells.
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Publication
- | J:286241
     
First Author: Avrutskaya A
Year: 2019
Journal: Cancer Res
Title: Abstract LB-063: Validation of humanized PD-1 knock-in mice as an emerging model to evaluate human specific PD-1 therapeutics.
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Publication
22210912 | J:180746
First Author: Ioannou M
Year: 2012
Journal: J Immunol
Title: Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Volume: 188
Issue: 3
Pages: 1136-46
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Publication
29980219 | J:273684
First Author: Liu T
Year: 2018
Journal: Parasit Vectors
Title: PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion.
Volume: 11
Issue: 1
Pages: 397
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Publication
34899751 | J:324802
 
First Author: Kaltenmeier C
Year: 2021
Journal: Front Immunol
Title: Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment.
Volume: 12
Pages: 785222
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Publication
33320839 | J:305064
 
First Author: Triantafyllou E
Year: 2021
Journal: J Clin Invest
Title: PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury.
Volume: 131
Issue: 4
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Publication
33117347 | J:336798
 
First Author: Wang Z
Year: 2020
Journal: Front Immunol
Title: Excretory/Secretory Products From Trichinella spiralis Adult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization.
Volume: 11
Pages: 563784
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Publication
23242415 | J:192538
First Author: Sage PT
Year: 2013
Journal: Nat Immunol
Title: The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Volume: 14
Issue: 2
Pages: 152-61
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Publication
30257954 | J:266879
 
First Author: Celada LJ
Year: 2018
Journal: Sci Transl Med
Title: PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
Volume: 10
Issue: 460
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