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Search results 1 to 100 out of 237 for Pdcd4

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0.393s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Programmed cell death protein 4 (PDCD4) binds to eukaryotic initiation factor 4A (eIF4A), inhibits translation initiation, and acts as a tumour suppressor. It contains two C-terminal MA3 domains that bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) [[cite:PUB00049359], [cite:PUB00051704], [cite:PUB00050443]].This entry also includes MRF1/2/3/4 from plants. They are involved in target of rapamycin (TOR)-egulated translation control, especially under energy-deficient conditions [[cite:PUB00093083]].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Loh PG
Year: 2009
Journal: EMBO J
Title: Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Volume: 28
Issue: 3
Pages: 274-85
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Schmid T
Year: 2008
Journal: Cancer Res
Title: Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion.
Volume: 68
Issue: 5
Pages: 1254-60
Publication
First Author: Suzuki C
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.
Volume: 105
Issue: 9
Pages: 3274-9
Publication
First Author: Palamarchuk A
Year: 2005
Journal: Cancer Res
Title: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.
Volume: 65
Issue: 24
Pages: 11282-6
Publication
First Author: Sheedy FJ
Year: 2010
Journal: Nat Immunol
Title: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
Volume: 11
Issue: 2
Pages: 141-7
Publication
First Author: Bai Y
Year: 2016
Journal: PLoS One
Title: Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet.
Volume: 11
Issue: 7
Pages: e0159568
Publication
First Author: Bitomsky N
Year: 2004
Journal: Oncogene
Title: Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun.
Volume: 23
Issue: 45
Pages: 7484-93
Publication
First Author: Merline R
Year: 2011
Journal: Sci Signal
Title: Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
Volume: 4
Issue: 199
Pages: ra75
Publication
First Author: Dennis MD
Year: 2012
Journal: J Biol Chem
Title: Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.
Volume: 287
Issue: 51
Pages: 42890-9
Publication
First Author: Yang HS
Year: 2003
Journal: Mol Cell Biol
Title: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
Volume: 23
Issue: 1
Pages: 26-37
Publication
First Author: Junker F
Year: 2015
Journal: Blood
Title: Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.
Volume: 126
Issue: 8
Pages: 993-1004
Protein
Organism: Mus musculus
Length: 469  
Fragment?: false
Publication
First Author: Chang JH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the eIF4A-PDCD4 complex.
Volume: 106
Issue: 9
Pages: 3148-53
Publication
First Author: Lee DH
Year: 2017
Journal: Plant Cell
Title: MRF Family Genes Are Involved in Translation Control, Especially under Energy-Deficient Conditions, and Their Expression and Functions Are Modulated by the TOR Signaling Pathway.
Volume: 29
Issue: 11
Pages: 2895-2920
Publication
First Author: Jansen AP
Year: 2005
Journal: Cancer Res
Title: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.
Volume: 65
Issue: 14
Pages: 6034-41
Publication
First Author: Hilliard A
Year: 2006
Journal: J Immunol
Title: Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4.
Volume: 177
Issue: 11
Pages: 8095-102
Publication
First Author: Ruan Q
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.
Volume: 108
Issue: 29
Pages: 12030-5
Publication
First Author: Subedi A
Year: 2013
Journal: FEBS Lett
Title: Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-κB pathway.
Volume: 587
Issue: 10
Pages: 1556-61
Publication
First Author: Cohen TS
Year: 2013
Journal: PLoS Pathog
Title: Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4.
Volume: 9
Issue: 10
Pages: e1003682
Publication
First Author: Yasuda M
Year: 2009
Journal: Carcinogenesis
Title: Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Volume: 30
Issue: 7
Pages: 1209-16
Publication
First Author: Li Z
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: MicroRNA-21 mediates high phosphate-induced endothelial cell apoptosis.
Volume: 315
Issue: 6
Pages: C830-C838
Publication
First Author: Lingel H
Year: 2017
Journal: Cell Death Differ
Title: CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.
Volume: 24
Issue: 10
Pages: 1739-1749
Publication
First Author: Kroczynska B
Year: 2012
Journal: Mol Cell Biol
Title: Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.
Volume: 32
Issue: 14
Pages: 2809-22
Publication
First Author: Wang Q
Year: 2013
Journal: Diabetes
Title: Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance.
Volume: 62
Issue: 12
Pages: 4132-43
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Shibahara K
Year: 1995
Journal: Gene
Title: Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
Volume: 166
Issue: 2
Pages: 297-301
Publication
First Author: Onishi Y
Year: 1998
Journal: Gene
Title: Cloning of the TIS gene suppressed by topoisomerase inhibitors.
Volume: 215
Issue: 2
Pages: 453-9
Publication  
First Author: Hu CH
Year: 2017
Journal: Sci Rep
Title: miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice.
Volume: 7
Pages: 43191
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:1329698
Age: postnatal adult
Image: 4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 36
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 35
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 34
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 33
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 32
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 31
GXD Expression        
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Specimen Num: 30
GXD Expression        
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Specimen Num: 29
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 28
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 27
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 26
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 25
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 24
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 23
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 22
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 21
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 20
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 19
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 18
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 17
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 16
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 15
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 14
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289515
Age: embryonic day 2.0
Detected: false
Specimen Num: 13
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1329705
Age: embryonic day 1.0
Image: 5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1329698
Age: embryonic day 1.5
Image: 4
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1329698
Age: embryonic day 1.0
Image: 4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1329698
Age: embryonic day 1.0
Image: 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:1329698
Age: embryonic day 2.5
Image: 4
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:1329698
Age: embryonic day 2.5
Image: 4
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:1329698
Age: embryonic day 3.0
Image: 4
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:1329698
Age: embryonic day 3.0
Image: 4
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:1329705
Age: embryonic day 0.5
Image: 5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:1329698
Age: embryonic day 0.5
Image: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1329679
Assay Type: Northern blot
Annotation Date: 1999-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:1329698
Age: embryonic day 0.5
Image: 4
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Specimen Num: 2
GXD Expression        
Probe: MGI:5289004
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289515
Age: embryonic day 1.5
Specimen Num: 1