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Search results 1 to 100 out of 100 for Pdk2

0.039s

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5164 | PDK2
Type: gene
Organism: human
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Gene
524075 | PDK2
Type: gene
Organism: cattle
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Gene
704169 | PDK2
Type: gene
Organism: macaque, rhesus
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Gene
81530 | Pdk2
Type: gene
Organism: rat
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Gene
491075 | PDK2
Type: gene
Organism: dog, domestic
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Gene
468402 | PDK2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1343087 | Pdk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27385159 | J:247017
First Author: Go Y
Year: 2016
Journal: Diabetes
Title: Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
Volume: 65
Issue: 10
Pages: 2876-87
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Publication
22123926 | J:181147
First Author: Contractor T
Year: 2012
Journal: Cancer Res
Title: p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
Volume: 72
Issue: 2
Pages: 560-7
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Publication
21190881 | J:168464
First Author: Ushikai M
Year: 2011
Journal: Mol Genet Metab
Title: Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.
Volume: 102
Issue: 3
Pages: 349-55
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Publication
34552205 | J:331530
First Author: Kang HJ
Year: 2021
Journal: Exp Mol Med
Title: Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.
Volume: 53
Issue: 9
Pages: 1390-1401
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Publication
31134063 | J:296474
 
First Author: Min BK
Year: 2019
Journal: Front Immunol
Title: Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Volume: 10
Pages: 944
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Publication
23290136 | J:194930
First Author: Takubo K
Year: 2013
Journal: Cell Stem Cell
Title: Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Volume: 12
Issue: 1
Pages: 49-61
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Publication
21411764 | J:172411
First Author: Dunford EC
Year: 2011
Journal: Am J Physiol Regul Integr Comp Physiol
Title: PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
Volume: 300
Issue: 6
Pages: R1487-93
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Publication
26490872 | J:226685
First Author: Jha MK
Year: 2015
Journal: J Neurosci
Title: Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
Volume: 35
Issue: 42
Pages: 14353-69
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Publication
25991547 | J:232907
First Author: Hou X
Year: 2015
Journal: J Cell Sci
Title: Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
Volume: 128
Issue: 13
Pages: 2319-29
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Publication
30482839 | J:274759
First Author: Klyuyeva A
Year: 2019
Journal: J Biol Chem
Title: Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.
Volume: 294
Issue: 3
Pages: 838-851
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Publication
23940800 | J:205902
First Author: Tao R
Year: 2013
Journal: PLoS One
Title: Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
Volume: 8
Issue: 8
Pages: e71997
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Protein Coding Gene
MGP_CAROLIEiJ_G0016999 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018943 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1343087 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018128 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017844 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6712279
Assay Type: Western blot
Annotation Date: 2021-05-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6712284
Age: postnatal adult
Specimen Label: KO
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6712279
Assay Type: Western blot
Annotation Date: 2021-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6712284
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860126
Stage: TS26
Assay Id: MGI:7471114
Age: embryonic day 18.5
Image: 1
Specimen Label: fetal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860127
Stage: TS27
Assay Id: MGI:7471114
Age: postnatal day 1
Image: 1
Specimen Label: d1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:7471114
Age: postnatal day 5
Image: 1
Specimen Label: d5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:7471114
Age: postnatal day 15
Image: 1
Specimen Label: d15
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:7471114
Age: postnatal day 25
Image: 1
Specimen Label: d25
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7471080
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:7471114
Age: postnatal week 8
Image: 1
Specimen Label: 8w
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4416697
Assay Type: RNA in situ
Annotation Date: 2024-01-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:7575749
Age: embryonic day 14.5
Note: Caudal expression was greater than rostral.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
- | J:77854
   
First Author: Jeoung NH
Year: 2000
Journal: GenBank Submission
Title: Mus musculus pyruvate dehydrogenase kinase 2 (Pdk2) mRNA, complete cds
Pages: AF267660
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Publication
22360721 | J:185475
First Author: Jeoung NH
Year: 2012
Journal: Biochem J
Title: Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice.
Volume: 443
Issue: 3
Pages: 829-39
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Publication
25368185 | J:216745
First Author: Rahimi Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
Volume: 111
Issue: 46
Pages: 16508-13
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Publication
31242425 | J:286018
First Author: Yucel N
Year: 2019
Journal: Cell Rep
Title: Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function.
Volume: 27
Issue: 13
Pages: 3939-3955.e6
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Publication
24892705 | J:213805
First Author: Harris PC
Year: 2014
Journal: J Clin Invest
Title: Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.
Volume: 124
Issue: 6
Pages: 2315-24
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Publication
23357539 | J:195164
First Author: Takao D
Year: 2013
Journal: Dev Biol
Title: Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation.
Volume: 376
Issue: 1
Pages: 23-30
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Publication
33773101 | J:303714
First Author: Heinemann-Yerushalmi L
Year: 2021
Journal: Dev Cell
Title: BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.
Volume: 56
Issue: 8
Pages: 1182-1194.e6
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Publication
22983710 | J:187958
First Author: Yoshiba S
Year: 2012
Journal: Science
Title: Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
Volume: 338
Issue: 6104
Pages: 226-31
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Publication
9806826 | J:51104
First Author: Mohlke KL
Year: 1998
Journal: Genomics
Title: Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level.
Volume: 54
Issue: 1
Pages: 19-30
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Publication
27824289 | J:318371
First Author: Ye A
Year: 2016
Journal: Epigenetics
Title: PEG3 binds to H19-ICR as a transcriptional repressor.
Volume: 11
Issue: 12
Pages: 889-900
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Publication
37198424 | J:335822
First Author: Capriati M
Year: 2023
Journal: Sci Rep
Title: Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.
Volume: 13
Issue: 1
Pages: 8003
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Publication
32913122 | J:299531
First Author: Wei L
Year: 2020
Journal: J Biol Chem
Title: GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.
Volume: 295
Issue: 47
Pages: 15988-16001
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Publication
27215380 | J:236179
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pdk2<em1Smoc> | MGI:7291592
Name: pyruvate dehydrogenase kinase, isoenzyme 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
16962653 | J:125618
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
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Publication
29109438 | J:255926
First Author: Li J
Year: 2017
Journal: Nat Commun
Title: VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Volume: 8
Issue: 1
Pages: 1322
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Publication
30581117 | J:275104
First Author: Hao X
Year: 2019
Journal: Cell Metab
Title: Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Volume: 29
Issue: 4
Pages: 950-965.e6
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Publication
17669420 | J:166353
First Author: Degenhardt T
Year: 2007
Journal: J Mol Biol
Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
Volume: 372
Issue: 2
Pages: 341-55
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Publication
11697863 | J:72837
First Author: Sugden MC
Year: 2001
Journal: Arch Biochem Biophys
Title: Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.
Volume: 395
Issue: 2
Pages: 246-52
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Publication
22057724 | J:321353
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
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Publication
28182733 | J:245919
First Author: Halvarsson C
Year: 2017
Journal: PLoS One
Title: Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function.
Volume: 12
Issue: 2
Pages: e0171714
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Publication
33251681 | J:303693
First Author: Bhusal A
Year: 2021
Journal: Glia
Title: Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin-2 and pyruvate dehydrogenase kinase-2 axis in the dorsal root ganglion.
Volume: 69
Issue: 4
Pages: 971-996
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Publication
28123081 | J:277553
First Author: Naia L
Year: 2017
Journal: J Neurosci
Title: Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease.
Volume: 37
Issue: 10
Pages: 2776-2794
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