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Search results 1 to 100 out of 377 for Pdpk1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [], and Ksg1 []and Ppk21 from S. pombe [].PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [, ]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) []and the members of protein kinase C (PKC) family []. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc []. It is a key regulator of cell migration and tumor invasion []. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling []. Deficiency of PDK1 in liver results in glucose intolerance [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Mora A
Year: 2005
Journal: Biochem J
Title: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
Volume: 385
Issue: Pt 3
Pages: 639-48
Publication
First Author: Fiory F
Year: 2005
Journal: Mol Cell Biol
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Volume: 25
Issue: 24
Pages: 10803-14
Publication
First Author: Le Good JA
Year: 1998
Journal: Science
Title: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Volume: 281
Issue: 5385
Pages: 2042-5
Publication
First Author: Casamayor A
Year: 1999
Journal: Curr Biol
Title: Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Volume: 9
Issue: 4
Pages: 186-97
Publication
First Author: Gräub R
Year: 2003
Journal: J Basic Microbiol
Title: Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Volume: 43
Issue: 6
Pages: 473-82
Publication
First Author: Bimbó A
Year: 2005
Journal: Mol Biol Cell
Title: Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Volume: 16
Issue: 7
Pages: 3162-75
Publication
First Author: Alessi DR
Year: 1997
Journal: Curr Biol
Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Volume: 7
Issue: 4
Pages: 261-9
Publication  
First Author: Currie RA
Year: 1999
Journal: Biochem J
Title: Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
Volume: 337 ( Pt 3)
Pages: 575-83
Publication  
First Author: Di Blasio L
Year: 2017
Journal: Cancers (Basel)
Title: Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.
Volume: 9
Issue: 3
Publication  
First Author: Gagliardi PA
Year: 2018
Journal: Semin Cancer Biol
Title: PDK1: At the crossroad of cancer signaling pathways.
Volume: 48
Pages: 27-35
Publication  
First Author: Kobayashi T
Year: 1999
Journal: Biochem J
Title: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Volume: 339 ( Pt 2)
Pages: 319-28
Publication
First Author: Zhao J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Volume: 486
Issue: 4
Pages: 865-871
Protein
Organism: Mus musculus
Length: 432  
Fragment?: false
Protein
Organism: Mus musculus
Length: 111  
Fragment?: true
Protein
Organism: Mus musculus
Length: 128  
Fragment?: true
Protein
Organism: Mus musculus
Length: 434  
Fragment?: true
Protein
Organism: Mus musculus
Length: 559  
Fragment?: false
Protein
Organism: Mus musculus
Length: 522  
Fragment?: false
Protein
Organism: Mus musculus
Length: 559  
Fragment?: false
Protein
Organism: Mus musculus
Length: 532  
Fragment?: false
Protein
Organism: Mus musculus
Length: 551  
Fragment?: true
Protein
Organism: Mus musculus
Length: 559  
Fragment?: false
Protein
Organism: Mus musculus
Length: 532  
Fragment?: false
Protein
Organism: Mus musculus
Length: 457  
Fragment?: false
Publication
First Author: Noh J
Year: 2015
Journal: J Mol Cell Cardiol
Title: Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
Volume: 89
Issue: Pt B
Pages: 297-305
Publication  
First Author: Grego-Bessa J
Year: 2016
Journal: Elife
Title: The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
Volume: 5
Pages: e12034
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Dong LQ
Year: 1999
Journal: J Biol Chem
Title: Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.
Volume: 274
Issue: 12
Pages: 8117-22
Publication
First Author: Shumilina E
Year: 2010
Journal: Cell Physiol Biochem
Title: Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.
Volume: 26
Issue: 4-5
Pages: 699-706
Publication
First Author: Dong LQ
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
Volume: 294
Issue: 1
Pages: 136-44
Publication
First Author: Reddy P
Year: 2009
Journal: Hum Mol Genet
Title: PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
Volume: 18
Issue: 15
Pages: 2813-24
Publication
First Author: Kelly AP
Year: 2006
Journal: FEBS Lett
Title: Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.
Volume: 580
Issue: 8
Pages: 2135-40
Publication
First Author: Hinton HJ
Year: 2004
Journal: Nat Immunol
Title: The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Volume: 5
Issue: 5
Pages: 539-45
Publication
First Author: Chen X
Year: 2013
Journal: Blood
Title: PDK1 regulates platelet activation and arterial thrombosis.
Volume: 121
Issue: 18
Pages: 3718-26
Publication
First Author: Münzer P
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.
Volume: 36
Issue: 8
Pages: 1507-16
Publication
First Author: McManus EJ
Year: 2004
Journal: EMBO J
Title: The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
Volume: 23
Issue: 10
Pages: 2071-82
Publication
First Author: Lawlor MA
Year: 2002
Journal: EMBO J
Title: Essential role of PDK1 in regulating cell size and development in mice.
Volume: 21
Issue: 14
Pages: 3728-38
Publication
First Author: Zaru R
Year: 2008
Journal: J Biol Chem
Title: 3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.
Volume: 283
Issue: 2
Pages: 929-39
Publication
First Author: Budas GR
Year: 2006
Journal: FASEB J
Title: 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.
Volume: 20
Issue: 14
Pages: 2556-8
Publication
First Author: Finlay DK
Year: 2010
Journal: J Immunol
Title: Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.
Volume: 185
Issue: 10
Pages: 5973-82
Publication
First Author: Bayascas JR
Year: 2006
Journal: J Biol Chem
Title: Evaluation of approaches to generation of tissue-specific knock-in mice.
Volume: 281
Issue: 39
Pages: 28772-81
Publication
First Author: Rexhepaj R
Year: 2006
Journal: FASEB J
Title: Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.
Volume: 20
Issue: 13
Pages: 2214-22
Publication
First Author: Artunc F
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.
Volume: 291
Issue: 5
Pages: R1533-8
Publication
First Author: Zhang Y
Year: 2009
Journal: FEBS Lett
Title: Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.
Volume: 583
Issue: 18
Pages: 3101-6
Publication
First Author: Sakaue H
Year: 2003
Journal: J Biol Chem
Title: Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
Volume: 278
Issue: 40
Pages: 38870-4
Publication
First Author: Han Z
Year: 2015
Journal: PLoS One
Title: Deletion of PDK1 causes cardiac sodium current reduction in mice.
Volume: 10
Issue: 3
Pages: e0122436
Publication
First Author: Mora A
Year: 2003
Journal: EMBO J
Title: Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
Volume: 22
Issue: 18
Pages: 4666-76
Publication
First Author: Sanchez Canedo C
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
Volume: 298
Issue: 4
Pages: E761-9
Publication
First Author: Collins BJ
Year: 2003
Journal: EMBO J
Title: In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
Volume: 22
Issue: 16
Pages: 4202-11
Publication
First Author: Collins BJ
Year: 2005
Journal: J Cell Sci
Title: In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Volume: 118
Issue: Pt 21
Pages: 5023-34
Publication
First Author: Takeda A
Year: 2008
Journal: Kobe J Med Sci
Title: Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.
Volume: 54
Issue: 3
Pages: E183-90
Publication
First Author: Koarada S
Year: 2004
Journal: Immunogenetics
Title: Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17.
Volume: 56
Issue: 5
Pages: 333-7
Publication
First Author: Wood CD
Year: 2007
Journal: FEBS Lett
Title: Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.
Volume: 581
Issue: 18
Pages: 3494-8
Publication
First Author: Tamgüney T
Year: 2008
Journal: Exp Cell Res
Title: Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Volume: 314
Issue: 11-12
Pages: 2299-312
Publication
First Author: El Ouaamari A
Year: 2008
Journal: Diabetes
Title: miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.
Volume: 57
Issue: 10
Pages: 2708-17
Publication
First Author: Sturm EM
Year: 2015
Journal: Eur J Immunol
Title: Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Volume: 45
Issue: 5
Pages: 1548-59
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4944080
Assay Type: RT-PCR
Annotation Date: 2011-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:4944181
Age: embryonic day 10.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3800909
Assay Type: Northern blot
Annotation Date: 2008-08-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3800981
Age: embryonic day 11.5
Image: 4
Specimen Num: 4
GXD Expression      
Probe: MGI:3800909
Assay Type: Northern blot
Annotation Date: 2008-08-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3800981
Age: embryonic day 11.5
Image: 4
Specimen Num: 3
GXD Expression      
Probe: MGI:3800909
Assay Type: Northern blot
Annotation Date: 2008-08-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3800981
Age: embryonic day 12.5
Image: 4
Specimen Num: 2
GXD Expression      
Probe: MGI:3800909
Assay Type: Northern blot
Annotation Date: 2008-08-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3800981
Age: embryonic day 12.5
Image: 4
Specimen Num: 1
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:1347404
Age: embryonic day 17.0
Image: 2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:1347404
Age: embryonic day 15.0
Image: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:1347404
Age: embryonic day 11.0
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:1347404
Age: embryonic day 7.0
Image: 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4944080
Assay Type: RT-PCR
Annotation Date: 2011-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:4944181
Age: embryonic day 12.5
Detected: true
Specimen Num: 2