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Search results 1 to 100 out of 429 for Pdpk1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5170 | PDPK1
Type: gene
Organism: human
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Gene
779524 | pdpk1
Type: gene
Organism: frog, western clawed
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Gene
81745 | Pdpk1
Type: gene
Organism: rat
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Gene
479875 | PDPK1
Type: gene
Organism: dog, domestic
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Gene
467875 | PDPK1
Type: gene
Organism: chimpanzee
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Gene
100138102 | PDPK1
Type: gene
Organism: cattle
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Gene
416588 | PDPK1
Type: gene
Organism: chicken
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Gene
697523 | PDPK1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR039046 | PDPK1
Type: Family
Description: This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [], and Ksg1 []and Ppk21 from S. pombe [].PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [, ]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) []and the members of protein kinase C (PKC) family []. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc []. It is a key regulator of cell migration and tumor invasion []. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling []. Deficiency of PDK1 in liver results in glucose intolerance [].
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Protein Coding Gene
MGI:1338068 | Pdpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15554902 | J:117521
First Author: Mora A
Year: 2005
Journal: Biochem J
Title: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
Volume: 385
Issue: Pt 3
Pages: 639-48
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Publication
16314505 | J:103767
First Author: Fiory F
Year: 2005
Journal: Mol Cell Biol
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Volume: 25
Issue: 24
Pages: 10803-14
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Publication
9748166 | -
First Author: Le Good JA
Year: 1998
Journal: Science
Title: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Volume: 281
Issue: 5385
Pages: 2042-5
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Publication
10074427 | -
First Author: Casamayor A
Year: 1999
Journal: Curr Biol
Title: Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Volume: 9
Issue: 4
Pages: 186-97
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Publication
14625898 | -
First Author: Gräub R
Year: 2003
Journal: J Basic Microbiol
Title: Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Volume: 43
Issue: 6
Pages: 473-82
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Publication
15857958 | -
First Author: Bimbó A
Year: 2005
Journal: Mol Biol Cell
Title: Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Volume: 16
Issue: 7
Pages: 3162-75
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Publication
9094314 | -
First Author: Alessi DR
Year: 1997
Journal: Curr Biol
Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Volume: 7
Issue: 4
Pages: 261-9
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Publication
9895304 | -
 
First Author: Currie RA
Year: 1999
Journal: Biochem J
Title: Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
Volume: 337 ( Pt 3)
Pages: 575-83
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Publication
28287465 | -
 
First Author: Di Blasio L
Year: 2017
Journal: Cancers (Basel)
Title: Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.
Volume: 9
Issue: 3
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Publication
28473254 | J:261093
 
First Author: Gagliardi PA
Year: 2018
Journal: Semin Cancer Biol
Title: PDK1: At the crossroad of cancer signaling pathways.
Volume: 48
Pages: 27-35
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Publication
10191262 | -
 
First Author: Kobayashi T
Year: 1999
Journal: Biochem J
Title: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Volume: 339 ( Pt 2)
Pages: 319-28
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Publication
36698722 | J:332861
First Author: Hu YJ
Year: 2023
Journal: iScience
Title: Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
Volume: 26
Issue: 2
Pages: 105932
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Protein
F2Z400
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q3UEW8
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Publication
31055616 | J:282688
First Author: Obata A
Year: 2019
Journal: Diabetologia
Title: Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.
Volume: 62
Issue: 7
Pages: 1225-1236
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Protein
Q9Z2A0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q3UHZ0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q8K3L3
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q3UGN6
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
F2Z3X6
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q810Z4
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: true
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Protein
Q3TRL2
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Publication
28322786 | J:251423
First Author: Zhao J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Volume: 486
Issue: 4
Pages: 865-871
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Publication
26476238 | J:251507
First Author: Noh J
Year: 2015
Journal: J Mol Cell Cardiol
Title: Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
Volume: 89
Issue: Pt B
Pages: 297-305
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Publication
26809587 | J:230653
 
First Author: Grego-Bessa J
Year: 2016
Journal: Elife
Title: The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
Volume: 5
Pages: e12034
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Protein Coding Gene
MGP_CAROLIEiJ_G0021173 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023253 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1338068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022989 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023118 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023734 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022264 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022578 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023489 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022083 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10075713 | J:53564
First Author: Dong LQ
Year: 1999
Journal: J Biol Chem
Title: Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.
Volume: 274
Issue: 12
Pages: 8117-22
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Publication
21063107 | J:178435
First Author: Shumilina E
Year: 2010
Journal: Cell Physiol Biochem
Title: Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells.
Volume: 26
Issue: 4-5
Pages: 699-706
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Publication
12054753 | J:77027
First Author: Dong LQ
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.
Volume: 294
Issue: 1
Pages: 136-44
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Publication
16887794 | J:117278
First Author: Bayascas JR
Year: 2006
Journal: J Biol Chem
Title: Evaluation of approaches to generation of tissue-specific knock-in mice.
Volume: 281
Issue: 39
Pages: 28772-81
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Publication
12970179 | J:85498
First Author: Mora A
Year: 2003
Journal: EMBO J
Title: Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
Volume: 22
Issue: 18
Pages: 4666-76
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Publication
25781322 | J:229632
First Author: Han Z
Year: 2015
Journal: PLoS One
Title: Deletion of PDK1 causes cardiac sodium current reduction in mice.
Volume: 10
Issue: 3
Pages: e0122436
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Publication
20944007 | J:165626
First Author: Finlay DK
Year: 2010
Journal: J Immunol
Title: Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.
Volume: 185
Issue: 10
Pages: 5973-82
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Publication
16219676 | J:102388
First Author: Collins BJ
Year: 2005
Journal: J Cell Sci
Title: In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Volume: 118
Issue: Pt 21
Pages: 5023-34
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Publication
19246967 | J:224808
First Author: Takeda A
Year: 2008
Journal: Kobe J Med Sci
Title: Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.
Volume: 54
Issue: 3
Pages: E183-90
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Publication
15116068 | J:90081
First Author: McManus EJ
Year: 2004
Journal: EMBO J
Title: The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
Volume: 23
Issue: 10
Pages: 2071-82
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Publication
22108800 | J:283469
First Author: Tawaramoto K
Year: 2012
Journal: Mol Endocrinol
Title: Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis.
Volume: 26
Issue: 1
Pages: 95-109
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Publication
12110585 | J:85894
First Author: Lawlor MA
Year: 2002
Journal: EMBO J
Title: Essential role of PDK1 in regulating cell size and development in mice.
Volume: 21
Issue: 14
Pages: 3728-38
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Publication
17991746 | J:130347
First Author: Zaru R
Year: 2008
Journal: J Biol Chem
Title: 3-phosphoinositide-dependent kinase 1 deficiency perturbs Toll-like receptor signaling events and actin cytoskeleton dynamics in dendritic cells.
Volume: 283
Issue: 2
Pages: 929-39
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Publication
19716369 | J:153076
First Author: Zhang Y
Year: 2009
Journal: FEBS Lett
Title: Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.
Volume: 583
Issue: 18
Pages: 3101-6
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Publication
17077284 | J:117110
First Author: Budas GR
Year: 2006
Journal: FASEB J
Title: 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.
Volume: 20
Issue: 14
Pages: 2556-8
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Publication
16741145 | J:141516
First Author: Artunc F
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.
Volume: 291
Issue: 5
Pages: R1533-8
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Publication
23444402 | J:197452
First Author: Chen X
Year: 2013
Journal: Blood
Title: PDK1 regulates platelet activation and arterial thrombosis.
Volume: 121
Issue: 18
Pages: 3718-26
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Publication
17077298 | J:129748
First Author: Rexhepaj R
Year: 2006
Journal: FASEB J
Title: Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.
Volume: 20
Issue: 13
Pages: 2214-22
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Publication
16563390 | J:107639
First Author: Kelly AP
Year: 2006
Journal: FEBS Lett
Title: Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes.
Volume: 580
Issue: 8
Pages: 2135-40
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Publication
15077109 | J:89811
First Author: Hinton HJ
Year: 2004
Journal: Nat Immunol
Title: The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Volume: 5
Issue: 5
Pages: 539-45
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Publication
27339458 | J:246381
First Author: Münzer P
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.
Volume: 36
Issue: 8
Pages: 1507-16
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Publication
12855688 | J:85804
First Author: Sakaue H
Year: 2003
Journal: J Biol Chem
Title: Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
Volume: 278
Issue: 40
Pages: 38870-4
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Publication
20051528 | J:162895
First Author: Sanchez Canedo C
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
Volume: 298
Issue: 4
Pages: E761-9
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Publication
15309345 | J:92304
First Author: Koarada S
Year: 2004
Journal: Immunogenetics
Title: Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17.
Volume: 56
Issue: 5
Pages: 333-7
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Publication
12912918 | J:85056
First Author: Collins BJ
Year: 2003
Journal: EMBO J
Title: In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
Volume: 22
Issue: 16
Pages: 4202-11
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Publication
19423553 | J:150212
First Author: Reddy P
Year: 2009
Journal: Hum Mol Genet
Title: PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
Volume: 18
Issue: 15
Pages: 2813-24
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Publication
32457586 | J:288698
 
First Author: Giménez-Llort L
Year: 2020
Journal: Front Behav Neurosci
Title: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.
Volume: 14
Pages: 61
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Publication
33377210 | J:327221
First Author: Bai Y
Year: 2021
Journal: J Cell Physiol
Title: Conditional knockout of the PDK-1 gene in osteoblasts affects osteoblast differentiation and bone formation.
Volume: 236
Issue: 7
Pages: 5432-5445
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Publication
17617409 | J:123728
First Author: Wood CD
Year: 2007
Journal: FEBS Lett
Title: Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.
Volume: 581
Issue: 18
Pages: 3494-8
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Publication
18514190 | J:138007
First Author: Tamgüney T
Year: 2008
Journal: Exp Cell Res
Title: Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Volume: 314
Issue: 11-12
Pages: 2299-312
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Publication
18591395 | J:141895
First Author: El Ouaamari A
Year: 2008
Journal: Diabetes
Title: miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.
Volume: 57
Issue: 10
Pages: 2708-17
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Publication
25645675 | J:229644
First Author: Sturm EM
Year: 2015
Journal: Eur J Immunol
Title: Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Volume: 45
Issue: 5
Pages: 1548-59
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Heart
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: SK Muscle
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1347403
Age: postnatal week 8-12
Image: 2
Specimen Label: Testis
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:1347404
Age: embryonic day 7.0
Image: 2
Specimen Label: 7
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:1347404
Age: embryonic day 11.0
Image: 2
Specimen Label: 11
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:1347404
Age: embryonic day 15.0
Image: 2
Specimen Label: 15
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1347400
Assay Type: Northern blot
Annotation Date: 1999-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:1347404
Age: embryonic day 17.0
Image: 2
Specimen Label: 17
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Specimen Label: 1
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1347406
Assay Type: Western blot
Annotation Date: 1999-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1347445
Age: postnatal month 3-6
Image: 3
Specimen Label: 2
Detected: true
Specimen Num: 2
•
•
•
•
•




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