Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
McQueen CM |
Year: |
2018 |
Journal: |
Development |
Title: |
PER2 regulation of mammary gland development. |
Volume: |
145 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Guo L |
Year: |
2023 |
Journal: |
Theranostics |
Title: |
PER2 integrates circadian disruption and pituitary tumorigenesis. |
Volume: |
13 |
Issue: |
8 |
Pages: |
2657-2672 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mteyrek A |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
Clock gene Per2 as a controller of liver carcinogenesis. |
Volume: |
7 |
Issue: |
52 |
Pages: |
85832-85847 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miki T |
Year: |
2012 |
Journal: |
EMBO J |
Title: |
PML regulates PER2 nuclear localization and circadian function. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1427-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feillet CA |
Year: |
2006 |
Journal: |
Curr Biol |
Title: |
Lack of food anticipation in Per2 mutant mice. |
Volume: |
16 |
Issue: |
20 |
Pages: |
2016-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimaldi B |
Year: |
2010 |
Journal: |
Cell Metab |
Title: |
PER2 controls lipid metabolism by direct regulation of PPARγ. |
Volume: |
12 |
Issue: |
5 |
Pages: |
509-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen P |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. |
Volume: |
174 |
Issue: |
1 |
Pages: |
63-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brenna A |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
PER2 mediates CREB-dependent light induction of the clock gene Per1. |
Volume: |
11 |
Issue: |
1 |
Pages: |
21766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eide EJ |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. |
Volume: |
25 |
Issue: |
7 |
Pages: |
2795-807 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asher G |
Year: |
2008 |
Journal: |
Cell |
Title: |
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. |
Volume: |
134 |
Issue: |
2 |
Pages: |
317-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuda S |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. |
Volume: |
117 |
Issue: |
20 |
Pages: |
10888-10896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Narasimamurthy R |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CK1Γ/ε protein kinase primes the PER2 circadian phosphoswitch. |
Volume: |
115 |
Issue: |
23 |
Pages: |
5986-5991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spanagel R |
Year: |
2005 |
Journal: |
Nat Med |
Title: |
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. |
Volume: |
11 |
Issue: |
1 |
Pages: |
35-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chappuis S |
Year: |
2013 |
Journal: |
Mol Metab |
Title: |
Role of the circadian clock gene Per2 in adaptation to cold temperature. |
Volume: |
2 |
Issue: |
3 |
Pages: |
184-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayasaka N |
Year: |
2017 |
Journal: |
Elife |
Title: |
Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Viswambharan H |
Year: |
2007 |
Journal: |
Circulation |
Title: |
Mutation of the circadian clock gene Per2 alters vascular endothelial function. |
Volume: |
115 |
Issue: |
16 |
Pages: |
2188-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Levine DC |
Year: |
2020 |
Journal: |
Mol Cell |
Title: |
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. |
Volume: |
78 |
Issue: |
5 |
Pages: |
835-849.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyazaki K |
Year: |
2007 |
Journal: |
Genes Cells |
Title: |
PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus. |
Volume: |
12 |
Issue: |
11 |
Pages: |
1225-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ralph MR |
Year: |
2021 |
Journal: |
PLoS Comput Biol |
Title: |
Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice. |
Volume: |
17 |
Issue: |
5 |
Pages: |
e1008987 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pilorz V |
Year: |
2008 |
Journal: |
Reproduction |
Title: |
Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing? |
Volume: |
135 |
Issue: |
4 |
Pages: |
559-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirata Y |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Circadian rhythms in Per1, PER2 and Ca2+ of a solitary SCN neuron cultured on a microisland. |
Volume: |
9 |
Issue: |
1 |
Pages: |
18271 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang RH |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. |
Volume: |
6 |
|
Pages: |
28633 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikegami K |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Circadian clock gene Per2 is not necessary for the photoperiodic response in mice. |
Volume: |
8 |
Issue: |
3 |
Pages: |
e58482 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhatwadekar AD |
Year: |
2013 |
Journal: |
Diabetes |
Title: |
Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. |
Volume: |
62 |
Issue: |
1 |
Pages: |
273-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chou CF |
Year: |
2015 |
Journal: |
J Lipid Res |
Title: |
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. |
Volume: |
56 |
Issue: |
2 |
Pages: |
227-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Q |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Loss of the clock protein PER2 shortens the erythrocyte life span in mice. |
Volume: |
292 |
Issue: |
30 |
Pages: |
12679-12690 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shrestha TC |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks. |
Volume: |
8 |
Issue: |
1 |
Pages: |
15547 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eckle T |
Year: |
2012 |
Journal: |
Nat Med |
Title: |
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. |
Volume: |
18 |
Issue: |
5 |
Pages: |
774-82 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191070 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Per2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191070 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Per2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191070 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Per2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191070 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Per2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191070 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Per2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191070 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Per2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180422 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191070 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Per2 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gamsby JJ |
Year: |
2013 |
Journal: |
Behav Brain Res |
Title: |
The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels. |
Volume: |
249 |
|
Pages: |
15-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
MiliÄeviÄ N |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis. |
Volume: |
35 |
Issue: |
7 |
Pages: |
e21722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang X |
Year: |
2009 |
Journal: |
J Biochem |
Title: |
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. |
Volume: |
145 |
Issue: |
3 |
Pages: |
289-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozber N |
Year: |
2010 |
Journal: |
BMC Mol Biol |
Title: |
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. |
Volume: |
11 |
|
Pages: |
69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mansingh S |
Year: |
2024 |
Journal: |
J Physiol |
Title: |
More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα. |
Volume: |
602 |
Issue: |
23 |
Pages: |
6373-6402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Langmesser S |
Year: |
2008 |
Journal: |
BMC Mol Biol |
Title: |
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. |
Volume: |
9 |
|
Pages: |
41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zani F |
Year: |
2013 |
Journal: |
Mol Metab |
Title: |
PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. |
Volume: |
2 |
Issue: |
3 |
Pages: |
292-305 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmalen I |
Year: |
2014 |
Journal: |
Cell |
Title: |
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. |
Volume: |
157 |
Issue: |
5 |
Pages: |
1203-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
2016 |
Journal: |
Nat Cell Biol |
Title: |
Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. |
Volume: |
18 |
Issue: |
5 |
Pages: |
480-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shu YY |
Year: |
2022 |
Journal: |
Oxid Med Cell Longev |
Title: |
Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis. |
Volume: |
2022 |
|
Pages: |
8063897 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimomura H |
Year: |
2001 |
Journal: |
Eur J Neurosci |
Title: |
Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice. |
Volume: |
13 |
Issue: |
4 |
Pages: |
687-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura TJ |
Year: |
2008 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. |
Volume: |
295 |
Issue: |
5 |
Pages: |
E1025-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Granados-Fuentes D |
Year: |
2015 |
Journal: |
J Biol Rhythms |
Title: |
IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus. |
Volume: |
30 |
Issue: |
5 |
Pages: |
396-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Husse J |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52983 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamayo AG |
Year: |
2015 |
Journal: |
Nat Struct Mol Biol |
Title: |
Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback. |
Volume: |
22 |
Issue: |
10 |
Pages: |
759-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wendrich KS |
Year: |
2023 |
Journal: |
Clocks Sleep |
Title: |
Deletion of the Circadian Clock Gene Per2 in the Whole Body, but Not in Neurons or Astroglia, Affects Sleep in Response to Sleep Deprivation. |
Volume: |
5 |
Issue: |
2 |
Pages: |
204-225 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonney S |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e71493 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki M |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. |
Volume: |
284 |
Issue: |
37 |
Pages: |
25149-59 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
period circadian clock 2; targeted mutation 1.2 Urs Albrecht |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Baba K |
Year: |
2010 |
Journal: |
Mol Vis |
Title: |
Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid. |
Volume: |
16 |
|
Pages: |
2605-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durgan DJ |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. |
Volume: |
286 |
Issue: |
52 |
Pages: |
44606-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoo SH |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. |
Volume: |
102 |
Issue: |
7 |
Pages: |
2608-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chavan R |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Liver-derived ketone bodies are necessary for food anticipation. |
Volume: |
7 |
|
Pages: |
10580 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Zavalia N |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner. |
Volume: |
4 |
Issue: |
1 |
Pages: |
1227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schoettner K |
Year: |
2022 |
Journal: |
Front Physiol |
Title: |
Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2. |
Volume: |
13 |
|
Pages: |
922080 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Alessandro M |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
A tunable artificial circadian clock in clock-defective mice. |
Volume: |
6 |
|
Pages: |
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