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Search results 1 to 98 out of 98 for Pex19

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Hits by Strain

Type Details Score
Gene
5824 | PEX19
Type: gene
Organism: human
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Gene
100145099 | pex19
Type: gene
Organism: frog, western clawed
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Gene
106993172 | PEX19
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR006708 | Pex19
Type: Family
Description: Peroxisome(s) form an intracellular compartment, bounded by a typical lipid bilayer membrane. Peroxisome functions are often specialised by organism and cell type; two widely distributed and well-conserved functions are H2O2-based respiration and fatty acid beta-oxidation. Other functions include ether lipid (plasmalogen) synthesis and cholesterol synthesis inanimals, the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves, glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.PEX genes encode the machinery ("peroxins") required to assemble the peroxisome. Membrane assembly and maintenance requires three of these (peroxins 3, 16, and 19) and may occur without the import of the matrix (lumen) enzymes. Matrix protein import follows a branched pathway of soluble recycling receptors, with one branch for each class of peroxisome targeting sequence (two are well characterised), and a common trunk for all. At least one of these receptors, Pex5p, enters and exits peroxisomes as it functions. Proliferation of the organelle is regulated by Pex11p. Peroxisome biogenesis is remarkably conserved among eukaryotes. A group of fatal, inherited neuropathologies are recognised as peroxisome biogenesis diseases. Pex19 is involved in membrane assembly and maintenance and functions as a receptor and chaperone of peroxisomal membrane proteins (PMPs) [].
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Gene
478972 | PEX19
Type: gene
Organism: dog, domestic
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Gene
746746 | PEX19
Type: gene
Organism: chimpanzee
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Gene
289233 | Pex19
Type: gene
Organism: rat
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Gene
521522 | PEX19
Type: gene
Organism: cattle
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Gene
324778 | pex19
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:1334458 | Pex19
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8VCI5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q3TDI5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Publication
20531392 | -
First Author: Schueller N
Year: 2010
Journal: EMBO J
Title: The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.
Volume: 29
Issue: 15
Pages: 2491-500
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Protein Coding Gene
MGP_CAROLIEiJ_G0014886 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1334458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017180 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016516 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016647 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016184 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028123 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015690 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3655277
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3655277
Age: embryonic day 8.5
Specimen Label: +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3655277
Age: embryonic day 9.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3655277
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3655277
Age: embryonic day 8.5
Specimen Label: Lp/Lp
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3655277
Age: embryonic day 9.5
Specimen Label: Lp/Lp
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3655267
Assay Type: RT-PCR
Annotation Date: 2006-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3655277
Age: embryonic day 10.5
Specimen Label: Lp/Lp
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:7567790
Assay Type: RT-PCR
Annotation Date: 2023-12-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185819
Stage: TS19
Assay Id: MGI:7567800
Age: embryonic day 11.5
Image: 4
Specimen Label: head
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7567790
Assay Type: RT-PCR
Annotation Date: 2023-12-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185719
Stage: TS19
Assay Id: MGI:7567800
Age: embryonic day 11.5
Image: 4
Specimen Label: rostral
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7567790
Assay Type: RT-PCR
Annotation Date: 2023-12-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185719
Stage: TS19
Assay Id: MGI:7567800
Age: embryonic day 11.5
Image: 4
Specimen Label: inter-limb
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7567790
Assay Type: RT-PCR
Annotation Date: 2023-12-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674819
Stage: TS19
Assay Id: MGI:7567800
Age: embryonic day 11.5
Image: 4
Specimen Label: tail
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1616617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Higher expression in the developing motor neurons at the level of the forelimb bud.
Specimen Label: 4L, +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1616617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Expression in this mutant is the same as in wild-type embryos.
Specimen Label: 4M, Lp/Lp
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Specimen Label: 4L, +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Expression in this mutant is the same as in wild-type embryos.
Specimen Label: 4M, Lp/Lp
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Ubiquitous expression.
Specimen Label: 4L, +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Ubiquitous expression. Expression in this mutant is the same as in wild-type embryos.
Specimen Label: 4M, Lp/Lp
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Ubiquitous expression.
Specimen Label: 4N, +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3655159
Age: embryonic day 10.5
Note: Ubiquitous expression. Expression in this mutant is the same as in wild-type embryos.
Specimen Label: 4O, Lp/Lp
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3655159
Age: embryonic day 9.5
Note: Ubiquitous expression.
Specimen Label: Table 3, +/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3655158
Assay Type: RNA in situ
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3655159
Age: embryonic day 9.5
Note: Ubiquitous expression. Expression in this mutant is the same as in wild-type embryos.
Specimen Label: Table 3, -/-
Detected: true
Specimen Num: 6
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Publication
19010322 | J:184126
First Author: Kashiwayama Y
Year: 2009
Journal: Exp Cell Res
Title: 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.
Volume: 315
Issue: 2
Pages: 190-205
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Publication
11259404 | J:143694
First Author: Sugihara T
Year: 2001
Journal: J Biol Chem
Title: Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.
Volume: 276
Issue: 22
Pages: 18649-52
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Publication
37569637 | J:339094
 
First Author: Wu CC
Year: 2023
Journal: Int J Mol Sci
Title: Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis.
Volume: 24
Issue: 15
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Publication
11709546 | J:72911
First Author: Murdoch JN
Year: 2001
Journal: Hum Mol Genet
Title: Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
Volume: 10
Issue: 22
Pages: 2593-601
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Publication
11431695 | J:70272
First Author: Kibar Z
Year: 2001
Journal: Nat Genet
Title: Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
Volume: 28
Issue: 3
Pages: 251-5
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Publication
11401431 | J:68343
First Author: Doudney K
Year: 2001
Journal: Genomics
Title: Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.
Volume: 72
Issue: 2
Pages: 180-92
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Publication
10051400 | J:52606
First Author: Eddleston J
Year: 1999
Journal: Genomics
Title: Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).
Volume: 56
Issue: 2
Pages: 149-59
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28817674 | J:248401
First Author: Colasante C
Year: 2017
Journal: PLoS One
Title: New insights into the distribution, protein abundance and subcellular localisation of the endogenous peroxisomal biogenesis proteins PEX3 and PEX19 in different organs and cell types of the adult mouse.
Volume: 12
Issue: 8
Pages: e0183150
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Publication
10704444 | -
First Author: Sacksteder KA
Year: 2000
Journal: J Cell Biol
Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
Volume: 148
Issue: 5
Pages: 931-44
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DO Term
DOID:0080486 | peroxisome biogenesis disorder 12A
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Publication
23460677 | J:196604
First Author: Yagita Y
Year: 2013
Journal: J Cell Biol
Title: Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.
Volume: 200
Issue: 5
Pages: 651-66
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Publication
25446110 | J:220286
First Author: Liu X
Year: 2015
Journal: Biochem Biophys Res Commun
Title: ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue.
Volume: 456
Issue: 1
Pages: 129-34
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Protein Domain
IPR038322 | Pex19_C_sf
Type: Homologous_superfamily
Description: Peroxisome(s) form an intracellular compartment, bounded by a typical lipid bilayer membrane. Peroxisome functions are often specialised by organism and cell type; two widely distributed and well-conserved functions are H2O2-based respiration and fatty acid beta-oxidation. Other functions include ether lipid (plasmalogen) synthesis and cholesterol synthesis inanimals, the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves, glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.PEX genes encode the machinery ("peroxins") required to assemble the peroxisome. Membrane assembly and maintenance requires three of these (peroxins 3, 16, and 19) and may occur without the import of the matrix (lumen) enzymes. Matrix protein import follows a branched pathway of soluble recycling receptors, with one branch for each class of peroxisome targeting sequence (two are well characterised), and a common trunk for all. At least one of these receptors, Pex5p, enters and exits peroxisomes as it functions. Proliferation of the organelle is regulated by Pex11p. Peroxisome biogenesis is remarkably conserved among eukaryotes. A group of fatal, inherited neuropathologies are recognised as peroxisome biogenesis diseases. Pex19 is involved in membrane assembly and maintenance and functions as a receptor and chaperone of peroxisomal membrane proteins (PMPs) [].This superfamily represents the C-terminal domain of Pex19, which is assembled in a three-helical bundle and represents the mPTS (PMP-targeting signal) binding site [].
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