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Search results 1 to 100 out of 190 for Pfn1

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0.766s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Profilins (PFNs) are a group of small eukaryotic proteins that bind to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation. Profilins also bind to polyphosphoinositides such as PIP2 []. Other ligands include members of the Ena/VASP and formin families []. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding. Four Profilins have been identified in mammals, PFN1-4. PFN1 and PFN2 differentially regulate membrane protrusion, motility, and invasion; these processes are promoted by PFN1 and suppressed by PFN2 []. This entry represents PFN1.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Teyssou E
Year: 2022
Journal: Int J Mol Sci
Title: The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
Volume: 23
Issue: 10
Publication  
First Author: Brettle M
Year: 2019
Journal: Front Mol Neurosci
Title: Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.
Volume: 12
Pages: 231
Publication
First Author: Figley MD
Year: 2014
Journal: J Neurosci
Title: Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.
Volume: 34
Issue: 24
Pages: 8083-97
Publication
First Author: Kursula P
Year: 2008
Journal: J Mol Biol
Title: High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.
Volume: 375
Issue: 1
Pages: 270-90
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
Publication  
First Author: Di Nardo A
Year: 2000
Journal: J Cell Sci
Title: Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms.
Volume: 113 Pt 21
Pages: 3795-803
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: false
Publication
First Author: Zheng J
Year: 2014
Journal: Blood
Title: Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
Volume: 123
Issue: 7
Pages: 992-1001
Publication
First Author: Miyajima D
Year: 2012
Journal: J Biol Chem
Title: Profilin1 regulates sternum development and endochondral bone formation.
Volume: 287
Issue: 40
Pages: 33545-53
Publication
First Author: Gau D
Year: 2023
Journal: J Biol Chem
Title: Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer.
Volume: 299
Issue: 8
Pages: 105044
Publication
First Author: Scotto di Carlo F
Year: 2023
Journal: Commun Biol
Title: Profilin 1 deficiency drives mitotic defects and reduces genome stability.
Volume: 6
Issue: 1
Pages: 9
Publication  
First Author: Tian X
Year: 2023
Journal: J Clin Invest
Title: Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases.
Volume: 133
Issue: 24
Publication
First Author: Gau D
Year: 2017
Journal: Angiogenesis
Title: Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis.
Volume: 20
Issue: 4
Pages: 663-672
Publication
First Author: Gau D
Year: 2020
Journal: J Biol Chem
Title: Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization.
Volume: 295
Issue: 28
Pages: 9618-9629
Publication
First Author: Kullmann JA
Year: 2011
Journal: EMBO Rep
Title: Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons.
Volume: 13
Issue: 1
Pages: 75-82
Publication  
First Author: Bender M
Year: 2014
Journal: Nat Commun
Title: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Volume: 5
Pages: 4746
Publication
First Author: Shirakawa J
Year: 2019
Journal: JBMR Plus
Title: Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice.
Volume: 3
Issue: 6
Pages: e10130
Publication
First Author: Michaelsen-Preusse K
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome.
Volume: 113
Issue: 12
Pages: 3365-70
Publication
First Author: Montani L
Year: 2014
Journal: Development
Title: Profilin 1 is required for peripheral nervous system myelination.
Volume: 141
Issue: 7
Pages: 1553-61
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Kullmann JA
Year: 2012
Journal: Neuroscience
Title: Purkinje cell loss and motor coordination defects in profilin1 mutant mice.
Volume: 223
Pages: 355-64
Publication
First Author: Böttcher RT
Year: 2009
Journal: EMBO J
Title: Profilin 1 is required for abscission during late cytokinesis of chondrocytes.
Volume: 28
Issue: 8
Pages: 1157-69
Publication
First Author: Lin W
Year: 2018
Journal: J Cell Physiol
Title: Profilin1 is expressed in osteocytes and regulates cell shape and migration.
Volume: 233
Issue: 1
Pages: 259-268
Publication
First Author: Görlich A
Year: 2012
Journal: PLoS One
Title: Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice.
Volume: 7
Issue: 1
Pages: e30068
Publication
First Author: Romeo GR
Year: 2013
Journal: Diabetes
Title: Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis.
Volume: 62
Issue: 11
Pages: 3718-26
Publication
First Author: Gurniak CB
Year: 2007
Journal: Eur J Cell Biol
Title: HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics.
Volume: 86
Issue: 1
Pages: 3-12
Publication  
First Author: Aihara E
Year: 2018
Journal: J Cell Sci
Title: Cell injury triggers actin polymerization to initiate epithelial restitution.
Volume: 131
Issue: 16
Publication
First Author: Kooij V
Year: 2016
Journal: Cardiovasc Res
Title: Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.
Volume: 110
Issue: 2
Pages: 238-48
Publication
First Author: Kanaujiya JK
Year: 2013
Journal: Proteomics
Title: Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells.
Volume: 13
Issue: 14
Pages: 2100-12
Publication
First Author: Kwiatkowski DJ
Year: 1988
Journal: J Biol Chem
Title: Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.
Volume: 263
Issue: 12
Pages: 5910-5
Publication
First Author: Kwiatkowski DJ
Year: 1990
Journal: Am J Hum Genet
Title: Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome.
Volume: 46
Issue: 3
Pages: 559-67
Publication
First Author: Laochumroonvorapong P
Year: 1997
Journal: Infect Immun
Title: Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice.
Volume: 65
Issue: 1
Pages: 127-32
Publication
First Author: Moustafa-Bayoumi M
Year: 2007
Journal: J Biol Chem
Title: Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1.
Volume: 282
Issue: 52
Pages: 37632-9
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: spleen
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: thymus
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: lung
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: kidney
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624728
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: gut
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: liver
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2676030
Age: postnatal adult
Image: 1
Specimen Label: brain
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:2676031
Age: embryonic day 10.0
Image: 1
Specimen Label: E10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2676031
Age: embryonic day 13.0
Image: 1
Specimen Label: E13
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2676031
Age: embryonic day 15.0
Image: 1
Specimen Label: E15
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2676031
Age: embryonic day 17.0
Image: 1
Specimen Label: E17
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2003-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2676031
Age: embryonic day 20.0
Image: 1
Specimen Label: E20
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: spleen
Specimen Num: 1
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: lung
Specimen Num: 2
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: thymus
Specimen Num: 3
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: kidney
Specimen Num: 4
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: heart
Specimen Num: 5
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: liver
Specimen Num: 6
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: spleen
Specimen Num: 7
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: lung
Specimen Num: 8
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: thymus
Specimen Num: 9
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: kidney
Specimen Num: 10
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: heart
Specimen Num: 11
GXD Expression        
Probe: MGI:2684182
Assay Type: Northern blot
Annotation Date: 2004-01-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2684185
Age: postnatal
Specimen Label: liver
Specimen Num: 12
GXD Expression      
Probe: MGI:2684188
Assay Type: Western blot
Annotation Date: 2004-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:2684198
Age: embryonic day 10.0
Specimen Label: 10
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2684188
Assay Type: Western blot
Annotation Date: 2004-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2684198
Age: embryonic day 13.0
Specimen Label: 13
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2684188
Assay Type: Western blot
Annotation Date: 2004-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2684198
Age: embryonic day 15.0
Specimen Label: 15
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2684188
Assay Type: Western blot
Annotation Date: 2004-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2684198
Age: embryonic day 17.0
Specimen Label: 17
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2684188
Assay Type: Western blot
Annotation Date: 2004-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:2684198
Age: embryonic day 20.0
Specimen Label: 20
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2008-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1633228
Stage: TS28
Assay Id: MGI:3798415
Age: postnatal
Image: 4
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2676025
Assay Type: Western blot
Annotation Date: 2008-07-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1633228
Stage: TS28
Assay Id: MGI:3798415
Age: postnatal
Image: 4
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7506845
Assay Type: RT-PCR
Annotation Date: 2023-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7506967
Age: postnatal day 30
Image: S5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7506845
Assay Type: RT-PCR
Annotation Date: 2023-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7506967
Age: postnatal day 30
Image: S5
Specimen Label: DKO
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6705086
Assay Type: Immunohistochemistry
Annotation Date: 2021-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6705090
Age: embryonic day 12.5
Image: 2B/C
Specimen Label: 2B/C
Detected: true
Specimen Num: 1