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Search results 1 to 100 out of 116 for Phactr1

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Hits by Strain

Hits by Category

Type Details Score
Gene
221692 | PHACTR1
Type: gene
Organism: human
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Gene
478723 | PHACTR1
Type: gene
Organism: dog, domestic
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Gene
537594 | PHACTR1
Type: gene
Organism: cattle
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Gene
395093 | PHACTR1
Type: gene
Organism: chicken
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Gene
100334776 | phactr1
Type: gene
Organism: zebrafish
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Gene
700226 | PHACTR1
Type: gene
Organism: macaque, rhesus
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Gene
100216198 | phactr1
Type: gene
Organism: frog, western clawed
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Gene
306844 | Phactr1
Type: gene
Organism: rat
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Gene
462438 | PHACTR1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR029987 | Phactr1
Type: Family
Description: Phosphatase and actin regulator (PHACTR) family members bind to actin and regulate protein phosphatase 1 (PP1) []. PHACTRs are comprised of four family members (Phactr1-4) with distinct expression patterns in the adult brain. They appear to be involved in the regulation of synaptic plasticity via modulating PP1 activity []. Phactr1 is highly enriched in mature neurons, and appears to play a role in development of dendritic spines and axons []. In non-neuronal cells, it plays significant roles in actin remodelling, affecting tubulogenesis and lamellipodial dynamics []. Phactr1 is involved in the migration and actin dynamics of breast cancer cells []. The structure of Phactr1 has been solved [].
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Protein Coding Gene
MGI:2659021 | Phactr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22766235 | J:192507
 
First Author: Kim JY
Year: 2012
Journal: Neuroscience
Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
Volume: 221
Pages: 37-46
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Publication
23041370 | -
First Author: Mouilleron S
Year: 2012
Journal: Structure
Title: Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.
Volume: 20
Issue: 11
Pages: 1960-70
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Publication
30256902 | J:276495
First Author: Hamada N
Year: 2018
Journal: Brain
Title: De novo PHACTR1 mutations in West syndrome and their pathophysiological effects.
Volume: 141
Issue: 11
Pages: 3098-3114
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Publication
22976292 | J:196227
First Author: Wiezlak M
Year: 2012
Journal: J Cell Sci
Title: G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.
Volume: 125
Issue: Pt 23
Pages: 5860-72
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Publication
33630758 | J:305798
 
First Author: Kasikara C
Year: 2021
Journal: J Clin Invest
Title: Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
Volume: 131
Issue: 8
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Publication
35653516 | J:335230
First Author: Wood A
Year: 2023
Journal: Cardiovasc Res
Title: PHACTR1 modulates vascular compliance but not endothelial function: a translational study.
Volume: 119
Issue: 2
Pages: 599-610
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Publication
28803787 | J:261960
 
First Author: Ito H
Year: 2018
Journal: Neurosci Res
Title: Expression analyses of Phactr1 (phosphatase and actin regulator 1) during mouse brain development.
Volume: 128
Pages: 50-57
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Publication
23479725 | -
First Author: Fils-Aimé N
Year: 2013
Journal: J Biol Chem
Title: MicroRNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1), a new signaling route through which transforming growth factor-β Mediates the migration and actin dynamics of breast cancer cells.
Volume: 288
Issue: 17
Pages: 11807-23
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Publication
21939755 | -
First Author: Allain B
Year: 2012
Journal: Cell Signal
Title: Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells.
Volume: 24
Issue: 1
Pages: 214-23
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Protein
Q2M3X8
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
A0A668KL56
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
B1B1B8
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
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Protein
Q80ZP7
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
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Publication
15107502 | -
First Author: Allen PB
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins.
Volume: 101
Issue: 18
Pages: 7187-92
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Publication
32975518 | J:299011
   
First Author: Fedoryshchak RO
Year: 2020
Journal: Elife
Title: Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme.
Volume: 9
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Publication
35387477 | J:341800
First Author: Rubin S
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice.
Volume: 42
Issue: 5
Pages: 597-609
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Protein Coding Gene
MGP_CAROLIEiJ_G0018465 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2659021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019821 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019533 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019344 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1909527
Pattern: Ubiquitous
Stage: TS27
Assay Id: MGI:7469616
Age: postnatal day 7
Note: Ubiquitous expression in areas where neuronal cell bodies are enriched.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1909528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3D
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3533828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3F
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3E
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778727
Pattern: Ubiquitous
Stage: TS27
Assay Id: MGI:7469616
Age: postnatal day 7
Note: Ubiquitous expression in areas where neuronal cell bodies are enriched.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3F
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7469616
Age: embryonic day 16.0
Specimen Label: 1E inset
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Ubiquitous
Stage: TS27
Assay Id: MGI:7469616
Age: postnatal day 7
Note: Ubiquitous expression in areas where neuronal cell bodies are enriched.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3D
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3525327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7469616
Age: postnatal day 7
Note: Only marginal expression in fiber-containing regions.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3561628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3D
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Ubiquitous
Stage: TS27
Assay Id: MGI:7469616
Age: postnatal day 7
Note: Ubiquitous expression in areas where neuronal cell bodies are enriched.
Specimen Label: 1I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3E
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1647024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7469616
Age: embryonic day 16.0
Note: Abundant expression in central nervous system.
Specimen Label: 1E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3586087
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7469616
Age: embryonic day 16.0
Note: Weak expression in peripheral tissues.
Specimen Label: 1E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3586087
Age: embryonic day 18.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586087
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586087
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal day 4-5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586087
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3586087
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3E
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3B
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Specimen Label: 3C
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:7469515
Assay Type: RNA in situ
Annotation Date: 2023-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7469616
Age: postnatal adult
Note: Expression distributed in most brain regions containing neurons.
Specimen Label: 3A
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3586087
Age: embryonic day 12.0
Note: Expression was detected in a subset of cells in the outer neuroblastic layer.
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3584974
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3586087
Age: embryonic day 14.0
Note: Expression was detected in a subset of cells in the outer neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 2
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Publication
- | J:83243
   
First Author: Strausberg R
Year: 2003
Journal: GenBank Submission
Title: Mus musculus, similar to Q9H4T4 like, clone IMAGE: 6469030, mRNA, partial cds
Pages: BC048407
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Publication
16359841 | J:105793
First Author: de Chaldée M
Year: 2006
Journal: Genomics
Title: Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease.
Volume: 87
Issue: 2
Pages: 200-7
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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