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Search results 1 to 100 out of 389 for Pias1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: PIAS1 is an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and acts as a SUMO-tethering factor []. SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
Publication
First Author: Kadaré G
Year: 2003
Journal: J Biol Chem
Title: PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.
Volume: 278
Issue: 48
Pages: 47434-40
Publication
First Author: Rabellino A
Year: 2012
Journal: Cancer Res
Title: The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
Volume: 72
Issue: 9
Pages: 2275-84
Protein
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
Publication
First Author: Su HL
Year: 2002
Journal: Gene
Title: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.
Volume: 296
Issue: 1-2
Pages: 65-73
Publication
First Author: Rabellino A
Year: 2016
Journal: Cell Rep
Title: PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
Volume: 15
Issue: 10
Pages: 2266-2278
Publication
First Author: Ochaba J
Year: 2016
Journal: Neuron
Title: PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
Volume: 90
Issue: 3
Pages: 507-20
Publication
First Author: Lee H
Year: 2006
Journal: Genes Dev
Title: PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.
Volume: 20
Issue: 7
Pages: 784-94
Publication
First Author: Oh HJ
Year: 2007
Journal: Mol Reprod Dev
Title: PIAS1 interacts with and represses SOX9 transactivation activity.
Volume: 74
Issue: 11
Pages: 1446-55
Publication
First Author: Ilmarinen T
Year: 2008
Journal: Mol Immunol
Title: Functional interaction of AIRE with PIAS1 in transcriptional regulation.
Volume: 45
Issue: 7
Pages: 1847-62
Publication
First Author: Gur I
Year: 2014
Journal: PLoS One
Title: Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
Volume: 9
Issue: 6
Pages: e99503
Publication
First Author: Liu B
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of Stat1-mediated gene activation by PIAS1.
Volume: 95
Issue: 18
Pages: 10626-31
Publication
First Author: Liu B
Year: 2004
Journal: Nat Immunol
Title: PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
Volume: 5
Issue: 9
Pages: 891-8
Publication
First Author: Liu B
Year: 2014
Journal: EMBO J
Title: PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells.
Volume: 33
Issue: 2
Pages: 101-13
Publication
First Author: Liu B
Year: 2010
Journal: Science
Title: The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
Volume: 330
Issue: 6003
Pages: 521-5
Publication
First Author: Constanzo JD
Year: 2016
Journal: Dev Biol
Title: Pias1 is essential for erythroid and vascular development in the mouse embryo.
Volume: 415
Issue: 1
Pages: 98-110
Publication
First Author: Zhao X
Year: 2007
Journal: J Immunol
Title: Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
Volume: 179
Issue: 12
Pages: 8297-304
Publication
First Author: Diao Y
Year: 2009
Journal: Mol Cell Biol
Title: SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Volume: 29
Issue: 18
Pages: 5084-93
Publication
First Author: Belaguli NS
Year: 2012
Journal: PLoS One
Title: PIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation.
Volume: 7
Issue: 4
Pages: e35717
Publication
First Author: Hanke NT
Year: 2014
Journal: Eur J Immunol
Title: PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15.
Volume: 44
Issue: 8
Pages: 2489-2499
Publication
First Author: Tahk S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation.
Volume: 104
Issue: 28
Pages: 11643-8
Publication
First Author: Heo KS
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Volume: 33
Issue: 2
Pages: 321-9
Publication
First Author: Siatecka M
Year: 2007
Journal: Mol Cell Biol
Title: Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis.
Volume: 27
Issue: 24
Pages: 8547-60
GXD Expression
Probe: MGI:7574626
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:2910621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7574628
Age: embryonic day 13.0
Image: 2A
Note: Expression co-localized with Sox9. Pias1 was positive within a few dot-like structures in the Sertoli cells.
Specimen Label: 2A
Detected: true
Specimen Num: 1
Publication
First Author: Liu Y
Year: 2013
Journal: Mol Cell Biol
Title: Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein β (C/EBPβ) during adipogenesis.
Volume: 33
Issue: 22
Pages: 4606-17
Publication
First Author: Sturm S
Year: 2000
Journal: J Mol Neurosci
Title: Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.
Volume: 14
Issue: 1-2
Pages: 107-21
Publication
First Author: Park SW
Year: 2007
Journal: Nat Struct Mol Biol
Title: SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.
Volume: 14
Issue: 1
Pages: 68-75
Publication
First Author: Liu B
Year: 2005
Journal: Mol Cell Biol
Title: Negative regulation of NF-kappaB signaling by PIAS1.
Volume: 25
Issue: 3
Pages: 1113-23
Publication
First Author: Wang G
Year: 2022
Journal: PLoS Pathog
Title: PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.
Volume: 18
Issue: 4
Pages: e1010446
Publication
First Author: Marongiu M
Year: 2010
Journal: PLoS One
Title: The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
Volume: 5
Issue: 3
Pages: e9477
Publication
First Author: Du JX
Year: 2007
Journal: J Biol Chem
Title: Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.
Volume: 282
Issue: 7
Pages: 4782-93
Publication
First Author: Wang J
Year: 2004
Journal: J Biol Chem
Title: SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.
Volume: 279
Issue: 47
Pages: 49091-8
Publication  
First Author: Beketaev I
Year: 2014
Journal: Int J Biochem Cell Biol
Title: Potentiation of Tbx5-mediated transactivation by SUMO conjugation and protein inhibitor of activated STAT 1 (PIAS1).
Volume: 50
Pages: 82-92
Publication
First Author: Soares IN
Year: 2013
Journal: Mol Cell Proteomics
Title: Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.
Volume: 12
Issue: 11
Pages: 3253-70
Publication
First Author: Ohshima T
Year: 2004
Journal: J Biol Chem
Title: Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification.
Volume: 279
Issue: 28
Pages: 29551-7
Publication
First Author: Wang J
Year: 2007
Journal: J Mol Biol
Title: The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation.
Volume: 370
Issue: 1
Pages: 27-38
Publication
First Author: Wang J
Year: 2013
Journal: J Biol Chem
Title: Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.
Volume: 288
Issue: 18
Pages: 12580-95
Publication
First Author: Liu Y
Year: 2015
Journal: Diabetes
Title: Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue.
Volume: 64
Issue: 12
Pages: 4061-74
Publication
First Author: Tiefenbach J
Year: 2006
Journal: Mol Biol Cell
Title: SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
Volume: 17
Issue: 4
Pages: 1643-51
Publication
First Author: Jennewein C
Year: 2008
Journal: J Immunol
Title: Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.
Volume: 181
Issue: 8
Pages: 5646-52
Publication
First Author: Zhang Y
Year: 2012
Journal: J Biol Chem
Title: A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
Volume: 287
Issue: 45
Pages: 37973-85
Publication
First Author: Paces-Fessy M
Year: 2004
Journal: Biochem J
Title: The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
Volume: 378
Issue: Pt 2
Pages: 353-62
Publication
First Author: Prigge JR
Year: 2006
Journal: J Biol Chem
Title: Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.
Volume: 281
Issue: 18
Pages: 12260-9
Publication  
First Author: Scortegagna M
Year: 2017
Journal: JCI Insight
Title: The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.
Volume: 2
Issue: 23
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816809
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816809
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816809
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816809
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816809
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816809
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816809
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3816005
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816809
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5529469
Assay Type: RT-PCR
Annotation Date: 2014-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289724
Stage: TS24
Assay Id: MGI:5529471
Age: embryonic day 16.5
Image: 6C
Specimen Label: Mo
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5529469
Assay Type: RT-PCR
Annotation Date: 2014-01-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288924
Stage: TS24
Assay Id: MGI:5529471
Age: embryonic day 16.5
Image: 6C
Specimen Label: In
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:5909882
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5909882
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5909882
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5909882
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5909882
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5909882
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5909882
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:5909882
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: liver
Specimen Num: 1
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: lung
Specimen Num: 4
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5909877
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5909885
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 7