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Search results 1 to 100 out of 233 for Pias3

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0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: PIAS3 is an E3-type small ubiquitin-like modifier (SUMO) ligases, stabilising the interaction between UBE2I and Ubc9 respectively and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway [, , , ].PIAS3 sumoylates CCAR2, promoting its interaction with SIRT1 []and diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus [].SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Rödel B
Year: 2000
Journal: EMBO J
Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.
Volume: 19
Issue: 21
Pages: 5845-55
Publication
First Author: Chung CD
Year: 1997
Journal: Science
Title: Specific inhibition of Stat3 signal transduction by PIAS3.
Volume: 278
Issue: 5344
Pages: 1803-5
Publication
First Author: Duval D
Year: 2003
Journal: FEBS Lett
Title: The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L.
Volume: 554
Issue: 1-2
Pages: 111-8
Protein
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
Publication
First Author: Levy C
Year: 2002
Journal: J Biol Chem
Title: A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor.
Volume: 277
Issue: 3
Pages: 1962-6
Protein
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
Publication  
First Author: Park JH
Year: 2014
Journal: Nat Commun
Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
Volume: 5
Pages: 5483
Publication
First Author: Sun X
Year: 2014
Journal: PLoS One
Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.
Volume: 9
Issue: 3
Pages: e92746
Publication
First Author: Jiménez-Lara AM
Year: 2002
Journal: FEBS Lett
Title: PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2.
Volume: 526
Issue: 1-3
Pages: 142-6
Publication
First Author: Hikata T
Year: 2009
Journal: Blood
Title: PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.
Volume: 113
Issue: 10
Pages: 2202-12
Protein
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: true
Publication
First Author: Iwasaki K
Year: 2007
Journal: J Biol Chem
Title: PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element.
Volume: 282
Issue: 31
Pages: 22335-43
Publication
First Author: Su HL
Year: 2002
Journal: Gene
Title: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.
Volume: 296
Issue: 1-2
Pages: 65-73
Publication
First Author: Jiang Q
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Down-regulation of ATBF1 activates STAT3 signaling via PIAS3 in pacing-induced HL-1 atrial myocytes.
Volume: 449
Issue: 3
Pages: 278-83
Publication
First Author: Campla CK
Year: 2017
Journal: Biol Open
Title: Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation.
Volume: 6
Issue: 6
Pages: 881-890
Publication
First Author: Sturm S
Year: 2000
Journal: J Mol Neurosci
Title: Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.
Volume: 14
Issue: 1-2
Pages: 107-21
Publication
First Author: Kuwata T
Year: 2008
Journal: Genes Cells
Title: BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body.
Volume: 13
Issue: 9
Pages: 931-40
Publication
First Author: Yagil Z
Year: 2009
Journal: J Immunol
Title: A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells.
Volume: 182
Issue: 4
Pages: 2168-75
Publication
First Author: Okumura F
Year: 2010
Journal: J Cell Sci
Title: TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
Volume: 123
Issue: Pt 13
Pages: 2238-45
Publication
First Author: Long J
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).
Volume: 101
Issue: 1
Pages: 99-104
Publication  
First Author: Liu T
Year: 2014
Journal: Bone
Title: A novel microRNA regulates osteoclast differentiation via targeting protein inhibitor of activated STAT3 (PIAS3).
Volume: 67
Pages: 156-65
Publication
First Author: Onishi A
Year: 2010
Journal: Nat Neurosci
Title: Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation.
Volume: 13
Issue: 9
Pages: 1059-65
Publication
First Author: Onishi A
Year: 2009
Journal: Neuron
Title: Pias3-dependent SUMOylation directs rod photoreceptor development.
Volume: 61
Issue: 2
Pages: 234-46
Publication
First Author: Mautsa N
Year: 2011
Journal: J Mol Recognit
Title: The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3.
Volume: 24
Issue: 5
Pages: 795-803
Publication
First Author: Deng J
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Protein inhibitor of activated STAT3 inhibits adipogenic gene expression.
Volume: 339
Issue: 3
Pages: 923-31
Publication
First Author: Levy C
Year: 2003
Journal: Mol Cell Biol
Title: Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3.
Volume: 23
Issue: 24
Pages: 9073-80
Publication
First Author: Levy C
Year: 2006
Journal: Blood
Title: Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.
Volume: 107
Issue: 7
Pages: 2839-45
Publication
First Author: Sonnenblick A
Year: 2004
Journal: Mol Cell Biol
Title: Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes.
Volume: 24
Issue: 24
Pages: 10584-92
Publication
First Author: Kim K
Year: 2007
Journal: J Immunol
Title: Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
Volume: 178
Issue: 9
Pages: 5588-94
Publication
First Author: Usui N
Year: 2017
Journal: Biol Psychiatry
Title: Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.
Volume: 81
Issue: 3
Pages: 220-230
Protein
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Takahashi K
Year: 2001
Journal: J Biol Chem
Title: DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.
Volume: 276
Issue: 40
Pages: 37556-63
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816811
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816811
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816811
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816811
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816811
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816811
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816811
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3816007
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816811
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:5909881
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5909881
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5909881
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5909881
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5909881
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5909881
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5909881
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:5909881
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: liver
Specimen Num: 1
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: lung
Specimen Num: 4
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: cerebellum
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5909876
Assay Type: RT-PCR
Annotation Date: 2017-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5909884
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4844909
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848715
Age: embryonic day 11.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777821
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4844909
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848715
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754921
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506831
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539801
Age: embryonic day 15.5
Image: GUDMAP:6182
Specimen Label: GUDMAP:6182
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3584978
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1721324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585445
Age: embryonic day 16.0
Note: Expression was detected in bone.
Specimen Label: Embryo
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3506831
Assay Type: RNA in situ
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3152723
Stage: TS23
Assay Id: MGI:6513514
Age: embryonic day 15.5
Specimen Label: Table S1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665921
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507058
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:3508502
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3584978
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:3585445
Age: embryonic day 14.0
Image: E14
Specimen Label: E14
Detected: false
Specimen Num: 1