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Search results 1 to 100 out of 644 for Picalm

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
8301 | PICALM
Type: gene
Organism: human
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Gene
100327242 | picalm
Type: gene
Organism: frog, western clawed
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Gene
89816 | Picalm
Type: gene
Organism: rat
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Gene
476780 | PICALM
Type: gene
Organism: dog, domestic
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Gene
451725 | PICALM
Type: gene
Organism: chimpanzee
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Gene
513579 | PICALM
Type: gene
Organism: cattle
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Gene
425991 | PICALM
Type: gene
Organism: chicken
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Gene
706003 | PICALM
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030412 | PICALM
Type: Family
Description: PICALM (also known as clathrin assembly lymphoid myeloid leukemia protein, CALM) is a phosphatidylinositol-binding clathrin assembly protein that plays important roles in clathrin-mediated endocytosis in all cell types [, ]. It modulates autophagy activity and tau accumulation, thus may influence the severity of Alzheimer's disease (AD) [, ]. PICALM is required for erythroid maturation and transferrin internalisation in mice []. PICALM deficiency in mice results in impaired hematopoiesis, anemia, abnormal iron metabolism, growth defects, and shortened life span. It plays a key role in iron homeostasis and cell proliferation [].
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Protein Coding Gene
MGI:2385902 | Picalm
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22952941 | J:191647
First Author: Scotland PB
Year: 2012
Journal: PLoS One
Title: The PICALM protein plays a key role in iron homeostasis and cell proliferation.
Volume: 7
Issue: 8
Pages: e44252
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Publication
22363754 | J:185312
First Author: Suzuki M
Year: 2012
Journal: PLoS One
Title: The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.
Volume: 7
Issue: 2
Pages: e31854
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Publication
25241929 | -
 
First Author: Moreau K
Year: 2014
Journal: Nat Commun
Title: PICALM modulates autophagy activity and tau accumulation.
Volume: 5
Pages: 4998
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Publication
25186232 | -
First Author: Xu W
Year: 2015
Journal: Mol Neurobiol
Title: The Role of PICALM in Alzheimer's Disease.
Volume: 52
Issue: 1
Pages: 399-413
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Gene
54478 | PIMREG
Type: gene
Organism: human
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Publication
31925534 | J:310496
First Author: Ando K
Year: 2020
Journal: Acta Neuropathol
Title: Picalm reduction exacerbates tau pathology in a murine tauopathy model.
Volume: 139
Issue: 4
Pages: 773-789
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Publication
26005850 | J:221101
First Author: Zhao Z
Year: 2015
Journal: Nat Neurosci
Title: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
Volume: 18
Issue: 7
Pages: 978-87
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Publication
25552701 | J:220728
First Author: Ishikawa Y
Year: 2015
Journal: Haematologica
Title: Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.
Volume: 100
Issue: 4
Pages: 439-51
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Publication
36707892 | J:344571
First Author: Kisler K
Year: 2023
Journal: Mol Neurodegener
Title: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier.
Volume: 18
Issue: 1
Pages: 7
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Publication
12832620 | J:84426
First Author: Klebig ML
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.
Volume: 100
Issue: 14
Pages: 8360-5
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Publication
23589030 | -
First Author: Ando K
Year: 2013
Journal: Acta Neuropathol
Title: Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.
Volume: 125
Issue: 6
Pages: 861-78
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Protein
A0A1L1SUR7
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: true
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Publication
22639918 | -
First Author: Maritzen T
Year: 2012
Journal: Biol Cell
Title: Turning CALM into excitement: AP180 and CALM in endocytosis and disease.
Volume: 104
Issue: 10
Pages: 588-602
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Protein
Q7M6Y3
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
A0A140LHG9
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
Q570Z8
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: true
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Protein
A0A140LHQ8
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: true
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Protein
Q3TD51
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
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Publication
27466196 | J:238571
First Author: Kanatsu K
Year: 2016
Journal: Hum Mol Genet
Title: Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.
Volume: 25
Issue: 18
Pages: 3988-3997
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Publication
22539346 | J:186509
First Author: Xiao Q
Year: 2012
Journal: J Biol Chem
Title: Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis.
Volume: 287
Issue: 25
Pages: 21279-89
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Publication
21151910 | J:167733
First Author: Grizenkova J
Year: 2010
Journal: PLoS One
Title: The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
Volume: 5
Issue: 12
Pages: e15019
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Protein Coding Gene
MGP_CAROLIEiJ_G0029981 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032503 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032488 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2385902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031530 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032322 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032278 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032312 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033008 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031647 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013201 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031091 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9292517 | J:43350
First Author: Potter MD
Year: 1997
Journal: Blood
Title: Mutations in the murine fitness 1 gene result in defective hematopoiesis.
Volume: 90
Issue: 5
Pages: 1850-7
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Publication
- | J:49310
First Author: Schultze AE
Year: 1998
Journal: Comp Haematol Int
Title: Alterations in serum and tissue iron profiles associated with mutations in the fitness1(4226SB) locus of mice.
Volume: 8
Issue: 2
Pages: 72-76
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Publication
- | J:43923
First Author: Schultze AE
Year: 1997
Journal: Comp Haematol Int
Title: Alterations in growth, haematopoiesis and serum chemistry profiles in fitness 1(4226SB) mutant mice.
Volume: 7
Issue: 3
Pages: 143-151
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Publication
10403440 | J:55619
First Author: Schultze AE
Year: 1999
Journal: Lab Anim Sci
Title: Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of mice.
Volume: 49
Issue: 3
Pages: 260-8
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Publication
24577224 | J:207966
 
First Author: Kanatsu K
Year: 2014
Journal: Nat Commun
Title: Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase.
Volume: 5
Pages: 3386
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Publication
18182011 | J:154896
First Author: Harel A
Year: 2008
Journal: Traffic
Title: Evidence for CALM in directing VAMP2 trafficking.
Volume: 9
Issue: 3
Pages: 417-29
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Publication
18842885 | J:156045
First Author: Bushlin I
Year: 2008
Journal: J Neurosci
Title: Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons.
Volume: 28
Issue: 41
Pages: 10257-71
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Publication
22851330 | J:207810
First Author: Petralia RS
Year: 2013
Journal: Neuromolecular Med
Title: Reduction of AP180 and CALM produces defects in synaptic vesicle size and density.
Volume: 15
Issue: 1
Pages: 49-60
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GXD Expression
GXD Expression
     
Probe: MGI:3759128
Assay Type: RT-PCR
Annotation Date: 2007-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:3759277
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3759128
Assay Type: RT-PCR
Annotation Date: 2007-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:3759277
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Aorta
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Muscle
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Heart
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Spleen
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Thymus
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5660010
Age: postnatal
Specimen Label: Brain
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #6
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #2
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Western blot
Annotation Date: 2015-08-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5660012
Age: embryonic day 12.5
Specimen Label: #3
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7525326
Assay Type: RT-PCR
Annotation Date: 2023-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7525358
Age: embryonic day 18.5
Image: 4
Specimen Label: E18.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525326
Assay Type: RT-PCR
Annotation Date: 2023-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7525358
Age: postnatal day 0.5
Image: 4
Specimen Label: P0.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525326
Assay Type: RT-PCR
Annotation Date: 2023-09-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7525358
Age: postnatal day 4.5
Image: 4
Specimen Label: P4.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Stage: TS28
Assay Id: MGI:7543177
Age: postnatal day 16
Image: S3
Specimen Label: Purkinje layer WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Stage: TS28
Assay Id: MGI:7543177
Age: postnatal day 16
Image: S3
Specimen Label: Purkinje layer Srrm3
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Stage: TS28
Assay Id: MGI:7543177
Age: postnatal day 16
Image: S3
Specimen Label: Granular layer WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Stage: TS28
Assay Id: MGI:7543177
Age: postnatal day 16
Image: S3
Specimen Label: Granular layer Srrm3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543238
Age: embryonic day 19.0
Image: S4
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7542992
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543238
Age: embryonic day 19.0
Image: S4
Specimen Label: dMut
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5659955
Assay Type: Immunohistochemistry
Annotation Date: 2015-08-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Pattern: Punctate
Stage: TS21
Assay Id: MGI:5660014
Age: embryonic day 13.5
Specimen Label: 1B +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5659955
Assay Type: Immunohistochemistry
Annotation Date: 2015-08-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:5660014
Age: embryonic day 13.5
Specimen Label: 1B -/-
Detected: false
Specimen Num: 2
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Publication
- | J:81267
   
First Author: Klebig ML
Year: 2003
Journal: GenBank Submission
Title: Mus musculus phosphatidylinositol-binding clathrin assembly protein (Picalm) mRNA, complete cds
Pages: AY206701
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Gene
360559 | Pimreg
Type: gene
Organism: rat
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Gene
489446 | PIMREG
Type: gene
Organism: dog, domestic
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Gene
455249 | PIMREG
Type: gene
Organism: chimpanzee
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Gene
540455 | PIMREG
Type: gene
Organism: cattle
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Gene
712701 | PIMREG
Type: gene
Organism: macaque, rhesus
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Gene
100490131 | pimreg
Type: gene
Organism: frog, western clawed
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Publication
26399746 | J:227223
 
First Author: Gimber N
Year: 2015
Journal: Nat Commun
Title: Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.
Volume: 6
Pages: 8392
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Publication
7558026 | J:27749
First Author: Holdener BC
Year: 1995
Journal: Genomics
Title: Physical localization of eed: a region of mouse chromosome 7 required for gastrulation.
Volume: 27
Issue: 3
Pages: 447-56
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Publication
35613266 | J:325702
First Author: Azarnia Tehran D
Year: 2022
Journal: Sci Adv
Title: Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Volume: 8
Issue: 21
Pages: eabl5032
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7767008 | J:22809
First Author: Potter MD
Year: 1995
Journal: Mamm Genome
Title: Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7.
Volume: 6
Issue: 2
Pages: 70-5
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2300582 | J:10283
First Author: Rinchik EM
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.
Volume: 87
Issue: 3
Pages: 896-900
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Publication
10224267 | J:54592
First Author: Rinchik EM
Year: 1999
Journal: Genetics
Title: N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.
Volume: 152
Issue: 1
Pages: 373-83
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First Author: Schwab KR
Year: 2007
Journal: BMC Biol
Title: Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
Volume: 5
Pages: 15
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37143315 | J:338401
     
First Author: Nutter CA
Year: 2023
Journal: Brain
Title: Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
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First Author: Oak Ridge National Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN
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