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Search results 1 to 100 out of 633 for Pik3ca

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Type Details Score
Gene
5290 | PIK3CA
Type: gene
Organism: human
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Gene
460858 | PIK3CA
Type: gene
Organism: chimpanzee
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Gene
424971 | PIK3CA
Type: gene
Organism: chicken
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Gene
561737 | pik3ca
Type: gene
Organism: zebrafish
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Gene
709959 | PIK3CA
Type: gene
Organism: macaque, rhesus
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Gene
100144924 | pik3ca
Type: gene
Organism: frog, western clawed
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Gene
282306 | PIK3CA
Type: gene
Organism: cattle
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Gene
488084 | PIK3CA
Type: gene
Organism: dog, domestic
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Gene
170911 | Pik3ca
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101928739 | PIK3CA-DT
Type: gene
Organism: human
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Publication
27030594 | J:246143
First Author: Castel P
Year: 2016
Journal: Sci Transl Med
Title: Somatic PIK3CA mutations as a driver of sporadic venous malformations.
Volume: 8
Issue: 332
Pages: 332ra42
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Publication
19172191 | J:144834
First Author: Liang S
Year: 2009
Journal: PLoS One
Title: Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.
Volume: 4
Issue: 1
Pages: e4295
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Publication
33910229 | J:308740
First Author: Ren AA
Year: 2021
Journal: Nature
Title: PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Volume: 594
Issue: 7862
Pages: 271-276
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Publication
29346447 | J:257014
First Author: Chang HJ
Year: 2018
Journal: PLoS One
Title: Pik3ca is required for mouse uterine gland development and pregnancy.
Volume: 13
Issue: 1
Pages: e0191433
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Publication
29170395 | J:255747
First Author: Berenjeno IM
Year: 2017
Journal: Nat Commun
Title: Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Volume: 8
Issue: 1
Pages: 1773
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Publication
37544503 | J:342856
First Author: Shuman L
Year: 2023
Journal: Am J Pathol
Title: Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer.
Volume: 193
Issue: 12
Pages: 2133-2143
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Publication
19196980 | J:146491
First Author: Gustin JP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Volume: 106
Issue: 8
Pages: 2835-40
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Publication
30332649 | J:270695
First Author: An Y
Year: 2018
Journal: Cell Rep
Title: Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Volume: 25
Issue: 3
Pages: 702-714.e6
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Publication
26266985 | J:225868
First Author: Van Keymeulen A
Year: 2015
Journal: Nature
Title: Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.
Volume: 525
Issue: 7567
Pages: 119-23
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Publication
23384338 | J:213102
First Author: Koren S
Year: 2013
Journal: FEBS J
Title: Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.
Volume: 280
Issue: 12
Pages: 2758-65
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Publication
23940356 | J:200744
First Author: Hanker AB
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.
Volume: 110
Issue: 35
Pages: 14372-7
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Publication
23708654 | J:212593
First Author: Deming DA
Year: 2014
Journal: Oncogene
Title: PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Volume: 33
Issue: 17
Pages: 2245-54
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Publication
36490341 | J:332935
First Author: Ladraa S
Year: 2022
Journal: Sci Adv
Title: PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.
Volume: 8
Issue: 49
Pages: eade7823
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Publication
24770869 | J:211098
First Author: Charles RP
Year: 2014
Journal: Mol Cancer Res
Title: Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.
Volume: 12
Issue: 7
Pages: 979-86
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Publication
32513927 | J:292002
First Author: Martinez-Corral I
Year: 2020
Journal: Nat Commun
Title: Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.
Volume: 11
Issue: 1
Pages: 2869
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Publication
26814435 | J:314627
First Author: Liu JC
Year: 2016
Journal: Oncotarget
Title: Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.
Volume: 7
Issue: 8
Pages: 9060-8
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Publication
27030595 | J:246606
First Author: Castillo SD
Year: 2016
Journal: Sci Transl Med
Title: Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.
Volume: 8
Issue: 332
Pages: 332ra43
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Publication
33431926 | J:300290
First Author: Xie S
Year: 2021
Journal: Sci Rep
Title: The role of the PIK3CA gene in the development and aging of the brain.
Volume: 11
Issue: 1
Pages: 291
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Publication
22214849 | J:184382
First Author: Kinross KM
Year: 2012
Journal: J Clin Invest
Title: An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
Volume: 122
Issue: 2
Pages: 553-7
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Publication
25826091 | J:309312
First Author: Li X
Year: 2015
Journal: Oncotarget
Title: Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver.
Volume: 6
Issue: 12
Pages: 10102-15
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Publication
26716908 | J:316024
First Author: Wang C
Year: 2016
Journal: Liver Int
Title: Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.
Volume: 36
Issue: 8
Pages: 1176-86
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Publication
26876212 | J:230809
First Author: Du L
Year: 2016
Journal: Oncogene
Title: Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.
Volume: 35
Issue: 35
Pages: 4641-52
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Publication
29505847 | J:320365
First Author: Liu JJ
Year: 2018
Journal: J Hepatol
Title: Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.
Volume: 69
Issue: 1
Pages: 79-88
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Publication
23633485 | J:199017
First Author: Young CD
Year: 2013
Journal: Cancer Res
Title: Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Volume: 73
Issue: 13
Pages: 4075-85
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Publication
23499052 | J:195346
First Author: Wu R
Year: 2013
Journal: Am J Pathol
Title: Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.
Volume: 182
Issue: 4
Pages: 1391-9
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Publication
26276752 | J:317006
First Author: Hadac JN
Year: 2015
Journal: Cancer Prev Res (Phila)
Title: Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.
Volume: 8
Issue: 10
Pages: 952-61
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Publication
30530704 | J:295632
First Author: Shin MK
Year: 2019
Journal: Clin Cancer Res
Title: Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes.
Volume: 25
Issue: 6
Pages: 1889-1900
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Publication
32152233 | J:289003
First Author: García-Carracedo D
Year: 2020
Journal: Mol Cancer Res
Title: PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice.
Volume: 18
Issue: 6
Pages: 822-834
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Publication
29581176 | J:262548
First Author: Pearson HB
Year: 2018
Journal: Cancer Discov
Title: Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.
Volume: 8
Issue: 6
Pages: 764-779
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Publication
25625625 | J:219794
 
First Author: Chandler RL
Year: 2015
Journal: Nat Commun
Title: Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Volume: 6
Pages: 6118
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Publication
19822807 | J:167494
First Author: Inuzuka Y
Year: 2009
Journal: Circulation
Title: Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice.
Volume: 120
Issue: 17
Pages: 1695-703
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Publication
25937176 | J:310694
 
First Author: De Blasio MJ
Year: 2015
Journal: Free Radic Biol Med
Title: Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling.
Volume: 87
Pages: 137-47
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Publication
17060635 | J:115274
First Author: Zhao JJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.
Volume: 103
Issue: 44
Pages: 16296-300
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Publication
19679877 | J:152896
First Author: Pretorius L
Year: 2009
Journal: Am J Pathol
Title: Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.
Volume: 175
Issue: 3
Pages: 998-1009
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Publication
22370636 | J:193377
First Author: Yuan W
Year: 2013
Journal: Oncogene
Title: Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.
Volume: 32
Issue: 3
Pages: 318-26
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Publication
10835352 | J:62707
First Author: Shioi T
Year: 2000
Journal: EMBO J
Title: The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
Volume: 19
Issue: 11
Pages: 2537-48
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Publication
23001375 | J:194561
First Author: Ritchie RH
Year: 2012
Journal: Diabetologia
Title: Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Volume: 55
Issue: 12
Pages: 3369-81
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Publication
26633882 | J:269511
   
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
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Publication
31094678 | J:276596
   
First Author: Roy A
Year: 2019
Journal: Elife
Title: PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice.
Volume: 8
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Publication
26863299 | J:249168
First Author: Yueh AE
Year: 2016
Journal: PLoS One
Title: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.
Volume: 11
Issue: 2
Pages: e0148730
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Publication
23142539 | J:192823
 
First Author: McLean BA
Year: 2013
Journal: J Mol Cell Cardiol
Title: Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling.
Volume: 54
Pages: 9-18
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Publication
21703185 | J:279560
First Author: Kudo Y
Year: 2011
Journal: J Hepatol
Title: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Volume: 55
Issue: 6
Pages: 1400-8
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Publication
17202264 | J:119070
First Author: McMullen JR
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.
Volume: 104
Issue: 2
Pages: 612-7
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Publication
22038742 | J:194876
First Author: Yang KC
Year: 2012
Journal: Cardiovasc Res
Title: Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.
Volume: 93
Issue: 2
Pages: 252-62
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Publication
14597618 | J:87944
First Author: McMullen JR
Year: 2004
Journal: J Biol Chem
Title: The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
Volume: 279
Issue: 6
Pages: 4782-93
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Publication
27681437 | J:240566
First Author: Kim M
Year: 2016
Journal: Cell Rep
Title: Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer.
Volume: 17
Issue: 1
Pages: 275-288
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Publication
33577435 | J:305039
First Author: Weeks KL
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Volume: 320
Issue: 4
Pages: H1470-H1485
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Publication
33031974 | J:301202
 
First Author: Dasgupta K
Year: 2021
Journal: Bone
Title: Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues.
Volume: 142
Pages: 115674
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Publication
22666336 | J:187299
First Author: Tikoo A
Year: 2012
Journal: PLoS One
Title: Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.
Volume: 7
Issue: 5
Pages: e36924
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Publication
28692045 | J:248094
First Author: Nakatsuka T
Year: 2017
Journal: Oncogene
Title: Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Volume: 36
Issue: 45
Pages: 6262-6271
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Publication
31391455 | J:279481
First Author: Wilson MR
Year: 2019
Journal: Nat Commun
Title: ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Volume: 10
Issue: 1
Pages: 3554
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Publication
20237330 | J:172261
First Author: Lin RC
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Volume: 30
Issue: 4
Pages: 724-32
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Publication
25698082 | J:220252
First Author: Joshi A
Year: 2015
Journal: Am J Pathol
Title: Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.
Volume: 185
Issue: 4
Pages: 1104-13
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Publication
24320611 | J:210498
First Author: Hare LM
Year: 2014
Journal: Biochem J
Title: Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.
Volume: 458
Issue: 2
Pages: 251-8
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Publication
35538223 | J:326552
First Author: Simond AM
Year: 2022
Journal: Oncogene
Title: Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer.
Volume: 41
Issue: 25
Pages: 3445-3451
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Publication
33876772 | J:304843
 
First Author: Sharma V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Volume: 118
Issue: 15
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Publication
25550458 | J:327062
First Author: Kinross KM
Year: 2015
Journal: FASEB J
Title: Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.
Volume: 29
Issue: 4
Pages: 1426-34
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Publication
31844152 | J:287333
First Author: Zhao Y
Year: 2019
Journal: Sci Rep
Title: Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo.
Volume: 9
Issue: 1
Pages: 19180
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Publication
26567140 | J:227253
First Author: Green S
Year: 2015
Journal: Cancer Res
Title: PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.
Volume: 75
Issue: 24
Pages: 5378-91
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Publication
27910071 | J:320634
 
First Author: Joshi A
Year: 2017
Journal: Adv Exp Med Biol
Title: PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.
Volume: 943
Pages: 261-273
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Publication
30568254 | J:292538
First Author: Patel VB
Year: 2018
Journal: Nat Commun
Title: PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Volume: 9
Issue: 1
Pages: 5390
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Publication
29581096 | J:275039
 
First Author: Wang G
Year: 2018
Journal: EMBO J
Title: p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells.
Volume: 37
Issue: 8
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Publication
31881983 | J:301082
First Author: Yuan W
Year: 2019
Journal: Breast Cancer Res
Title: S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.
Volume: 21
Issue: 1
Pages: 152
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Publication
24019382 | J:204513
First Author: Trejo CL
Year: 2013
Journal: Cancer Res
Title: Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.
Volume: 73
Issue: 21
Pages: 6448-61
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Publication
27482546 | J:251785
First Author: Sheen MR
Year: 2015
Journal: Open Life Sci
Title: Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects.
Volume: 10
Issue: 1
Pages: 461-478
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Publication
26279473 | J:227728
First Author: Zhai Y
Year: 2016
Journal: J Pathol
Title: Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.
Volume: 238
Issue: 1
Pages: 21-30
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Publication
25311989 | J:225421
First Author: Wu CY
Year: 2014
Journal: Gastroenterology
Title: PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Volume: 147
Issue: 6
Pages: 1405-16.e7
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Publication
21367821 | J:171508
First Author: Ikegami D
Year: 2011
Journal: Development
Title: Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Volume: 138
Issue: 8
Pages: 1507-19
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Publication
25958091 | J:224939
First Author: Hare LM
Year: 2015
Journal: Dev Biol
Title: Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.
Volume: 404
Issue: 1
Pages: 14-26
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Publication
26238783 | J:225884
First Author: Remy E
Year: 2015
Journal: Cancer Res
Title: A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis.
Volume: 75
Issue: 19
Pages: 4042-52
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Protein Coding Gene
MGP_CAROLIEiJ_G0024915 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026851 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1206581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027554 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026930 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
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Protein Coding Gene
MGP_PWKPhJ_G0026037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_WSBEiJ_G0026378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_PahariEiJ_G0026360 | -
Type: protein_coding_gene
Organism: Mus pahari
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•
•
•
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Protein Coding Gene
MGP_SPRETEiJ_G0025849 | -
Type: protein_coding_gene
Organism: Mus spretus
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•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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