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Search results 1 to 100 out of 549 for Pik3ca

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Liang S
Year: 2009
Journal: PLoS One
Title: Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.
Volume: 4
Issue: 1
Pages: e4295
Publication
First Author: Castel P
Year: 2016
Journal: Sci Transl Med
Title: Somatic PIK3CA mutations as a driver of sporadic venous malformations.
Volume: 8
Issue: 332
Pages: 332ra42
Publication
First Author: Ren AA
Year: 2021
Journal: Nature
Title: PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Volume: 594
Issue: 7862
Pages: 271-276
Publication
First Author: Chang HJ
Year: 2018
Journal: PLoS One
Title: Pik3ca is required for mouse uterine gland development and pregnancy.
Volume: 13
Issue: 1
Pages: e0191433
Publication
First Author: Berenjeno IM
Year: 2017
Journal: Nat Commun
Title: Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Volume: 8
Issue: 1
Pages: 1773
Publication
First Author: Gustin JP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Volume: 106
Issue: 8
Pages: 2835-40
Publication
First Author: Van Keymeulen A
Year: 2015
Journal: Nature
Title: Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.
Volume: 525
Issue: 7567
Pages: 119-23
Publication
First Author: Koren S
Year: 2013
Journal: FEBS J
Title: Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.
Volume: 280
Issue: 12
Pages: 2758-65
Publication
First Author: Hanker AB
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.
Volume: 110
Issue: 35
Pages: 14372-7
Publication
First Author: Deming DA
Year: 2014
Journal: Oncogene
Title: PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Volume: 33
Issue: 17
Pages: 2245-54
Publication
First Author: Charles RP
Year: 2014
Journal: Mol Cancer Res
Title: Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.
Volume: 12
Issue: 7
Pages: 979-86
Publication
First Author: Martinez-Corral I
Year: 2020
Journal: Nat Commun
Title: Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.
Volume: 11
Issue: 1
Pages: 2869
Publication
First Author: An Y
Year: 2018
Journal: Cell Rep
Title: Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Volume: 25
Issue: 3
Pages: 702-714.e6
Publication
First Author: Castillo SD
Year: 2016
Journal: Sci Transl Med
Title: Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.
Volume: 8
Issue: 332
Pages: 332ra43
Publication
First Author: Xie S
Year: 2021
Journal: Sci Rep
Title: The role of the PIK3CA gene in the development and aging of the brain.
Volume: 11
Issue: 1
Pages: 291
Publication
First Author: Kinross KM
Year: 2012
Journal: J Clin Invest
Title: An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
Volume: 122
Issue: 2
Pages: 553-7
Publication
First Author: Li X
Year: 2015
Journal: Oncotarget
Title: Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver.
Volume: 6
Issue: 12
Pages: 10102-15
Publication
First Author: Du L
Year: 2016
Journal: Oncogene
Title: Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.
Volume: 35
Issue: 35
Pages: 4641-52
Publication
First Author: Young CD
Year: 2013
Journal: Cancer Res
Title: Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Volume: 73
Issue: 13
Pages: 4075-85
Publication
First Author: Wu R
Year: 2013
Journal: Am J Pathol
Title: Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.
Volume: 182
Issue: 4
Pages: 1391-9
Publication
First Author: Shin MK
Year: 2019
Journal: Clin Cancer Res
Title: Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes.
Volume: 25
Issue: 6
Pages: 1889-1900
Publication
First Author: García-Carracedo D
Year: 2020
Journal: Mol Cancer Res
Title: PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice.
Volume: 18
Issue: 6
Pages: 822-834
Publication
First Author: Pearson HB
Year: 2018
Journal: Cancer Discov
Title: Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.
Volume: 8
Issue: 6
Pages: 764-779
Publication
First Author: Inuzuka Y
Year: 2009
Journal: Circulation
Title: Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice.
Volume: 120
Issue: 17
Pages: 1695-703
Publication
First Author: Shioi T
Year: 2000
Journal: EMBO J
Title: The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
Volume: 19
Issue: 11
Pages: 2537-48
Publication
First Author: Ritchie RH
Year: 2012
Journal: Diabetologia
Title: Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Volume: 55
Issue: 12
Pages: 3369-81
Publication
First Author: Pretorius L
Year: 2009
Journal: Am J Pathol
Title: Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.
Volume: 175
Issue: 3
Pages: 998-1009
Publication  
First Author: Chandler RL
Year: 2015
Journal: Nat Commun
Title: Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Volume: 6
Pages: 6118
Publication
First Author: McMullen JR
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.
Volume: 104
Issue: 2
Pages: 612-7
Publication
First Author: McMullen JR
Year: 2004
Journal: J Biol Chem
Title: The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
Volume: 279
Issue: 6
Pages: 4782-93
Publication  
First Author: McLean BA
Year: 2013
Journal: J Mol Cell Cardiol
Title: Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling.
Volume: 54
Pages: 9-18
Publication
First Author: Lin RC
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Volume: 30
Issue: 4
Pages: 724-32
Publication
First Author: Zhao JJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.
Volume: 103
Issue: 44
Pages: 16296-300
Publication
First Author: Yuan W
Year: 2013
Journal: Oncogene
Title: Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.
Volume: 32
Issue: 3
Pages: 318-26
Publication
First Author: Patel VB
Year: 2018
Journal: Nat Commun
Title: PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Volume: 9
Issue: 1
Pages: 5390
Publication    
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
Publication    
First Author: Roy A
Year: 2019
Journal: Elife
Title: PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice.
Volume: 8
Publication
First Author: Yueh AE
Year: 2016
Journal: PLoS One
Title: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.
Volume: 11
Issue: 2
Pages: e0148730
Publication
First Author: Kudo Y
Year: 2011
Journal: J Hepatol
Title: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Volume: 55
Issue: 6
Pages: 1400-8
Publication
First Author: Yang KC
Year: 2012
Journal: Cardiovasc Res
Title: Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.
Volume: 93
Issue: 2
Pages: 252-62
Publication
First Author: Kim M
Year: 2016
Journal: Cell Rep
Title: Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer.
Volume: 17
Issue: 1
Pages: 275-288
Publication
First Author: Tikoo A
Year: 2012
Journal: PLoS One
Title: Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.
Volume: 7
Issue: 5
Pages: e36924
Publication  
First Author: Dasgupta K
Year: 2021
Journal: Bone
Title: Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues.
Volume: 142
Pages: 115674
Publication
First Author: Nakatsuka T
Year: 2017
Journal: Oncogene
Title: Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Volume: 36
Issue: 45
Pages: 6262-6271
Publication
First Author: Wilson MR
Year: 2019
Journal: Nat Commun
Title: ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Volume: 10
Issue: 1
Pages: 3554
Publication
First Author: Hare LM
Year: 2014
Journal: Biochem J
Title: Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.
Volume: 458
Issue: 2
Pages: 251-8
Publication
First Author: Joshi A
Year: 2015
Journal: Am J Pathol
Title: Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.
Volume: 185
Issue: 4
Pages: 1104-13
Publication  
First Author: Wang G
Year: 2018
Journal: EMBO J
Title: p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells.
Volume: 37
Issue: 8
Publication  
First Author: Sharma V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
Volume: 118
Issue: 15
Publication
First Author: Green S
Year: 2015
Journal: Cancer Res
Title: PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.
Volume: 75
Issue: 24
Pages: 5378-91
Publication
First Author: Zhao Y
Year: 2019
Journal: Sci Rep
Title: Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo.
Volume: 9
Issue: 1
Pages: 19180
Publication
First Author: Yuan W
Year: 2019
Journal: Breast Cancer Res
Title: S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.
Volume: 21
Issue: 1
Pages: 152
Publication
First Author: Trejo CL
Year: 2013
Journal: Cancer Res
Title: Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.
Volume: 73
Issue: 21
Pages: 6448-61
Publication
First Author: Sheen MR
Year: 2015
Journal: Open Life Sci
Title: Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects.
Volume: 10
Issue: 1
Pages: 461-478
Publication
First Author: Zhai Y
Year: 2016
Journal: J Pathol
Title: Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.
Volume: 238
Issue: 1
Pages: 21-30
Publication
First Author: Wu CY
Year: 2014
Journal: Gastroenterology
Title: PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Volume: 147
Issue: 6
Pages: 1405-16.e7
Publication
First Author: Ikegami D
Year: 2011
Journal: Development
Title: Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Volume: 138
Issue: 8
Pages: 1507-19
Publication
First Author: Hare LM
Year: 2015
Journal: Dev Biol
Title: Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.
Volume: 404
Issue: 1
Pages: 14-26
Publication
First Author: Remy E
Year: 2015
Journal: Cancer Res
Title: A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis.
Volume: 75
Issue: 19
Pages: 4042-52
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Klippel A
Year: 1994
Journal: Mol Cell Biol
Title: The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.
Volume: 14
Issue: 4
Pages: 2675-85
Publication
First Author: Vantler M
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Class IA Phosphatidylinositol 3-Kinase Isoform p110α Mediates Vascular Remodeling.
Volume: 35
Issue: 6
Pages: 1434-44
Publication  
First Author: Rajala RV
Year: 2015
Journal: Biochimie
Title: The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival.
Volume: 112
Pages: 35-40
Publication  
First Author: Saito K
Year: 2016
Journal: Sci Rep
Title: PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice.
Volume: 6
Pages: 23459
Publication
First Author: Molinaro A
Year: 2019
Journal: Cell Metab
Title: Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS.
Volume: 29
Issue: 6
Pages: 1400-1409.e5
Publication
First Author: Xu Y
Year: 2010
Journal: Cell Metab
Title: PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.
Volume: 12
Issue: 1
Pages: 88-95
Publication
First Author: Chaudhari A
Year: 2015
Journal: Mol Cell Biol
Title: p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.
Volume: 35
Issue: 19
Pages: 3258-73
Publication
First Author: Sopasakis VR
Year: 2010
Journal: Cell Metab
Title: Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Volume: 11
Issue: 3
Pages: 220-30
Publication
First Author: Valer JA
Year: 2019
Journal: EMBO Mol Med
Title: Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification.
Volume: 11
Issue: 9
Pages: e10567
Publication
First Author: Alliouachene S
Year: 2016
Journal: Diabetologia
Title: Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.
Volume: 59
Issue: 7
Pages: 1503-1512
Publication
First Author: Moore SF
Year: 2019
Journal: Sci Rep
Title: Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.
Volume: 9
Issue: 1
Pages: 1468
Publication
First Author: Araiz C
Year: 2019
Journal: Nat Commun
Title: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.
Volume: 10
Issue: 1
Pages: 1546
Publication
First Author: Laurent PA
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis.
Volume: 38
Issue: 9
Pages: 2041-2053
Publication
First Author: Kim SY
Year: 2016
Journal: Cancer Res
Title: Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors.
Volume: 76
Issue: 13
Pages: 3851-61
Publication  
First Author: Liu W
Year: 2014
Journal: Nat Commun
Title: Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling.
Volume: 5
Pages: 5684
Publication
First Author: Johanson SO
Year: 1999
Journal: Exp Cell Res
Title: A p85 subunit-independent p110alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibers and regulates thrombin-stimulated stress fiber formation in swiss 3T3 cells.
Volume: 248
Issue: 1
Pages: 223-33
Publication
First Author: Aksoy IA
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.
Volume: 262
Issue: 2
Pages: 438-42