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Search results 1 to 100 out of 371 for Pikfyve

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). It catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. The dynamic interconversion of PI3P and PI(3,5)P2 is regulated by a protein complex which is conserved from yeast to mammals. It includes at least five proteins in yeast, located in the vacuole membrane: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p. Homologues of Fab1p, Vac14p and Fig4p are found in all eukaryotes which in mammalian cells, are known as Fab1/PIKfyve/PIP5K3, Fig4/Sac3, and Vac14/ArPIKfyve, located on early and late endosomes. Fab1, Vac14, and Fig4 form a ternary complex where Fab1 lipid kinase and Fig4 lipid phosphatase bind to opposite ends of Vac14. A conformational change of Vac14 allows a quick effect on kinase and phosphatase activities. This complex is required for endocytic-vacuolar pathway and nuclear migration. It plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes in mammals, being essential for nervous tissue function. It has been shown that alterations in this complex leads to reduced intracellular levels of PI(3,5)P2, cytoplasmic vacuolisation and neurodegeneration [, ].This entry represents the 1-phosphatidylinositol-3phosphate-5-kinase (PIKfyve) found in eukaryotes.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sbrissa D
Year: 2007
Journal: J Biol Chem
Title: Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
Volume: 282
Issue: 33
Pages: 23878-91
Publication
First Author: Liggins MC
Year: 2018
Journal: PLoS Genet
Title: PIKfyve regulates melanosome biogenesis.
Volume: 14
Issue: 3
Pages: e1007290
Protein
Organism: Mus musculus/domesticus
Length: 2097  
Fragment?: false
Publication
First Author: Sbrissa D
Year: 2008
Journal: J Mol Biol
Title: ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Volume: 384
Issue: 4
Pages: 766-79
Publication
First Author: Krishna S
Year: 2016
Journal: Dev Cell
Title: PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.
Volume: 38
Issue: 5
Pages: 536-47
Publication
First Author: Sultana F
Year: 2020
Journal: J Cell Biochem
Title: Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
Volume: 121
Issue: 4
Pages: 2927-2937
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Hung ST
Year: 2023
Journal: Cell
Title: PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Volume: 186
Issue: 4
Pages: 786-802.e28
Publication  
First Author: Tsuruta F
Year: 2015
Journal: Neurosci Lett
Title: PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites.
Volume: 605
Pages: 18-23
Publication
First Author: Jin N
Year: 2008
Journal: EMBO J
Title: VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
Volume: 27
Issue: 24
Pages: 3221-34
Publication
First Author: Shisheva A
Year: 2001
Journal: J Biol Chem
Title: Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes.
Volume: 276
Issue: 15
Pages: 11859-69
Publication
First Author: Ikonomov OC
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Volume: 305
Issue: 1
Pages: E119-31
Publication  
First Author: Choy CH
Year: 2018
Journal: J Cell Sci
Title: Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.
Volume: 131
Issue: 10
Publication
First Author: Kawasaki T
Year: 2017
Journal: EMBO J
Title: Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
Volume: 36
Issue: 12
Pages: 1707-1718
Publication
First Author: Dayam RM
Year: 2017
Journal: J Immunol
Title: The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Volume: 199
Issue: 6
Pages: 2096-2105
Publication
First Author: Sbrissa D
Year: 2000
Journal: Biochemistry
Title: PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation.
Volume: 39
Issue: 51
Pages: 15980-9
Publication  
First Author: Min SH
Year: 2014
Journal: Nat Commun
Title: Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.
Volume: 5
Pages: 4691
Publication
First Author: Sbrissa D
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
Volume: 303
Issue: 4
Pages: C436-46
Publication  
First Author: Min SH
Year: 2019
Journal: Mol Cell Biol
Title: PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.
Volume: 39
Issue: 21
Publication
First Author: Ikonomov OC
Year: 2009
Journal: J Biol Chem
Title: Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
Volume: 284
Issue: 6
Pages: 3750-61
Publication
First Author: Ikonomov OC
Year: 2003
Journal: J Biol Chem
Title: Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
Volume: 278
Issue: 51
Pages: 50863-71
Protein
Organism: Mus musculus/domesticus
Length: 2052  
Fragment?: false
Publication
First Author: Ikonomov OC
Year: 2011
Journal: J Biol Chem
Title: The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
Volume: 286
Issue: 15
Pages: 13404-13
Publication
First Author: Zolov SN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
Volume: 109
Issue: 43
Pages: 17472-7
Protein
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
Publication
First Author: Ikonomov OC
Year: 2015
Journal: Biochim Biophys Acta
Title: Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
Volume: 1853
Issue: 5
Pages: 1240-50
Publication
First Author: Ikonomov OC
Year: 2009
Journal: J Biol Chem
Title: PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
Volume: 284
Issue: 51
Pages: 35794-806
Gene
Type: gene
Organism: chicken
Publication
First Author: Cai X
Year: 2014
Journal: J Immunol
Title: PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.
Volume: 192
Issue: 7
Pages: 3383-9
Publication
First Author: Sbrissa D
Year: 2002
Journal: J Biol Chem
Title: Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
Volume: 277
Issue: 8
Pages: 6073-9
Publication
First Author: Ikonomov OC
Year: 2001
Journal: J Biol Chem
Title: Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve.
Volume: 276
Issue: 28
Pages: 26141-7
Publication
First Author: Bridges D
Year: 2012
Journal: Mol Biol Cell
Title: Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.
Volume: 23
Issue: 15
Pages: 2955-62
Publication
First Author: Sbrissa D
Year: 1999
Journal: J Biol Chem
Title: PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin.
Volume: 274
Issue: 31
Pages: 21589-97
Publication    
First Author: Mironova YA
Year: 2016
Journal: Elife
Title: PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.
Volume: 5
Publication
First Author: Venkatareddy M
Year: 2016
Journal: J Am Soc Nephrol
Title: Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.
Volume: 27
Issue: 9
Pages: 2702-19
Publication
First Author: Vaccari I
Year: 2011
Journal: PLoS Genet
Title: Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.
Volume: 7
Issue: 10
Pages: e1002319
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Shisheva A
Year: 1999
Journal: Mol Cell Biol
Title: Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells.
Volume: 19
Issue: 1
Pages: 623-34
GXD Expression    
Probe: MGI:3714829
Assay Type: Northern blot
Annotation Date: 2007-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3714840
Age: postnatal day 21
Image: 1
Specimen Label: 3
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3534528
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 21
Specimen Label: Table 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3526028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 21
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 21
Note: Expression is absent in the septum.
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507060
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5540017
Age: embryonic day 15.5
Image: GUDMAP:6502
Specimen Label: GUDMAP:6502
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3507060
Assay Type: RNA in situ
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3152723
Stage: TS23
Assay Id: MGI:6513516
Age: embryonic day 15.5
Specimen Label: Table S1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 7
Image: 8a
Specimen Label: 8a
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 7
Image: 8c
Specimen Label: 8c
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3525728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 21
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3714829
Assay Type: RNA in situ
Annotation Date: 2007-07-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3714854
Age: postnatal day 21
Specimen Label: Table 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310169
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5423493
Age: embryonic day 14.5
Specimen Label: EH1882; Specimen C2744
Detected: false
Specimen Num: 1