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Search results 1 to 100 out of 901 for Pkd1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Thivierge C
Year: 2006
Journal: Mol Cell Biol
Title: Overexpression of PKD1 causes polycystic kidney disease.
Volume: 26
Issue: 4
Pages: 1538-48
Publication
First Author: Coxam B
Year: 2014
Journal: Cell Rep
Title: Pkd1 regulates lymphatic vascular morphogenesis during development.
Volume: 7
Issue: 3
Pages: 623-33
Publication
First Author: Nie X
Year: 2013
Journal: Mech Dev
Title: Pkd1 is required for male reproductive tract development.
Volume: 130
Issue: 11-12
Pages: 567-76
Publication
First Author: Kurbegovic A
Year: 2013
Journal: Hum Mol Genet
Title: Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain.
Volume: 22
Issue: 12
Pages: 2361-75
Publication
First Author: Takakura A
Year: 2008
Journal: J Am Soc Nephrol
Title: Pkd1 inactivation induced in adulthood produces focal cystic disease.
Volume: 19
Issue: 12
Pages: 2351-63
Publication
First Author: Ahrabi AK
Year: 2007
Journal: J Am Soc Nephrol
Title: PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice.
Volume: 18
Issue: 6
Pages: 1740-53
Publication
First Author: Wu Y
Year: 2016
Journal: J Cell Sci
Title: Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.
Volume: 129
Issue: 19
Pages: 3675-3684
Publication  
First Author: Garcia-Gonzalez MA
Year: 2010
Journal: PLoS One
Title: Pkd1 and Pkd2 are required for normal placental development.
Volume: 5
Issue: 9
Publication
First Author: Saigusa T
Year: 2016
Journal: FASEB J
Title: Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model.
Volume: 30
Issue: 1
Pages: 370-9
Publication
First Author: Qiu N
Year: 2012
Journal: PLoS One
Title: Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.
Volume: 7
Issue: 9
Pages: e46038
Publication
First Author: Xiao Z
Year: 2011
Journal: FASEB J
Title: Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.
Volume: 25
Issue: 7
Pages: 2418-32
Publication
First Author: Dackowski WR
Year: 2002
Journal: Genomics
Title: Canine PKD1 is a single-copy gene: genomic organization and comparative analysis.
Volume: 80
Issue: 1
Pages: 105-12
Publication
First Author: Wu G
Year: 2002
Journal: Hum Mol Genet
Title: Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.
Volume: 11
Issue: 16
Pages: 1845-54
Publication
First Author: Lu W
Year: 1997
Journal: Nat Genet
Title: Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation.
Volume: 17
Issue: 2
Pages: 179-81
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2004
Journal: Hum Mol Genet
Title: Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease.
Volume: 13
Issue: 24
Pages: 3069-77
Publication
First Author: Kurbegovic A
Year: 2010
Journal: Hum Mol Genet
Title: Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.
Volume: 19
Issue: 7
Pages: 1174-89
Publication
First Author: Xiao Z
Year: 2010
Journal: J Biol Chem
Title: Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.
Volume: 285
Issue: 2
Pages: 1177-87
Publication
First Author: Bastos AP
Year: 2009
Journal: J Am Soc Nephrol
Title: Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion.
Volume: 20
Issue: 11
Pages: 2389-402
Publication
First Author: Pritchard L
Year: 2000
Journal: Hum Mol Genet
Title: A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.
Volume: 9
Issue: 18
Pages: 2617-27
Publication
First Author: Leuenroth SJ
Year: 2010
Journal: Nephrol Dial Transplant
Title: Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
Volume: 25
Issue: 7
Pages: 2187-94
Publication
First Author: Hassane S
Year: 2010
Journal: J Pathol
Title: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Volume: 222
Issue: 1
Pages: 21-31
Publication
First Author: Hughes P
Year: 2006
Journal: Cell Death Differ
Title: Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.
Volume: 13
Issue: 7
Pages: 1123-7
Publication
First Author: Piontek KB
Year: 2004
Journal: J Am Soc Nephrol
Title: A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Volume: 15
Issue: 12
Pages: 3035-43
Publication
First Author: Boulter C
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene.
Volume: 98
Issue: 21
Pages: 12174-9
Publication
First Author: Natoli TA
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
Volume: 294
Issue: 1
Pages: F73-83
Publication
First Author: Guillaume R
Year: 2000
Journal: Mech Dev
Title: Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.
Volume: 93
Issue: 1-2
Pages: 179-83
Publication  
First Author: Olsson PG
Year: 1996
Journal: Cytogenet Cell Genet
Title: A comparative clone map of the region containing the PKD1 gene in mouse
Volume: 72
Pages: 292 (Abstr.)
Publication
First Author: Chang JK
Year: 2017
Journal: J Biol Chem
Title: Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.
Volume: 292
Issue: 23
Pages: 9523-9539
Publication
First Author: Smithline ZB
Year: 2014
Journal: PLoS One
Title: Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Volume: 9
Issue: 12
Pages: e114403
Publication
First Author: Raphael KL
Year: 2009
Journal: Kidney Int
Title: Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.
Volume: 75
Issue: 6
Pages: 626-33
Publication
First Author: Muto S
Year: 2002
Journal: Hum Mol Genet
Title: Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Volume: 11
Issue: 15
Pages: 1731-42
Publication
First Author: Nishio S
Year: 2005
Journal: J Clin Invest
Title: Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation.
Volume: 115
Issue: 4
Pages: 910-8
Publication
First Author: Guillaume R
Year: 1999
Journal: Dev Dyn
Title: Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning.
Volume: 214
Issue: 4
Pages: 337-48
Publication
First Author: Ohata S
Year: 2015
Journal: J Neurosci
Title: Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.
Volume: 35
Issue: 31
Pages: 11153-68
Publication  
First Author: Li S
Year: 2017
Journal: Sci Rep
Title: A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development.
Volume: 7
Pages: 40505
Publication
First Author: Piontek KB
Year: 1999
Journal: Mamm Genome
Title: Murine Pkd1 introns 21 and 22 lack the extreme polypyrimidine bias present in human PKD1.
Volume: 10
Issue: 2
Pages: 194-6
Publication
First Author: Karcher C
Year: 2005
Journal: Differentiation
Title: Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia.
Volume: 73
Issue: 8
Pages: 425-32
Publication
First Author: Qiu N
Year: 2010
Journal: PLoS One
Title: Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.
Volume: 5
Issue: 12
Pages: e15240
Publication
First Author: Lantinga-van Leeuwen IS
Year: 2007
Journal: Hum Mol Genet
Title: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.
Volume: 16
Issue: 24
Pages: 3188-96
Publication
First Author: Paul BM
Year: 2011
Journal: Dev Dyn
Title: Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.
Volume: 240
Issue: 6
Pages: 1493-501
Publication
First Author: Bhunia AK
Year: 2002
Journal: Cell
Title: PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.
Volume: 109
Issue: 2
Pages: 157-68
Publication
First Author: Tan M
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
Volume: 307
Issue: 11
Pages: F1179-86
Publication
First Author: Yu S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.
Volume: 104
Issue: 47
Pages: 18688-93
Publication
First Author: Kurbegovic A
Year: 2014
Journal: Mol Cell Biol
Title: Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease.
Volume: 34
Issue: 17
Pages: 3341-53
Publication
First Author: Rowe I
Year: 2013
Journal: Nat Med
Title: Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
Volume: 19
Issue: 4
Pages: 488-93
Publication
First Author: Kwon M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.
Volume: 109
Issue: 52
Pages: 21462-7
Publication
First Author: Schneider MC
Year: 1996
Journal: Mol Med Today
Title: Advances in polycystic kidney disease.
Volume: 2
Issue: 2
Pages: 70-5
Publication
First Author: Himmelbauer H
Year: 1992
Journal: Genomics
Title: Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1).
Volume: 13
Issue: 1
Pages: 35-8
Publication
First Author: Löhning C
Year: 1997
Journal: Mamm Genome
Title: The mouse homolog of PKD1: sequence analysis and alternative splicing.
Volume: 8
Issue: 5
Pages: 307-11
Publication
First Author: Shillingford JM
Year: 2010
Journal: J Am Soc Nephrol
Title: Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.
Volume: 21
Issue: 3
Pages: 489-97
Publication
First Author: Takakura A
Year: 2009
Journal: Hum Mol Genet
Title: Renal injury is a third hit promoting rapid development of adult polycystic kidney disease.
Volume: 18
Issue: 14
Pages: 2523-31
Publication
First Author: Dooley R
Year: 2013
Journal: Mol Cell Endocrinol
Title: Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells.
Volume: 372
Issue: 1-2
Pages: 86-95
Publication
First Author: Takakura A
Year: 2011
Journal: Hum Mol Genet
Title: Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Volume: 20
Issue: 21
Pages: 4143-54
Publication
First Author: Lu W
Year: 2001
Journal: Hum Mol Genet
Title: Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.
Volume: 10
Issue: 21
Pages: 2385-96
Publication
First Author: Fan LX
Year: 2012
Journal: Kidney Int
Title: Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.
Volume: 81
Issue: 1
Pages: 76-85
Publication
First Author: Happé H
Year: 2013
Journal: Kidney Int
Title: Cyst expansion and regression in a mouse model of polycystic kidney disease.
Volume: 83
Issue: 6
Pages: 1099-108
Publication
First Author: Hassane S
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.
Volume: 27
Issue: 10
Pages: 2177-83
Publication
First Author: Happé H
Year: 2009
Journal: Hum Mol Genet
Title: Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways.
Volume: 18
Issue: 14
Pages: 2532-42
Publication
First Author: Rowe I
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.
Volume: 444
Issue: 4
Pages: 473-9
Publication
First Author: Geng L
Year: 1997
Journal: Am J Physiol
Title: Distribution and developmentally regulated expression of murine polycystin.
Volume: 272
Issue: 4 Pt 2
Pages: F451-9
Publication
First Author: Zhu P
Year: 2017
Journal: Hum Mol Genet
Title: Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model.
Volume: 26
Issue: 1
Pages: 158-172
Publication
First Author: Piontek K
Year: 2007
Journal: Nat Med
Title: A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.
Volume: 13
Issue: 12
Pages: 1490-5
Publication  
First Author: Menezes LF
Year: 2016
Journal: EBioMedicine
Title: Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.
Volume: 5
Pages: 183-92
Publication
First Author: Hassane S
Year: 2011
Journal: Lab Invest
Title: Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.
Volume: 91
Issue: 1
Pages: 24-32
Publication
First Author: Parnell SC
Year: 2018
Journal: Hum Mol Genet
Title: A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.
Volume: 27
Issue: 19
Pages: 3313-3324
Publication
First Author: Seeger-Nukpezah T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Volume: 110
Issue: 31
Pages: 12786-91
Publication
First Author: Zhou X
Year: 2015
Journal: Hum Mol Genet
Title: Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Volume: 24
Issue: 14
Pages: 3982-93
Publication
First Author: Battini L
Year: 2008
Journal: Hum Mol Genet
Title: Loss of polycystin-1 causes centrosome amplification and genomic instability.
Volume: 17
Issue: 18
Pages: 2819-33
Publication
First Author: Luyten A
Year: 2010
Journal: J Am Soc Nephrol
Title: Aberrant regulation of planar cell polarity in polycystic kidney disease.
Volume: 21
Issue: 9
Pages: 1521-32
Publication
First Author: Yanda MK
Year: 2018
Journal: J Biol Chem
Title: A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector.
Volume: 293
Issue: 29
Pages: 11513-11526
Publication
First Author: Starremans PG
Year: 2008
Journal: Kidney Int
Title: A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.
Volume: 73
Issue: 12
Pages: 1394-405
Publication
First Author: Leonhard WN
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
Volume: 300
Issue: 5
Pages: F1193-202
Publication
First Author: Boca M
Year: 2007
Journal: Mol Biol Cell
Title: Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.
Volume: 18
Issue: 10
Pages: 4050-61
Publication
First Author: Woodward OM
Year: 2010
Journal: PLoS One
Title: Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.
Volume: 5
Issue: 8
Pages: e12305
Publication
First Author: Zhu J
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.
Volume: 108
Issue: 25
Pages: 10133-8
Publication
First Author: Griffin MD
Year: 1997
Journal: Kidney Int
Title: Expression of polycystin in mouse metanephros and extra-metanephric tissues.
Volume: 52
Issue: 5
Pages: 1196-205
Publication
First Author: Rees S
Year: 2014
Journal: J Am Soc Nephrol
Title: Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Volume: 25
Issue: 2
Pages: 232-7
Publication
First Author: Pose-Utrilla J
Year: 2017
Journal: Nat Commun
Title: Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Volume: 8
Issue: 1
Pages: 2275
Publication
First Author: Sharif-Naeini R
Year: 2009
Journal: Cell
Title: Polycystin-1 and -2 dosage regulates pressure sensing.
Volume: 139
Issue: 3
Pages: 587-96
Publication
First Author: Kim K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Polycystin 1 is required for the structural integrity of blood vessels.
Volume: 97
Issue: 4
Pages: 1731-6
Publication
First Author: Allen E
Year: 2006
Journal: Hum Mol Genet
Title: Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
Volume: 15
Issue: 1
Pages: 11-21
Publication
First Author: Fielitz J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Requirement of protein kinase D1 for pathological cardiac remodeling.
Volume: 105
Issue: 8
Pages: 3059-63
Publication  
First Author: Pema M
Year: 2016
Journal: Nat Commun
Title: mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Volume: 7
Pages: 10786
Publication
First Author: Olsson PG
Year: 1996
Journal: Genomics
Title: The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.
Volume: 34
Issue: 2
Pages: 233-5
Publication
First Author: Le Corre S
Year: 2015
Journal: Nephron
Title: Cystic gene dosage influences kidney lesions after nephron reduction.
Volume: 129
Issue: 1
Pages: 42-51
Publication
First Author: Verschuren EHJ
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.
Volume: 315
Issue: 3
Pages: F537-F546
Publication
First Author: Kolpakova-Hart E
Year: 2008
Journal: Dev Biol
Title: Growth of cranial synchondroses and sutures requires polycystin-1.
Volume: 321
Issue: 2
Pages: 407-19
Publication
First Author: Flowers EM
Year: 2018
Journal: Nat Commun
Title: Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.
Volume: 9
Issue: 1
Pages: 814
Publication
First Author: Kolpakova-Hart E
Year: 2008
Journal: Matrix Biol
Title: Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.
Volume: 27
Issue: 6
Pages: 505-12
Publication
First Author: Hopp K
Year: 2012
Journal: J Clin Invest
Title: Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.
Volume: 122
Issue: 11
Pages: 4257-73
Publication
First Author: Li LX
Year: 2017
Journal: J Clin Invest
Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
Volume: 127
Issue: 7
Pages: 2751-2764
Publication
First Author: Li X
Year: 2008
Journal: Biochim Biophys Acta
Title: Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.
Volume: 1782
Issue: 1
Pages: 1-9
Publication
First Author: Outeda P
Year: 2014
Journal: Cell Rep
Title: Polycystin signaling is required for directed endothelial cell migration and lymphatic development.
Volume: 7
Issue: 3
Pages: 634-44
Publication
First Author: Distefano G
Year: 2009
Journal: Mol Cell Biol
Title: Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.
Volume: 29
Issue: 9
Pages: 2359-71
Publication
First Author: Miller MM
Year: 2011
Journal: Kidney Int
Title: T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease.
Volume: 80
Issue: 2
Pages: 146-53
Publication
First Author: Ittner A
Year: 2012
Journal: J Exp Med
Title: Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.
Volume: 209
Issue: 12
Pages: 2229-46
Publication
First Author: Murakami M
Year: 2005
Journal: J Biol Chem
Title: Genomic organization and functional analysis of murine PKD2L1.
Volume: 280
Issue: 7
Pages: 5626-35