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Search results 1 to 100 out of 673 for Pkd2

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Type Details Score
Gene
5311 | PKD2
Type: gene
Organism: human
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Gene
461367 | PKD2
Type: gene
Organism: chimpanzee
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Gene
530393 | PKD2
Type: gene
Organism: cattle
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Gene
422585 | PKD2
Type: gene
Organism: chicken
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Gene
432387 | pkd2
Type: gene
Organism: zebrafish
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Gene
702179 | PKD2
Type: gene
Organism: macaque, rhesus
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Gene
100038156 | pkd2
Type: gene
Organism: frog, western clawed
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Gene
498328 | Pkd2
Type: gene
Organism: rat
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Gene
487852 | PKD2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1099818 | Pkd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
- | J:334619
     
First Author: Haycraft CJ
Year: 2023
Journal: MGI Direct Data Submission
Title: Direct Data Submission for a Pkd2 Allele.
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Publication
9568711 | J:47035
First Author: Wu G
Year: 1998
Journal: Cell
Title: Somatic inactivation of Pkd2 results in polycystic kidney disease.
Volume: 93
Issue: 2
Pages: 177-88
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Publication
10873385 | J:63279
First Author: Park JH
Year: 2000
Journal: Genomics
Title: Cloning and characterization of the murine pkd2 promoter.
Volume: 66
Issue: 3
Pages: 305-12
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Publication
24951251 | J:214978
First Author: Nie X
Year: 2014
Journal: Differentiation
Title: Novel roles of Pkd2 in male reproductive system development.
Volume: 87
Issue: 3-4
Pages: 161-71
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Publication
19729489 | J:153052
First Author: Prasad S
Year: 2009
Journal: Am J Pathol
Title: Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury.
Volume: 175
Issue: 4
Pages: 1493-503
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Publication
19939939 | J:166881
First Author: Kim I
Year: 2009
Journal: J Am Soc Nephrol
Title: Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.
Volume: 20
Issue: 12
Pages: 2556-69
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Publication
19098310 | J:148377
First Author: Park EY
Year: 2009
Journal: J Biol Chem
Title: Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.
Volume: 284
Issue: 11
Pages: 7214-22
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Publication
31822608 | J:285899
     
First Author: Hasan R
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: SUMO1 modification of PKD2 channels regulates arterial contractility.
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Publication
35965273 | J:327383
First Author: Lakhia R
Year: 2022
Journal: Nat Commun
Title: PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
Volume: 13
Issue: 1
Pages: 4765
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Publication
20862291 | J:165114
 
First Author: Garcia-Gonzalez MA
Year: 2010
Journal: PLoS One
Title: Pkd1 and Pkd2 are required for normal placental development.
Volume: 5
Issue: 9
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Publication
32364494 | J:290991
   
First Author: MacKay CE
Year: 2020
Journal: Elife
Title: Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure.
Volume: 9
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Publication
30511640 | J:269113
   
First Author: Bulley S
Year: 2018
Journal: Elife
Title: Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure.
Volume: 7
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Publication
12874107 | J:84691
First Author: Qian Q
Year: 2003
Journal: Hum Mol Genet
Title: Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells.
Volume: 12
Issue: 15
Pages: 1875-80
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Publication
12140187 | J:78422
First Author: Wu G
Year: 2002
Journal: Hum Mol Genet
Title: Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.
Volume: 11
Issue: 16
Pages: 1845-54
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Publication
26435415 | J:227204
First Author: Li A
Year: 2015
Journal: Am J Pathol
Title: Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.
Volume: 185
Issue: 10
Pages: 2843-60
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Publication
25464512 | J:225694
First Author: Xiao Z
Year: 2014
Journal: PLoS One
Title: Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity.
Volume: 9
Issue: 12
Pages: e114198
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Publication
23103499 | J:192850
First Author: Brookes ZL
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone.
Volume: 304
Issue: 1
Pages: H33-41
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Publication
10770959 | J:169812
First Author: Foggensteiner L
Year: 2000
Journal: J Am Soc Nephrol
Title: Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.
Volume: 11
Issue: 5
Pages: 814-27
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Publication
10781953 | J:62085
First Author: Guillaume R
Year: 2000
Journal: Mech Dev
Title: Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.
Volume: 93
Issue: 1-2
Pages: 179-83
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Publication
30378388 | J:265803
First Author: Da Silva-Álvarez S
Year: 2018
Journal: Int J Dev Biol
Title: Pkd2 deletion during embryo development does not alter mesonephric programmed cell senescence.
Volume: 62
Issue: 9-10
Pages: 637-640
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Publication
26245976 | J:225874
First Author: Ohata S
Year: 2015
Journal: J Neurosci
Title: Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.
Volume: 35
Issue: 31
Pages: 11153-68
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Publication
15123714 | J:182402
First Author: Rundle DR
Year: 2004
Journal: J Biol Chem
Title: PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles.
Volume: 279
Issue: 28
Pages: 29728-39
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Publication
8650545 | J:48348
First Author: Mochizuki T
Year: 1996
Journal: Science
Title: PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.
Volume: 272
Issue: 5266
Pages: 1339-42
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Publication
22983710 | J:187958
First Author: Yoshiba S
Year: 2012
Journal: Science
Title: Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
Volume: 338
Issue: 6104
Pages: 226-31
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Publication
24515114 | J:241979
First Author: Park EY
Year: 2014
Journal: J Biol Chem
Title: Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease.
Volume: 289
Issue: 13
Pages: 9254-62
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Publication
25934702 | J:225446
First Author: Lee EJ
Year: 2015
Journal: FASEB J
Title: Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation.
Volume: 29
Issue: 8
Pages: 3506-14
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Publication
9339380 | J:41134
First Author: Wu G
Year: 1997
Journal: Genomics
Title: Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2.
Volume: 45
Issue: 1
Pages: 220-3
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Publication
9716661 | J:49651
First Author: Pennekamp P
Year: 1998
Journal: Mamm Genome
Title: Characterization of the murine polycystic kidney disease (Pkd2) gene.
Volume: 9
Issue: 9
Pages: 749-52
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Publication
31492868 | J:279353
First Author: Walker RV
Year: 2019
Journal: Nat Commun
Title: Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model.
Volume: 10
Issue: 1
Pages: 4072
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Publication
18754774 | J:143130
First Author: Chen XZ
Year: 2008
Journal: FEBS J
Title: Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton.
Volume: 275
Issue: 19
Pages: 4675-83
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Publication
29443690 | J:310479
   
First Author: Liu X
Year: 2018
Journal: Elife
Title: Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.
Volume: 7
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Publication
19879844 | J:157302
First Author: Sharif-Naeini R
Year: 2009
Journal: Cell
Title: Polycystin-1 and -2 dosage regulates pressure sensing.
Volume: 139
Issue: 3
Pages: 587-96
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Publication
16192288 | J:104127
First Author: Hackmann K
Year: 2005
Journal: Hum Mol Genet
Title: A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1.
Volume: 14
Issue: 21
Pages: 3249-62
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Publication
10615132 | J:59314
First Author: Wu G
Year: 2000
Journal: Nat Genet
Title: Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
Volume: 24
Issue: 1
Pages: 75-8
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Publication
28244683 | J:265516
First Author: Li A
Year: 2017
Journal: J Cell Mol Med
Title: Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.
Volume: 21
Issue: 8
Pages: 1619-1635
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Publication
31411061 | J:279967
First Author: Sang D
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of TRPP2 in mouse airway smooth muscle tension and respiration.
Volume: 317
Issue: 4
Pages: L466-L474
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Publication
34345895 | J:327006
 
First Author: Grosch M
Year: 2021
Journal: J Cell Sci
Title: A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.
Volume: 134
Issue: 16
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Publication
20686448 | J:184250
First Author: Zafar I
Year: 2010
Journal: Kidney Int
Title: Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease.
Volume: 78
Issue: 8
Pages: 754-61
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Publication
24847003 | J:214310
First Author: Ravichandran K
Year: 2014
Journal: Hum Mol Genet
Title: An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2.
Volume: 23
Issue: 18
Pages: 4919-31
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Publication
19265036 | J:182484
First Author: AbouAlaiwi WA
Year: 2009
Journal: Circ Res
Title: Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades.
Volume: 104
Issue: 7
Pages: 860-9
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Publication
15843396 | J:182397
First Author: Li Q
Year: 2005
Journal: Hum Mol Genet
Title: Alpha-actinin associates with polycystin-2 and regulates its channel activity.
Volume: 14
Issue: 12
Pages: 1587-603
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Publication
10409293 | J:152213
First Author: Markowitz GS
Year: 1999
Journal: Am J Physiol
Title: Polycystin-2 expression is developmentally regulated.
Volume: 277
Issue: 1 Pt 2
Pages: F17-25
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Publication
21389971 | J:195613
First Author: Miller MM
Year: 2011
Journal: Kidney Int
Title: T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease.
Volume: 80
Issue: 2
Pages: 146-53
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Publication
29042084 | J:277063
First Author: Wang Q
Year: 2018
Journal: Kidney Int
Title: Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Volume: 93
Issue: 2
Pages: 403-415
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Publication
29475398 | J:274265
First Author: Shin Y
Year: 2018
Journal: FASEB J
Title: Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis.
Volume: 32
Issue: 7
Pages: 3574-3582
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Publication
20408813 | J:182478
First Author: Molland KL
Year: 2010
Journal: Biochem J
Title: Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2.
Volume: 429
Issue: 1
Pages: 171-83
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Publication
22258321 | J:196541
First Author: Parikh CR
Year: 2012
Journal: Kidney Int
Title: Evaluation of urine biomarkers of kidney injury in polycystic kidney disease.
Volume: 81
Issue: 8
Pages: 784-90
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HT Experiment
E-GEOD-69556 | Next Generation Sequencing of PKD2 mutant mice kidneys
Series Id: GSE69556
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24767998 | J:211806
First Author: Outeda P
Year: 2014
Journal: Cell Rep
Title: Polycystin signaling is required for directed endothelial cell migration and lymphatic development.
Volume: 7
Issue: 3
Pages: 634-44
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Publication
18782757 | J:143124
First Author: Kim I
Year: 2008
Journal: J Biol Chem
Title: Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.
Volume: 283
Issue: 46
Pages: 31559-66
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Publication
25574838 | J:220561
First Author: Gainullin VG
Year: 2015
Journal: J Clin Invest
Title: Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
Volume: 125
Issue: 2
Pages: 607-20
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Publication
23357539 | J:195164
First Author: Takao D
Year: 2013
Journal: Dev Biol
Title: Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation.
Volume: 376
Issue: 1
Pages: 23-30
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Publication
10655152 | J:60518
First Author: Wu G
Year: 2000
Journal: Mol Genet Metab
Title: Molecular genetics and mechanism of autosomal dominant polycystic kidney disease.
Volume: 69
Issue: 1
Pages: 1-15
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Publication
23390129 | J:194972
First Author: Streets AJ
Year: 2013
Journal: Hum Mol Genet
Title: Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.
Volume: 22
Issue: 10
Pages: 1924-39
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Publication
24459142 | J:317220
First Author: Cebotaru V
Year: 2014
Journal: J Biol Chem
Title: Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.
Volume: 289
Issue: 10
Pages: 6404-6414
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Publication
32946258 | J:299876
First Author: DiNello E
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve.
Volume: 319
Issue: 5
Pages: H1021-H1035
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Publication
18235088 | J:143394
First Author: Kim I
Year: 2008
Journal: J Am Soc Nephrol
Title: Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.
Volume: 19
Issue: 3
Pages: 455-68
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Publication
18263604 | J:135301
First Author: Shibazaki S
Year: 2008
Journal: Hum Mol Genet
Title: Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.
Volume: 17
Issue: 11
Pages: 1505-16
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Publication
34199520 | J:321356
 
First Author: Talbi K
Year: 2021
Journal: Int J Mol Sci
Title: Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.
Volume: 22
Issue: 11
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Publication
21270095 | J:171475
First Author: Belibi F
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Volume: 300
Issue: 5
Pages: F1235-43
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Publication
23390131 | J:194970
First Author: Khonsari RH
Year: 2013
Journal: Hum Mol Genet
Title: Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2).
Volume: 22
Issue: 9
Pages: 1873-85
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Publication
31313950 | J:283228
First Author: Saigusa T
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct.
Volume: 317
Issue: 3
Pages: F632-F637
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Publication
27826057 | J:321490
First Author: Spirli C
Year: 2017
Journal: J Hepatol
Title: Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Volume: 66
Issue: 3
Pages: 571-580
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Publication
25537744 | J:284609
First Author: Ravichandran K
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2.
Volume: 308
Issue: 4
Pages: F349-57
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Publication
19959710 | J:185863
First Author: Nishio S
Year: 2010
Journal: J Am Soc Nephrol
Title: Loss of oriented cell division does not initiate cyst formation.
Volume: 21
Issue: 2
Pages: 295-302
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Publication
33046531 | J:338058
First Author: Zhang C
Year: 2021
Journal: J Am Soc Nephrol
Title: Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.
Volume: 32
Issue: 1
Pages: 41-51
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Publication
30799240 | J:284006
First Author: Legué E
Year: 2019
Journal: Curr Biol
Title: Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease.
Volume: 29
Issue: 5
Pages: 803-812.e5
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Publication
29716997 | J:263878
First Author: Aboudehen K
Year: 2018
Journal: J Biol Chem
Title: Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.
Volume: 293
Issue: 24
Pages: 9388-9398
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Publication
16316413 | J:103305
First Author: Karcher C
Year: 2005
Journal: Differentiation
Title: Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia.
Volume: 73
Issue: 8
Pages: 425-32
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Publication
20215348 | J:158678
First Author: Tran U
Year: 2010
Journal: Development
Title: The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.
Volume: 137
Issue: 7
Pages: 1107-16
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Publication
12062060 | J:77401
First Author: Pennekamp P
Year: 2002
Journal: Curr Biol
Title: The ion channel polycystin-2 is required for left-right axis determination in mice.
Volume: 12
Issue: 11
Pages: 938-43
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Publication
21307093 | J:170490
First Author: Field S
Year: 2011
Journal: Development
Title: Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
Volume: 138
Issue: 6
Pages: 1131-42
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Publication
19766642 | J:195258
First Author: Spirli C
Year: 2010
Journal: Gastroenterology
Title: ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.
Volume: 138
Issue: 1
Pages: 360-371.e7
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Publication
37953472 | J:345935
First Author: Weisser I
Year: 2024
Journal: J Am Soc Nephrol
Title: Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
Volume: 35
Issue: 1
Pages: 41-55
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Publication
25715394 | J:220325
First Author: Lemaire LA
Year: 2015
Journal: Development
Title: Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis.
Volume: 142
Issue: 5
Pages: 858-70
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Publication
20487527 | J:161404
 
First Author: Stevens J
Year: 2010
Journal: BMC Dev Biol
Title: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.
Volume: 10
Pages: 54
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DO Term
DOID:0110859 | polycystic kidney disease 2
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Protein Coding Gene
MGP_CAROLIEiJ_G0027481 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029815 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029727 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1099818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
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Protein Coding Gene
MGP_CBAJ_G0029484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_DBA2J_G0029628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0029587 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0029716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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