| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1073
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Azzedine H |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. |
| Volume: |
22 |
| Issue: |
20 |
| Pages: |
4224-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hutchings AJ |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
8622 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lüningschrör P |
| Year: |
2020 |
| Journal: |
Front Cell Neurosci |
| Title: |
Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves. |
| Volume: |
14 |
|
| Pages: |
185 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lüningschrör P |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
678 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ngok SP |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx. |
| Volume: |
199 |
| Issue: |
7 |
| Pages: |
1103-15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:3028641 |
| Age: |
embryonic day 13.0 |
| Image: |
2 |
|
| Specimen Label: |
E13 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689425 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:3028641 |
| Age: |
embryonic day 17.0 |
| Image: |
2 |
|
| Specimen Label: |
E17 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3028641 |
| Age: |
postnatal day 7 |
| Image: |
2 |
|
| Specimen Label: |
P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3028641 |
| Age: |
postnatal adult |
| Image: |
2 |
|
| Specimen Label: |
adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Not Specified |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3028641 |
| Age: |
postnatal adult |
| Image: |
2 |
|
| Specimen Label: |
L |
|
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3028640 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2004-02-24 |
| Strength: |
Not Specified |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1797228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3028641 |
| Age: |
postnatal adult |
| Image: |
2 |
|
| Specimen Label: |
T |
|
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1841520 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
not shown |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1733820 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
1F,G Syx |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1701420 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
not shown |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1620420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Expression in the endothelium of the aorta. |
| Specimen Label: |
1F,G Syx |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274520 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
1F,G Syx |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4430722 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2010-03-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1620120 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:4430725 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Expression in coronary vessels. |
| Specimen Label: |
1F,G Syx |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garnaas MK |
| Year: |
2008 |
| Journal: |
Circ Res |
| Title: |
Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. |
| Volume: |
103 |
| Issue: |
7 |
| Pages: |
710-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang J |
| Year: |
2016 |
| Journal: |
Sci Signal |
| Title: |
RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms. |
| Volume: |
9 |
| Issue: |
438 |
| Pages: |
ra76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu C |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. |
| Volume: |
286 |
| Issue: |
26 |
| Pages: |
23511-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu M |
| Year: |
2006 |
| Journal: |
Mol Biol Cell |
| Title: |
A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. |
| Volume: |
17 |
| Issue: |
4 |
| Pages: |
1880-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ernkvist M |
| Year: |
2009 |
| Journal: |
Blood |
| Title: |
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. |
| Volume: |
113 |
| Issue: |
1 |
| Pages: |
244-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshizawa M |
| Year: |
2003 |
| Journal: |
Gene Expr Patterns |
| Title: |
Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. |
| Volume: |
3 |
| Issue: |
3 |
| Pages: |
375-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki N |
| Year: |
2003 |
| Journal: |
DNA Res |
| Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
| Volume: |
10 |
| Issue: |
4 |
| Pages: |
167-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Strausberg RL |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| Volume: |
99 |
| Issue: |
26 |
| Pages: |
16899-903 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
pleckstrin homology domain containing, family G (with RhoGef domain) member 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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| DO Term |
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