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Search results 1 to 100 out of 342 for Plk4

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0.056s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Polo-like kinases (Plks) belong to the serine/threonine kinase subfamily, and are characterized by the presence of the signature motif called Polo-box domain. Plks are key regulators of cell cycle and cell division in eukaryotes [, ]. Unicellular organisms contain one Plk whereas higher eukaryotes have as many as four Plks: Plk1, Plk2, Plk3 andPlk4.Plk4 (also called Sak) is the most structurally divergent member of the Plks. It plays a pivotal role in centriole duplication [, , , , ]and is required for centriolar satellite function and ciliogenesis []. Substrates identified for Plk4 include Cdc25C and Chk2 [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Bonni S
Year: 2008
Journal: Cell Cycle
Title: Human Plk4 phosphorylates Cdc25C.
Volume: 7
Issue: 4
Pages: 545-7
Publication
First Author: Habedanck R
Year: 2005
Journal: Nat Cell Biol
Title: The Polo kinase Plk4 functions in centriole duplication.
Volume: 7
Issue: 11
Pages: 1140-6
Protein
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
Publication
First Author: Hori A
Year: 2016
Journal: EMBO Rep
Title: A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.
Volume: 17
Issue: 3
Pages: 326-37
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
Publication
First Author: Ko MA
Year: 2005
Journal: Nat Genet
Title: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.
Volume: 37
Issue: 8
Pages: 883-8
Protein
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: false
Publication
First Author: Petrinac S
Year: 2009
Journal: Cell Cycle
Title: Polo-like kinase 4 phosphorylates Chk2.
Volume: 8
Issue: 2
Pages: 327-9
Publication
First Author: Vaid R
Year: 2016
Journal: Protein Pept Lett
Title: Functions of Polo-Like Kinases: A Journey From Yeast To Humans.
Volume: 23
Issue: 2
Pages: 185-97
Publication
First Author: Nigg EA
Year: 2011
Journal: Nat Cell Biol
Title: The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries.
Volume: 13
Issue: 10
Pages: 1154-60
Publication
First Author: Barr FA
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: Polo-like kinases and the orchestration of cell division.
Volume: 5
Issue: 6
Pages: 429-40
Publication
First Author: Bettencourt-Dias M
Year: 2005
Journal: Curr Biol
Title: SAK/PLK4 is required for centriole duplication and flagella development.
Volume: 15
Issue: 24
Pages: 2199-207
Publication
First Author: Nigg EA
Year: 2007
Journal: Trends Cell Biol
Title: Centrosome duplication: of rules and licenses.
Volume: 17
Issue: 5
Pages: 215-21
Publication
First Author: Luo YB
Year: 2015
Journal: Biol Reprod
Title: PLK4 is essential for meiotic resumption in mouse oocytes.
Volume: 92
Issue: 4
Pages: 101
Publication
First Author: Serçin Ö
Year: 2016
Journal: Nat Cell Biol
Title: Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
Volume: 18
Issue: 1
Pages: 100-10
Publication
First Author: Kleylein-Sohn J
Year: 2007
Journal: Dev Cell
Title: Plk4-induced centriole biogenesis in human cells.
Volume: 13
Issue: 2
Pages: 190-202
Publication    
First Author: LoMastro GM
Year: 2022
Journal: Elife
Title: PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells.
Volume: 11
Publication
First Author: Rosario CO
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Volume: 107
Issue: 15
Pages: 6888-93
Publication
First Author: Coelho PA
Year: 2013
Journal: Dev Cell
Title: Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.
Volume: 27
Issue: 5
Pages: 586-97
Publication
First Author: Bury L
Year: 2017
Journal: J Cell Biol
Title: Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes.
Volume: 216
Issue: 11
Pages: 3571-3590
Protein
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
Publication
First Author: Phan TP
Year: 2022
Journal: Genes Dev
Title: Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells.
Volume: 36
Issue: 11-12
Pages: 718-736
Publication
First Author: Fode C
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.
Volume: 91
Issue: 14
Pages: 6388-92
Publication
First Author: Fode C
Year: 1996
Journal: Mol Cell Biol
Title: Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation.
Volume: 16
Issue: 9
Pages: 4665-72
Publication
First Author: Hudson JW
Year: 2001
Journal: Curr Biol
Title: Late mitotic failure in mice lacking Sak, a polo-like kinase.
Volume: 11
Issue: 6
Pages: 441-6
Publication
First Author: Zhao H
Year: 2013
Journal: Nat Cell Biol
Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Volume: 15
Issue: 12
Pages: 1434-44
Publication
First Author: Martindill DM
Year: 2007
Journal: Nat Cell Biol
Title: Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.
Volume: 9
Issue: 10
Pages: 1131-41
Publication
First Author: Holland AJ
Year: 2010
Journal: J Cell Biol
Title: Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.
Volume: 188
Issue: 2
Pages: 191-8
Publication
First Author: Holland AJ
Year: 2012
Journal: Mol Biol Cell
Title: Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.
Volume: 23
Issue: 10
Pages: 1838-45
Publication  
First Author: Fan G
Year: 2015
Journal: Nat Commun
Title: Loss of KLF14 triggers centrosome amplification and tumorigenesis.
Volume: 6
Pages: 8450
Publication
First Author: Harris RM
Year: 2011
Journal: Endocrinology
Title: Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
Volume: 152
Issue: 10
Pages: 3975-85
Publication
First Author: Ward A
Year: 2014
Journal: PLoS One
Title: p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.
Volume: 9
Issue: 1
Pages: e87918
Publication
First Author: Hamada N
Year: 2022
Journal: Dev Neurosci
Title: Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development.
Volume: 44
Issue: 6
Pages: 643-650
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Swallow CJ
Year: 2005
Journal: Oncogene
Title: Sak/Plk4 and mitotic fidelity.
Volume: 24
Issue: 2
Pages: 306-12
Publication
First Author: Kulukian A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Epidermal development, growth control, and homeostasis in the face of centrosome amplification.
Volume: 112
Issue: 46
Pages: E6311-20
Publication
First Author: Leung GC
Year: 2007
Journal: FEBS Lett
Title: Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays.
Volume: 581
Issue: 1
Pages: 77-83
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 4
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 5
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 6
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 13
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 15
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 16
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 17
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 19
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 20
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 21
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 22
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 23
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1742828
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 24
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3288928
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 25
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 26
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 27
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1683328
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1788628
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 29
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1789128
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Not Specified
Sex: Pooled
Emaps: EMAPS:1885228
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Specimen Num: 31
GXD Expression    
Probe: MGI:1205532
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1866628
Stage: TS28
Assay Id: MGI:1205534
Age: postnatal week 6-8
Image: st97_570
Specimen Label: None
Detected: false
Specimen Num: 32