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Search results 1 to 100 out of 199 for Pnkp

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
11284 | PNKP
Type: gene
Organism: human
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Gene
747683 | PNKP
Type: gene
Organism: chimpanzee
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Gene
484373 | PNKP
Type: gene
Organism: dog, domestic
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Gene
616621 | PNKP
Type: gene
Organism: cattle
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Gene
569462 | pnkp
Type: gene
Organism: zebrafish
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Gene
719084 | PNKP
Type: gene
Organism: macaque, rhesus
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Gene
100145800 | pnkp
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR006550 | PNKP
Type: Family
Description: This entry includes bifunctional polynucleotide phosphatase/kinase PNKP from animals. PNKP plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. It has been shown that the DNA 3'-phosphatase activity of PNKP takes precedence over its DNA 5'-kinase activity in vitro []. It contains a forkhead-associated domain, which is a protein-protein interaction domain required for the association of PNKP with CK2-phosphorylated XRCC1 and XRCC4, and independent DNA 3'-phosphatase and 5'-kinase domains [].
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Gene
308576 | Pnkp
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1891698 | Pnkp
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22210862 | -
First Author: Tahbaz N
Year: 2012
Journal: Nucleic Acids Res
Title: Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair.
Volume: 40
Issue: 8
Pages: 3484-95
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Publication
16648365 | -
First Author: Dobson CJ
Year: 2006
Journal: Nucleic Acids Res
Title: The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks.
Volume: 34
Issue: 8
Pages: 2230-7
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Publication
34226276 | J:322582
 
First Author: Shin W
Year: 2021
Journal: Life Sci Alliance
Title: PNKP is required for maintaining the integrity of progenitor cell populations in adult mice.
Volume: 4
Issue: 9
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Publication
23042680 | J:200259
First Author: Parsons JL
Year: 2012
Journal: Nucleic Acids Res
Title: Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.
Volume: 40
Issue: 22
Pages: 11404-15
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Protein
Q9JLV6
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
G5E8N7
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
A0A0J9YVJ6
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Cortex Pnkp +/Nes-Cre
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Cortex Pnkp Nes-Cre
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Liver Pnkp +/Nes-Cre
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Liver Pnkp Nes-Cre
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6358698
Age: postnatal day 21
Specimen Label: cortex Pnkp Neo/Neo
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6358698
Age: postnatal day 21
Specimen Label: liver Pnkp Neo/Neo
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Cortex Pnkp Neo/Neo
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Cerebellum Pnkp Neo/Neo
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Spleen Pnkp Neo/Neo
Detected: true
Specimen Num: 6
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Gene
200558 | APLF
Type: gene
Organism: human
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Publication
22171004 | J:180135
First Author: Coquelle N
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Volume: 108
Issue: 52
Pages: 21022-7
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Publication
11586300 | J:71922
First Author: Moreira MC
Year: 2001
Journal: Nat Genet
Title: The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin.
Volume: 29
Issue: 2
Pages: 189-93
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Publication
26290337 | J:226703
First Author: Shimada M
Year: 2015
Journal: EMBO J
Title: Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.
Volume: 34
Issue: 19
Pages: 2465-80
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Protein Coding Gene
MGP_CAROLIEiJ_G0029679 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891698 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032011 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012904 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030777 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19671525 | J:173021
First Author: Bernstein NK
Year: 2009
Journal: Nucleic Acids Res
Title: Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.
Volume: 37
Issue: 18
Pages: 6161-73
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Cortex control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:6358697
Age: embryonic day 15.5
Specimen Label: Liver control
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6358698
Age: postnatal day 21
Specimen Label: cortex control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6358698
Age: postnatal day 21
Specimen Label: liver control
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Cortex control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Cerebellum control
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6358692
Assay Type: Western blot
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6358699
Age: postnatal month 8
Specimen Label: Spleen control
Detected: true
Specimen Num: 5
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Publication
- | J:65063
   
First Author: Jilanil A
Year: 2000
Journal: GenBank Submission
Title: Mus musculus polynucleotide kinase 3'-phosphatase mRNA, complete cds
Pages: AF129451
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Publication
26774286 | J:232858
First Author: Zhang Q
Year: 2016
Journal: Mol Cell
Title: FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Volume: 61
Issue: 3
Pages: 419-433
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Publication
23042675 | J:200260
First Author: Prasad R
Year: 2012
Journal: Nucleic Acids Res
Title: Pol β associated complex and base excision repair factors in mouse fibroblasts.
Volume: 40
Issue: 22
Pages: 11571-82
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Publication
24793032 | J:212924
First Author: Katyal S
Year: 2014
Journal: Nat Neurosci
Title: Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
Volume: 17
Issue: 6
Pages: 813-21
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
27711078 | J:339876
First Author: Tong KI
Year: 2016
Journal: Cell Death Dis
Title: Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Volume: 7
Issue: 10
Pages: e2401
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Protein Coding Gene
MGI:1919353 | Aplf
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
500247 | Aplf
Type: gene
Organism: rat
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Gene
481405 | APLF
Type: gene
Organism: dog, domestic
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Gene
459293 | APLF
Type: gene
Organism: chimpanzee
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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