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Search results 1 to 100 out of 264 for Pnpla2

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Type Details Score
Gene
57104 | PNPLA2
Type: gene
Organism: human
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Gene
450937 | PNPLA2
Type: gene
Organism: chimpanzee
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Gene
508493 | PNPLA2
Type: gene
Organism: cattle
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Gene
431066 | PNPLA2
Type: gene
Organism: chicken
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Gene
700824 | PNPLA2
Type: gene
Organism: macaque, rhesus
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Gene
101887155 | pnpla2
Type: gene
Organism: zebrafish
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Gene
780152 | pnpla2
Type: gene
Organism: frog, western clawed
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Gene
361676 | Pnpla2
Type: gene
Organism: rat
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Gene
611403 | PNPLA2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR033903 | PNPLA2
Type: Domain
Description: Patatin-like phospholipase domain-containing protein 2 (PNPLA2) plays a key role in hydrolysis of stored triacylglecerols and is also known as adipose triglyceride lipase (ATGL) []. Members of this family share a patatin domain, initially discovered in potato tubers [, ]. ATGL is expressed in white and brown adipose tissue in high mRNA levels. Mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) leads to neutral lipid storage disease (NLSD) which is characterized by the accumulation of triglycerides in multiple tissues []. ATGL mutations are also commonly associated with severe forms of skeletal- and cardio-myopathy. ATGL is regulated by insulin []. PNPLA2/ATGL is also known as TTS-2.2 (transport-secretion protein 2.2), iPLA2-zeta (calcium-independent phospholipase A2), and desnutrin [, , ].
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Protein Coding Gene
MGI:1914103 | Pnpla2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15337759 | J:322693
First Author: Villena JA
Year: 2004
Journal: J Biol Chem
Title: Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis.
Volume: 279
Issue: 45
Pages: 47066-75
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Publication
15550674 | J:289460
First Author: Zimmermann R
Year: 2004
Journal: Science
Title: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Volume: 306
Issue: 5700
Pages: 1383-6
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Publication
36763501 | J:333454
First Author: Hara M
Year: 2023
Journal: Cell Rep
Title: PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Volume: 42
Issue: 2
Pages: 112091
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Publication
28459858 | J:243296
First Author: Wu JW
Year: 2017
Journal: PLoS Genet
Title: Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.
Volume: 13
Issue: 5
Pages: e1006716
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Publication
19401457 | -
First Author: Schweiger M
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5.
Volume: 297
Issue: 2
Pages: E289-96
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Publication
21644917 | -
First Author: Chakrabarti P
Year: 2011
Journal: Curr Diabetes Rev
Title: Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin.
Volume: 7
Issue: 4
Pages: 270-7
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Publication
15364929 | -
First Author: Jenkins CM
Year: 2004
Journal: J Biol Chem
Title: Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Volume: 279
Issue: 47
Pages: 48968-75
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Publication
17603008 | -
First Author: Gao JG
Year: 2007
Journal: Biochem Biophys Res Commun
Title: A comparative study of human GS2, its paralogues, and its rat orthologue.
Volume: 360
Issue: 2
Pages: 501-6
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Protein
Q8BJ56
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Publication
19029121 | -
 
First Author: Kienesberger PC
Year: 2009
Journal: J Lipid Res
Title: Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.
Volume: 50 Suppl
Pages: S63-8
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Publication
16799181 | -
First Author: Wilson PA
Year: 2006
Journal: J Lipid Res
Title: Characterization of the human patatin-like phospholipase family.
Volume: 47
Issue: 9
Pages: 1940-9
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Publication
23835334 | J:207007
First Author: Sitnick MT
Year: 2013
Journal: Diabetes
Title: Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.
Volume: 62
Issue: 10
Pages: 3350-61
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Publication
21951135 | J:178474
First Author: Etschmaier K
Year: 2011
Journal: J Neurochem
Title: Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers.
Volume: 119
Issue: 5
Pages: 1016-28
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Publication
35731039 | J:325967
   
First Author: Li Z
Year: 2022
Journal: Elife
Title: Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits.
Volume: 11
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Publication
35045287 | J:327098
First Author: Yue F
Year: 2022
Journal: Cell Rep
Title: Lipid droplet dynamics regulate adult muscle stem cell fate.
Volume: 38
Issue: 3
Pages: 110267
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Publication
33605986 | J:302529
First Author: Bullock J
Year: 2021
Journal: Invest Ophthalmol Vis Sci
Title: Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).
Volume: 62
Issue: 2
Pages: 30
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Protein
E9Q4A0
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Publication
27858140 | J:238725
First Author: Kaltenecker D
Year: 2017
Journal: Diabetologia
Title: Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.
Volume: 60
Issue: 2
Pages: 296-305
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Protein Coding Gene
MGP_CAROLIEiJ_G0030699 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032929 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032259 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033148 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013898 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031810 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16675698 | J:108546
First Author: Haemmerle G
Year: 2006
Journal: Science
Title: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.
Volume: 312
Issue: 5774
Pages: 734-7
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Publication
19067489 | J:144712
First Author: Beller M
Year: 2008
Journal: PLoS Biol
Title: COPI complex is a regulator of lipid homeostasis.
Volume: 6
Issue: 11
Pages: e292
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Publication
27677764 | J:237358
First Author: Attané C
Year: 2016
Journal: Diabetologia
Title: A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice.
Volume: 59
Issue: 12
Pages: 2654-2663
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Publication
32302523 | J:337656
First Author: Shook BA
Year: 2020
Journal: Cell Stem Cell
Title: Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Volume: 26
Issue: 6
Pages: 880-895.e6
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Publication
36229459 | J:337666
First Author: Stephenson EJ
Year: 2022
Journal: Nat Commun
Title: Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue.
Volume: 13
Issue: 1
Pages: 6062
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Publication
25193997 | J:216296
First Author: Mottillo EP
Year: 2014
Journal: J Lipid Res
Title: Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation.
Volume: 55
Issue: 11
Pages: 2276-86
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Publication
26196542 | J:227572
First Author: Schoiswohl G
Year: 2015
Journal: Endocrinology
Title: Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.
Volume: 156
Issue: 10
Pages: 3610-24
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Publication
29932770 | J:265151
First Author: Parajuli N
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.
Volume: 315
Issue: 4
Pages: H879-H884
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Publication
35676490 | J:330448
First Author: Patel R
Year: 2022
Journal: Nature
Title: ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Volume: 606
Issue: 7916
Pages: 968-975
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Publication
34185433 | J:330609
First Author: Kaur S
Year: 2021
Journal: Clin Transl Med
Title: Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice.
Volume: 11
Issue: 6
Pages: e417
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Publication
37777008 | J:342062
 
First Author: Zhou C
Year: 2023
Journal: Mol Metab
Title: Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents.
Volume: 78
Pages: 101813
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Publication
25783895 | J:224153
First Author: Dubé JJ
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice.
Volume: 308
Issue: 10
Pages: E879-90
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Publication
35269472 | J:321955
 
First Author: Goeritzer M
Year: 2022
Journal: Cells
Title: Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Volume: 11
Issue: 5
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Publication
22374972 | J:185000
First Author: Wu JW
Year: 2012
Journal: Endocrinology
Title: Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase.
Volume: 153
Issue: 5
Pages: 2198-207
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Publication
29320510 | J:256988
First Author: Salatzki J
Year: 2018
Journal: PLoS Genet
Title: Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
Volume: 14
Issue: 1
Pages: e1007171
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Publication
35265813 | J:327466
First Author: Romero AR
Year: 2022
Journal: iScience
Title: Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance.
Volume: 25
Issue: 3
Pages: 103941
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Publication
26260790 | J:264656
First Author: Foryst-Ludwig A
Year: 2015
Journal: J Biol Chem
Title: Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate.
Volume: 290
Issue: 39
Pages: 23603-15
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Publication
21465509 | J:185116
First Author: Wu JW
Year: 2011
Journal: Hepatology
Title: Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.
Volume: 54
Issue: 1
Pages: 122-32
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Publication
26508640 | J:227475
First Author: Schreiber R
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Volume: 112
Issue: 45
Pages: 13850-5
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Publication
21196579 | J:170551
First Author: Aflaki E
Year: 2011
Journal: J Biol Chem
Title: Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages.
Volume: 286
Issue: 9
Pages: 7418-28
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Publication
28194887 | J:313234
First Author: Chen W
Year: 2017
Journal: FEBS J
Title: Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage.
Volume: 284
Issue: 7
Pages: 1070-1081
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Publication
23740967 | J:330438
First Author: Chitraju C
Year: 2013
Journal: J Lipid Res
Title: The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes.
Volume: 54
Issue: 8
Pages: 2185-2194
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Publication
26109679 | J:242732
First Author: Schlager S
Year: 2015
Journal: J Leukoc Biol
Title: Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
Volume: 98
Issue: 5
Pages: 837-50
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Publication
28510703 | J:330434
First Author: Masaki H
Year: 2017
Journal: Mol Hum Reprod
Title: Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice.
Volume: 23
Issue: 7
Pages: 452-460
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Publication
31806624 | J:285335
First Author: Paluchova V
Year: 2020
Journal: Diabetes
Title: Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice.
Volume: 69
Issue: 3
Pages: 300-312
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Publication
21106876 | J:330618
First Author: Hoy AJ
Year: 2011
Journal: Endocrinology
Title: Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation.
Volume: 152
Issue: 1
Pages: 48-58
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Publication
24657704 | J:212479
First Author: Schrammel A
Year: 2014
Journal: Biochim Biophys Acta
Title: Endothelial dysfunction in adipose triglyceride lipase deficiency.
Volume: 1841
Issue: 6
Pages: 906-17
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Publication
23583398 | J:201857
First Author: Lin Y
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity.
Volume: 434
Issue: 3
Pages: 534-40
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Publication
19965578 | J:159033
First Author: Schoiswohl G
Year: 2010
Journal: J Lipid Res
Title: Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
Volume: 51
Issue: 3
Pages: 490-9
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Publication
27213586 | J:316021
First Author: Al-Zoughbi W
Year: 2016
Journal: Oncotarget
Title: Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
Volume: 7
Issue: 23
Pages: 33832-40
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Publication
26236747 | J:330617
 
First Author: Coelho M
Year: 2015
Journal: J Diabetes Res
Title: Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics.
Volume: 2015
Pages: 542029
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Publication
22101529 | J:182364
First Author: van de Weijer T
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents.
Volume: 302
Issue: 3
Pages: H709-15
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Publication
32661391 | J:325215
First Author: Suriben R
Year: 2020
Journal: Nat Med
Title: Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Volume: 26
Issue: 8
Pages: 1264-1270
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Publication
19389712 | J:151207
First Author: Peyot ML
Year: 2009
Journal: J Biol Chem
Title: Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.
Volume: 284
Issue: 25
Pages: 16848-59
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Publication
27357546 | J:235664
First Author: MacPherson RE
Year: 2016
Journal: Am J Physiol Cell Physiol
Title: Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue.
Volume: 311
Issue: 2
Pages: C269-76
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Publication
23867907 | J:204107
First Author: Schrammel A
Year: 2013
Journal: Biochim Biophys Acta
Title: Cardiac oxidative stress in a mouse model of neutral lipid storage disease.
Volume: 1831
Issue: 11
Pages: 1600-8
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Publication
20424161 | J:330436
First Author: Chandak PG
Year: 2010
Journal: J Biol Chem
Title: Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase.
Volume: 285
Issue: 26
Pages: 20192-201
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Publication
34387896 | J:330435
First Author: Fuchs CD
Year: 2022
Journal: Hepatology
Title: Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Volume: 75
Issue: 1
Pages: 125-139
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Publication
22496349 | J:187111
First Author: Nunes PM
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice.
Volume: 303
Issue: 1
Pages: E71-81
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Publication
22158969 | J:183643
First Author: Kienesberger PC
Year: 2012
Journal: Mol Cell Biol
Title: Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.
Volume: 32
Issue: 4
Pages: 740-50
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Publication
16267052 | J:105667
First Author: Kurat CF
Year: 2006
Journal: J Biol Chem
Title: Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.
Volume: 281
Issue: 1
Pages: 491-500
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Publication
18952573 | J:146095
First Author: Zechner R
Year: 2009
Journal: J Lipid Res
Title: Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Volume: 50
Issue: 1
Pages: 3-21
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Publication
19136649 | J:151046
First Author: Ahmadian M
Year: 2009
Journal: Diabetes
Title: Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.
Volume: 58
Issue: 4
Pages: 855-66
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Publication
19692632 | J:157416
First Author: Duncan RE
Year: 2010
Journal: J Lipid Res
Title: Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells.
Volume: 51
Issue: 2
Pages: 309-17
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Publication
24801391 | J:215263
First Author: Xie X
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Identification of a novel phosphorylation site in adipose triglyceride lipase as a regulator of lipid droplet localization.
Volume: 306
Issue: 12
Pages: E1449-59
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Publication
25852007 | J:224218
First Author: Meex RC
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle.
Volume: 308
Issue: 11
Pages: E960-70
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Publication
35150895 | J:321542
First Author: Korbelius M
Year: 2022
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis.
Volume: 1867
Issue: 4
Pages: 159121
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GXD Expression
GXD Expression
   
Probe: MGI:7384719
Assay Type: RT-PCR
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:7384919
Age: embryonic day 18.5
Image: 5
Specimen Label: +/+ or -/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7384719
Assay Type: RT-PCR
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:7384919
Age: embryonic day 18.5
Image: 5
Specimen Label: -/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7447254
Assay Type: Western blot
Annotation Date: 2023-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920924
Stage: TS24
Assay Id: MGI:7447316
Age: embryonic day 16.5
Specimen Label: E16.5 C
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7447254
Assay Type: Western blot
Annotation Date: 2023-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920924
Stage: TS24
Assay Id: MGI:7447316
Age: embryonic day 16.5
Specimen Label: E16.5 K
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7447254
Assay Type: Western blot
Annotation Date: 2023-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:7447316
Age: embryonic day 18.5
Specimen Label: E18.5 C
Detected: true
Specimen Num: 3
•
•
•
•
•




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