|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 87 out of 87 for Pnpla8

0.028s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
50640 | PNPLA8
Type: gene
Organism: human
•
•
•
•
•
Gene
472484 | PNPLA8
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
475880 | PNPLA8
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
535496 | PNPLA8
Type: gene
Organism: cattle
•
•
•
•
•
Gene
417785 | PNPLA8
Type: gene
Organism: chicken
•
•
•
•
•
Gene
100126812 | pnpla8
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
700851 | PNPLA8
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
100038186 | pnpla8
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
314075 | Pnpla8
Type: gene
Organism: rat
•
•
•
•
•
Protein Coding Gene
MGI:1914702 | Pnpla8
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
36719796 | J:333442
First Author: Hirabayashi T
Year: 2023
Journal: Cell Rep
Title: Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Volume: 42
Issue: 2
Pages: 111940
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0017725 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0019711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0019675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0019646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0019653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0019457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1914702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0020100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0019010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0019429 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0019542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0019531 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0019612 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0019567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0020140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0018777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0019060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0029482 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0018567 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
17923475 | J:128989
First Author: Mancuso DJ
Year: 2007
Journal: J Biol Chem
Title: Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
Volume: 282
Issue: 48
Pages: 34611-22
•
•
•
•
•
Publication
28442572 | J:246027
First Author: Liu GY
Year: 2017
Journal: J Biol Chem
Title: The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.
Volume: 292
Issue: 25
Pages: 10672-10684
•
•
•
•
•
Publication
32161117 | J:286821
First Author: Liu X
Year: 2020
Journal: J Biol Chem
Title: 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout.
Volume: 295
Issue: 16
Pages: 5307-5320
•
•
•
•
•
Publication
23429536 | J:199736
First Author: Sharma J
Year: 2013
Journal: Infect Immun
Title: The absence of myocardial calcium-independent phospholipase A2γ results in impaired prostaglandin E2 production and decreased survival in mice with acute Trypanosoma cruzi infection.
Volume: 81
Issue: 7
Pages: 2278-87
•
•
•
•
•
Publication
20179248 | J:162883
First Author: Song H
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.
Volume: 298
Issue: 6
Pages: E1097-114
•
•
•
•
•
Publication
25313821 | J:223561
First Author: Yoda E
Year: 2014
Journal: PLoS One
Title: Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
Volume: 9
Issue: 10
Pages: e109409
•
•
•
•
•
Publication
31700134 | J:287002
First Author: Elimam H
Year: 2019
Journal: Sci Rep
Title: Genetic Ablation of Calcium-independent Phospholipase A2γ Exacerbates Glomerular Injury in Adriamycin Nephrosis in Mice.
Volume: 9
Issue: 1
Pages: 16229
•
•
•
•
•
Publication
19840936 | J:158203
First Author: Mancuso DJ
Year: 2009
Journal: J Biol Chem
Title: Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.
Volume: 284
Issue: 51
Pages: 35632-44
•
•
•
•
•
Publication
20625036 | J:165451
First Author: Yoda E
Year: 2010
Journal: J Lipid Res
Title: Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice.
Volume: 51
Issue: 10
Pages: 3003-15
•
•
•
•
•
Publication
27453526 | J:236927
First Author: Moon SH
Year: 2016
Journal: J Biol Chem
Title: Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size.
Volume: 291
Issue: 37
Pages: 19687-700
•
•
•
•
•
Publication
37275531 | J:341027
First Author: Moon SH
Year: 2023
Journal: iScience
Title: Genetic deletion of skeletal muscle iPLA(2)γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism.
Volume: 26
Issue: 6
Pages: 106895
•
•
•
•
•
Publication
17213206 | J:120895
First Author: Mancuso DJ
Year: 2007
Journal: J Biol Chem
Title: Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
Volume: 282
Issue: 12
Pages: 9216-27
•
•
•
•
•
Publication
20817734 | J:166869
First Author: Mancuso DJ
Year: 2010
Journal: J Biol Chem
Title: Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
Volume: 285
Issue: 47
Pages: 36495-510
•
•
•
•
•
Publication
25492867 | J:219357
First Author: Elimam H
Year: 2015
Journal: J Biol Chem
Title: Calcium-independent phospholipase A2γ enhances activation of the ATF6 transcription factor during endoplasmic reticulum stress.
Volume: 290
Issue: 5
Pages: 3009-20
•
•
•
•
•
Publication
21191104 | J:171167
First Author: Sharma J
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells.
Volume: 300
Issue: 4
Pages: C872-9
•
•
•
•
•
Publication
22389508 | J:184885
First Author: Moon SH
Year: 2012
Journal: J Biol Chem
Title: Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.
Volume: 287
Issue: 18
Pages: 14880-95
•
•
•
•
•
Publication
26206229 | J:226333
First Author: Rauckhorst AJ
Year: 2015
Journal: FEBS Lett
Title: The iPLA(2)γ is identified as the membrane potential sensitive phospholipase in liver mitochondria.
Volume: 589
Issue: 18
Pages: 2367-71
•
•
•
•
•
Publication
22778252 | J:190421
First Author: Moon SH
Year: 2012
Journal: J Biol Chem
Title: Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.
Volume: 287
Issue: 35
Pages: 29837-50
•
•
•
•
•
Publication
27226532 | J:235458
First Author: Elimam H
Year: 2016
Journal: J Biol Chem
Title: Genetic Ablation of Calcium-independent Phospholipase A2γ Induces Glomerular Injury in Mice.
Volume: 291
Issue: 28
Pages: 14468-82
•
•
•
•
•
Publication
29035365 | J:254385
First Author: Shimanaka Y
Year: 2017
Journal: Nat Med
Title: Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Volume: 23
Issue: 11
Pages: 1287-1297
•
•
•
•
•
Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
•
•
•
•
•
Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
15908428 | -
First Author: Yan W
Year: 2005
Journal: J Biol Chem
Title: The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
Volume: 280
Issue: 29
Pages: 26669-79
•
•
•
•
•
Publication
17475618 | -
First Author: Yang W
Year: 2007
Journal: J Biol Chem
Title: AtPLAI is an acyl hydrolase involved in basal jasmonic acid production and Arabidopsis resistance to Botrytis cinerea.
Volume: 282
Issue: 25
Pages: 18116-18128
•
•
•
•
•
Protein Domain
IPR045217 | PNPLA8-like
Type: Domain
Description: Patatin-like phospholipase domain containing protein 8 (PNPLA8, also known as iPLA2-gamma) is a Ca-independent myocardial phospholipase which maintains mitochondrial integrity. In humans, it is predominantly expressed in heart tissue. iPLA2-gamma can catalyse both phospholipase A1 and A2 reactions (PLA1 and PLA2 respectively). This family includes PNPLA8 (iPLA2-gamma) from mammals [, , ]and AtPLAI from Arabidopsis [].
•
•
•
•
•
Protein
Q8K1N1
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
•
•
•
•
•
Protein
E9PXB0
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
•
•
•
•
•
Protein
E9QAC9
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
•
•
•
•
•
Publication
19029121 | -
 
First Author: Kienesberger PC
Year: 2009
Journal: J Lipid Res
Title: Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.
Volume: 50 Suppl
Pages: S63-8
•
•
•
•
•
Publication
16799181 | -
First Author: Wilson PA
Year: 2006
Journal: J Lipid Res
Title: Characterization of the human patatin-like phospholipase family.
Volume: 47
Issue: 9
Pages: 1940-9
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom