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Search results 1 to 100 out of 159 for Pofut1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: hamster, Chinese
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: GDP-fucose protein O-fucosyltransferase 1 (POFUT1) transfers fucose residues to acceptor sites on serine and threonine residues of epidermal growth factor-like repeats of recipient proteins. It is essential for Notch signal transduction in mammals []. Mutations in the POFUT1 gene cause Dowling-Degos disease 2 (DDD2), a type of rare autosomal-dominant genodermatosis characterised by reticular hyperpigmentation and hypopigmentation of the flexures []. The structure of POFUT1 has been determined [].
Publication
First Author: Stahl M
Year: 2008
Journal: J Biol Chem
Title: Roles of Pofut1 and O-fucose in mammalian Notch signaling.
Volume: 283
Issue: 20
Pages: 13638-51
Publication
First Author: Guilmeau S
Year: 2008
Journal: Gastroenterology
Title: Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis.
Volume: 135
Issue: 3
Pages: 849-60, 860.e1-6
Publication
First Author: Zhang S
Year: 2020
Journal: Am J Transl Res
Title: POFUT1 is dispensable for structure, function and survival of mouse podocytes.
Volume: 12
Issue: 5
Pages: 2212-2224
Publication
First Author: Ajima R
Year: 2017
Journal: PLoS One
Title: Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.
Volume: 12
Issue: 11
Pages: e0187248
Publication
First Author: Okamura Y
Year: 2008
Journal: Mech Dev
Title: Pofut1 is required for the proper localization of the Notch receptor during mouse development.
Volume: 125
Issue: 8
Pages: 663-73
Publication  
First Author: Schuster-Gossler K
Year: 2009
Journal: BMC Dev Biol
Title: Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.
Volume: 9
Pages: 6
Publication
First Author: Li M
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease.
Volume: 92
Issue: 6
Pages: 895-903
Publication
First Author: McMillan BJ
Year: 2017
Journal: Glycobiology
Title: Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.
Volume: 27
Issue: 8
Pages: 777-786
GXD Expression      
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191110
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Pofut1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191110
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Pofut1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191110
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Pofut1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191110
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Pofut1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191110
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Pofut1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191110
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Pofut1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6180932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191110
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Pofut1
Detected: true
Specimen Num: 5
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
Publication  
First Author: Zygmunt DA
Year: 2017
Journal: Mol Cell Biol
Title: Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans.
Volume: 37
Issue: 10
Publication
First Author: Shi S
Year: 2005
Journal: Mol Cell Biol
Title: Canonical Notch signaling is dispensable for early cell fate specifications in mammals.
Volume: 25
Issue: 21
Pages: 9503-8
Publication
First Author: Der Vartanian A
Year: 2015
Journal: Mol Cell Biol
Title: Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway.
Volume: 35
Issue: 2
Pages: 391-405
Publication
First Author: Wang Y
Year: 2001
Journal: J Biol Chem
Title: Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Volume: 276
Issue: 43
Pages: 40338-45
Publication
First Author: Huang H
Year: 2021
Journal: Cell
Title: In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Volume: 184
Issue: 5
Pages: 1245-1261.e21
Publication
First Author: Buono KD
Year: 2006
Journal: Dev Biol
Title: The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.
Volume: 293
Issue: 2
Pages: 565-80
Publication
First Author: Yao D
Year: 2011
Journal: Blood
Title: Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions.
Volume: 117
Issue: 21
Pages: 5652-62
Publication
First Author: Nauman M
Year: 2023
Journal: Sci Rep
Title: EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1.
Volume: 13
Issue: 1
Pages: 17473
Publication
First Author: Kim ML
Year: 2008
Journal: Mol Cell Neurosci
Title: O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors.
Volume: 39
Issue: 3
Pages: 452-64
Publication
First Author: Batista F
Year: 2012
Journal: Biol Reprod
Title: Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis.
Volume: 86
Issue: 6
Pages: 179
Publication
First Author: Lin HY
Year: 2011
Journal: PLoS One
Title: Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.
Volume: 6
Issue: 1
Pages: e15842
Publication
First Author: Wang Y
Year: 2017
Journal: Nat Commun
Title: Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.
Volume: 8
Issue: 1
Pages: 578
Publication
First Author: Tsao PN
Year: 2009
Journal: Development
Title: Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Volume: 136
Issue: 13
Pages: 2297-307
Publication
First Author: Tsao PN
Year: 2011
Journal: Development
Title: Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.
Volume: 138
Issue: 16
Pages: 3533-43
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wang W
Year: 2015
Journal: Stem Cells
Title: Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.
Volume: 33
Issue: 7
Pages: 2280-93
Publication
First Author: Shi S
Year: 2007
Journal: J Biol Chem
Title: The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling.
Volume: 282
Issue: 28
Pages: 20133-41
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160396
Stage: TS06
Assay Id: MGI:3655525
Age: embryonic day 4.5
Specimen Label: 4.5
Specimen Num: 1
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160397
Stage: TS07
Assay Id: MGI:3655525
Age: embryonic day 5.5
Specimen Label: 5.5
Specimen Num: 2
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3655525
Age: embryonic day 6.5
Specimen Label: 6.5
Specimen Num: 3
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3655525
Age: embryonic day 7.5
Specimen Label: 7.5
Specimen Num: 4
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3655525
Age: embryonic day 8.5
Specimen Label: 8.5
Specimen Num: 5
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3655525
Age: embryonic day 9.5
Specimen Label: 9.5
Specimen Num: 6
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3655525
Age: embryonic day 10.5
Specimen Label: 10.5
Specimen Num: 7
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3655525
Age: embryonic day 11.5
Specimen Label: 11.5
Specimen Num: 8
GXD Expression        
Probe: MGI:3655524
Assay Type: Northern blot
Annotation Date: 2006-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3655525
Age: embryonic day 12.5
Specimen Label: 12.5
Specimen Num: 9
GXD Expression      
Probe: MGI:3655521
Assay Type: RT-PCR
Annotation Date: 2006-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3655526
Age: embryonic day 6.5
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3655521
Assay Type: RT-PCR
Annotation Date: 2006-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3655526
Age: embryonic day 6.5
Specimen Label: +/delta
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3655521
Assay Type: RT-PCR
Annotation Date: 2006-09-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3655526
Age: embryonic day 6.5
Specimen Label: delta/delta
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3655521
Assay Type: RT-PCR
Annotation Date: 2006-09-22
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3655522
Age: postnatal
Specimen Label: F/F
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557819
Stage: TS19
Assay Id: MGI:6476926
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271623
Stage: TS23
Assay Id: MGI:6476926
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271627
Stage: TS27
Assay Id: MGI:6476926
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271628
Stage: TS28
Assay Id: MGI:6476926
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271628
Stage: TS28
Assay Id: MGI:6476926
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 5
GXD Expression        
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3271628
Stage: TS28
Assay Id: MGI:6476926
Age: postnatal day 21
Specimen Label: P21
Specimen Num: 6
GXD Expression        
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3271628
Stage: TS28
Assay Id: MGI:6476926
Age: postnatal day 42
Specimen Label: P42
Specimen Num: 7
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6476930
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6476930
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6476930
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6476930
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6476930
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6476930
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6476912
Assay Type: RT-PCR
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6476930
Age: postnatal day 42
Specimen Label: P42
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6476919
Assay Type: Western blot
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271623
Stage: TS23
Assay Id: MGI:6476932
Age: embryonic day 15.5
Specimen Label: E15
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6476919
Assay Type: Western blot
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271625
Stage: TS25
Assay Id: MGI:6476932
Age: embryonic day 17.5
Specimen Label: E17
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6476919
Assay Type: Western blot
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271626
Stage: TS26
Assay Id: MGI:6476932
Age: embryonic day 20.5
Specimen Label: E20
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6476919
Assay Type: Western blot
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271627
Stage: TS27
Assay Id: MGI:6476932
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6476919
Assay Type: Western blot
Annotation Date: 2020-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271628
Stage: TS28
Assay Id: MGI:6476932
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 5