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Search results 1 to 100 out of 359 for Polr2a

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Pontes-Quero S
Year: 2017
Journal: Cell
Title: Dual ifgMosaic: A Versatile Method for Multispectral and Combinatorial Mosaic Gene-Function Analysis.
Volume: 170
Issue: 4
Pages: 800-814.e18
Publication
First Author: Jimenez-Guri E
Year: 2010
Journal: PLoS One
Title: Clonal analysis in mice underlines the importance of rhombomeric boundaries in cell movement restriction during hindbrain segmentation.
Volume: 5
Issue: 4
Pages: e10112
Publication
First Author: Nechanitzky R
Year: 2013
Journal: Nat Immunol
Title: Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.
Volume: 14
Issue: 8
Pages: 867-75
Publication
First Author: Pérez de Castro I
Year: 2013
Journal: Cancer Res
Title: Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Volume: 73
Issue: 22
Pages: 6804-15
Publication
First Author: Álvarez-Fernández M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.
Volume: 110
Issue: 43
Pages: 17374-9
Publication  
First Author: Batista S
Year: 2014
Journal: Nat Commun
Title: Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.
Volume: 5
Pages: 5054
Publication
First Author: Ambrogio C
Year: 2014
Journal: Cancer Res
Title: Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts.
Volume: 74
Issue: 21
Pages: 5978-88
Publication
First Author: Roselló-Díez A
Year: 2014
Journal: Development
Title: Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning.
Volume: 141
Issue: 7
Pages: 1534-43
Publication    
First Author: Le Garrec JF
Year: 2017
Journal: Elife
Title: A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics.
Volume: 6
Publication
First Author: de Cárcer G
Year: 2017
Journal: Nat Med
Title: Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.
Volume: 23
Issue: 8
Pages: 964-974
Publication
First Author: Mainardi S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.
Volume: 111
Issue: 1
Pages: 255-60
Publication
First Author: Micucci C
Year: 2014
Journal: PLoS One
Title: Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Volume: 9
Issue: 8
Pages: e105550
Publication
First Author: Hached K
Year: 2019
Journal: J Cell Biol
Title: ENSA and ARPP19 differentially control cell cycle progression and development.
Volume: 218
Issue: 2
Pages: 541-558
Publication
First Author: Manchado E
Year: 2010
Journal: Cancer Cell
Title: Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Volume: 18
Issue: 6
Pages: 641-54
Publication
First Author: Calés C
Year: 2008
Journal: Mol Cell Biol
Title: Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.
Volume: 28
Issue: 3
Pages: 1018-28
Publication
First Author: Guerra C
Year: 2003
Journal: Cancer Cell
Title: Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Volume: 4
Issue: 2
Pages: 111-20
Publication
First Author: Ventura JJ
Year: 2007
Journal: Nat Genet
Title: p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Volume: 39
Issue: 6
Pages: 750-8
Publication  
First Author: Blas-Rus N
Year: 2016
Journal: Nat Commun
Title: Aurora A drives early signalling and vesicle dynamics during T-cell activation.
Volume: 7
Pages: 11389
Publication
First Author: Drori A
Year: 2014
Journal: PLoS One
Title: Lack of XBP-1 impedes murine cytomegalovirus gene expression.
Volume: 9
Issue: 10
Pages: e110942
Publication
First Author: Hatchi E
Year: 2011
Journal: J Exp Med
Title: E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
Volume: 208
Issue: 7
Pages: 1403-17
Publication
First Author: Lacroix M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.
Volume: 107
Issue: 49
Pages: 21076-81
Publication
First Author: Baltanás FC
Year: 2013
Journal: Mol Cell Biol
Title: Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.
Volume: 33
Issue: 22
Pages: 4562-78
Publication      
First Author: Liceras-Boillos P
Year: 2018
Journal: Mol Cell Biol
Title: DIFFERENTIAL ROLE OF THE RasGEFs SOS1 AND SOS2 IN MOUSE SKIN HOMEOSTASIS AND CARCINOGENESIS.
Publication
First Author: Mijimolle N
Year: 2005
Journal: Cancer Cell
Title: Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Volume: 7
Issue: 4
Pages: 313-24
Publication
First Author: Györy I
Year: 2012
Journal: Genes Dev
Title: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.
Volume: 26
Issue: 7
Pages: 668-82
Publication
First Author: Calés C
Year: 2015
Journal: Mol Cell Biol
Title: Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis.
Volume: 36
Issue: 6
Pages: 900-12
Publication
First Author: Sánchez-Aguilera A
Year: 2014
Journal: Cell Stem Cell
Title: Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.
Volume: 15
Issue: 6
Pages: 791-804
Publication
First Author: Hernández-Porras I
Year: 2016
Journal: J Pathol
Title: K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.
Volume: 239
Issue: 2
Pages: 206-17
Publication
First Author: Barrière C
Year: 2007
Journal: Mol Oncol
Title: Mice thrive without Cdk4 and Cdk2.
Volume: 1
Issue: 1
Pages: 72-83
Publication
First Author: Dankort D
Year: 2007
Journal: Genes Dev
Title: A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.
Volume: 21
Issue: 4
Pages: 379-84
Publication
First Author: Suire S
Year: 2019
Journal: J Leukoc Biol
Title: Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.
Volume: 106
Issue: 4
Pages: 815-822
Publication  
First Author: Reichenbach B
Year: 2018
Journal: EMBO J
Title: Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.
Volume: 37
Issue: 9
Publication
First Author: Benhamron S
Year: 2015
Journal: Mol Cell Biol
Title: mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.
Volume: 35
Issue: 1
Pages: 153-66
Publication
First Author: Bigi A
Year: 2016
Journal: Oncogene
Title: Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.
Volume: 35
Issue: 39
Pages: 5132-43
Publication
First Author: Sanclemente M
Year: 2018
Journal: Cancer Cell
Title: c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.
Volume: 33
Issue: 2
Pages: 217-228.e4
Publication
First Author: Puyol M
Year: 2010
Journal: Cancer Cell
Title: A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Volume: 18
Issue: 1
Pages: 63-73
Publication
First Author: Joshi J
Year: 2008
Journal: EMBO J
Title: Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
Volume: 27
Issue: 16
Pages: 2181-93
Publication
First Author: Efeyan A
Year: 2009
Journal: PLoS One
Title: Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Volume: 4
Issue: 5
Pages: e5475
Publication
First Author: Navas C
Year: 2012
Journal: Cancer Cell
Title: EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
Volume: 22
Issue: 3
Pages: 318-30
Publication    
First Author: Ivanovitch K
Year: 2017
Journal: Elife
Title: Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis.
Volume: 6
Publication
First Author: Blasco RB
Year: 2011
Journal: Cancer Cell
Title: c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Volume: 19
Issue: 5
Pages: 652-63
Publication
First Author: Drosten M
Year: 2010
Journal: EMBO J
Title: Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
Volume: 29
Issue: 6
Pages: 1091-104
Publication    
First Author: Menchero S
Year: 2019
Journal: Elife
Title: Transitions in cell potency during early mouse development are driven by Notch.
Volume: 8
Publication
First Author: Drosten M
Year: 2014
Journal: Oncogene
Title: Ras signaling is essential for skin development.
Volume: 33
Issue: 22
Pages: 2857-65
Publication    
First Author: Celaya AM
Year: 2019
Journal: Elife
Title: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.
Volume: 8
Publication
First Author: Gee JM
Year: 2014
Journal: Neuron
Title: Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.
Volume: 83
Issue: 5
Pages: 1058-72
Allele
Name: polymerase (RNA) II (DNA directed) polypeptide A; targeted mutation 1, Mariano Barbacid
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: targeted mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: targeted mutation, mutant strain, congenic
Genotype
Symbol: Fntb/Fntb Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fntb/Fntb Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fntb/Fntb Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Braf/Braf<+> Polr2a/Polr2a<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mapk14/Mapk14 Polr2a/Polr2a<+>
Background: involves: 129 * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras<+> Mapk14/Mapk14 Polr2a/Polr2a<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras<+> Mapk14/Mapk14<+> Polr2a/Polr2a<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mapk14/Mapk14 Polr2a/Polr2a<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk2/Cdk2 Cdk4/Cdk4 Polr2a/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Polr2a/Polr2a<+> Rnf2/Rnf2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk2/Cdk2 Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk2/Cdk2 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk4/Cdk4 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk4/Cdk4 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk4/Cdk4 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdk6/Cdk6 Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a E4f1/E4f1 Polr2a/Polr2a<+>
Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: E4f1/E4f1 Polr2a/Polr2a<+>
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdc20/Cdc20 Polr2a/Polr2a<+>
Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ebf1/Ebf1 Polr2a/Polr2a<+> Tg(BCL2)#Wehi/?
Background: involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ebf1/Ebf1 Polr2a/Polr2a<+>
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mapk1/Mapk1 Mapk3/Mapk3 Polr2a/Polr2a
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Map2k1/Map2k1 Map2k2/Map2k2 Polr2a/Polr2a
Background: involves: 129/Sv * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Braf/Braf Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kras/Kras<+> Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mastl/Mastl Polr2a/Polr2a<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Publication  
First Author: Reinhart KM
Year: 2018
Journal: Exp Neurol
Title: Ketamine reduces deleterious consequences of spreading depolarizations.
Volume: 305
Pages: 121-128
Publication
First Author: Rogers RC
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Response of catecholaminergic neurons in the mouse hindbrain to glucoprivic stimuli is astrocyte dependent.
Volume: 315
Issue: 1
Pages: R153-R164
Publication
First Author: Barrera LO
Year: 2008
Journal: Genome Res
Title: Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.
Volume: 18
Issue: 1
Pages: 46-59
Publication
First Author: Delvalle NM
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cholinergic activation of enteric glia is a physiological mechanism that contributes to the regulation of gastrointestinal motility.
Volume: 315
Issue: 4
Pages: G473-G483
Publication
First Author: McClain JL
Year: 2017
Journal: J Neurophysiol
Title: The acute inhibition of enteric glial metabolism with fluoroacetate alters calcium signaling, hemichannel function, and the expression of key proteins.
Volume: 117
Issue: 1
Pages: 365-375
Publication
First Author: Shandra O
Year: 2019
Journal: J Neurosci
Title: Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures.
Volume: 39
Issue: 10
Pages: 1944-1963
Publication
First Author: Holman HA
Year: 2020
Journal: iScience
Title: Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris.
Volume: 23
Issue: 8
Pages: 101407
Publication
First Author: Umpierre AD
Year: 2019
Journal: J Neurosci
Title: Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.
Volume: 39
Issue: 4
Pages: 727-742
Publication  
First Author: Nortley R
Year: 2019
Journal: Science
Title: Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Volume: 365
Issue: 6450
Publication
First Author: Kaczmarczyk L
Year: 2021
Journal: Sci Rep
Title: Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background.
Volume: 11
Issue: 1
Pages: 5412
Publication
First Author: Alcaino C
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.
Volume: 115
Issue: 32
Pages: E7632-E7641
Publication
First Author: Schiessl IM
Year: 2018
Journal: J Am Soc Nephrol
Title: Renal Interstitial Platelet-Derived Growth Factor Receptor-β Cells Support Proximal Tubular Regeneration.
Volume: 29
Issue: 5
Pages: 1383-1396
Publication
First Author: Marx C
Year: 2019
Journal: Blood
Title: Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps.
Volume: 134
Issue: 21
Pages: 1859-1872
Publication
First Author: Delvalle NM
Year: 2018
Journal: Cell Mol Gastroenterol Hepatol
Title: Communication Between Enteric Neurons, Glia, and Nociceptors Underlies the Effects of Tachykinins on Neuroinflammation.
Volume: 6
Issue: 3
Pages: 321-344
Publication
First Author: Gaertner F
Year: 2017
Journal: Cell
Title: Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.
Volume: 171
Issue: 6
Pages: 1368-1382.e23