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Search results 1 to 100 out of 1757 for Pomc

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Type Details Score
Gene
key_980062 | Pomc
Type: gene
Organism: Not Specified
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Gene
5443 | POMC
Type: gene
Organism: human
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Gene
422011 | POMC
Type: gene
Organism: chicken
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Gene
694430 | POMC
Type: gene
Organism: macaque, rhesus
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Gene
496777 | pomc
Type: gene
Organism: frog, western clawed
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Gene
281416 | POMC
Type: gene
Organism: cattle
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Gene
24664 | Pomc
Type: gene
Organism: rat
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Gene
403659 | POMC
Type: gene
Organism: dog, domestic
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Gene
459074 | POMC
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:97742 | Pomc
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
108167315 | LOC108167315
Type: gene
Organism: human
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Gene
106728414 | LOC106728414
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5645063
Age: embryonic day 11.5
Image: 1B POMC e11.5
Specimen Label: 1B POMC e11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689620
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5645063
Age: embryonic day 12.5
Image: 1B POMC e12.5
Specimen Label: 1B POMC e12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689621
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5645063
Age: embryonic day 13.5
Image: 1B POMC e13.5
Specimen Label: 1B POMC e13.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5645063
Age: embryonic day 14.5
Image: 1B POMC e14.5
Specimen Label: 1B POMC e14.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5645063
Age: embryonic day 15.5
Image: 1B POMC e15.5
Specimen Label: 1B POMC e15.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5645063
Age: embryonic day 17.5
Image: 2B POMC Ct
Specimen Label: 2B POMC Ct
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5645063
Age: embryonic day 17.5
Image: 1B POMC BETA2 (-/-)
Note: Authors report only a minor alteration in expression compared with wild type embryos.
Specimen Label: 1B POMC BETA2 (-/-)
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5645063
Age: embryonic day 12.5
Image: 1B POMC e12.5
Note: Expression in Tbx19-expressing cells in caudoventral aspect of developing pituitary.
Specimen Label: 1B POMC e12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5645063
Age: embryonic day 13.5
Image: 1B POMC e13.5
Specimen Label: 1B POMC e13.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5645063
Age: embryonic day 14.5
Image: 1B POMC e14.5
Specimen Label: 1B POMC e14.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5645063
Age: embryonic day 15.5
Image: 1B POMC e15.5
Specimen Label: 1B POMC e15.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751425
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5645063
Age: embryonic day 17.5
Image: 2B POMC Ct
Specimen Label: 2B POMC Ct
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751425
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5645063
Age: embryonic day 17.5
Image: 1B POMC BETA2 (-/-)
Note: Authors report only a minor alteration in expression compared with wild type embryos.
Specimen Label: 1B POMC BETA2 (-/-)
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:7525890
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7526036
Age: embryonic day 18.5
Image: 5 POMC +/+
Specimen Label: 5 POMC +/+
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:7525890
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7526036
Age: embryonic day 18.5
Image: 5 POMC -/-
Note: Expression unchanged compared to wild type.
Specimen Label: 5 POMC -/-
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5645033
Assay Type: RNA in situ
Annotation Date: 2015-07-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672419
Stage: TS19
Assay Id: MGI:5645063
Age: embryonic day 11.5
Image: 1B POMC e11.5
Specimen Label: 1B POMC e11.5
Detected: false
Specimen Num: 1
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Publication
23823479 | J:199234
First Author: Shi X
Year: 2013
Journal: Cell Metab
Title: Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons.
Volume: 18
Issue: 1
Pages: 86-98
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Publication
22319636 | J:185235
First Author: Plum L
Year: 2012
Journal: PLoS One
Title: InsR/FoxO1 signaling curtails hypothalamic POMC neuron number.
Volume: 7
Issue: 2
Pages: e31487
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Publication
34644574 | J:337686
First Author: Saucisse N
Year: 2021
Journal: Cell Rep
Title: Functional heterogeneity of POMC neurons relies on mTORC1 signaling.
Volume: 37
Issue: 2
Pages: 109800
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Publication
20103739 | J:162892
First Author: Iskandar K
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Volume: 298
Issue: 4
Pages: E787-98
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Publication
22166984 | J:182457
First Author: Padilla SL
Year: 2012
Journal: Endocrinology
Title: Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.
Volume: 153
Issue: 3
Pages: 1219-31
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Publication
22326958 | J:184572
First Author: Berglund ED
Year: 2012
Journal: J Clin Invest
Title: Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.
Volume: 122
Issue: 3
Pages: 1000-9
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Publication
29040444 | J:251907
First Author: Townsend KL
Year: 2017
Journal: Endocrinology
Title: Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.
Volume: 158
Issue: 12
Pages: 4233-4245
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Publication
20160350 | J:158568
First Author: Banno R
Year: 2010
Journal: J Clin Invest
Title: PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.
Volume: 120
Issue: 3
Pages: 720-34
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Publication
30311908 | J:294413
   
First Author: Croizier S
Year: 2018
Journal: Elife
Title: Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis.
Volume: 7
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Publication
21406615 | J:172299
First Author: De Jonghe BC
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
Volume: 300
Issue: 6
Pages: E1002-11
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Publication
29351427 | J:260258
First Author: Aberdein N
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance.
Volume: 314
Issue: 3
Pages: R478-R488
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Publication
28190775 | J:251962
First Author: Santoro A
Year: 2017
Journal: Cell Metab
Title: DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.
Volume: 25
Issue: 3
Pages: 647-660
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Publication
32244188 | J:310050
 
First Author: Yu H
Year: 2020
Journal: Mol Metab
Title: Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.
Volume: 35
Pages: 100957
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Publication
25051442 | J:218345
First Author: Burke LK
Year: 2014
Journal: Endocrinology
Title: 5-HT obesity medication efficacy via POMC activation is maintained during aging.
Volume: 155
Issue: 10
Pages: 3732-8
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Publication
25127258 | J:261705
First Author: Hu J
Year: 2014
Journal: PLoS One
Title: Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons.
Volume: 9
Issue: 8
Pages: e105080
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Publication
25594696 | J:235109
First Author: Lam DD
Year: 2015
Journal: Endocrinology
Title: Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism.
Volume: 156
Issue: 4
Pages: 1292-302
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Publication
26563310 | J:324494
First Author: Dey S
Year: 2016
Journal: J Mol Endocrinol
Title: Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response.
Volume: 56
Issue: 2
Pages: 55-67
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Publication
30957016 | J:288799
 
First Author: Jones GL
Year: 2019
Journal: eNeuro
Title: Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network.
Volume: 6
Issue: 2
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Publication
21193556 | J:329224
First Author: Langlais D
Year: 2011
Journal: Mol Endocrinol
Title: A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.
Volume: 25
Issue: 2
Pages: 348-59
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Publication
36374777 | J:331452
 
First Author: Coppola I
Year: 2022
Journal: Mol Metab
Title: Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Volume: 66
Pages: 101627
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Publication
23341784 | J:195170
First Author: Mercer RE
Year: 2013
Journal: PLoS Genet
Title: Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.
Volume: 9
Issue: 1
Pages: e1003207
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Publication
29528284 | J:269652
   
First Author: Caron A
Year: 2018
Journal: Elife
Title: POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels.
Volume: 7
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Publication
11447259 | J:70462
First Author: Liu J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Tbx19, a tissue-selective regulator of POMC gene expression.
Volume: 98
Issue: 15
Pages: 8674-9
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Publication
17991729 | J:141451
First Author: Linhart KB
Year: 2008
Journal: Endocrinology
Title: Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin.
Volume: 149
Issue: 2
Pages: 681-6
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Publication
35044906 | J:319845
   
First Author: Yu H
Year: 2022
Journal: Elife
Title: Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.
Volume: 11
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Publication
34626854 | J:335831
 
First Author: Dong Y
Year: 2021
Journal: Mol Metab
Title: Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.
Volume: 54
Pages: 101352
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Publication
17728716 | J:125165
First Author: Parton LE
Year: 2007
Journal: Nature
Title: Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
Volume: 449
Issue: 7159
Pages: 228-32
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Publication
25510553 | J:221378
First Author: Ma W
Year: 2015
Journal: Biochem J
Title: FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3.
Volume: 466
Issue: 2
Pages: 291-8
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Publication
11290323 | J:68454
First Author: Lamolet B
Year: 2001
Journal: Cell
Title: A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins.
Volume: 104
Issue: 6
Pages: 849-59
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Publication
25671638 | J:224010
First Author: Lam DD
Year: 2015
Journal: PLoS Genet
Title: Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.
Volume: 11
Issue: 2
Pages: e1004935
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Publication
28667175 | J:246578
First Author: Rau AR
Year: 2017
Journal: J Neurosci
Title: The Relevance of AgRP Neuron-Derived GABA Inputs to POMC Neurons Differs for Spontaneous and Evoked Release.
Volume: 37
Issue: 31
Pages: 7362-7372
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Publication
18439911 | J:136249
First Author: Hirosawa M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.
Volume: 371
Issue: 2
Pages: 320-3
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Publication
21363936 | J:173850
First Author: Corander MP
Year: 2011
Journal: Endocrinology
Title: Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.
Volume: 152
Issue: 5
Pages: 1819-28
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Publication
21586695 | J:182057
First Author: Reiter MH
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release.
Volume: 301
Issue: 2
Pages: E336-41
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Publication
30673296 | J:273073
First Author: Wang Z
Year: 2019
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation.
Volume: 316
Issue: 4
Pages: R338-R351
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Publication
12859669 | J:84637
First Author: Miller R
Year: 2003
Journal: J Neurochem
Title: Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice.
Volume: 86
Issue: 3
Pages: 556-63
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Publication
26467632 | J:246705
First Author: Chhabra KH
Year: 2016
Journal: Diabetes
Title: Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.
Volume: 65
Issue: 3
Pages: 660-72
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Publication
21074524 | J:168022
First Author: Pelling M
Year: 2011
Journal: Dev Biol
Title: Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.
Volume: 349
Issue: 2
Pages: 406-16
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Publication
27689000 | J:273988
First Author: Chhabra KH
Year: 2016
Journal: Mol Metab
Title: Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity.
Volume: 5
Issue: 10
Pages: 869-881
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Publication
26977396 | J:238329
First Author: Burke LK
Year: 2016
Journal: Mol Metab
Title: Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.
Volume: 5
Issue: 3
Pages: 245-52
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Publication
32311511 | J:329571
 
First Author: Trotta M
Year: 2020
Journal: Mol Metab
Title: Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice.
Volume: 37
Pages: 100985
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Publication
32180559 | J:287264
 
First Author: Hael CE
Year: 2020
Journal: Mol Metab
Title: The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight.
Volume: 34
Pages: 43-53
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Publication
23370526 | J:345179
First Author: Shi X
Year: 2013
Journal: Diabetologia
Title: Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter.
Volume: 56
Issue: 4
Pages: 925-36
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Publication
16959830 | J:129517
First Author: Tung YC
Year: 2006
Journal: Endocrinology
Title: A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice.
Volume: 147
Issue: 12
Pages: 5940-7
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Publication
29031726 | J:263144
First Author: Chhabra KH
Year: 2017
Journal: Mol Metab
Title: Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.
Volume: 6
Issue: 10
Pages: 1274-1285
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Publication
9105908 | J:39928
First Author: Chesnokova V
Year: 1997
Journal: Horm Metab Res
Title: Different effects of IL-2 in vivo treatment and emotional stress on POMC gene expression in the pituitary of mice.
Volume: 29
Issue: 2
Pages: 88-9
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Publication
15358786 | J:95194
First Author: Corre S
Year: 2004
Journal: J Biol Chem
Title: UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1).
Volume: 279
Issue: 49
Pages: 51226-33
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Publication
17023536 | J:119209
First Author: Xu AW
Year: 2007
Journal: Endocrinology
Title: Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.
Volume: 148
Issue: 1
Pages: 72-80
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Publication
18559987 | J:139994
First Author: Karpac J
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.
Volume: 295
Issue: 2
Pages: E446-55
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Publication
18396135 | J:134336
First Author: Belgardt BF
Year: 2008
Journal: Cell Metab
Title: PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.
Volume: 7
Issue: 4
Pages: 291-301
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Publication
29590552 | J:263896
First Author: Rau AR
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Various transgenic mouse lines to study proopiomelanocortin cells in the brain stem label disparate populations of GABAergic and glutamatergic neurons.
Volume: 315
Issue: 1
Pages: R144-R152
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Publication
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