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Search results 1 to 100 out of 135 for Pot1a

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lee Y
Year: 2014
Journal: J Neurosci
Title: Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.
Volume: 34
Issue: 23
Pages: 7836-44
Publication
First Author: Kibe T
Year: 2010
Journal: Mol Cell Biol
Title: Telomere protection by TPP1 is mediated by POT1a and POT1b.
Volume: 30
Issue: 4
Pages: 1059-66
Publication
First Author: Akbay EA
Year: 2013
Journal: Oncogene
Title: Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.
Volume: 32
Issue: 17
Pages: 2211-9
Publication
First Author: Hockemeyer D
Year: 2006
Journal: Cell
Title: Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Volume: 126
Issue: 1
Pages: 63-77
Publication
First Author: Pinzaru AM
Year: 2016
Journal: Cell Rep
Title: Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.
Volume: 15
Issue: 10
Pages: 2170-2184
Publication
First Author: Takai KK
Year: 2011
Journal: Mol Cell
Title: Telomere protection by TPP1/POT1 requires tethering to TIN2.
Volume: 44
Issue: 4
Pages: 647-59
Publication
First Author: Wu L
Year: 2006
Journal: Cell
Title: Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Volume: 126
Issue: 1
Pages: 49-62
Publication
First Author: He H
Year: 2006
Journal: EMBO J
Title: POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.
Volume: 25
Issue: 21
Pages: 5180-90
Publication
First Author: Zaug AJ
Year: 2010
Journal: Genes Dev
Title: Functional interaction between telomere protein TPP1 and telomerase.
Volume: 24
Issue: 6
Pages: 613-22
Publication
First Author: Wu P
Year: 2008
Journal: Mol Cell Biol
Title: No overt nucleosome eviction at deprotected telomeres.
Volume: 28
Issue: 18
Pages: 5724-35
Publication
First Author: Palm W
Year: 2009
Journal: Mol Cell Biol
Title: Functional dissection of human and mouse POT1 proteins.
Volume: 29
Issue: 2
Pages: 471-82
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Miyake Y
Year: 2009
Journal: Mol Cell
Title: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.
Volume: 36
Issue: 2
Pages: 193-206
Publication
First Author: Rai R
Year: 2011
Journal: Nat Struct Mol Biol
Title: The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.
Volume: 18
Issue: 12
Pages: 1400-7
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kappei D
Year: 2013
Journal: EMBO J
Title: HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Volume: 32
Issue: 12
Pages: 1681-701
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Denchi EL
Year: 2007
Journal: Nature
Title: Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Volume: 448
Issue: 7157
Pages: 1068-71
Publication
First Author: Rai R
Year: 2019
Journal: Cell Rep
Title: The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function.
Volume: 29
Issue: 11
Pages: 3708-3725.e5
Publication
First Author: Gu P
Year: 2017
Journal: Oncogene
Title: Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.
Volume: 36
Issue: 14
Pages: 1939-1951
Publication
First Author: Gong Y
Year: 2017
Journal: Genes Dev
Title: PHF11 promotes DSB resection, ATR signaling, and HR.
Volume: 31
Issue: 1
Pages: 46-58
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Doksani Y
Year: 2013
Journal: Cell
Title: Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Volume: 155
Issue: 2
Pages: 345-356
Publication
First Author: Baumann P
Year: 2002
Journal: Mol Cell Biol
Title: Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.
Volume: 22
Issue: 22
Pages: 8079-87
Publication
First Author: Hockemeyer D
Year: 2007
Journal: Nat Struct Mol Biol
Title: Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Volume: 14
Issue: 8
Pages: 754-61
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication
First Author: Frescas D
Year: 2014
Journal: Mol Cell Biol
Title: TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.
Volume: 34
Issue: 7
Pages: 1349-62
Publication
First Author: Ahmad T
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Volume: 56
Issue: 1
Pages: 38-49
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3692944
Age: embryonic day 7.0
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3692944
Age: embryonic day 11.0
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3692944
Age: embryonic day 15.0
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3692944
Age: embryonic day 17.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3692953
Age: embryonic day 7.0
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3692953
Age: embryonic day 11.0
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3692953
Age: embryonic day 15.0
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3692953
Age: embryonic day 17.0
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3692943
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3692944
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3692949
Assay Type: RT-PCR
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3692953
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_01
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2007-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3692958
Age: embryonic day 13.5
Note: There is near ubiquitous expression during embryonic development.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_23
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_09
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_10
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_11
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_15
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_16
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_17
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_18
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:1070011
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827337
Age: embryonic day 14.5
Image: euxassay_000324_19
Detected: true
Specimen Num: 15