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Search results 1 to 100 out of 365 for Pou4f3

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0.093s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: POU4F3 is a transcription factor that is linked to inherited progressive hearing loss in humans [, , ]. It has an important role in the maturation, differentiation and survival of cochlear hair cells [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Frenz S
Year: 2015
Journal: Neuroreport
Title: Mosaic pattern of Cre recombinase expression in cochlear outer hair cells of the Brn3.1 Cre mouse.
Volume: 26
Issue: 6
Pages: 309-13
Publication
First Author: Du H
Year: 2020
Journal: Cell Rep
Title: The Cation Channel TMEM63B Is an Osmosensor Required for Hearing.
Volume: 31
Issue: 5
Pages: 107596
Publication
First Author: Freitas ÉL
Year: 2014
Journal: Eur J Med Genet
Title: Deletion of the entire POU4F3 gene in a familial case of autosomal dominant non-syndromic hearing loss.
Volume: 57
Issue: 4
Pages: 125-8
Publication
First Author: Vahava O
Year: 1998
Journal: Science
Title: Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.
Volume: 279
Issue: 5358
Pages: 1950-4
Publication
First Author: Collin RW
Year: 2008
Journal: Hum Mutat
Title: Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding.
Volume: 29
Issue: 4
Pages: 545-54
Publication
First Author: Kim HJ
Year: 2013
Journal: PLoS One
Title: SNP linkage analysis and whole exome sequencing identify a novel POU4F3 mutation in autosomal dominant late-onset nonsyndromic hearing loss (DFNA15).
Volume: 8
Issue: 11
Pages: e79063
Publication  
First Author: Masuda M
Year: 2011
Journal: Neuroscience
Title: Regulation of POU4F3 gene expression in hair cells by 5' DNA in mice.
Volume: 197
Pages: 48-64
Allele
Name: POU domain, class 4, transcription factor 3; targeted mutation 1, Kristen Rak
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication  
First Author: Fukui H
Year: 2012
Journal: Sci Rep
Title: BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.
Volume: 2
Pages: 838
Publication      
First Author: Frankel WN
Year: 1999
Journal: Personal Communication
Title: The mutant mouse dreidel (ddl) contains a mutation in the Pou4f3 gene
Publication
First Author: Walters BJ
Year: 2017
Journal: Cell Rep
Title: In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice.
Volume: 19
Issue: 2
Pages: 307-320
Publication
First Author: Hertzano R
Year: 2007
Journal: Eur J Neurosci
Title: Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
Volume: 25
Issue: 4
Pages: 999-1005
Publication
First Author: Hertzano R
Year: 2004
Journal: Hum Mol Genet
Title: Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene.
Volume: 13
Issue: 18
Pages: 2143-53
Protein
Organism: Mus musculus
Length: 338  
Fragment?: false
Protein
Organism: Mus musculus
Length: 256  
Fragment?: false
Publication  
First Author: Yu HV
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism.
Volume: 118
Issue: 29
Publication
First Author: Towers ER
Year: 2011
Journal: J Cell Sci
Title: Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.
Volume: 124
Issue: Pt 7
Pages: 1145-55
Publication      
First Author: Badea T
Year: 2011
Journal: MGI Direct Data Submission
Title: Creation of a conditional knock-in alkaline phosphatase reporter in Pou4f3
Publication
First Author: Cox BC
Year: 2012
Journal: J Assoc Res Otolaryngol
Title: Conditional gene expression in the mouse inner ear using Cre-loxP.
Volume: 13
Issue: 3
Pages: 295-322
Publication
First Author: Mizutari K
Year: 2013
Journal: Neuron
Title: Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.
Volume: 77
Issue: 1
Pages: 58-69
Publication
First Author: Davis N
Year: 2011
Journal: Development
Title: Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium.
Volume: 138
Issue: 1
Pages: 127-38
Publication
First Author: Fujimoto C
Year: 2017
Journal: Cell Death Dis
Title: Autophagy is essential for hearing in mice.
Volume: 8
Issue: 5
Pages: e2780
Allele
Name: POU domain, class 4, transcription factor 3; endonuclease-mediated mutation 1, Yun Stone Shi
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Allele
Name: transgene insertion 1, Douglas Vetter
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Sage C
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Essential role of retinoblastoma protein in mammalian hair cell development and hearing.
Volume: 103
Issue: 19
Pages: 7345-50
Publication
First Author: Friedman LM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: MicroRNAs are essential for development and function of inner ear hair cells in vertebrates.
Volume: 106
Issue: 19
Pages: 7915-20
Publication  
First Author: Kurioka T
Year: 2015
Journal: Sci Rep
Title: ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss.
Volume: 5
Pages: 16839
Genotype
Symbol: Rb1/Rb1 Tg(Pou4f3-cre)1Devet/?
Background: involves: 129 * 129S/SvEv
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pou4f3/Pou4f3<+> Tmem63b/Tmem63b
Background: involves: C57BL/6N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pou4f3-cre)1Devet/?
Background: involves: 129S/SvEv * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rb1/Rb1 Tg(Pou4f3-cre)1Devet/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rb1/Rb1<+> Tg(Pou4f3-cre)1Devet/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pou4f3/Pou4f3<+>
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Qian ZJ
Year: 2020
Journal: Sci Rep
Title: Effects of cochlear hair cell ablation on spatial learning/memory.
Volume: 10
Issue: 1
Pages: 20687
Publication
First Author: Zhu GJ
Year: 2020
Journal: PLoS Genet
Title: Aldh inhibitor restores auditory function in a mouse model of human deafness.
Volume: 16
Issue: 9
Pages: e1009040
Publication
First Author: Golub JS
Year: 2012
Journal: J Neurosci
Title: Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin.
Volume: 32
Issue: 43
Pages: 15093-105
Publication
First Author: Tong L
Year: 2015
Journal: J Neurosci
Title: Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons.
Volume: 35
Issue: 20
Pages: 7878-91
Publication
First Author: Tornari C
Year: 2014
Journal: PLoS One
Title: Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
Volume: 9
Issue: 11
Pages: e112247
Publication  
First Author: Kaur T
Year: 2015
Journal: Front Cell Neurosci
Title: Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle.
Volume: 9
Pages: 150
Publication
First Author: Atar O
Year: 2010
Journal: Neuroscience
Title: Anti-apoptotic factor z-Val-Ala-Asp-fluoromethylketone promotes the survival of cochlear hair cells in a mouse model for human deafness.
Volume: 168
Issue: 3
Pages: 851-7
Publication
First Author: Hesse K
Year: 2011
Journal: PLoS One
Title: AP-2δ is a crucial transcriptional regulator of the posterior midbrain.
Volume: 6
Issue: 8
Pages: e23483
Publication
First Author: Duncan JS
Year: 2013
Journal: PLoS One
Title: Continued expression of GATA3 is necessary for cochlear neurosensory development.
Volume: 8
Issue: 4
Pages: e62046
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Mahrt EJ
Year: 2013
Journal: J Neurosci
Title: Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience.
Volume: 33
Issue: 13
Pages: 5573-83
Publication  
First Author: Kurioka T
Year: 2016
Journal: Neuroscience
Title: Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus.
Volume: 332
Pages: 242-57
Publication  
First Author: Lee S
Year: 2021
Journal: Neuroscience
Title: Scar Formation and Debris Elimination during Hair Cell Degeneration in the Adult DTR Mouse.
Volume: 453
Pages: 57-68
Publication  
First Author: Xiang M
Year: 2003
Journal: BMC Neurosci
Title: Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
Volume: 4
Pages: 2
Publication
First Author: Borse V
Year: 2021
Journal: Sci Rep
Title: Dynamic patterns of YAP1 expression and cellular localization in the developing and injured utricle.
Volume: 11
Issue: 1
Pages: 2140
Publication
First Author: Murakami DM
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Evidence for vestibular regulation of autonomic functions in a mouse genetic model.
Volume: 99
Issue: 26
Pages: 17078-82
Publication
First Author: Keithley EM
Year: 1999
Journal: Hear Res
Title: Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging.
Volume: 134
Issue: 1-2
Pages: 71-6
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619324
Stage: TS24
Assay Id: MGI:6514439
Age: embryonic day 16.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619324
Stage: TS24
Assay Id: MGI:6514439
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619326
Stage: TS26
Assay Id: MGI:6514439
Age: embryonic day 18.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619326
Stage: TS26
Assay Id: MGI:6514439
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524720
Stage: TS20
Assay Id: MGI:6514443
Age: embryonic day 12.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524721
Stage: TS21
Assay Id: MGI:6514443
Age: embryonic day 13.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524722
Stage: TS22
Assay Id: MGI:6514443
Age: embryonic day 14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524726
Stage: TS26
Assay Id: MGI:6514443
Age: embryonic day 18.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:6514443
Age: postnatal day 0
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:6514443
Age: postnatal day 3
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6514434
Assay Type: RT-PCR
Annotation Date: 2021-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524723
Stage: TS23
Assay Id: MGI:6514443
Age: embryonic day 15.75
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185818
Stage: TS18
Assay Id: MGI:3040648
Age: embryonic day 11.0
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:3040648
Age: embryonic day 13.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185823
Stage: TS23
Assay Id: MGI:3040648
Age: embryonic day 15.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185825
Stage: TS25
Assay Id: MGI:3040648
Age: embryonic day 17.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185826
Stage: TS26
Assay Id: MGI:3040648
Age: embryonic day 19.0
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185827
Stage: TS27
Assay Id: MGI:3040648
Age: postnatal day 1
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3040084
Assay Type: RT-PCR
Annotation Date: 2004-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185828
Stage: TS28
Assay Id: MGI:3040648
Age: postnatal adult
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3507573
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:3507573
Age: postnatal newborn
Image: 2
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3508788
Age: embryonic day 10.5
Image: 1
Note: Expression was detected in ventral rhombencephalon.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777821
Stage: TS21
Assay Id: MGI:3507573
Age: embryonic day 13.5
Image: 1
Note: The tissue was olfactory epithelium and/or bulb.
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754921
Stage: TS21
Assay Id: MGI:3507573
Age: embryonic day 13.5
Image: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754927
Stage: TS27
Assay Id: MGI:3507573
Age: postnatal newborn
Image: 2
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697421
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3507573
Age: embryonic day 13.5
Image: 1
Note: Expression was detected in some cells.
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:3507573
Age: postnatal newborn
Image: 2
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:3506077
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3508788
Age: embryonic day 10.5
Image: 1
Note: Expression was detected in ventral mesencephalon.
Detected: true
Specimen Num: 1