| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
rabbit, European |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alsina KM |
| Year: |
2019 |
| Journal: |
Circulation |
| Title: |
Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. |
| Volume: |
140 |
| Issue: |
8 |
| Pages: |
681-693 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cordero P |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
2760 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Savage DB |
| Year: |
2008 |
| Journal: |
PLoS Med |
| Title: |
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. |
| Volume: |
5 |
| Issue: |
1 |
| Pages: |
e27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Delibegovic M |
| Year: |
2003 |
| Journal: |
Diabetes |
| Title: |
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. |
| Volume: |
52 |
| Issue: |
3 |
| Pages: |
596-604 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki Y |
| Year: |
2001 |
| Journal: |
Mol Cell Biol |
| Title: |
Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. |
| Volume: |
21 |
| Issue: |
8 |
| Pages: |
2683-94 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Toole BJ |
| Year: |
2007 |
| Journal: |
Cell Signal |
| Title: |
The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. |
| Volume: |
19 |
| Issue: |
5 |
| Pages: |
1044-55 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7284888 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2022-06-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610519 |
|
| Stage: |
TS19 |
| Assay Id: |
MGI:7284927 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Hand1f/f |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7284888 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2022-06-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610519 |
|
| Stage: |
TS19 |
| Assay Id: |
MGI:7284927 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Nkx2.5-Cre/+;Hand1f/f |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lann?r C |
| Year: |
2001 |
| Journal: |
Arch Biochem Biophys |
| Title: |
Gene structure and expression of the targeting subunit, RGL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G. |
| Volume: |
388 |
| Issue: |
1 |
| Pages: |
135-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aschenbach WG |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. |
| Volume: |
276 |
| Issue: |
43 |
| Pages: |
39959-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang W |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Relationship between glycogen accumulation and the laforin dual specificity phosphatase. |
| Volume: |
350 |
| Issue: |
3 |
| Pages: |
588-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Edler MC |
| Year: |
2018 |
| Journal: |
ACS Chem Neurosci |
| Title: |
Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin. |
| Volume: |
9 |
| Issue: |
11 |
| Pages: |
2701-2712 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rose M |
| Year: |
2008 |
| Journal: |
Mol Cell Neurosci |
| Title: |
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. |
| Volume: |
37 |
| Issue: |
4 |
| Pages: |
808-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Firulli BA |
| Year: |
2020 |
| Journal: |
Cardiovasc Res |
| Title: |
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. |
| Volume: |
116 |
| Issue: |
3 |
| Pages: |
605-618 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bailey PJ |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
A global genomic transcriptional code associated with CNS-expressed genes. |
| Volume: |
312 |
| Issue: |
16 |
| Pages: |
3108-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and Ensembl Genome Database Project |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Strain Genome Feature and Gene Model Load from Ensembl. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang PM |
| Year: |
1991 |
| Journal: |
J Biol Chem |
| Title: |
Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase. |
| Volume: |
266 |
| Issue: |
24 |
| Pages: |
15782-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xia J |
| Year: |
1998 |
| Journal: |
Diabetes |
| Title: |
A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. |
| Volume: |
47 |
| Issue: |
9 |
| Pages: |
1519-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen L |
| Year: |
1995 |
| Journal: |
Hum Mol Genet |
| Title: |
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. |
| Volume: |
4 |
| Issue: |
8 |
| Pages: |
1313-20 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the protein phosphatase 1 catalytic subunit (PP1c) binding region found in protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and related proteins. PPP1R3A acts as a glycogen-targeting subunit for protein phosphatase 1 (PP1), which is essential for cell division and participates in the regulation of glycogen metabolism, muscle contractility, and protein synthesis [, ]. This domain mediates the interaction between the regulatory subunit and the PP1 catalytic subunit. In PPP1R3A, this binding region sits near the N terminus and is followed by a carbohydrate-binding type-21 (CBM21) domain that localises the complex to glycogen, as well as a long unannotated C-terminal region [, , ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Israelian L |
| Year: |
2021 |
| Journal: |
J Neurochem |
| Title: |
Ppp1r3d deficiency preferentially inhibits neuronal and cardiac Lafora body formation in a mouse model of the fatal epilepsy Lafora disease. |
| Volume: |
157 |
| Issue: |
6 |
| Pages: |
1897-1910 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu J |
| Year: |
2018 |
| Journal: |
FEBS J |
| Title: |
Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits. |
| Volume: |
285 |
| Issue: |
24 |
| Pages: |
4646-4659 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1089
 |
| Fragment?: |
false |
|
•
•
•
•
•
|