Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
PRCD is a secreted protein and a photoreceptor outer segment (OS) disc-specific protein involved in vision [, ]. Defects in the corresponding genes causes autosomal recessive retinal degeneration []. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Murphy J |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. |
Volume: |
291 |
Issue: |
44 |
Pages: |
23036-23046 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zangerl B |
Year: |
2006 |
Journal: |
Genomics |
Title: |
Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. |
Volume: |
88 |
Issue: |
5 |
Pages: |
551-63 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
53
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Remez L |
Year: |
2014 |
Journal: |
Exp Eye Res |
Title: |
The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway. |
Volume: |
125 |
|
Pages: |
217-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spencer WJ |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
PRCD is essential for high-fidelity photoreceptor disc formation. |
Volume: |
116 |
Issue: |
26 |
Pages: |
13087-13096 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skiba NP |
Year: |
2013 |
Journal: |
J Proteome Res |
Title: |
Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration. |
Volume: |
12 |
Issue: |
6 |
Pages: |
3010-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sechrest ER |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Loss of PRCD alters number and packaging density of rhodopsin in rod photoreceptor disc membranes. |
Volume: |
10 |
Issue: |
1 |
Pages: |
17885 |
|
•
•
•
•
•
|
Publication |
First Author: |
Remez L |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. |
Volume: |
21 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Spencer WJ |
Year: |
2016 |
Journal: |
Biochemistry |
Title: |
Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability. |
Volume: |
55 |
Issue: |
36 |
Pages: |
5028-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allon G |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation. |
Volume: |
28 |
Issue: |
24 |
Pages: |
4078-4088 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469318 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6469332 |
Age: |
embryonic day 14.0 |
|
|
Specimen Label: |
E14 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469318 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6469332 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469318 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6469332 |
Age: |
postnatal day 150 |
|
|
Specimen Label: |
P150 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469318 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6469349 |
Age: |
postnatal week 10 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469318 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-10-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6469349 |
Age: |
postnatal week 10 |
|
|
Specimen Label: |
-/- |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6469334 |
Age: |
postnatal week 10 |
|
|
Specimen Label: |
3E wt |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6469334 |
Age: |
postnatal week 10 |
|
|
Specimen Label: |
3E ko |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6469334 |
Age: |
postnatal adult |
|
Note: |
Expression is seen exclusively in the photoreceptor outer segments; the high background of the rod labeling made it difficult to determine if this included expression in the cones. |
Specimen Label: |
1E |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6469334 |
Age: |
postnatal adult |
|
Note: |
Expression is seen exclusively in the photoreceptor outer segments; double labeling demonstrates this includes expression in the rods. |
Specimen Label: |
1B |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6469334 |
Age: |
postnatal adult |
|
Note: |
Expression is seen in the photoreceptor outer segments; since these mutants lack rods, this demonstrates there is expression in the cones. |
Specimen Label: |
1H |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6469344 |
Age: |
postnatal adult |
|
Note: |
Expression is concentrated in the compartment of disc neogenesis at the outer segment base; it is also seen at the rim of the outer segment in both the disc and plasma membranes. This is a rod cell. |
Specimen Label: |
2A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6469344 |
Age: |
postnatal adult |
|
Note: |
Expression is concentrated in the compartment of disc neogenesis at the outer segment base of the rod cell pictured in (A). |
Specimen Label: |
2B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6469344 |
Age: |
postnatal adult |
|
Note: |
Expression is seen on the disc rim, in disc membranes and the plasma membrane; this is a rod cell. |
Specimen Label: |
2C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6469344 |
Age: |
postnatal adult |
|
Note: |
Expression is concentrated in the compartment of disc neogenesis at the outer segment base; this is a rod cell. |
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6469322 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6469344 |
Age: |
postnatal adult |
|
Note: |
Expression is concentrated in the compartment of disc neogenesis at the outer segment base; this is a cone cell. |
Specimen Label: |
2E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin Q |
Year: |
2006 |
Journal: |
Nucleic Acids Res |
Title: |
Mutagenesis of diploid mammalian genes by gene entrapment. |
Volume: |
34 |
Issue: |
20 |
Pages: |
e139 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and VEGA Genome Database Project |
Year: |
2006 |
Journal: |
Database Release |
Title: |
Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Collin GB |
Year: |
2020 |
Journal: |
Cells |
Title: |
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. |
Volume: |
9 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Photoreceptor disk component PRCD |
Type: |
chain |
End: |
53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu W |
Year: |
1999 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Evaluation of the APOH gene as a positional candidate for prcd in dogs. |
Volume: |
40 |
Issue: |
6 |
Pages: |
1229-37 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ray K |
Year: |
1996 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Nonallelism of erd and prcd and exclusion of the canine RDS/peripherin gene as a candidate for both retinal degeneration loci. |
Volume: |
37 |
Issue: |
5 |
Pages: |
783-94 |
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DO Term |
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Publication |
First Author: |
Cocito C |
Year: |
2016 |
Journal: |
Front Cell Neurosci |
Title: |
Alterations of Cell Proliferation and Apoptosis in the Hypoplastic Reeler Cerebellum. |
Volume: |
10 |
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Pages: |
141 |
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Publication |
First Author: |
Zangerl B |
Year: |
2002 |
Journal: |
Gene |
Title: |
Molecular cloning, characterization and mapping of the canine glucocorticoid receptor DNA binding factor 1 (GRLF1). |
Volume: |
294 |
Issue: |
1-2 |
Pages: |
167-76 |
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Publication |
First Author: |
Ray K |
Year: |
1997 |
Journal: |
Curr Eye Res |
Title: |
Canine rod transducin alpha-1: cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophy. |
Volume: |
16 |
Issue: |
1 |
Pages: |
71-7 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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