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Search results 1 to 100 out of 908 for Prdm1

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Hits by Category

Hits by Strain

Type Details Score
Gene
key_980067 | Prdm1
Type: gene
Organism: Not Specified
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Gene
639 | PRDM1
Type: gene
Organism: human
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Gene
493207 | prdm1
Type: gene
Organism: frog, western clawed
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Gene
309871 | Prdm1
Type: gene
Organism: rat
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Gene
481947 | PRDM1
Type: gene
Organism: dog, domestic
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Gene
462904 | PRDM1
Type: gene
Organism: chimpanzee
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Gene
538384 | PRDM1
Type: gene
Organism: cattle
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Gene
445340 | PRDM1
Type: gene
Organism: chicken
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Gene
696757 | PRDM1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR016608 | PRDM1
Type: Family
Description: PR domain zinc finger protein 1 (PRDM1, also known as BLIMP-1) is a transcriptional repressor that is essential for cellular development. This entry includes BLIMP-1 from vertebrates and its homologues from invertebrates. In vertebrates, PRDM1 is also known as B lymphocyte-induced maturation protein 1 (BLIMP-1) or positive regulatory domain I-binding factor (PRDI-BF1). It is essential for the differentiation of B and T cells []. In Caenorhabditis elegans, it regulates the spatiotemporal cell migration pattern []. The degradation of PRDM1 by DRE-1/FBXO11-dependent mechanism regulates the C. elegans developmental timing and maturation [].
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Protein Coding Gene
MGI:99655 | Prdm1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:3834406
Assay Type: RNA in situ
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:3834847
Age: embryonic day 17.5
Image: 5 Prdm1
Note: Expression was detected at the scleral border of the retina (early photoreceptor precursor pattern).
Specimen Label: 5 Prdm1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5811457
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823693
Age: embryonic day 10.5
Image: S1A - Prdm1 - E10.5
Note: This gene exhibits category 3 expression: staining is observed in the posterior-proximal limb bud.
Specimen Label: S1A - Prdm1 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5811457
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823693
Age: embryonic day 11.5
Image: S1A - Prdm1 - E11.5
Note: This gene exhibits category 3 expression: staining is observed in the posterior-proximal limb bud.
Specimen Label: S1A - Prdm1 - E11.5
Detected: true
Specimen Num: 2
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Publication
24968003 | -
First Author: Huang TF
Year: 2014
Journal: PLoS Genet
Title: BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
Volume: 10
Issue: 6
Pages: e1004428
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Publication
25015830 | -
First Author: Boulet S
Year: 2014
Journal: J Immunol
Title: IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation.
Volume: 193
Issue: 4
Pages: 1847-54
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Publication
24613396 | -
First Author: Horn M
Year: 2014
Journal: Dev Cell
Title: DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
Volume: 28
Issue: 6
Pages: 697-710
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Publication
28701508 | J:251447
First Author: Roberts NA
Year: 2017
Journal: J Immunol
Title: Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.
Volume: 199
Issue: 4
Pages: 1250-1260
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Protein
Q60636
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
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Protein
I7CPP0
Organism: Mus musculus/domesticus
Length: 823  
Fragment?: false
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Protein
Q8C0I0
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Publication
32562755 | J:293797
First Author: Goodson NB
Year: 2020
Journal: Dev Biol
Title: Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells.
Volume: 464
Issue: 2
Pages: 111-123
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Publication
20064451 | J:156176
First Author: Kwon H
Year: 2009
Journal: Immunity
Title: Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.
Volume: 31
Issue: 6
Pages: 941-52
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Publication
26586842 | J:237560
First Author: Yamashiro C
Year: 2016
Journal: Biol Reprod
Title: Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice.
Volume: 94
Issue: 1
Pages: 7
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Publication
32541005 | J:333909
 
First Author: Goodson NB
Year: 2020
Journal: Development
Title: Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes.
Volume: 147
Issue: 13
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Publication
24821700 | J:213584
First Author: Vincent SD
Year: 2014
Journal: Hum Mol Genet
Title: Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.
Volume: 23
Issue: 19
Pages: 5087-101
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Publication
22522309 | J:186268
First Author: Vincent SD
Year: 2012
Journal: Mol Biol Evol
Title: Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo.
Volume: 29
Issue: 10
Pages: 3181-91
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Publication
- | J:147111
     
First Author: Nussenzweig MC
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a Prdm1 reporter allele
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Publication
32655552 | J:298211
 
First Author: De Trez C
Year: 2020
Journal: Front Immunol
Title: A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection.
Volume: 11
Pages: 1085
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Publication
31474988 | J:281421
 
First Author: Wang YH
Year: 2019
Journal: Front Immunol
Title: Blimp-1 Contributes to the Development and Function of Regulatory B Cells.
Volume: 10
Pages: 1909
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GXD Expression
GXD Expression
Probe: MGI:7439081
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187615
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:7439174
Age: embryonic day 9.5
Image: 1H
Note: Prdm1 expression is seen in 10-20% of the diploid cells in spongiotrophoblast layer; they are dividing. Prdm1 expression is also seen in the spiral artery-associated trophoblast giant cells (SpA-TGCs); they are not dividing.
Specimen Label: 1H
Detected: true
Specimen Num: 6
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Publication
28698287 | J:244121
First Author: Savage HP
Year: 2017
Journal: J Exp Med
Title: Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells.
Volume: 214
Issue: 9
Pages: 2777-2794
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Publication
36890795 | J:334983
First Author: Pioli KT
Year: 2023
Journal: iScience
Title: Thymus antibody-secreting cells possess an interferon gene signature and are preferentially expanded in young female mice.
Volume: 26
Issue: 3
Pages: 106223
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Publication
26365183 | J:236661
First Author: Wu T
Year: 2015
Journal: Cell Rep
Title: TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
Volume: 12
Issue: 12
Pages: 2099-110
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Publication
31138796 | J:280253
First Author: Feldman A
Year: 2019
Journal: Nat Commun
Title: Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro.
Volume: 10
Issue: 1
Pages: 2348
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Publication
37172104 | J:359630
First Author: Nguyen QP
Year: 2023
Journal: Sci Immunol
Title: Transcriptional programming of CD4(+) T(RM) differentiation in viral infection balances effector- and memory-associated gene expression.
Volume: 8
Issue: 83
Pages: eabq7486
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Publication
32433949 | J:288332
First Author: Milner JJ
Year: 2020
Journal: Immunity
Title: Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Volume: 52
Issue: 5
Pages: 808-824.e7
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Publication
36736893 | J:334950
First Author: Yang W
Year: 2023
Journal: Cell Mol Gastroenterol Hepatol
Title: Intrinsic STING Switches off Pathogenetic Programs of Th1 Cells to Inhibit Colitis.
Volume: 15
Issue: 5
Pages: 1161-1179
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Publication
33351782 | J:307556
 
First Author: Beppu LY
Year: 2021
Journal: JCI Insight
Title: Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis.
Volume: 6
Issue: 3
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Publication
39394532 | J:361012
First Author: He K
Year: 2024
Journal: Nat Immunol
Title: Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T(H)2 cells in response to inhaled allergen.
Volume: 25
Issue: 11
Pages: 2124-2139
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Publication
32399548 | J:302511
 
First Author: He K
Year: 2020
Journal: J Exp Med
Title: Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung.
Volume: 217
Issue: 7
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Publication
30936494 | J:282635
First Author: Sawant DV
Year: 2019
Journal: Nat Immunol
Title: Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Volume: 20
Issue: 6
Pages: 724-735
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Publication
30759395 | J:277464
First Author: Garg G
Year: 2019
Journal: Cell Rep
Title: Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Volume: 26
Issue: 7
Pages: 1854-1868.e5
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Publication
28713870 | J:361201
 
First Author: Poholek AC
Year: 2016
Journal: Sci Immunol
Title: IL-10 induces a STAT3-dependent autoregulatory loop in T(H)2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.
Volume: 1
Issue: 5
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Publication
18622394 | J:138571
First Author: Yamaji M
Year: 2008
Journal: Nat Genet
Title: Critical function of Prdm14 for the establishment of the germ cell lineage in mice.
Volume: 40
Issue: 8
Pages: 1016-22
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Publication
30612739 | J:294855
First Author: Rojas OL
Year: 2019
Journal: Cell
Title: Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Volume: 176
Issue: 3
Pages: 610-624.e18
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Publication
19915049 | J:157392
First Author: Chan YH
Year: 2009
Journal: J Immunol
Title: Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function.
Volume: 183
Issue: 11
Pages: 7039-46
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Publication
17509907 | J:123593
First Author: Kallies A
Year: 2007
Journal: Immunity
Title: Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.
Volume: 26
Issue: 5
Pages: 555-66
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Publication
29158490 | J:257197
First Author: Elias S
Year: 2017
Journal: Nat Commun
Title: Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life.
Volume: 8
Issue: 1
Pages: 1714
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Publication
34852224 | J:328285
First Author: Niimi K
Year: 2021
Journal: Cell Rep
Title: FOXO1 represses lymphatic valve formation and maintenance via PRDM1.
Volume: 37
Issue: 9
Pages: 110048
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Publication
19737919 | J:153979
First Author: Morgan MA
Year: 2009
Journal: Mol Cell Biol
Title: Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.
Volume: 29
Issue: 21
Pages: 5813-27
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Publication
19329782 | J:149363
First Author: D'Costa K
Year: 2009
Journal: Blood
Title: Blimp1 is limiting for transformation in a mouse plasmacytoma model.
Volume: 113
Issue: 23
Pages: 5911-9
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Publication
28692065 | J:259383
First Author: Kim SJ
Year: 2017
Journal: Nat Immunol
Title: Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus.
Volume: 18
Issue: 9
Pages: 1016-1024
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Publication
23576729 | J:196147
First Author: Chiang MF
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice.
Volume: 110
Issue: 16
Pages: 6476-81
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Publication
23052053 | J:194560
First Author: Lin MH
Year: 2013
Journal: Diabetologia
Title: B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells.
Volume: 56
Issue: 1
Pages: 136-46
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Publication
18725523 | J:138810
First Author: Martins GA
Year: 2008
Journal: J Exp Med
Title: Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival.
Volume: 205
Issue: 9
Pages: 1959-65
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Publication
26214740 | J:238050
First Author: Xu L
Year: 2015
Journal: Nat Immunol
Title: The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
Volume: 16
Issue: 9
Pages: 991-9
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Publication
30257949 | J:266413
First Author: Andreani V
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.
Volume: 115
Issue: 41
Pages: E9630-E9639
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Publication
30498131 | J:321896
 
First Author: Bönelt P
Year: 2019
Journal: EMBO J
Title: Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
Volume: 38
Issue: 2
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Publication
27261530 | J:236268
First Author: Wöhner M
Year: 2016
Journal: J Exp Med
Title: Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.
Volume: 213
Issue: 7
Pages: 1201-21
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Publication
22406686 | J:185377
First Author: Oestreich KJ
Year: 2012
Journal: Nat Immunol
Title: Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile.
Volume: 13
Issue: 4
Pages: 405-11
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Publication
33168576 | J:300733
First Author: Sungnak W
Year: 2020
Journal: J Immunol
Title: T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.
Volume: 205
Issue: 12
Pages: 3247-3262
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Publication
27731422 | J:250177
 
First Author: Morita M
Year: 2016
Journal: Sci Rep
Title: Smad4 is required to inhibit osteoclastogenesis and maintain bone mass.
Volume: 6
Pages: 35221
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Publication
28012163 | J:246411
First Author: Suzuki-Yamazaki N
Year: 2017
Journal: Eur J Immunol
Title: IL-10 production in murine IgM+ CD138hi cells is driven by Blimp-1 and downregulated in class-switched cells.
Volume: 47
Issue: 3
Pages: 493-503
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Publication
24487434 | J:208773
First Author: Afshar-Sterle S
Year: 2014
Journal: Nat Med
Title: Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.
Volume: 20
Issue: 3
Pages: 283-90
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Publication
27696611 | J:237427
First Author: Mikedis MM
Year: 2017
Journal: Dev Dyn
Title: PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.
Volume: 246
Issue: 1
Pages: 50-71
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Publication
26786103 | J:231228
First Author: Tanaka H
Year: 2016
Journal: J Biol Chem
Title: Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3.
Volume: 291
Issue: 12
Pages: 6316-30
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Publication
36618345 | J:340155
 
First Author: Wöhner M
Year: 2022
Journal: Front Immunol
Title: The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.
Volume: 13
Pages: 859598
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Publication
20133620 | J:157572
First Author: Nishikawa K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
Volume: 107
Issue: 7
Pages: 3117-22
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Publication
28439269 | J:352902
 
First Author: Saelee P
Year: 2017
Journal: Front Immunol
Title: Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1.
Volume: 8
Pages: 383
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Publication
32179158 | J:304734
First Author: Koh B
Year: 2020
Journal: J Allergy Clin Immunol
Title: Bcl6 and Blimp1 reciprocally regulate ST2+ Treg-cell development in the context of allergic airway inflammation.
Volume: 146
Issue: 5
Pages: 1121-1136.e9
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Publication
33238123 | J:300359
First Author: Zhang H
Year: 2020
Journal: Cell Rep
Title: An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.
Volume: 33
Issue: 8
Pages: 108433
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Publication
23349024 | J:195056
First Author: Iwasaki Y
Year: 2013
Journal: Eur J Immunol
Title: Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells.
Volume: 43
Issue: 4
Pages: 1063-73
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Publication
21505187 | J:185998
First Author: Yasuda T
Year: 2011
Journal: Sci Signal
Title: ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation.
Volume: 4
Issue: 169
Pages: ra25
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Publication
29899446 | J:265317
First Author: Chihara N
Year: 2018
Journal: Nature
Title: Induction and transcriptional regulation of the co-inhibitory gene module in T cells.
Volume: 558
Issue: 7710
Pages: 454-459
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Publication
22116829 | J:180587
First Author: Panchanathan R
Year: 2012
Journal: J Immunol
Title: Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.
Volume: 188
Issue: 1
Pages: 270-8
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Allele
Prdm1<tm3.1Liz> | MGI:5491215
Name: PR domain containing 1, with ZNF domain; targeted mutation 3.1, Elizabeth K Bikoff
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Modified isoform(s)
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Publication
36973489 | J:337849
First Author: Solé P
Year: 2023
Journal: Cell Mol Immunol
Title: A T follicular helper cell origin for T regulatory type 1 cells.
Volume: 20
Issue: 5
Pages: 489-511
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Publication
28288836 | J:242163
 
First Author: Aavani T
Year: 2017
Journal: Gene Expr Patterns
Title: Temporal profiling of photoreceptor lineage gene expression during murine retinal development.
Volume: 23-24
Pages: 32-44
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Protein Coding Gene
MGP_CAROLIEiJ_G0015295 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016937 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017042 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017117 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030712 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016104 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8168136 | J:17825
First Author: Turner CA Jr
Year: 1994
Journal: Cell
Title: Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells.
Volume: 77
Issue: 2
Pages: 297-306
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Publication
11121475 | J:66441
First Author: Tunyaplin C
Year: 2000
Journal: Nucleic Acids Res
Title: Characterization of the B lymphocyte-induced maturation protein-1 (Blimp-1) gene, mRNA isoforms and basal promoter.
Volume: 28
Issue: 24
Pages: 4846-55
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