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Search results 1 to 100 out of 355 for Prkar1a

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5573 | PRKAR1A
Type: gene
Organism: human
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Gene
454845 | PRKAR1A
Type: gene
Organism: chimpanzee
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Gene
480459 | PRKAR1A
Type: gene
Organism: dog, domestic
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Gene
615074 | PRKAR1A
Type: gene
Organism: cattle
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Gene
417438 | PRKAR1A
Type: gene
Organism: chicken
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Gene
719021 | PRKAR1A
Type: gene
Organism: macaque, rhesus
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Gene
594933 | prkar1a
Type: gene
Organism: frog, western clawed
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Gene
key_28524 | PRKAR1A
Type: gene
Organism: pig, domestic
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Gene
25725 | Prkar1a
Type: gene
Organism: rat
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Protein Coding Gene
MGI:104878 | Prkar1a
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:7572383
Assay Type: RNA in situ
Annotation Date: 2024-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Pattern: Widespread
Stage: TS16
Assay Id: MGI:7572398
Age: embryonic day 10.0
Note: Authors report that all candidate genes are broadly expressed in embryo.
Specimen Label: 3E Prkar1a
Detected: true
Specimen Num: 1
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Publication
32212257 | J:331362
First Author: Liu Y
Year: 2020
Journal: Physiol Rep
Title: PRKAR1A deficiency impedes hypertrophy and reduces heart size.
Volume: 8
Issue: 6
Pages: e14405
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Publication
27803029 | J:316520
First Author: Saloustros E
Year: 2017
Journal: Endocr Relat Cancer
Title: Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis.
Volume: 24
Issue: 1
Pages: 31-40
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Publication
15371594 | J:93393
First Author: Veugelers M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.
Volume: 101
Issue: 39
Pages: 14222-7
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Publication
17975024 | J:130264
First Author: Yin Z
Year: 2008
Journal: Mol Endocrinol
Title: Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.
Volume: 22
Issue: 2
Pages: 380-7
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Publication
18953430 | J:245735
First Author: Jones GN
Year: 2008
Journal: Neoplasia
Title: Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
Volume: 10
Issue: 11
Pages: 1213-21
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Publication
20548949 | J:161521
First Author: Sahut-Barnola I
Year: 2010
Journal: PLoS Genet
Title: Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Volume: 6
Issue: 6
Pages: e1000980
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Publication
8662216 | J:33554
First Author: Moskow JJ
Year: 1996
Journal: Mamm Genome
Title: Mapping of the Prkar1a gene to mouse chromosome 11.
Volume: 7
Issue: 6
Pages: 464-5
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Publication
32821937 | J:296585
First Author: Schernthaner-Reiter MH
Year: 2020
Journal: Hum Mol Genet
Title: Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Volume: 29
Issue: 17
Pages: 2951-2961
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Publication
18316483 | J:142482
First Author: Yin Z
Year: 2008
Journal: Circulation
Title: Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Volume: 117
Issue: 11
Pages: 1414-22
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Publication
20697156 | J:165282
First Author: Molyneux SD
Year: 2010
Journal: J Clin Invest
Title: Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.
Volume: 120
Issue: 9
Pages: 3310-25
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Publication
17932105 | J:130063
First Author: Pavel E
Year: 2008
Journal: Mol Endocrinol
Title: Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Volume: 22
Issue: 2
Pages: 430-40
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Publication
18413734 | J:133962
First Author: Nadella KS
Year: 2008
Journal: Cancer Res
Title: Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Volume: 68
Issue: 8
Pages: 2671-7
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Publication
29289659 | J:273968
 
First Author: Russart KLG
Year: 2018
Journal: Horm Behav
Title: Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.
Volume: 98
Pages: 121-129
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Publication
25012505 | J:230136
First Author: Gangoda L
Year: 2014
Journal: Cell Death Differ
Title: Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.
Volume: 21
Issue: 11
Pages: 1815-24
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Publication
20534695 | J:182862
First Author: Jones GN
Year: 2010
Journal: Mol Endocrinol
Title: Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.
Volume: 24
Issue: 8
Pages: 1559-68
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Publication
27589370 | J:303060
First Author: Le Stunff C
Year: 2017
Journal: J Bone Miner Res
Title: Knock-In of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis.
Volume: 32
Issue: 2
Pages: 333-346
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Publication
24512487 | J:225245
First Author: Pringle DR
Year: 2014
Journal: J Clin Endocrinol Metab
Title: Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.
Volume: 99
Issue: 5
Pages: E804-12
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Publication
15591278 | J:95465
First Author: Griffin KJ
Year: 2004
Journal: J Med Genet
Title: A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Volume: 41
Issue: 12
Pages: 923-31
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Publication
20080939 | J:158372
First Author: Almeida MQ
Year: 2010
Journal: Hum Mol Genet
Title: Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.
Volume: 19
Issue: 8
Pages: 1387-98
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Publication
16491075 | J:107347
First Author: Wilkes D
Year: 2006
Journal: Nat Rev Cancer
Title: Inherited disposition to cardiac myxoma development.
Volume: 6
Issue: 2
Pages: 157-65
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Publication
24755349 | J:211302
First Author: de Sousa SF
Year: 2014
Journal: Gene Expr Patterns
Title: PKA regulatory subunit expression in tooth development.
Volume: 15
Issue: 1
Pages: 46-51
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Publication
21533282 | J:172384
First Author: Willis BS
Year: 2011
Journal: PLoS One
Title: Cell-type specific expression of a dominant negative PKA mutation in mice.
Volume: 6
Issue: 4
Pages: e18772
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Publication
22514108 | J:241066
First Author: Pringle DR
Year: 2012
Journal: Endocr Relat Cancer
Title: Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.
Volume: 19
Issue: 3
Pages: 435-46
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Publication
24227708 | J:204176
First Author: Guo L
Year: 2013
Journal: J Neurosci
Title: The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.
Volume: 33
Issue: 46
Pages: 17967-75
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Publication
15930266 | J:98799
First Author: Kirschner LS
Year: 2005
Journal: Cancer Res
Title: A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.
Volume: 65
Issue: 11
Pages: 4506-14
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Publication
16728532 | J:112929
First Author: Burton KA
Year: 2006
Journal: Mol Endocrinol
Title: Haploinsufficiency at the protein kinase A RI alpha gene locus leads to fertility defects in male mice and men.
Volume: 20
Issue: 10
Pages: 2504-13
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Publication
24506536 | J:212994
First Author: Zhang M
Year: 2014
Journal: Mol Endocrinol
Title: Knockdown of PRKAR1A, the gene responsible for Carney complex, interferes with differentiation in osteoblastic cells.
Volume: 28
Issue: 3
Pages: 295-307
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Publication
27341185 | J:259777
First Author: Aguileta MA
Year: 2016
Journal: Cell Death Differ
Title: A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress.
Volume: 23
Issue: 10
Pages: 1670-80
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Publication
32735622 | J:292566
First Author: Soundarapandian MM
Year: 2020
Journal: PLoS One
Title: Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
Volume: 15
Issue: 7
Pages: e0236892
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Publication
24865460 | J:219251
First Author: de Joussineau C
Year: 2014
Journal: Hum Mol Genet
Title: mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).
Volume: 23
Issue: 20
Pages: 5418-28
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Publication
23531435 | J:201355
 
First Author: Keil MF
Year: 2013
Journal: Neuroscience
Title: Threat bias in mice with inactivating mutations of Prkar1a.
Volume: 241
Pages: 206-14
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Publication
27498419 | J:252825
 
First Author: Saloustros E
Year: 2017
Journal: Mol Cell Endocrinol
Title: Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
Volume: 439
Pages: 165-174
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Publication
26992826 | J:242436
 
First Author: Briassoulis G
Year: 2016
Journal: Behav Brain Res
Title: Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA's catalytic subunits in anxiety.
Volume: 307
Pages: 1-10
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Publication
20421483 | J:160299
First Author: Tsang KM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Volume: 107
Issue: 19
Pages: 8683-8
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Publication
31798532 | J:312029
 
First Author: Kari S
Year: 2019
Journal: Front Endocrinol (Lausanne)
Title: PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer.
Volume: 10
Pages: 769
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Publication
26608815 | J:240009
 
First Author: Saloustros E
Year: 2015
Journal: J Exp Clin Cancer Res
Title: Hematopoietic neoplasms in Prkar2a-deficient mice.
Volume: 34
Pages: 143
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Publication
28615245 | J:281864
First Author: Ye H
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.
Volume: 313
Issue: 3
Pages: F677-F686
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Publication
26246497 | J:226324
First Author: Liu S
Year: 2015
Journal: Hum Mol Genet
Title: Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.
Volume: 24
Issue: 21
Pages: 6080-92
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Publication
16963469 | J:114898
First Author: Mavrakis M
Year: 2006
Journal: Hum Mol Genet
Title: Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency.
Volume: 15
Issue: 19
Pages: 2962-71
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Publication
21852354 | J:244130
First Author: Yin Z
Year: 2011
Journal: Mol Endocrinol
Title: Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.
Volume: 25
Issue: 10
Pages: 1786-93
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Publication
33338547 | J:302971
 
First Author: Leal LF
Year: 2021
Journal: Mol Cell Endocrinol
Title: Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.
Volume: 522
Pages: 111117
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Publication
29882482 | J:311903
First Author: Huk DJ
Year: 2018
Journal: Thyroid
Title: Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Volume: 28
Issue: 9
Pages: 1153-1161
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Publication
23045281 | J:199975
First Author: Manchanda PK
Year: 2013
Journal: Oncogene
Title: Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.
Volume: 32
Issue: 30
Pages: 3491-9
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Publication
35568059 | J:325352
     
First Author: Sahut-Barnola I
Year: 2022
Journal: J Invest Dermatol
Title: Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.
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Publication
20451576 | J:163198
First Author: Kirschner LS
Year: 2010
Journal: Mol Cell Endocrinol
Title: PRKAR1A and the evolution of pituitary tumors.
Volume: 326
Issue: 1-2
Pages: 3-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0017352 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019274 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019279 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018482 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018198 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
30377251 | J:268936
First Author: Ricarte FR
Year: 2018
Journal: J Biol Chem
Title: Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling.
Volume: 293
Issue: 52
Pages: 20200-20213
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Publication
27702786 | J:236379
First Author: Nedvetsky PI
Year: 2016
Journal: Development
Title: cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner.
Volume: 143
Issue: 19
Pages: 3582-3590
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Publication
24695708 | J:208122
First Author: Yang L
Year: 2014
Journal: J Neurosci
Title: Selective expression of a dominant-negative type Iα PKA regulatory subunit in striatal medium spiny neurons impairs gene expression and leads to reduced feeding and locomotor activity.
Volume: 34
Issue: 14
Pages: 4896-904
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Publication
26258640 | J:224999
 
First Author: Burgoyne JR
Year: 2015
Journal: Nat Commun
Title: Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.
Volume: 6
Pages: 7920
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Publication
33035439 | J:299682
First Author: Trum M
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart.
Volume: 319
Issue: 6
Pages: H1347-H1357
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Publication
33185461 | J:331263
First Author: Simon JN
Year: 2021
Journal: Circulation
Title: Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release.
Volume: 143
Issue: 5
Pages: 449-465
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Publication
16387847 | J:231723
First Author: Pasqualucci L
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.
Volume: 103
Issue: 2
Pages: 395-400
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Publication
27910854 | J:243165
 
First Author: Fisher HS
Year: 2016
Journal: Nat Commun
Title: The genetic basis and fitness consequences of sperm midpiece size in deer mice.
Volume: 7
Pages: 13652
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Publication
24662820 | J:219256
First Author: Beristain AG
Year: 2015
Journal: Oncogene
Title: PKA signaling drives mammary tumorigenesis through Src.
Volume: 34
Issue: 9
Pages: 1160-73
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Publication
29625227 | J:262614
 
First Author: Ugolini M
Year: 2018
Journal: Behav Brain Res
Title: Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity.
Volume: 348
Pages: 22-30
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Publication
6147198 | J:7538
First Author: Killary AM
Year: 1984
Journal: Cell
Title: A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells.
Volume: 38
Issue: 2
Pages: 523-34
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Publication
2874483 | J:8370
First Author: Peterson TC
Year: 1985
Journal: Mol Cell Biol
Title: Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells.
Volume: 5
Issue: 9
Pages: 2491-4
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Publication
2902627 | J:9412
First Author: Lem J
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.
Volume: 85
Issue: 19
Pages: 7302-6
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Publication
15554923 | J:94150
First Author: Zhou W
Year: 2004
Journal: Immunology
Title: T cell receptor induced intracellular redistribution of type I protein kinase A.
Volume: 113
Issue: 4
Pages: 453-9
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Publication
16937372 | J:113419
First Author: Duncan FE
Year: 2006
Journal: Dev Dyn
Title: Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects.
Volume: 235
Issue: 11
Pages: 2961-8
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Publication
11296260 | J:167703
First Author: Barradeau S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Muscle-regulated expression and determinants for neuromuscular junctional localization of the mouse RIalpha regulatory subunit of cAMP-dependent protein kinase.
Volume: 98
Issue: 9
Pages: 5037-42
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Publication
29367455 | J:315617
 
First Author: Dumontet T
Year: 2018
Journal: JCI Insight
Title: PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.
Volume: 3
Issue: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4361613
Assay Type: Northern blot
Annotation Date: 2009-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1764220
Stage: TS20
Assay Id: MGI:4361619
Age: embryonic day 12.5
Specimen Label: day 12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4361613
Assay Type: Northern blot
Annotation Date: 2009-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1764221
Stage: TS21
Assay Id: MGI:4361619
Age: embryonic day 13.5
Specimen Label: day 13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4361613
Assay Type: Northern blot
Annotation Date: 2009-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1764222
Stage: TS22
Assay Id: MGI:4361619
Age: embryonic day 14.5
Specimen Label: day 14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4361613
Assay Type: Northern blot
Annotation Date: 2009-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4361620
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7261469
Assay Type: Western blot
Annotation Date: 2022-04-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7261472
Age: embryonic day 8.5
Image: 2
Specimen Label: -/-
Detected: false
Specimen Num: 1
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•
•
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GXD Expression
GXD Expression
   
Probe: MGI:7261469
Assay Type: Western blot
Annotation Date: 2022-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7261472
Age: embryonic day 8.5
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
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•
•
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•
GXD Expression
GXD Expression
   
Probe: MGI:7261469
Assay Type: Western blot
Annotation Date: 2022-04-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7261474
Age: embryonic day 8.5
Image: 3
Specimen Label: KO
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7261469
Assay Type: Western blot
Annotation Date: 2022-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7261474
Age: embryonic day 8.5
Image: 3
Specimen Label: WT
Detected: true
Specimen Num: 1
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•
•
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