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Search results 1 to 100 out of 571 for Prlr

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: sheep
Gene
Type: gene
Organism: goat
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: PRLR is a receptor for the anterior pituitary hormone prolactin (PRL) [, ]. PRL participates in a variety of physiological processes in vertebrates, including reproduction, osmo-regulation, growth and development, metabolism, immuno-regulation, energy balance, and behavior []. Upon ligand binding of PRL to PRLR, the Janus-activated kinase 2 (JAK2) is activated, which in turn initiates intracellular signalling cascades, including signal transducers and activators of transcription (STAT) family members STAT-1/3/5, and extracellular regulated kinases (ERK1/2) and AKT []. PRLR also acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT [].Mutations in the PRLR gene cause multiple fibroadenomas of the breast (MFAB) []and hyperprolactinemia (HPRL) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Publication  
First Author: Kan QE
Year: 2016
Journal: Int J Biol Macromol
Title: Different intracellular signalling pathways triggered by an anti-prolactin receptor (PRLR) antibody: Implication for a signal-specific PRLR agonist.
Volume: 82
Pages: 892-7
Publication
First Author: Kline JB
Year: 1999
Journal: J Biol Chem
Title: Functional characterization of the intermediate isoform of the human prolactin receptor.
Volume: 274
Issue: 50
Pages: 35461-8
Publication
First Author: Bole-Feysot C
Year: 1998
Journal: Endocr Rev
Title: Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Volume: 19
Issue: 3
Pages: 225-68
Publication
First Author: Trott JF
Year: 2003
Journal: J Mol Endocrinol
Title: Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.
Volume: 30
Issue: 1
Pages: 31-47
Publication
First Author: Bogorad RL
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Volume: 105
Issue: 38
Pages: 14533-8
Publication
First Author: Newey PJ
Year: 2013
Journal: N Engl J Med
Title: Mutant prolactin receptor and familial hyperprolactinemia.
Volume: 369
Issue: 21
Pages: 2012-2020
Publication
First Author: Pujianto DA
Year: 2010
Journal: Endocrinology
Title: Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation.
Volume: 151
Issue: 3
Pages: 1269-79
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
GXD Expression      
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191143
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Prlr
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191143
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Prlr
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191143
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Prlr
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191143
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Prlr
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Prlr
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Prlr
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Prlr
Detected: true
Specimen Num: 7
Protein
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
Publication  
First Author: Tian RH
Year: 2019
Journal: Brain Res
Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Volume: 1725
Pages: 146472
Protein
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
Publication
First Author: Yu J
Year: 2013
Journal: Diabetes
Title: PRLR regulates hepatic insulin sensitivity in mice via STAT5.
Volume: 62
Issue: 9
Pages: 3103-13
Publication
First Author: Lucas BK
Year: 1998
Journal: Endocrinology
Title: Null mutation of the prolactin receptor gene produces a defect in maternal behavior.
Volume: 139
Issue: 10
Pages: 4102-7
Publication
First Author: Touraine P
Year: 1994
Journal: Mol Cell Endocrinol
Title: Expression of short and long forms of prolactin receptor in murine lymphoid tissues.
Volume: 104
Issue: 2
Pages: 183-90
Publication
First Author: Baran N
Year: 2003
Journal: Biol Reprod
Title: Decysin, a new member of the metalloproteinase family, is regulated by prolactin and steroids during mouse pregnancy.
Volume: 68
Issue: 5
Pages: 1787-92
Publication
First Author: Freemark M
Year: 2001
Journal: Endocrinology
Title: Body weight and fat deposition in prolactin receptor-deficient mice.
Volume: 142
Issue: 2
Pages: 532-7
Publication
First Author: Kedzia C
Year: 2005
Journal: Cancer Res
Title: Medullary thyroid carcinoma arises in the absence of prolactin signaling.
Volume: 65
Issue: 18
Pages: 8497-503
Publication  
First Author: Grosdemouge I
Year: 2003
Journal: Reprod Biol Endocrinol
Title: Effects of deletion of the prolactin receptor on ovarian gene expression.
Volume: 1
Pages: 12
Publication
First Author: Binart N
Year: 2003
Journal: Mol Endocrinol
Title: A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice.
Volume: 17
Issue: 6
Pages: 1066-74
Publication
First Author: Belugin S
Year: 2013
Journal: J Biol Chem
Title: Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons.
Volume: 288
Issue: 48
Pages: 34943-55
Publication
First Author: Shrivastava V
Year: 2021
Journal: Sci Rep
Title: Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells.
Volume: 11
Issue: 1
Pages: 10372
Publication
First Author: Bouchard B
Year: 1999
Journal: J Immunol
Title: Immune system development and function in prolactin receptor-deficient mice.
Volume: 163
Issue: 2
Pages: 576-82
Publication
First Author: Aoki M
Year: 2019
Journal: Endocrinology
Title: Widespread Cell-Specific Prolactin Receptor Expression in Multiple Murine Organs.
Volume: 160
Issue: 11
Pages: 2587-2599
Publication
First Author: Saunier E
Year: 2003
Journal: Endocrinology
Title: Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation.
Volume: 144
Issue: 6
Pages: 2669-75
Publication
First Author: Pepin ME
Year: 2019
Journal: Endocrinology
Title: Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Volume: 160
Issue: 5
Pages: 1150-1163
Publication
First Author: Shao S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Ablation of prolactin receptor increases hepatic triglyceride accumulation.
Volume: 498
Issue: 3
Pages: 693-699
Publication  
First Author: Patil M
Year: 2019
Journal: iScience
Title: Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism.
Volume: 20
Pages: 449-465
Publication
First Author: Griffith OL
Year: 2016
Journal: Cell Rep
Title: Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.
Volume: 17
Issue: 1
Pages: 249-260
Publication
First Author: Bernard V
Year: 2018
Journal: FASEB J
Title: Autocrine actions of prolactin contribute to the regulation of lactotroph function in vivo.
Volume: 32
Issue: 9
Pages: 4791-4797
Publication
First Author: Paige C
Year: 2020
Journal: J Neurosci
Title: Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
Volume: 40
Issue: 37
Pages: 7080-7090
Publication
First Author: Kokay IC
Year: 2018
Journal: J Neuroendocrinol
Title: Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse.
Volume: 30
Issue: 9
Pages: e12634
Publication
First Author: Santos CR
Year: 2001
Journal: Gen Comp Endocrinol
Title: Cloning, characterization, and tissue distribution of prolactin receptor in the sea bream (Sparus aurata).
Volume: 121
Issue: 1
Pages: 32-47
Publication
First Author: Hilton HN
Year: 2008
Journal: Biochim Biophys Acta
Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.
Volume: 1783
Issue: 3
Pages: 383-93
Publication
First Author: Costanza M
Year: 2013
Journal: J Immunol
Title: Prolactin is not required for the development of severe chronic experimental autoimmune encephalomyelitis.
Volume: 191
Issue: 5
Pages: 2082-8
Publication
First Author: Brown RSE
Year: 2019
Journal: Endocrinology
Title: Acute Suppression of LH Secretion by Prolactin in Female Mice Is Mediated by Kisspeptin Neurons in the Arcuate Nucleus.
Volume: 160
Issue: 5
Pages: 1323-1332
Publication
First Author: Tabata H
Year: 2012
Journal: J Mol Endocrinol
Title: Characterization of multiple first exons in murine prolactin receptor gene and the effect of prolactin on their expression in the choroid plexus.
Volume: 48
Issue: 2
Pages: 169-76
Publication
First Author: Ling C
Year: 2001
Journal: Endocrinology
Title: PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro.
Volume: 142
Issue: 11
Pages: 4880-90
Publication
First Author: Bigsby RM
Year: 2011
Journal: Carcinogenesis
Title: The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis.
Volume: 32
Issue: 8
Pages: 1162-6
Publication
First Author: Schuff KG
Year: 2002
Journal: J Clin Invest
Title: Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms.
Volume: 110
Issue: 7
Pages: 973-81
Publication
First Author: Fleenor D
Year: 2005
Journal: Endocrinology
Title: Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.
Volume: 146
Issue: 1
Pages: 103-12
Publication
First Author: Craven AJ
Year: 2006
Journal: J Endocrinol
Title: Prolactin delays hair regrowth in mice.
Volume: 191
Issue: 2
Pages: 415-25
Publication  
First Author: Mecklenburg J
Year: 2022
Journal: Brain Behav Immun
Title: Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution.
Volume: 101
Pages: 246-263
Publication
First Author: Patil M
Year: 2019
Journal: J Neuroendocrinol
Title: Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
Volume: 31
Issue: 8
Pages: e12759
Publication
First Author: Phillipps HR
Year: 2019
Journal: FASEB J
Title: Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus.
Volume: 33
Issue: 5
Pages: 6115-6128
Publication
First Author: Banerjee RR
Year: 2016
Journal: Diabetes
Title: Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.
Volume: 65
Issue: 8
Pages: 2331-41
Publication
First Author: Ferraris J
Year: 2014
Journal: PLoS One
Title: Prolactin induces apoptosis of lactotropes in female rodents.
Volume: 9
Issue: 5
Pages: e97383
Publication
First Author: Goffin V
Year: 1999
Journal: Genet Anal
Title: From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models.
Volume: 15
Issue: 3-5
Pages: 189-201
Publication
First Author: Makkar G
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Lrrc55 is a novel prosurvival factor in pancreatic islets.
Volume: 317
Issue: 5
Pages: E794-E804
Publication
First Author: Harris J
Year: 2006
Journal: Mol Endocrinol
Title: Socs2 and elf5 mediate prolactin-induced mammary gland development.
Volume: 20
Issue: 5
Pages: 1177-87
Publication
First Author: Zhou J
Year: 2005
Journal: EMBO J
Title: Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.
Volume: 24
Issue: 3
Pages: 635-44
Publication    
First Author: Ladyman SR
Year: 2021
Journal: Elife
Title: A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin.
Volume: 10
Publication
First Author: Brown RSE
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior.
Volume: 114
Issue: 40
Pages: 10779-10784
Publication
First Author: Mason BN
Year: 2022
Journal: Headache
Title: Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine.
Volume: 62
Issue: 1
Pages: 11-25
Publication
First Author: Rawn SM
Year: 2015
Journal: Biol Reprod
Title: Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.
Volume: 93
Issue: 3
Pages: 75
Publication
First Author: Allan GJ
Year: 2002
Journal: Endocrinology
Title: Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.
Volume: 143
Issue: 11
Pages: 4310-9
Publication
First Author: Grimm SL
Year: 2002
Journal: Mol Endocrinol
Title: Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Volume: 16
Issue: 12
Pages: 2675-91
Publication
First Author: Viengchareun S
Year: 2008
Journal: PLoS One
Title: Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.
Volume: 3
Issue: 2
Pages: e1535
Publication
First Author: Gala RR
Year: 1995
Journal: Proc Soc Exp Biol Med
Title: Influence of thyroxine and thyroxine with growth hormone and prolactin on splenocyte subsets and on the expression of interleukin-2 and prolactin receptors on splenocyte subsets of Snell dwarf mice.
Volume: 210
Issue: 2
Pages: 117-25
Publication
First Author: Auffret J
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.
Volume: 305
Issue: 10
Pages: E1309-18
Publication
First Author: Gallego MI
Year: 2001
Journal: Dev Biol
Title: Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
Volume: 229
Issue: 1
Pages: 163-75
Publication
First Author: Miyoshi K
Year: 2001
Journal: J Cell Biol
Title: Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.
Volume: 155
Issue: 4
Pages: 531-42
Publication
First Author: Brown RS
Year: 2016
Journal: J Neurosci
Title: Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.
Volume: 36
Issue: 35
Pages: 9173-85
Publication
First Author: Reese J
Year: 2000
Journal: Endocrinology
Title: Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR.
Volume: 141
Issue: 5
Pages: 1872-81
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory