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Search results 1 to 100 out of 578 for Prlr

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5618 | PRLR
Type: gene
Organism: human
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Gene
100491566 | prlr
Type: gene
Organism: frog, western clawed
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Gene
281422 | PRLR
Type: gene
Organism: cattle
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Gene
key_36638 | PRLR
Type: gene
Organism: rabbit, European
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Gene
key_31764 | PRLR
Type: gene
Organism: sheep
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Gene
key_36637 | PRLR
Type: gene
Organism: pig, domestic
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Gene
key_31763 | PRLR
Type: gene
Organism: goat
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Gene
24684 | Prlr
Type: gene
Organism: rat
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Gene
479363 | PRLR
Type: gene
Organism: dog, domestic
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Gene
461925 | PRLR
Type: gene
Organism: chimpanzee
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Gene
395660 | PRLR
Type: gene
Organism: chicken
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Gene
699369 | PRLR
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033230 | PRLR
Type: Family
Description: PRLR is a receptor for the anterior pituitary hormone prolactin (PRL) [, ]. PRL participates in a variety of physiological processes in vertebrates, including reproduction, osmo-regulation, growth and development, metabolism, immuno-regulation, energy balance, and behavior []. Upon ligand binding of PRL to PRLR, the Janus-activated kinase 2 (JAK2) is activated, which in turn initiates intracellular signalling cascades, including signal transducers and activators of transcription (STAT) family members STAT-1/3/5, and extracellular regulated kinases (ERK1/2) and AKT []. PRLR also acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT [].Mutations in the PRLR gene cause multiple fibroadenomas of the breast (MFAB) []and hyperprolactinemia (HPRL) [].
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Protein Coding Gene
MGI:97763 | Prlr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C9F9
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
E9Q2L5
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
E9Q0U8
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
Q3UPQ1
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: true
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Protein
E9Q631
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
Q99JZ1
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q6I9G6
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
G3UVW6
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Publication
26526176 | -
 
First Author: Kan QE
Year: 2016
Journal: Int J Biol Macromol
Title: Different intracellular signalling pathways triggered by an anti-prolactin receptor (PRLR) antibody: Implication for a signal-specific PRLR agonist.
Volume: 82
Pages: 892-7
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Publication
10585417 | J:58894
First Author: Kline JB
Year: 1999
Journal: J Biol Chem
Title: Functional characterization of the intermediate isoform of the human prolactin receptor.
Volume: 274
Issue: 50
Pages: 35461-8
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Publication
9626554 | -
First Author: Bole-Feysot C
Year: 1998
Journal: Endocr Rev
Title: Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Volume: 19
Issue: 3
Pages: 225-68
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Publication
12580759 | -
First Author: Trott JF
Year: 2003
Journal: J Mol Endocrinol
Title: Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.
Volume: 30
Issue: 1
Pages: 31-47
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Publication
18779591 | -
First Author: Bogorad RL
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Volume: 105
Issue: 38
Pages: 14533-8
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Publication
24195502 | -
First Author: Newey PJ
Year: 2013
Journal: N Engl J Med
Title: Mutant prolactin receptor and familial hyperprolactinemia.
Volume: 369
Issue: 21
Pages: 2012-2020
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Publication
20032052 | -
First Author: Pujianto DA
Year: 2010
Journal: Endocrinology
Title: Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation.
Volume: 151
Issue: 3
Pages: 1269-79
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Protein
F6WEZ7
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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GXD Expression
GXD Expression
     
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191143
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Prlr
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191143
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Prlr
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191143
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Prlr
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191143
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Prlr
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Prlr
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Prlr
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6181333
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191143
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Prlr
Detected: true
Specimen Num: 7
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Protein
Q08501
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q8C7G1
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Publication
31545956 | J:282154
 
First Author: Tian RH
Year: 2019
Journal: Brain Res
Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
Volume: 1725
Pages: 146472
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Protein
Q4VA18
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Publication
23775766 | J:208953
First Author: Yu J
Year: 2013
Journal: Diabetes
Title: PRLR regulates hepatic insulin sensitivity in mice via STAT5.
Volume: 62
Issue: 9
Pages: 3103-13
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Publication
9751488 | J:83247
First Author: Lucas BK
Year: 1998
Journal: Endocrinology
Title: Null mutation of the prolactin receptor gene produces a defect in maternal behavior.
Volume: 139
Issue: 10
Pages: 4102-7
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Publication
7988746 | J:19963
First Author: Touraine P
Year: 1994
Journal: Mol Cell Endocrinol
Title: Expression of short and long forms of prolactin receptor in murine lymphoid tissues.
Volume: 104
Issue: 2
Pages: 183-90
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Publication
12606478 | J:306227
First Author: Baran N
Year: 2003
Journal: Biol Reprod
Title: Decysin, a new member of the metalloproteinase family, is regulated by prolactin and steroids during mouse pregnancy.
Volume: 68
Issue: 5
Pages: 1787-92
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Publication
33990661 | J:314449
First Author: Shrivastava V
Year: 2021
Journal: Sci Rep
Title: Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells.
Volume: 11
Issue: 1
Pages: 10372
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Publication
12646063 | J:102442
 
First Author: Grosdemouge I
Year: 2003
Journal: Reprod Biol Endocrinol
Title: Effects of deletion of the prolactin receptor on ovarian gene expression.
Volume: 1
Pages: 12
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Publication
24142695 | J:204967
First Author: Belugin S
Year: 2013
Journal: J Biol Chem
Title: Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons.
Volume: 288
Issue: 48
Pages: 34943-55
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Publication
11159821 | J:67354
First Author: Freemark M
Year: 2001
Journal: Endocrinology
Title: Body weight and fat deposition in prolactin receptor-deficient mice.
Volume: 142
Issue: 2
Pages: 532-7
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Publication
10395643 | J:56163
First Author: Bouchard B
Year: 1999
Journal: J Immunol
Title: Immune system development and function in prolactin receptor-deficient mice.
Volume: 163
Issue: 2
Pages: 576-82
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Publication
12624115 | J:83628
First Author: Binart N
Year: 2003
Journal: Mol Endocrinol
Title: A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice.
Volume: 17
Issue: 6
Pages: 1066-74
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Publication
16166330 | J:101609
First Author: Kedzia C
Year: 2005
Journal: Cancer Res
Title: Medullary thyroid carcinoma arises in the absence of prolactin signaling.
Volume: 65
Issue: 18
Pages: 8497-503
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Publication
31373638 | J:287813
First Author: Aoki M
Year: 2019
Journal: Endocrinology
Title: Widespread Cell-Specific Prolactin Receptor Expression in Multiple Murine Organs.
Volume: 160
Issue: 11
Pages: 2587-2599
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Publication
12746331 | J:83682
First Author: Saunier E
Year: 2003
Journal: Endocrinology
Title: Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation.
Volume: 144
Issue: 6
Pages: 2669-75
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Publication
31004482 | J:273642
First Author: Pepin ME
Year: 2019
Journal: Endocrinology
Title: Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Volume: 160
Issue: 5
Pages: 1150-1163
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Publication
29524401 | J:273787
First Author: Shao S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Ablation of prolactin receptor increases hepatic triglyceride accumulation.
Volume: 498
Issue: 3
Pages: 693-699
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Publication
31627131 | J:311667
 
First Author: Patil M
Year: 2019
Journal: iScience
Title: Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism.
Volume: 20
Pages: 449-465
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Publication
29596024 | J:280646
First Author: Bernard V
Year: 2018
Journal: FASEB J
Title: Autocrine actions of prolactin contribute to the regulation of lactotroph function in vivo.
Volume: 32
Issue: 9
Pages: 4791-4797
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Publication
30040149 | J:307688
First Author: Kokay IC
Year: 2018
Journal: J Neuroendocrinol
Title: Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse.
Volume: 30
Issue: 9
Pages: e12634
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Publication
32801151 | J:296017
First Author: Paige C
Year: 2020
Journal: J Neurosci
Title: Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
Volume: 40
Issue: 37
Pages: 7080-7090
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Publication
11161768 | J:67194
First Author: Santos CR
Year: 2001
Journal: Gen Comp Endocrinol
Title: Cloning, characterization, and tissue distribution of prolactin receptor in the sea bream (Sparus aurata).
Volume: 121
Issue: 1
Pages: 32-47
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Publication
18190796 | J:133423
First Author: Hilton HN
Year: 2008
Journal: Biochim Biophys Acta
Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.
Volume: 1783
Issue: 3
Pages: 383-93
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Publication
30901026 | J:275668
First Author: Brown RSE
Year: 2019
Journal: Endocrinology
Title: Acute Suppression of LH Secretion by Prolactin in Female Mice Is Mediated by Kisspeptin Neurons in the Arcuate Nucleus.
Volume: 160
Issue: 5
Pages: 1323-1332
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Publication
27681435 | J:240568
First Author: Griffith OL
Year: 2016
Journal: Cell Rep
Title: Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.
Volume: 17
Issue: 1
Pages: 249-260
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Publication
11606456 | J:72751
First Author: Ling C
Year: 2001
Journal: Endocrinology
Title: PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro.
Volume: 142
Issue: 11
Pages: 4880-90
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Publication
12370275 | J:79683
First Author: Schuff KG
Year: 2002
Journal: J Clin Invest
Title: Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms.
Volume: 110
Issue: 7
Pages: 973-81
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Publication
15388648 | J:95779
First Author: Fleenor D
Year: 2005
Journal: Endocrinology
Title: Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.
Volume: 146
Issue: 1
Pages: 103-12
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Publication
17088411 | J:114701
First Author: Craven AJ
Year: 2006
Journal: J Endocrinol
Title: Prolactin delays hair regrowth in mice.
Volume: 191
Issue: 2
Pages: 415-25
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Publication
21606321 | J:174984
First Author: Bigsby RM
Year: 2011
Journal: Carcinogenesis
Title: The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis.
Volume: 32
Issue: 8
Pages: 1162-6
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Publication
23885109 | J:205822
First Author: Costanza M
Year: 2013
Journal: J Immunol
Title: Prolactin is not required for the development of severe chronic experimental autoimmune encephalomyelitis.
Volume: 191
Issue: 5
Pages: 2082-8
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Publication
22294444 | J:324977
First Author: Tabata H
Year: 2012
Journal: J Mol Endocrinol
Title: Characterization of multiple first exons in murine prolactin receptor gene and the effect of prolactin on their expression in the choroid plexus.
Volume: 48
Issue: 2
Pages: 169-76
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Publication
27217483 | J:246931
First Author: Banerjee RR
Year: 2016
Journal: Diabetes
Title: Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.
Volume: 65
Issue: 8
Pages: 2331-41
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Publication
35065194 | J:330314
 
First Author: Mecklenburg J
Year: 2022
Journal: Brain Behav Immun
Title: Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution.
Volume: 101
Pages: 246-263
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Publication
31231869 | J:285629
First Author: Patil M
Year: 2019
Journal: J Neuroendocrinol
Title: Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
Volume: 31
Issue: 8
Pages: e12759
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Publication
30735445 | J:293817
First Author: Phillipps HR
Year: 2019
Journal: FASEB J
Title: Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus.
Volume: 33
Issue: 5
Pages: 6115-6128
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Publication
16469767 | J:108377
First Author: Harris J
Year: 2006
Journal: Mol Endocrinol
Title: Socs2 and elf5 mediate prolactin-induced mammary gland development.
Volume: 20
Issue: 5
Pages: 1177-87
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Publication
31526288 | J:281554
First Author: Makkar G
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Lrrc55 is a novel prosurvival factor in pancreatic islets.
Volume: 317
Issue: 5
Pages: E794-E804
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Publication
15650748 | J:96237
First Author: Zhou J
Year: 2005
Journal: EMBO J
Title: Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation.
Volume: 24
Issue: 3
Pages: 635-44
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Publication
34528511 | J:317360
   
First Author: Ladyman SR
Year: 2021
Journal: Elife
Title: A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin.
Volume: 10
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Publication
28923971 | J:252893
First Author: Brown RSE
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior.
Volume: 114
Issue: 40
Pages: 10779-10784
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Publication
34967003 | J:331792
First Author: Mason BN
Year: 2022
Journal: Headache
Title: Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine.
Volume: 62
Issue: 1
Pages: 11-25
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Publication
10596761 | J:58716
First Author: Goffin V
Year: 1999
Journal: Genet Anal
Title: From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models.
Volume: 15
Issue: 3-5
Pages: 189-201
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Publication
24859278 | J:216313
First Author: Ferraris J
Year: 2014
Journal: PLoS One
Title: Prolactin induces apoptosis of lactotropes in female rodents.
Volume: 9
Issue: 5
Pages: e97383
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Publication
26269505 | J:226254
First Author: Rawn SM
Year: 2015
Journal: Biol Reprod
Title: Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.
Volume: 93
Issue: 3
Pages: 75
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Publication
12399427 | J:80470
First Author: Allan GJ
Year: 2002
Journal: Endocrinology
Title: Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.
Volume: 143
Issue: 11
Pages: 4310-9
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Publication
12456789 | J:125450
First Author: Grimm SL
Year: 2002
Journal: Mol Endocrinol
Title: Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Volume: 16
Issue: 12
Pages: 2675-91
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Publication
7568281 | J:29337
First Author: Gala RR
Year: 1995
Journal: Proc Soc Exp Biol Med
Title: Influence of thyroxine and thyroxine with growth hormone and prolactin on splenocyte subsets and on the expression of interleukin-2 and prolactin receptors on splenocyte subsets of Snell dwarf mice.
Volume: 210
Issue: 2
Pages: 117-25
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Publication
18253483 | J:132155
First Author: Viengchareun S
Year: 2008
Journal: PLoS One
Title: Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.
Volume: 3
Issue: 2
Pages: e1535
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Publication
36163141 | J:348906
First Author: Smiley KO
Year: 2022
Journal: J Neurosci
Title: Prolactin Action Is Necessary for Parental Behavior in Male Mice.
Volume: 42
Issue: 44
Pages: 8308-8327
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Publication
24064341 | J:205003
First Author: Auffret J
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.
Volume: 305
Issue: 10
Pages: E1309-18
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Publication
11133161 | J:66900
First Author: Gallego MI
Year: 2001
Journal: Dev Biol
Title: Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
Volume: 229
Issue: 1
Pages: 163-75
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Publication
11706048 | J:72801
First Author: Miyoshi K
Year: 2001
Journal: J Cell Biol
Title: Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.
Volume: 155
Issue: 4
Pages: 531-42
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Publication
27581458 | J:235209
First Author: Brown RS
Year: 2016
Journal: J Neurosci
Title: Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.
Volume: 36
Issue: 35
Pages: 9173-85
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Publication
10803598 | J:61911
First Author: Reese J
Year: 2000
Journal: Endocrinology
Title: Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR.
Volume: 141
Issue: 5
Pages: 1872-81
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Protein Coding Gene
MGP_CAROLIEiJ_G0019661 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021678 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021656 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021461 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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