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Search results 1 to 100 out of 324 for Prmt5

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Type Details Score
Gene
10419 | PRMT5
Type: gene
Organism: human
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Gene
515594 | PRMT5
Type: gene
Organism: cattle
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Gene
368664 | prmt5
Type: gene
Organism: zebrafish
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Gene
712718 | PRMT5
Type: gene
Organism: macaque, rhesus
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Gene
101750306 | PRMT5
Type: gene
Organism: chicken
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Gene
100145788 | prmt5
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR035075 | PRMT5
Type: Domain
Description: This entry represents a domain found in arginine-N-methyltransferase PRMT5. Proteins containing this domain include Skb1 from S. pombe [], Hsl7 from S. cerevisiae []and their homologues PRMT5 from animals [, , ]and plants [].Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe []. Plant PMRT15 is involved in the post-transcriptional regulation of the circadian clock []. Human PRMT5 is a component of multiple protein complexes and contributes to essential cellular processes, such as RNA transport and splicing, cell cycle regulation, tumour growth, and chromatin remodelling, leading to either gene silencing or activation [].
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Gene
364382 | Prmt5
Type: gene
Organism: rat
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Gene
480242 | PRMT5
Type: gene
Organism: dog, domestic
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Gene
452789 | PRMT5
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1351645 | Prmt5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10531356 | J:58151
First Author: Pollack BP
Year: 1999
Journal: J Biol Chem
Title: The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.
Volume: 274
Issue: 44
Pages: 31531-42
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Publication
22269951 | -
First Author: Bandyopadhyay S
Year: 2012
Journal: Mol Cell Biol
Title: HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.
Volume: 32
Issue: 7
Pages: 1202-13
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Gene
101926933 | PRMT5-DT
Type: gene
Organism: human
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Protein
Q8CIG8
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
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Protein
Q9CQ13
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Gene
100505758 | PRMT5-AS1
Type: gene
Organism: human
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Publication
11152681 | -
First Author: Rho J
Year: 2001
Journal: J Biol Chem
Title: Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.
Volume: 276
Issue: 14
Pages: 11393-401
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Publication
11278267 | -
First Author: Bao S
Year: 2001
Journal: J Biol Chem
Title: The highly conserved protein methyltransferase, Skb1, is a mediator of hyperosmotic stress response in the fission yeast Schizosaccharomyces pombe.
Volume: 276
Issue: 18
Pages: 14549-52
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Publication
10903903 | -
First Author: Lee JH
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase.
Volume: 274
Issue: 1
Pages: 105-11
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Publication
17363895 | -
First Author: Wang X
Year: 2007
Journal: EMBO J
Title: SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in Arabidopsis.
Volume: 26
Issue: 7
Pages: 1934-41
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Publication
20962777 | -
First Author: Sanchez SE
Year: 2010
Journal: Nature
Title: A methyl transferase links the circadian clock to the regulation of alternative splicing.
Volume: 468
Issue: 7320
Pages: 112-6
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Protein
F6QQQ6
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Publication
17709427 | -
First Author: Gonsalvez GB
Year: 2007
Journal: J Cell Biol
Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.
Volume: 178
Issue: 5
Pages: 733-40
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Protein
A0A0R4J049
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
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Publication
37666668 | J:340548
 
First Author: Hernandez JE
Year: 2023
Journal: Life Sci Alliance
Title: The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
Volume: 6
Issue: 11
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Publication
34448450 | J:313033
   
First Author: Chen M
Year: 2021
Journal: Elife
Title: PRMT5 regulates ovarian follicle development by facilitating Wt1 translation.
Volume: 10
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Publication
32209476 | J:288230
First Author: Yang M
Year: 2020
Journal: Cell Rep
Title: OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Volume: 30
Issue: 12
Pages: 4165-4178.e7
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Publication
26258414 | J:226257
First Author: Liu F
Year: 2015
Journal: J Clin Invest
Title: Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis.
Volume: 125
Issue: 9
Pages: 3532-44
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Publication
26972221 | J:251601
First Author: Fan Z
Year: 2016
Journal: Biochim Biophys Acta
Title: The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription.
Volume: 1859
Issue: 5
Pages: 687-96
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Publication
28115626 | J:246661
First Author: Gao G
Year: 2017
Journal: Nucleic Acids Res
Title: PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.
Volume: 45
Issue: 8
Pages: 4359-4369
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Publication
25582697 | J:222599
First Author: Li Y
Year: 2015
Journal: Cancer Discov
Title: PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.
Volume: 5
Issue: 3
Pages: 288-303
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Publication
35379776 | J:338336
First Author: Liu H
Year: 2022
Journal: Cell Death Dis
Title: PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells.
Volume: 13
Issue: 4
Pages: 299
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Publication
26072710 | J:233549
 
First Author: Wang Y
Year: 2015
Journal: Sci Rep
Title: Prmt5 is required for germ cell survival during spermatogenesis in mice.
Volume: 5
Pages: 11031
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Publication
35531958 | J:324467
 
First Author: Ye Q
Year: 2022
Journal: JCI Insight
Title: Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury.
Volume: 7
Issue: 9
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Publication
37533053 | J:339721
First Author: Zheng Y
Year: 2023
Journal: J Neuroinflammation
Title: Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease.
Volume: 20
Issue: 1
Pages: 183
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Publication
33304767 | J:299758
First Author: Jia Z
Year: 2020
Journal: Adv Sci (Weinh)
Title: Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues.
Volume: 7
Issue: 23
Pages: 2002602
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Publication
25519955 | J:220035
First Author: Li Z
Year: 2015
Journal: EMBO J
Title: The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice.
Volume: 34
Issue: 6
Pages: 748-58
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Publication
35288471 | J:328668
First Author: Lewis BW
Year: 2022
Journal: J Immunol
Title: PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Volume: 208
Issue: 7
Pages: 1525-1533
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Publication
30057274 | J:270534
First Author: Calabretta S
Year: 2018
Journal: Dev Cell
Title: Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination.
Volume: 46
Issue: 4
Pages: 426-440.e5
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Publication
30184499 | J:271634
First Author: Hamard PJ
Year: 2018
Journal: Cell Rep
Title: PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes.
Volume: 24
Issue: 10
Pages: 2643-2657
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Publication
31539871 | J:281518
First Author: Ma J
Year: 2020
Journal: J Endocrinol
Title: Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice.
Volume: 244
Issue: 1
Pages: 41-52
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Publication
30604754 | J:271592
First Author: Litzler LC
Year: 2019
Journal: Nat Commun
Title: PRMT5 is essential for B cell development and germinal center dynamics.
Volume: 10
Issue: 1
Pages: 22
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Publication
26028225 | J:223040
 
First Author: Zhang T
Year: 2015
Journal: Nat Commun
Title: Prmt5 is a regulator of muscle stem cell expansion in adult mice.
Volume: 6
Pages: 7140
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Publication
32328070 | J:305343
 
First Author: Tanaka Y
Year: 2020
Journal: Front Immunol
Title: PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling.
Volume: 11
Pages: 621
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Publication
35500745 | J:334137
First Author: Wang J
Year: 2023
Journal: J Genet Genomics
Title: PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis.
Volume: 50
Issue: 2
Pages: 87-98
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Publication
30811983 | J:293103
First Author: Tan DQ
Year: 2019
Journal: Cell Rep
Title: PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells.
Volume: 26
Issue: 9
Pages: 2316-2328.e6
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Publication
34911774 | J:322495
First Author: Zheng Y
Year: 2022
Journal: J Immunol
Title: PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1+CD8+ Terminal Effector T Cells and Promotes Cancer Development.
Volume: 208
Issue: 2
Pages: 501-513
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Publication
34113620 | J:314458
 
First Author: Dong F
Year: 2021
Journal: Front Cell Dev Biol
Title: PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications.
Volume: 9
Pages: 673258
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Publication
31103260 | J:290389
First Author: Lu W
Year: 2019
Journal: Biochem Biophys Res Commun
Title: The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.
Volume: 514
Issue: 4
Pages: 1185-1191
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Publication
30941147 | J:294968
 
First Author: Webb LM
Year: 2019
Journal: Front Immunol
Title: NF-κB/mTOR/MYC Axis Drives PRMT5 Protein Induction After T Cell Activation via Transcriptional and Non-transcriptional Mechanisms.
Volume: 10
Pages: 524
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Publication
26935580 | J:246106
First Author: LeBlanc SE
Year: 2016
Journal: Nucleic Acids Res
Title: Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.
Volume: 44
Issue: 11
Pages: 5133-47
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Publication
25457166 | J:219506
First Author: Kim S
Year: 2014
Journal: Mol Cell
Title: PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.
Volume: 56
Issue: 4
Pages: 564-79
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Publication
28270438 | J:247077
First Author: Muhammad AB
Year: 2017
Journal: Am J Physiol Endocrinol Metab
Title: Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.
Volume: 313
Issue: 2
Pages: E148-E166
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Publication
17043109 | J:117644
First Author: Dacwag CS
Year: 2007
Journal: Mol Cell Biol
Title: The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.
Volume: 27
Issue: 1
Pages: 384-94
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Publication
37883229 | J:342326
First Author: Kim KH
Year: 2023
Journal: Cell Rep
Title: PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
Volume: 42
Issue: 11
Pages: 113329
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Publication
30082494 | J:269734
First Author: Lu X
Year: 2018
Journal: Blood
Title: PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival.
Volume: 132
Issue: 19
Pages: 2026-2039
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Publication
31442442 | J:282858
First Author: Ramachandran J
Year: 2019
Journal: Dev Biol
Title: PRMT5 is necessary to form distinct cartilage identities in the knee and long bone.
Volume: 456
Issue: 2
Pages: 154-163
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Publication
16699504 | J:109626
First Author: Ancelin K
Year: 2006
Journal: Nat Cell Biol
Title: Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.
Volume: 8
Issue: 6
Pages: 623-30
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Publication
30800128 | J:273205
 
First Author: Nagai Y
Year: 2019
Journal: Front Immunol
Title: PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy.
Volume: 10
Pages: 174
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Publication
21159818 | J:166736
First Author: Tee WW
Year: 2010
Journal: Genes Dev
Title: Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.
Volume: 24
Issue: 24
Pages: 2772-7
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Publication
27827819 | J:237505
First Author: Norrie JL
Year: 2016
Journal: Development
Title: PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud.
Volume: 143
Issue: 24
Pages: 4608-4619
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Publication
29950483 | J:264403
 
First Author: Li Q
Year: 2018
Journal: J Cell Sci
Title: Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling.
Volume: 131
Issue: 14
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Publication
20951943 | J:165553
First Author: Aggarwal P
Year: 2010
Journal: Cancer Cell
Title: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Volume: 18
Issue: 4
Pages: 329-40
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Publication
37364687 | J:338836
First Author: Li Q
Year: 2023
Journal: J Biol Chem
Title: Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63.
Volume: 299
Issue: 8
Pages: 104964
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Publication
31624244 | J:282235
First Author: Dong J
Year: 2019
Journal: Nat Commun
Title: UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells.
Volume: 10
Issue: 1
Pages: 4705
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Publication
21262773 | J:170762
First Author: Kanamaluru D
Year: 2011
Journal: Mol Cell Biol
Title: Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.
Volume: 31
Issue: 7
Pages: 1540-50
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Publication
28739930 | J:244088
First Author: Xu J
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.
Volume: 114
Issue: 32
Pages: 8620-8625
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Publication
22041901 | J:327839
First Author: Huang J
Year: 2011
Journal: J Biol Chem
Title: Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
Volume: 286
Issue: 52
Pages: 44424-32
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Publication
24013503 | J:201152
First Author: Bezzi M
Year: 2013
Journal: Genes Dev
Title: Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.
Volume: 27
Issue: 17
Pages: 1903-16
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Gene
55352 | COPRS
Type: gene
Organism: human
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Publication
23831350 | J:201673
 
First Author: Chittka A
Year: 2013
Journal: Neurosci Lett
Title: Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.
Volume: 550
Pages: 87-92
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Publication
31848143 | J:283043
 
First Author: Liu Z
Year: 2019
Journal: Dis Model Mech
Title: Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis.
Volume: 12
Issue: 12
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Publication
22193545 | J:196248
First Author: Paul C
Year: 2012
Journal: Cell Death Differ
Title: The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation.
Volume: 19
Issue: 5
Pages: 900-8
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Protein
A0A1B0GSQ9
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
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Publication
28238654 | J:241370
First Author: Clarke TL
Year: 2017
Journal: Mol Cell
Title: PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
Volume: 65
Issue: 5
Pages: 900-916.e7
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Publication
28087667 | J:247748
First Author: Webb LM
Year: 2017
Journal: J Immunol
Title: PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.
Volume: 198
Issue: 4
Pages: 1439-1451
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Publication
32091410 | J:287320
First Author: Webb LM
Year: 2020
Journal: J Clin Invest
Title: Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
Volume: 130
Issue: 4
Pages: 1683-1698
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Publication
22327218 | J:182516
First Author: Cho EC
Year: 2012
Journal: EMBO J
Title: Arginine methylation controls growth regulation by E2F-1.
Volume: 31
Issue: 7
Pages: 1785-97
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Publication
30323341 | J:282664
First Author: Inoue M
Year: 2018
Journal: Nat Immunol
Title: Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance.
Volume: 19
Issue: 11
Pages: 1265-1276
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Publication
30026560 | J:266513
First Author: Scaglione A
Year: 2018
Journal: Nat Commun
Title: PRMT5-mediated regulation of developmental myelination.
Volume: 9
Issue: 1
Pages: 2840
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Publication
33296647 | J:304672
First Author: Cui S
Year: 2020
Journal: Cell Rep
Title: Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5.
Volume: 33
Issue: 10
Pages: 108490
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Publication
28263986 | J:242066
First Author: Akpınar M
Year: 2017
Journal: PLoS Genet
Title: TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes.
Volume: 13
Issue: 3
Pages: e1006660
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Publication
32025719 | J:286624
First Author: Liu F
Year: 2020
Journal: Nucleic Acids Res
Title: PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2.
Volume: 48
Issue: 6
Pages: 2956-2968
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Publication
24097435 | J:211407
First Author: Girardot M
Year: 2014
Journal: Nucleic Acids Res
Title: PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.
Volume: 42
Issue: 1
Pages: 235-48
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Publication
27507053 | J:313242
First Author: Du W
Year: 2016
Journal: Oncotarget
Title: The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.
Volume: 7
Issue: 37
Pages: 60005-60020
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Publication
19188441 | J:147773
First Author: Dacwag CS
Year: 2009
Journal: Mol Cell Biol
Title: Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Volume: 29
Issue: 7
Pages: 1909-21
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Publication
23133559 | J:192252
First Author: Na J
Year: 2012
Journal: PLoS One
Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.
Volume: 7
Issue: 10
Pages: e48152
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Publication
18347060 | J:136087
First Author: Hou Z
Year: 2008
Journal: Mol Cell Biol
Title: The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.
Volume: 28
Issue: 10
Pages: 3198-207
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Publication
23048031 | J:222673
First Author: Chittka A
Year: 2012
Journal: J Biol Chem
Title: Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation.
Volume: 287
Issue: 51
Pages: 42995-3006
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Publication
15369763 | J:92481
First Author: Miranda TB
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus.
Volume: 323
Issue: 2
Pages: 382-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0019258 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021312 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
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Protein Coding Gene
MGP_C3HHeJ_G0021055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
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Protein Coding Gene
MGI_C57BL6J_1351645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_C57BL6NJ_G0021714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0020574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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