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Search results 1 to 100 out of 15778 for Proc

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Vetrano S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation.
Volume: 108
Issue: 49
Pages: 19830-5
Publication
First Author: Bock F
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.
Volume: 110
Issue: 2
Pages: 648-53
Publication
First Author: Murakawa M
Year: 1994
Journal: Br J Haematol
Title: A comparative study of partial primary structures of the catalytic region of mammalian protein C.
Volume: 86
Issue: 3
Pages: 590-600
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tada N
Year: 1992
Journal: J Biochem
Title: Isolation and characterization of a mouse protein C cDNA.
Volume: 111
Issue: 4
Pages: 491-5
Publication
First Author: Jalbert LR
Year: 1998
Journal: Thromb Haemost
Title: Nucleotide structure and characterization of the murine gene encoding anticoagulant protein C.
Volume: 79
Issue: 2
Pages: 310-6
Publication
First Author: Lay AJ
Year: 2005
Journal: J Clin Invest
Title: Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities.
Volume: 115
Issue: 6
Pages: 1552-61
Publication
First Author: Levi M
Year: 2003
Journal: Blood
Title: Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.
Volume: 101
Issue: 12
Pages: 4823-7
Publication
First Author: Ganopolsky JG
Year: 2004
Journal: Am J Pathol
Title: A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model.
Volume: 165
Issue: 4
Pages: 1433-46
Publication
First Author: Faioni EM
Year: 2000
Journal: Br J Haematol
Title: Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity.
Volume: 108
Issue: 2
Pages: 265-71
Publication
First Author: Gerlitz B
Year: 1996
Journal: J Biol Chem
Title: Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin.
Volume: 271
Issue: 37
Pages: 22285-8
Publication
First Author: Mosnier LO
Year: 2007
Journal: J Biol Chem
Title: Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.
Volume: 282
Issue: 45
Pages: 33022-33
Publication
First Author: Lay AJ
Year: 2007
Journal: Blood
Title: Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency.
Volume: 109
Issue: 5
Pages: 1984-91
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3841829
Age: embryonic day 14.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3841829
Age: embryonic day 13.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3841829
Age: embryonic day 12.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3841829
Age: embryonic day 11.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3841829
Age: embryonic day 10.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3841829
Age: embryonic day 9.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3841829
Age: embryonic day 8.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3841829
Age: embryonic day 7.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2658783
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276026
Stage: TS26
Assay Id: MGI:2658784
Age: embryonic day 19.0
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:2658783
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2658784
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2658783
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658784
Age: embryonic day 19.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2658783
Assay Type: Northern blot
Annotation Date: 2003-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:2658784
Age: embryonic day 19.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3841650
Assay Type: RT-PCR
Annotation Date: 2009-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3841829
Age: postnatal adult
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_24
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:931220
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827435
Age: embryonic day 14.5
Image: euxassay_000632_01
Detected: true
Specimen Num: 1
Publication
First Author: Yang TL
Year: 1998
Journal: Blood
Title: The structure and function of murine factor V and its inactivation by protein C.
Volume: 91
Issue: 12
Pages: 4593-9
Publication
First Author: Kowalska MA
Year: 2007
Journal: Blood
Title: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.
Volume: 110
Issue: 6
Pages: 1903-5
Publication
First Author: Pepler L
Year: 2015
Journal: Blood
Title: Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis.
Volume: 126
Issue: 5
Pages: 673-82
Publication
First Author: Starr ME
Year: 2010
Journal: Blood
Title: Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.
Volume: 115
Issue: 23
Pages: 4886-93
Publication
First Author: Weijer S
Year: 2005
Journal: Blood
Title: A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis.
Volume: 106
Issue: 8
Pages: 2761-8
Publication
First Author: Bezuhly M
Year: 2009
Journal: Blood
Title: Role of activated protein C and its receptor in inhibition of tumor metastasis.
Volume: 113
Issue: 14
Pages: 3371-4
Publication
First Author: Kager LM
Year: 2013
Journal: J Thromb Haemost
Title: Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis).
Volume: 11
Issue: 2
Pages: 282-92
Publication
First Author: Sinha RK
Year: 2018
Journal: Blood
Title: PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.
Volume: 131
Issue: 11
Pages: 1163-1171
Publication
First Author: Ouweneel AB
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Silencing of Anticoagulant Protein C Evokes Low-Incident but Spontaneous Atherothrombosis in Apolipoprotein E-Deficient Mice-Brief Report.
Volume: 37
Issue: 5
Pages: 782-785
Publication
First Author: Heestermans M
Year: 2018
Journal: Sci Rep
Title: Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice.
Volume: 8
Issue: 1
Pages: 15106
Publication
First Author: Jalbert LR
Year: 1998
Journal: J Clin Invest
Title: Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice.
Volume: 102
Issue: 8
Pages: 1481-8
Publication
First Author: Dayal S
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis.
Volume: 35
Issue: 8
Pages: 1798-804
Publication
First Author: Essalmani R
Year: 2017
Journal: J Biol Chem
Title: Thrombin activation of protein C requires prior processing by a liver proprotein convertase.
Volume: 292
Issue: 25
Pages: 10564-10573
Publication
First Author: Castellino FJ
Year: 2011
Journal: Blood
Title: An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.
Volume: 117
Issue: 1
Pages: 283-9
Publication
First Author: Krawczak M
Year: 1996
Journal: Hum Genet
Title: Molecular reconstruction and homology modelling of the catalytic domain of the common ancestor of the haemostatic vitamin-K-dependent serine proteinases.
Volume: 98
Issue: 3
Pages: 351-70
Publication
First Author: Guo H
Year: 2004
Journal: Neuron
Title: Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3.
Volume: 41
Issue: 4
Pages: 563-72
Publication
First Author: Isermann B
Year: 2003
Journal: Nat Med
Title: The thrombomodulin-protein C system is essential for the maintenance of pregnancy.
Volume: 9
Issue: 3
Pages: 331-7
Publication
First Author: Madhusudhan T
Year: 2017
Journal: Blood
Title: Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Volume: 130
Issue: 12
Pages: 1445-1455
Publication
First Author: Gur-Cohen S
Year: 2015
Journal: Nat Med
Title: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Volume: 21
Issue: 11
Pages: 1307-17
Publication
First Author: Liang HP
Year: 2015
Journal: Blood
Title: Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.
Volume: 126
Issue: 21
Pages: 2415-23
Publication
First Author: Ranjan S
Year: 2017
Journal: Nat Commun
Title: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Volume: 8
Issue: 1
Pages: 311
Publication
First Author: Chan JC
Year: 2000
Journal: J Clin Invest
Title: Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice.
Volume: 105
Issue: 7
Pages: 897-903
Publication
First Author: Jochheim A
Year: 2003
Journal: Differentiation
Title: Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays.
Volume: 71
Issue: 1
Pages: 62-72
Publication
First Author: Iwasaki H
Year: 2010
Journal: Blood
Title: Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.
Volume: 116
Issue: 4
Pages: 544-53
Publication
First Author: Odet F
Year: 2004
Journal: Endocrinology
Title: Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development.
Volume: 145
Issue: 3
Pages: 1481-9
Publication
First Author: Chan JC
Year: 2001
Journal: Am J Pathol
Title: The characterization of mice with a targeted combined deficiency of protein c and factor XI.
Volume: 158
Issue: 2
Pages: 469-79
Publication
First Author: Iwama A
Year: 1998
Journal: Nucleic Acids Res
Title: Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
Volume: 26
Issue: 12
Pages: 3034-43
Publication
First Author: Ong K
Year: 2000
Journal: Thromb Haemost
Title: Early embryonic expression of murine coagulation system components.
Volume: 84
Issue: 6
Pages: 1023-30