Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Prophet of Pit-1 (Prop1) is a homeodomain transcription factor involved in morphogenesis, apoptosis and proliferation in the developing pituitary, and in pituitary organogenesis including the differentiation of cell lineages [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Cushman LJ |
Year: |
2001 |
Journal: |
Hum Mol Genet |
Title: |
Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1141-53 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6117410 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-02-23 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1751426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6117447 |
Age: |
embryonic day 18.5 |
Image: |
4 Wt Prop1 |
Note: |
No expression in wild-type mice at this age. |
Specimen Label: |
4 Wt Prop1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida S |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
PROP1 coexists with SOX2 and induces PIT1-commitment cells. |
Volume: |
385 |
Issue: |
1 |
Pages: |
11-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ward RD |
Year: |
2005 |
Journal: |
Mol Endocrinol |
Title: |
Role of PROP1 in pituitary gland growth. |
Volume: |
19 |
Issue: |
3 |
Pages: |
698-710 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nasonkin IO |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Aged PROP1 deficient dwarf mice maintain ACTH production. |
Volume: |
6 |
Issue: |
12 |
Pages: |
e28355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu W |
Year: |
1998 |
Journal: |
Nat Genet |
Title: |
Mutations in PROP1 cause familial combined pituitary hormone deficiency. |
Volume: |
18 |
Issue: |
2 |
Pages: |
147-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nasonkin IO |
Year: |
2004 |
Journal: |
Hum Mol Genet |
Title: |
Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. |
Volume: |
13 |
Issue: |
22 |
Pages: |
2727-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pérez Millán MI |
Year: |
2016 |
Journal: |
Elife |
Title: |
PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ward RD |
Year: |
2007 |
Journal: |
Mamm Genome |
Title: |
Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene. |
Volume: |
18 |
Issue: |
6-7 |
Pages: |
521-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raetzman LT |
Year: |
2002 |
Journal: |
Development |
Title: |
Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. |
Volume: |
129 |
Issue: |
18 |
Pages: |
4229-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raetzman LT |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. |
Volume: |
265 |
Issue: |
2 |
Pages: |
329-40 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
223
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6191147 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Prop1 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6191147 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Prop1 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6191147 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Prop1 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6191147 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Prop1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6191147 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Prop1 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6191147 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Prop1 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6181362 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6191147 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Prop1 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davis SW |
Year: |
2016 |
Journal: |
Endocrinology |
Title: |
All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors. |
Volume: |
157 |
Issue: |
4 |
Pages: |
1385-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parks JS |
Year: |
1999 |
Journal: |
Growth Horm IGF Res |
Title: |
Transcription factors regulating pituitary development. |
Volume: |
9 Suppl B |
|
Pages: |
2-8; discussion 8-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youngblood JL |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
Regulation of Pituitary Progenitor Differentiation by β-Catenin. |
Volume: |
159 |
Issue: |
9 |
Pages: |
3287-3305 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dominici FP |
Year: |
2003 |
Journal: |
Mech Ageing Dev |
Title: |
The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver. |
Volume: |
124 |
Issue: |
7 |
Pages: |
819-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lantinga-van Leeuwen IS |
Year: |
2000 |
Journal: |
Cytogenet Cell Genet |
Title: |
Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. |
Volume: |
88 |
Issue: |
1-2 |
Pages: |
140-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dozmorov I |
Year: |
2001 |
Journal: |
J Gerontol A Biol Sci Med Sci |
Title: |
Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Prop1df. |
Volume: |
56 |
Issue: |
2 |
Pages: |
B72-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfäffle RW |
Year: |
1999 |
Journal: |
Acta Paediatr Suppl |
Title: |
Combined pituitary hormone deficiency: role of Pit-1 and Prop-1. |
Volume: |
88 |
Issue: |
433 |
Pages: |
33-41 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6471699 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2020-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6471711 |
Age: |
embryonic day 12.5 |
|
Note: |
Authors report no difference among wildtype, Hes1 mutant, Prop1 mutant or double mutant pituitary. |
Specimen Label: |
E12.5 Prop1 mutant not shown |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkmeier ML |
Year: |
2003 |
Journal: |
Mol Endocrinol |
Title: |
TCF and Groucho-related genes influence pituitary growth and development. |
Volume: |
17 |
Issue: |
11 |
Pages: |
2152-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ward RD |
Year: |
2006 |
Journal: |
Mol Endocrinol |
Title: |
Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. |
Volume: |
20 |
Issue: |
6 |
Pages: |
1378-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karolyi IJ |
Year: |
2007 |
Journal: |
Mamm Genome |
Title: |
Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice. |
Volume: |
18 |
Issue: |
8 |
Pages: |
596-608 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carvalho LR |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. |
Volume: |
24 |
Issue: |
4 |
Pages: |
754-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cha KB |
Year: |
2004 |
Journal: |
Mech Dev |
Title: |
WNT5A signaling affects pituitary gland shape. |
Volume: |
121 |
Issue: |
2 |
Pages: |
183-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mortensen AH |
Year: |
2011 |
Journal: |
Physiol Genomics |
Title: |
Candidate genes for panhypopituitarism identified by gene expression profiling. |
Volume: |
43 |
Issue: |
19 |
Pages: |
1105-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winningham AH |
Year: |
2023 |
Journal: |
Endocrinology |
Title: |
Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling. |
Volume: |
164 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vesper AH |
Year: |
2006 |
Journal: |
Endocrinology |
Title: |
Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. |
Volume: |
147 |
Issue: |
4 |
Pages: |
1654-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Himes AD |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. |
Volume: |
325 |
Issue: |
1 |
Pages: |
151-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nantie LB |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. |
Volume: |
28 |
Issue: |
5 |
Pages: |
731-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brinkmeier ML |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. |
Volume: |
130 |
Issue: |
8 |
Pages: |
4501-4515 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gualtieri A |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2028 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2015 |
Journal: |
Stem Cell Reports |
Title: |
Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland. |
Volume: |
5 |
Issue: |
6 |
Pages: |
1196-1209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bando H |
Year: |
2023 |
Journal: |
Hum Mol Genet |
Title: |
Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. |
Volume: |
32 |
Issue: |
3 |
Pages: |
367-385 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
González L |
Year: |
2007 |
Journal: |
Growth Horm IGF Res |
Title: |
Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver. |
Volume: |
17 |
Issue: |
2 |
Pages: |
104-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandrashekar V |
Year: |
1996 |
Journal: |
Biol Reprod |
Title: |
Influence of hypothalamus and ovary on pituitary function in transgenic mice expressing the bovine growth hormone gene and in growth hormone-deficient Ames dwarf mice. |
Volume: |
54 |
Issue: |
5 |
Pages: |
1002-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinney BA |
Year: |
2001 |
Journal: |
Horm Behav |
Title: |
Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. |
Volume: |
39 |
Issue: |
4 |
Pages: |
277-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choksi KB |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice. |
Volume: |
364 |
Issue: |
4 |
Pages: |
761-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phelps CJ |
Year: |
1993 |
Journal: |
Endocrinology |
Title: |
Developmental assessment of hypothalamic tuberoinfundibular dopamine in prolactin-deficient dwarf mice. |
Volume: |
132 |
Issue: |
6 |
Pages: |
2715-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeno Y |
Year: |
2003 |
Journal: |
J Gerontol A Biol Sci Med Sci |
Title: |
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. |
Volume: |
58 |
Issue: |
4 |
Pages: |
291-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muralikrishnan D |
Year: |
2002 |
Journal: |
Neurochem Res |
Title: |
Effect of MPTP on Dopamine metabolism in Ames dwarf mice. |
Volume: |
27 |
Issue: |
6 |
Pages: |
457-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villanua MA |
Year: |
1993 |
Journal: |
Acta Endocrinol (Copenh) |
Title: |
Thymostimulin effects on lymphoid organs in Ames dwarf mice. |
Volume: |
128 |
Issue: |
1 |
Pages: |
74-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kennedy MA |
Year: |
2003 |
Journal: |
Exp Gerontol |
Title: |
Long-living Ames dwarf mouse hepatocytes readily undergo apoptosis. |
Volume: |
38 |
Issue: |
9 |
Pages: |
997-1008 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang K |
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1993 |
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Endocrinology |
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132 |
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Gage PJ |
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Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion. |
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122 |
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Capitano ML |
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Blood Cells Mol Dis |
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Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen. |
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55 |
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Neuroendocrinology |
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Postnatal reduction in number of hypothalamic tuberoinfundibular dopaminergic neurons in prolactin-deficient dwarf mice. |
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59 |
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First Author: |
Hill CM |
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2016 |
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Aging Cell |
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Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure. |
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FASEB J |
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Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice. |
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Exp Biol Med (Maywood) |
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Exp Gerontol |
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Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice. |
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40 |
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Amador-Noguez D |
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2005 |
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Biochem Biophys Res Commun |
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Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. |
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332 |
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Int J Biol Sci |
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Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice. |
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Cell Rep |
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Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. |
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Endocrinology |
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Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. |
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2020 |
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Exp Gerontol |
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Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice. |
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132 |
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PLoS One |
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Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction. |
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Endocrinology |
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Prolactin replacement in adult dwarf mice does not reverse the deficit in tuberoinfundibular dopaminergic neuron number. |
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136 |
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8 |
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3238-46 |
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Dominici FP |
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2002 |
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J Endocrinol |
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Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. |
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173 |
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1 |
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Gage PJ |
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Endocrinology |
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Ames dwarf mice exhibit somatotrope commitment but lack growth hormone-releasing factor response. |
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136 |
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3 |
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1161-7 |
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