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Search results 1 to 100 out of 2008 for Psen1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Song XW
Year: 2018
Journal: J Cell Physiol
Title: Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.
Volume: 233
Issue: 2
Pages: 1548-1557
Publication
First Author: Zhang X
Year: 2012
Journal: J Neurosci
Title: A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Volume: 32
Issue: 25
Pages: 8633-48
Publication
First Author: Sasaguri H
Year: 2018
Journal: Nat Commun
Title: Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.
Volume: 9
Issue: 1
Pages: 2892
Publication
First Author: Takahashi Y
Year: 2003
Journal: Development
Title: Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.
Volume: 130
Issue: 18
Pages: 4259-68
Publication
First Author: Pratt KG
Year: 2011
Journal: Nat Neurosci
Title: Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
Volume: 14
Issue: 9
Pages: 1112-4
Publication
First Author: De Gasperi R
Year: 2008
Journal: Dev Dyn
Title: Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Volume: 237
Issue: 9
Pages: 2405-14
Publication
First Author: Ortega-Martinez S
Year: 2019
Journal: J Neurosci
Title: Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Volume: 39
Issue: 34
Pages: 6766-6780
Publication  
First Author: Guzmán EA
Year: 2014
Journal: Mol Neurodegener
Title: Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Volume: 9
Pages: 13
Publication
First Author: Creighton SD
Year: 2019
Journal: Sci Rep
Title: Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.
Volume: 9
Issue: 1
Pages: 57
Publication
First Author: Spangenberg E
Year: 2019
Journal: Nat Commun
Title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 3758
Publication
First Author: Wen PH
Year: 2005
Journal: Development
Title: Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice.
Volume: 132
Issue: 17
Pages: 3873-83
Publication
First Author: Wang ZH
Year: 2017
Journal: Mol Cell
Title: Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Volume: 67
Issue: 5
Pages: 812-825.e5
Publication
First Author: Wang ZH
Year: 2018
Journal: Nat Commun
Title: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1784
Publication
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
Publication
First Author: Bahn G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Volume: 116
Issue: 25
Pages: 12516-12523
Publication
First Author: Zenaro E
Year: 2015
Journal: Nat Med
Title: Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Volume: 21
Issue: 8
Pages: 880-6
UniProt Feature
Begin: 768
Description: Cleavage; by PSEN1
Type: site
End: 769
Publication  
First Author: Toussay X
Year: 2017
Journal: Neurobiol Aging
Title: Presenilin 1 mutation decreases both calcium and contractile responses in cerebral arteries.
Volume: 58
Pages: 201-212
Publication
First Author: Kastanenka KV
Year: 2019
Journal: Sci Rep
Title: Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology.
Volume: 9
Issue: 1
Pages: 8964
Publication
First Author: Pratt KG
Year: 2011
Journal: J Neurosci
Title: A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons.
Volume: 31
Issue: 3
Pages: 899-906
Publication
First Author: Yang Y
Year: 2004
Journal: Neuroscience
Title: Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
Volume: 124
Issue: 3
Pages: 501-5
Publication
First Author: Cook DG
Year: 2005
Journal: J Neurophysiol
Title: Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons.
Volume: 94
Issue: 6
Pages: 4421-9
Publication
First Author: Savastano A
Year: 2016
Journal: J Alzheimers Dis
Title: N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models.
Volume: 49
Issue: 1
Pages: 101-10
Publication
First Author: Wirths O
Year: 2017
Journal: Alzheimers Res Ther
Title: N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.
Volume: 9
Issue: 1
Pages: 80
Publication  
First Author: Christensen DZ
Year: 2009
Journal: Brain Res
Title: Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease.
Volume: 1301
Pages: 116-25
Publication
First Author: Deyts C
Year: 2019
Journal: Cell Rep
Title: APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Volume: 27
Issue: 5
Pages: 1345-1355.e6
Publication
First Author: He Y
Year: 2019
Journal: Nat Commun
Title: Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.
Volume: 10
Issue: 1
Pages: 1193
Publication
First Author: Shen J
Year: 1997
Journal: Cell
Title: Skeletal and CNS defects in Presenilin-1-deficient mice.
Volume: 89
Issue: 4
Pages: 629-39
Publication
First Author: Wen PH
Year: 2004
Journal: Neurosci Lett
Title: Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.
Volume: 371
Issue: 2-3
Pages: 249-54
Publication  
First Author: Findley CA
Year: 2019
Journal: ASN Neuro
Title: Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression.
Volume: 11
Pages: 1759091419855541
Publication
First Author: Citron M
Year: 1997
Journal: Nat Med
Title: Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Volume: 3
Issue: 1
Pages: 67-72
Publication
First Author: Greenough MA
Year: 2011
Journal: J Biol Chem
Title: Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
Volume: 286
Issue: 11
Pages: 9776-86
Publication
First Author: Wirths O
Year: 2010
Journal: J Biol Chem
Title: Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Volume: 285
Issue: 53
Pages: 41517-24
Publication
First Author: Song H
Year: 2013
Journal: Cell Death Differ
Title: Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.
Volume: 20
Issue: 4
Pages: 639-48
Publication
First Author: Reinert J
Year: 2014
Journal: J Alzheimers Dis
Title: Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Volume: 39
Issue: 4
Pages: 871-81
Publication
First Author: Handler M
Year: 2000
Journal: Development
Title: Presenilin-1 regulates neuronal differentiation during neurogenesis.
Volume: 127
Issue: 12
Pages: 2593-606
Publication
First Author: Yang Y
Year: 2004
Journal: J Neurochem
Title: Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake.
Volume: 88
Issue: 6
Pages: 1361-72
Publication
First Author: Lazarov O
Year: 2007
Journal: J Neurosci
Title: Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Volume: 27
Issue: 26
Pages: 7011-20
Publication    
First Author: Javier-Torrent M
Year: 2019
Journal: Elife
Title: Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA.
Volume: 8
Publication
First Author: Thinakaran G
Year: 1996
Journal: Neuron
Title: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Volume: 17
Issue: 1
Pages: 181-90
Publication
First Author: Guo Q
Year: 2013
Journal: PLoS One
Title: Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Volume: 8
Issue: 11
Pages: e80706
Publication
First Author: Choi SH
Year: 2008
Journal: Neuron
Title: Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Volume: 59
Issue: 4
Pages: 568-80
Publication
First Author: Veugelen S
Year: 2016
Journal: Neuron
Title: Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.
Volume: 90
Issue: 2
Pages: 410-6
Publication
First Author: Coen K
Year: 2012
Journal: J Cell Biol
Title: Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.
Volume: 198
Issue: 1
Pages: 23-35
Publication  
First Author: Azimi M
Year: 2018
Journal: Differentiation
Title: Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.
Volume: 102
Pages: 40-52
Publication
First Author: Jankowsky JL
Year: 2004
Journal: Neurobiol Aging
Title: APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Volume: 25
Issue: 7
Pages: 885-92
Publication
First Author: Tamboli IY
Year: 2008
Journal: J Neurosci
Title: Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Volume: 28
Issue: 46
Pages: 12097-106
Publication
First Author: Frost JL
Year: 2013
Journal: Am J Pathol
Title: Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Volume: 183
Issue: 2
Pages: 369-81
Publication
First Author: Lee JE
Year: 2013
Journal: Exp Neurobiol
Title: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.
Volume: 22
Issue: 2
Pages: 84-95
Publication
First Author: Dewachter I
Year: 2008
Journal: Neurobiol Aging
Title: Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1.
Volume: 29
Issue: 5
Pages: 639-52
Publication
First Author: Dewachter I
Year: 2000
Journal: J Neurosci
Title: Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
Volume: 20
Issue: 17
Pages: 6452-8
Publication
First Author: Kamphuis W
Year: 2016
Journal: Biochim Biophys Acta
Title: Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.
Volume: 1862
Issue: 10
Pages: 1847-60
Publication
First Author: Yuede CM
Year: 2016
Journal: J Exp Med
Title: Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model.
Volume: 213
Issue: 5
Pages: 677-85
Publication
First Author: Pistell PJ
Year: 2008
Journal: Neuroscience
Title: Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.
Volume: 152
Issue: 3
Pages: 594-600
Publication
First Author: Willuweit A
Year: 2009
Journal: PLoS One
Title: Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Volume: 4
Issue: 11
Pages: e7931
Publication
First Author: Howlett DR
Year: 2004
Journal: Brain Res
Title: Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Volume: 1017
Issue: 1-2
Pages: 130-6
Publication
First Author: Spencer JP
Year: 2006
Journal: Neuroscience
Title: Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.
Volume: 137
Issue: 3
Pages: 795-805
Publication  
First Author: Kuroda E
Year: 2020
Journal: Neuroscience
Title: Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ.
Volume: 438
Pages: 217-228
Publication
First Author: Boeras DI
Year: 2008
Journal: Neurobiol Aging
Title: Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.
Volume: 29
Issue: 3
Pages: 319-28
Publication
First Author: Duff K
Year: 1996
Journal: Nature
Title: Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Volume: 383
Issue: 6602
Pages: 710-3
Publication
First Author: Begley JG
Year: 1999
Journal: J Neurochem
Title: Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
Volume: 72
Issue: 3
Pages: 1030-9
Publication
First Author: Cummings M
Year: 2018
Journal: PLoS One
Title: Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis.
Volume: 13
Issue: 8
Pages: e0200752
Publication  
First Author: Habets RA
Year: 2019
Journal: Sci Transl Med
Title: Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
Volume: 11
Issue: 494
Publication
First Author: Reiserer RS
Year: 2007
Journal: Genes Brain Behav
Title: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
Volume: 6
Issue: 1
Pages: 54-65
Publication
First Author: Watanabe H
Year: 2012
Journal: J Neurosci
Title: Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.
Volume: 32
Issue: 15
Pages: 5085-96
Publication  
First Author: Mirnics K
Year: 2008
Journal: Mol Neurodegener
Title: Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
Volume: 3
Pages: 14
Publication  
First Author: Wang M
Year: 2018
Journal: Neurosci Lett
Title: Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
Volume: 685
Pages: 63-67
Publication
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
Publication
First Author: Jung CK
Year: 2011
Journal: J Neurochem
Title: Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo.
Volume: 119
Issue: 5
Pages: 1064-73
Publication
First Author: Saito T
Year: 2011
Journal: Nat Neurosci
Title: Potent amyloidogenicity and pathogenicity of Aβ43.
Volume: 14
Issue: 8
Pages: 1023-32
Publication
First Author: Baglietto-Vargas D
Year: 2017
Journal: Sci Rep
Title: Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 10085
Publication
First Author: Wirths O
Year: 2006
Journal: Exp Gerontol
Title: Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease.
Volume: 41
Issue: 2
Pages: 220-4
Publication
First Author: Takeuchi A
Year: 2000
Journal: Am J Pathol
Title: Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
Volume: 157
Issue: 1
Pages: 331-9
Publication
First Author: Guo Q
Year: 1999
Journal: Nat Med
Title: Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Volume: 5
Issue: 1
Pages: 101-6
Publication
First Author: Milhavet O
Year: 2002
Journal: J Neurochem
Title: Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.
Volume: 83
Issue: 3
Pages: 673-81
Publication
First Author: Wang G
Year: 2008
Journal: Glia
Title: Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes.
Volume: 56
Issue: 4
Pages: 449-56
Publication
First Author: Stutzmann GE
Year: 2004
Journal: J Neurosci
Title: Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.
Volume: 24
Issue: 2
Pages: 508-13
Publication
First Author: Zhu H
Year: 1999
Journal: Brain Res
Title: Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
Volume: 842
Issue: 1
Pages: 224-9
Publication
First Author: Kim S
Year: 2015
Journal: Neurobiol Aging
Title: Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.
Volume: 36
Issue: 12
Pages: 3239-3246
Publication
First Author: LaFontaine MA
Year: 2002
Journal: Neurochem Res
Title: Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease.
Volume: 27
Issue: 5
Pages: 417-21
Publication
First Author: Leissring MA
Year: 2000
Journal: J Cell Biol
Title: Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.
Volume: 149
Issue: 4
Pages: 793-8
Publication
First Author: Guo Q
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
Volume: 96
Issue: 7
Pages: 4125-30
Publication
First Author: Mattson MP
Year: 2000
Journal: J Neurosci
Title: Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Volume: 20
Issue: 4
Pages: 1358-64
Publication
First Author: Malik B
Year: 2008
Journal: J Neurochem
Title: Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
Volume: 106
Issue: 2
Pages: 912-6
Publication
First Author: Xie J
Year: 2001
Journal: Brain Res
Title: Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
Volume: 915
Issue: 1
Pages: 1-10
Publication
First Author: Guo Q
Year: 1999
Journal: J Neurochem
Title: Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
Volume: 72
Issue: 3
Pages: 1019-29
Publication
First Author: Chan SL
Year: 2000
Journal: J Biol Chem
Title: Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
Volume: 275
Issue: 24
Pages: 18195-200
Publication
First Author: Chu TH
Year: 2013
Journal: Cancer Lett
Title: miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Volume: 337
Issue: 1
Pages: 115-24
Publication
First Author: Wang Y
Year: 2009
Journal: Neurobiol Aging
Title: Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices.
Volume: 30
Issue: 7
Pages: 1061-8
Publication
First Author: Mastrangelo P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Volume: 102
Issue: 25
Pages: 8972-7
Publication
First Author: Tanaka Y
Year: 2018
Journal: J Immunol
Title: Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II.
Volume: 201
Issue: 8
Pages: 2256-2263
Publication  
First Author: Nikolakopoulou AM
Year: 2016
Journal: Neurobiol Aging
Title: Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.
Volume: 42
Pages: 41-9
Publication
First Author: Payette DJ
Year: 2007
Journal: Brain Res
Title: Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice.
Volume: 1135
Issue: 1
Pages: 12-21
Publication
First Author: Chan SL
Year: 2002
Journal: Neurobiol Dis
Title: Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
Volume: 11
Issue: 1
Pages: 2-19
Publication
First Author: Odero GL
Year: 2010
Journal: Neuroscience
Title: Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease.
Volume: 169
Issue: 1
Pages: 532-43
Publication
First Author: Saura CA
Year: 2011
Journal: PLoS One
Title: Presenilin/γ-secretase regulates neurexin processing at synapses.
Volume: 6
Issue: 4
Pages: e19430