|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 3238 for Psen1

<< First    < Previous  |  Next >    Last >>
0.027s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
5663 | PSEN1
Type: gene
Organism: human
•
•
•
•
•
Gene
394924 | psen1
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
key_38349 | PSEN1
Type: gene
Organism: lemur, mouse
•
•
•
•
•
Gene
29192 | Psen1
Type: gene
Organism: rat
•
•
•
•
•
Gene
403408 | PSEN1
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
739740 | PSEN1
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
282705 | PSEN1
Type: gene
Organism: cattle
•
•
•
•
•
Gene
373977 | PSEN1
Type: gene
Organism: chicken
•
•
•
•
•
Gene
30221 | psen1
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
696274 | PSEN1
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:1202717 | Psen1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
28617969 | J:273965
First Author: Song XW
Year: 2018
Journal: J Cell Physiol
Title: Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.
Volume: 233
Issue: 2
Pages: 1548-1557
•
•
•
•
•
Publication
34939719 | J:331779
First Author: Song XW
Year: 2022
Journal: Cell Biol Int
Title: Cardiovascular-specific PSEN1 deletion leads to abnormalities in calcium homeostasis.
Volume: 46
Issue: 3
Pages: 475-487
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932727
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932786
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 [d]e9/[d]e9
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932727
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932786
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 +/+
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932728
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932739
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 [d]e9/[d]e9
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932728
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932739
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 +/+
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Pattern: Widespread
Stage: TS20
Assay Id: MGI:6467356
Age: embryonic day 12.5
Note: Authors report widespread or ubiquitous expression.
Specimen Label: 1d Psen1
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
37608393 | J:358976
First Author: van Heusden FC
Year: 2023
Journal: Alzheimers Res Ther
Title: Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes.
Volume: 15
Issue: 1
Pages: 142
•
•
•
•
•
Publication
22723704 | J:185660
First Author: Zhang X
Year: 2012
Journal: J Neurosci
Title: A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Volume: 32
Issue: 25
Pages: 8633-48
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932728
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932739
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 +/[d] e9
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932727
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1932786
Age: embryonic day 14.5
Image: 2
Specimen Label: Psen1 +/[d] e9
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
30042426 | J:266488
First Author: Sasaguri H
Year: 2018
Journal: Nat Commun
Title: Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.
Volume: 9
Issue: 1
Pages: 2892
•
•
•
•
•
Publication
12900443 | J:84596
First Author: Takahashi Y
Year: 2003
Journal: Development
Title: Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.
Volume: 130
Issue: 18
Pages: 4259-68
•
•
•
•
•
Publication
35486730 | J:338551
First Author: Lie PPY
Year: 2022
Journal: Sci Adv
Title: Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function.
Volume: 8
Issue: 17
Pages: eabj5716
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191155
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Psen1
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191155
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Psen1
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191155
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Psen1
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191155
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Psen1
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191155
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Psen1
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191155
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Psen1
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6181474
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191155
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Psen1
Detected: true
Specimen Num: 6
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 768
Description: Cleavage; by PSEN1
Type: site
End: 769
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932729
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:1932840
Age: embryonic day 15.0
Image: 2
Specimen Label: Psen1 +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1932729
Assay Type: Western blot
Annotation Date: 2001-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:1932840
Age: embryonic day 15.0
Image: 2
Specimen Label: Psen1 [d]E9/[d]E9
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
21841774 | J:179786
First Author: Pratt KG
Year: 2011
Journal: Nat Neurosci
Title: Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
Volume: 14
Issue: 9
Pages: 1112-4
•
•
•
•
•
Publication
18729224 | J:138800
First Author: De Gasperi R
Year: 2008
Journal: Dev Dyn
Title: Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Volume: 237
Issue: 9
Pages: 2405-14
•
•
•
•
•
Publication
31217332 | J:278870
First Author: Ortega-Martinez S
Year: 2019
Journal: J Neurosci
Title: Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Volume: 39
Issue: 34
Pages: 6766-6780
•
•
•
•
•
Publication
35902630 | J:351375
First Author: Yang Y
Year: 2023
Journal: Mol Psychiatry
Title: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology.
Volume: 28
Issue: 12
Pages: 5359-5374
•
•
•
•
•
Publication
37421950 | J:339320
First Author: Xiang J
Year: 2023
Journal: Cell
Title: Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.
Volume: 186
Issue: 16
Pages: 3350-3367.e19
•
•
•
•
•
Publication
34850492 | J:353175
First Author: Nguyen P
Year: 2022
Journal: Microsc Res Tech
Title: An easy brain thick-section-clearing protocol to observe antigens in the brains of neurological disease mouse models by conventional epifluorescence and confocal laser scanning microscopy.
Volume: 85
Issue: 4
Pages: 1618-1626
•
•
•
•
•
Publication
36254251 | J:352636
First Author: Yu H
Year: 2022
Journal: MedComm (2020)
Title: Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease.
Volume: 3
Issue: 4
Pages: e180
•
•
•
•
•
Publication
32745992 | J:311234
 
First Author: Crapser JD
Year: 2020
Journal: EBioMedicine
Title: Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.
Volume: 58
Pages: 102919
•
•
•
•
•
Publication
34303222 | J:311302
 
First Author: Russo ML
Year: 2021
Journal: Neurobiol Aging
Title: Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons.
Volume: 106
Pages: 207-222
•
•
•
•
•
Publication
37409006 | J:346956
 
First Author: Weigel TK
Year: 2023
Journal: Front Aging Neurosci
Title: Altered circadian behavior and light sensing in mouse models of Alzheimer's disease.
Volume: 15
Pages: 1218193
•
•
•
•
•
Publication
39394468 | J:358361
First Author: Guo Y
Year: 2024
Journal: EMBO Mol Med
Title: Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice.
Volume: 16
Issue: 11
Pages: 2856-2881
•
•
•
•
•
Publication
36703981 | J:355400
 
First Author: Daini E
Year: 2022
Journal: Front Immunol
Title: Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice.
Volume: 13
Pages: 1082036
•
•
•
•
•
Publication
26969629 | J:351702
First Author: Roddick KM
Year: 2016
Journal: Chem Senses
Title: Sex and Genotype Differences in Odor Detection in the 3×Tg-AD and 5XFAD Mouse Models of Alzheimer's Disease at 6 Months of Age.
Volume: 41
Issue: 5
Pages: 433-40
•
•
•
•
•
Publication
33902708 | J:348523
First Author: Park JS
Year: 2021
Journal: Acta Neuropathol Commun
Title: Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 78
•
•
•
•
•
Publication
38117656 | J:355509
First Author: Xiang J
Year: 2024
Journal: STAR Protoc
Title: Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo.
Volume: 5
Issue: 1
Pages: 102788
•
•
•
•
•
Publication
24694184 | J:285067
 
First Author: Guzmán EA
Year: 2014
Journal: Mol Neurodegener
Title: Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Volume: 9
Pages: 13
•
•
•
•
•
Publication
32832679 | J:327386
First Author: Chen C
Year: 2020
Journal: Sci Adv
Title: Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Volume: 6
Issue: 31
Pages: eaba0466
•
•
•
•
•
Publication
37867176 | J:358195
First Author: Iyaswamy A
Year: 2023
Journal: Signal Transduct Target Ther
Title: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 404
•
•
•
•
•
Publication
37308288 | J:337909
 
First Author: Sanna PP
Year: 2023
Journal: eNeuro
Title: A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease.
Volume: 10
Issue: 7
•
•
•
•
•
Publication
30635592 | J:275422
First Author: Creighton SD
Year: 2019
Journal: Sci Rep
Title: Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.
Volume: 9
Issue: 1
Pages: 57
•
•
•
•
•
Publication
31434879 | J:279495
First Author: Spangenberg E
Year: 2019
Journal: Nat Commun
Title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 3758
•
•
•
•
•
Publication
35198070 | J:327457
First Author: Cai CZ
Year: 2022
Journal: Theranostics
Title: Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.
Volume: 12
Issue: 4
Pages: 1738-1755
•
•
•
•
•
Publication
37060096 | J:335721
First Author: Wu D
Year: 2023
Journal: Mol Neurodegener
Title: Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.
Volume: 18
Issue: 1
Pages: 23
•
•
•
•
•
Publication
29725016 | J:262986
First Author: Wang ZH
Year: 2018
Journal: Nat Commun
Title: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1784
•
•
•
•
•
Publication
34185417 | J:351257
First Author: Wu D
Year: 2021
Journal: Clin Transl Med
Title: Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Volume: 11
Issue: 6
Pages: e428
•
•
•
•
•
Publication
28826672 | J:271996
First Author: Wang ZH
Year: 2017
Journal: Mol Cell
Title: Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Volume: 67
Issue: 5
Pages: 812-825.e5
•
•
•
•
•
Publication
36170815 | J:329919
First Author: Rangan P
Year: 2022
Journal: Cell Rep
Title: Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.
Volume: 40
Issue: 13
Pages: 111417
•
•
•
•
•
Publication
23955714 | J:202038
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
•
•
•
•
•
Publication
31164420 | J:279242
First Author: Bahn G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Volume: 116
Issue: 25
Pages: 12516-12523
•
•
•
•
•
Publication
26214837 | J:228830
First Author: Zenaro E
Year: 2015
Journal: Nat Med
Title: Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Volume: 21
Issue: 8
Pages: 880-6
•
•
•
•
•
Publication
39110781 | J:353793
First Author: Han J
Year: 2024
Journal: Sci Transl Med
Title: Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas-based epigenome editing in Alzheimer's disease.
Volume: 16
Issue: 759
Pages: eadi4830
•
•
•
•
•
Publication
31858697 | J:358332
First Author: Song JX
Year: 2020
Journal: Aging Cell
Title: A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
Volume: 19
Issue: 2
Pages: e13069
•
•
•
•
•
Publication
31221985 | J:279897
First Author: Kastanenka KV
Year: 2019
Journal: Sci Rep
Title: Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology.
Volume: 9
Issue: 1
Pages: 8964
•
•
•
•
•
Publication
28753475 | J:249747
 
First Author: Toussay X
Year: 2017
Journal: Neurobiol Aging
Title: Presenilin 1 mutation decreases both calcium and contractile responses in cerebral arteries.
Volume: 58
Pages: 201-212
•
•
•
•
•
Publication
16079160 | J:100132
First Author: Wen PH
Year: 2005
Journal: Development
Title: Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice.
Volume: 132
Issue: 17
Pages: 3873-83
•
•
•
•
•
Publication
34505007 | J:313520
First Author: Aguilar-Pineda JA
Year: 2021
Journal: iScience
Title: Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
Volume: 24
Issue: 9
Pages: 102993
•
•
•
•
•
Publication
33846335 | J:311263
First Author: Kim K
Year: 2021
Journal: Nat Commun
Title: Therapeutic B-cell depletion reverses progression of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 2185
•
•
•
•
•
Publication
35961653 | J:352637
First Author: Israel LL
Year: 2022
Journal: ACS Nano
Title: Signature Effects of Vector-Guided Systemic Nano Bioconjugate Delivery Across Blood-Brain Barrier of Normal, Alzheimer's, and Tumor Mouse Models.
Volume: 16
Issue: 8
Pages: 11815-11832
•
•
•
•
•
Publication
35426376 | J:323934
 
First Author: Zou HY
Year: 2022
Journal: J Clin Invest
Title: Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.
Volume: 132
Issue: 8
•
•
•
•
•
Publication
35269588 | J:327470
 
First Author: Martínez-Iglesias O
Year: 2022
Journal: Int J Mol Sci
Title: Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 5
•
•
•
•
•
Publication
31042463 | J:284880
First Author: Deyts C
Year: 2019
Journal: Cell Rep
Title: APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Volume: 27
Issue: 5
Pages: 1345-1355.e6
•
•
•
•
•
Publication
26529393 | J:286210
First Author: Savastano A
Year: 2016
Journal: J Alzheimers Dis
Title: N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models.
Volume: 49
Issue: 1
Pages: 101-10
•
•
•
•
•
Publication
19751708 | J:158791
 
First Author: Christensen DZ
Year: 2009
Journal: Brain Res
Title: Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease.
Volume: 1301
Pages: 116-25
•
•
•
•
•
Publication
28978359 | J:285070
First Author: Wirths O
Year: 2017
Journal: Alzheimers Res Ther
Title: N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.
Volume: 9
Issue: 1
Pages: 80
•
•
•
•
•
Publication
30867420 | J:273276
First Author: He Y
Year: 2019
Journal: Nat Commun
Title: Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.
Volume: 10
Issue: 1
Pages: 1193
•
•
•
•
•
Publication
11070093 | J:65800
First Author: Grilli M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Volume: 97
Issue: 23
Pages: 12822-7
•
•
•
•
•
Publication
23306558 | J:228263
First Author: Song H
Year: 2013
Journal: Cell Death Differ
Title: Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.
Volume: 20
Issue: 4
Pages: 639-48
•
•
•
•
•
Publication
37028406 | J:334726
First Author: Li YD
Year: 2023
Journal: Cell Stem Cell
Title: Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.
Volume: 30
Issue: 4
Pages: 415-432.e6
•
•
•
•
•
Publication
38828204 | J:352620
 
First Author: Lin EY
Year: 2024
Journal: Int J Nanomedicine
Title: Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the β-Amyloid Accumulation in the Brains of Mice with Alzheimer's Disease.
Volume: 19
Pages: 4977-4994
•
•
•
•
•
Publication
36012331 | J:327939
 
First Author: Saleh B
Year: 2022
Journal: Int J Mol Sci
Title: FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 16
•
•
•
•
•
Publication
20971852 | J:167567
First Author: Wirths O
Year: 2010
Journal: J Biol Chem
Title: Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Volume: 285
Issue: 53
Pages: 41517-24
•
•
•
•
•
Publication
31213067 | J:277676
 
First Author: Findley CA
Year: 2019
Journal: ASN Neuro
Title: Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression.
Volume: 11
Pages: 1759091419855541
•
•
•
•
•
Publication
24305500 | J:286212
First Author: Reinert J
Year: 2014
Journal: J Alzheimers Dis
Title: Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Volume: 39
Issue: 4
Pages: 871-81
•
•
•
•
•
Publication
24278307 | J:209782
First Author: Guo Q
Year: 2013
Journal: PLoS One
Title: Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Volume: 8
Issue: 11
Pages: e80706
•
•
•
•
•
Publication
37402372 | J:340719
First Author: Wu Y
Year: 2023
Journal: Neuron
Title: Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer's disease in mice.
Volume: 111
Issue: 18
Pages: 2847-2862.e10
•
•
•
•
•
Publication
22753898 | J:190756
First Author: Coen K
Year: 2012
Journal: J Cell Biol
Title: Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.
Volume: 198
Issue: 1
Pages: 23-35
•
•
•
•
•
Publication
27100199 | J:239478
First Author: Veugelen S
Year: 2016
Journal: Neuron
Title: Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.
Volume: 90
Issue: 2
Pages: 410-6
•
•
•
•
•
Publication
33345400 | J:352826
First Author: Jang YN
Year: 2021
Journal: Neuropathol Appl Neurobiol
Title: RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Volume: 47
Issue: 5
Pages: 625-639
•
•
•
•
•
Publication
38776461 | J:360710
First Author: Kong Y
Year: 2024
Journal: ACS Chem Neurosci
Title: Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [(18)F]GSK1482160.
Volume: 15
Issue: 11
Pages: 2112-2120
•
•
•
•
•
Publication
18760694 | J:149876
First Author: Choi SH
Year: 2008
Journal: Neuron
Title: Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Volume: 59
Issue: 4
Pages: 568-80
•
•
•
•
•
Publication
8755489 | J:34323
First Author: Thinakaran G
Year: 1996
Journal: Neuron
Title: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Volume: 17
Issue: 1
Pages: 181-90
•
•
•
•
•
Publication
15212842 | J:102351
First Author: Jankowsky JL
Year: 2004
Journal: Neurobiol Aging
Title: APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Volume: 25
Issue: 7
Pages: 885-92
•
•
•
•
•
Publication
14980721 | J:89996
First Author: Yang Y
Year: 2004
Journal: Neuroscience
Title: Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
Volume: 124
Issue: 3
Pages: 501-5
•
•
•
•
•
Publication
21248114 | J:168562
First Author: Pratt KG
Year: 2011
Journal: J Neurosci
Title: A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons.
Volume: 31
Issue: 3
Pages: 899-906
•
•
•
•
•
Publication
16148264 | J:116810
First Author: Cook DG
Year: 2005
Journal: J Neurophysiol
Title: Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons.
Volume: 94
Issue: 6
Pages: 4421-9
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom