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Search results 1 to 100 out of 381 for Psen2

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5664 | PSEN2
Type: gene
Organism: human
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Gene
282010 | PSEN2
Type: gene
Organism: cattle
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Gene
374188 | PSEN2
Type: gene
Organism: chicken
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Gene
58026 | psen2
Type: gene
Organism: zebrafish
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Gene
698770 | PSEN2
Type: gene
Organism: macaque, rhesus
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Gene
549935 | psen2
Type: gene
Organism: frog, western clawed
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Gene
81751 | Psen2
Type: gene
Organism: rat
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Gene
490382 | PSEN2
Type: gene
Organism: dog, domestic
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Gene
457790 | PSEN2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:109284 | Psen2
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
     
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6191156
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Psen2
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191156
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Psen2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191156
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Psen2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191156
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Psen2
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6191156
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Psen2
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191156
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Psen2
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6181476
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191156
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Psen2
Detected: true
Specimen Num: 7
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Publication
27239030 | J:238101
First Author: Filadi R
Year: 2016
Journal: Cell Rep
Title: Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.
Volume: 15
Issue: 10
Pages: 2226-2238
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Publication
33494218 | J:332736
 
First Author: Rossi A
Year: 2021
Journal: Cells
Title: Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease.
Volume: 10
Issue: 2
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Publication
36634751 | J:333083
 
First Author: Knox KM
Year: 2023
Journal: Exp Neurol
Title: Chronic seizures induce sex-specific cognitive deficits with loss of presenilin 2 function.
Volume: 361
Pages: 114321
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Publication
31862541 | J:301170
 
First Author: Beckman M
Year: 2020
Journal: Neurobiol Dis
Title: Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.
Volume: 136
Pages: 104719
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Publication
37592944 | J:339707
 
First Author: Lehmann LM
Year: 2023
Journal: Front Neurol
Title: Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model.
Volume: 14
Pages: 1223472
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Publication
34758364 | J:321426
 
First Author: Si Y
Year: 2022
Journal: Behav Brain Res
Title: Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.
Volume: 418
Pages: 113652
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Publication
23952003 | J:327448
First Author: Jayadev S
Year: 2013
Journal: J Neurochem
Title: Presenilin 2 influences miR146 level and activity in microglia.
Volume: 127
Issue: 5
Pages: 592-9
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Publication
15649694 | J:134624
First Author: von Kienlin M
Year: 2005
Journal: Neurobiol Dis
Title: Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Volume: 18
Issue: 1
Pages: 32-9
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Publication
16204356 | J:104643
First Author: Takeda T
Year: 2005
Journal: FASEB J
Title: Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
Volume: 19
Issue: 14
Pages: 2069-71
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Publication
12039862 | J:76934
First Author: Hwang DY
Year: 2002
Journal: FASEB J
Title: Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.
Volume: 16
Issue: 8
Pages: 805-13
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Publication
24858037 | J:217025
First Author: Yun HM
Year: 2014
Journal: Oncogene
Title: Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.
Volume: 33
Issue: 44
Pages: 5193-200
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Publication
20926667 | J:165096
First Author: Peethumnongsin E
Year: 2010
Journal: J Neurosci
Title: Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
Volume: 30
Issue: 40
Pages: 13409-18
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Publication
30059908 | J:264269
 
First Author: Azimi M
Year: 2018
Journal: Differentiation
Title: Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.
Volume: 102
Pages: 40-52
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Publication
31878336 | J:346775
 
First Author: Leparulo A
Year: 2019
Journal: Cells
Title: Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer's Disease.
Volume: 9
Issue: 1
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Publication
15474363 | J:93093
First Author: Hébert SS
Year: 2004
Journal: Neurobiol Dis
Title: Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Volume: 17
Issue: 2
Pages: 260-72
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Publication
18539391 | J:138403
First Author: Gu F
Year: 2008
Journal: Neurosci Lett
Title: Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice.
Volume: 440
Issue: 1
Pages: 44-8
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Publication
18822370 | J:143331
First Author: Zhu M
Year: 2008
Journal: Free Radic Biol Med
Title: Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.
Volume: 45
Issue: 10
Pages: 1493-9
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Publication
12684521 | J:84109
First Author: Lai MT
Year: 2003
Journal: J Biol Chem
Title: Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Volume: 278
Issue: 25
Pages: 22475-81
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Publication
17499883 | J:140910
First Author: Wu P
Year: 2008
Journal: Neurobiol Aging
Title: Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.
Volume: 29
Issue: 10
Pages: 1502-11
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Publication
29867447 | J:275237
 
First Author: Cao T
Year: 2018
Journal: Front Aging Neurosci
Title: Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice.
Volume: 10
Pages: 137
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Publication
36805914 | J:339556
 
First Author: Si Y
Year: 2023
Journal: Sleep Med
Title: Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes.
Volume: 103
Pages: 146-158
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Publication
36370840 | J:332034
 
First Author: Lv J
Year: 2023
Journal: Exp Neurol
Title: Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice.
Volume: 359
Pages: 114271
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Publication
15148382 | J:90685
First Author: Feng R
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2.
Volume: 101
Issue: 21
Pages: 8162-7
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Publication
30316051 | J:271567
 
First Author: Zhang L
Year: 2019
Journal: Neurobiol Aging
Title: miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression.
Volume: 73
Pages: 41-49
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Publication
23792007 | J:205538
 
First Author: Yan L
Year: 2013
Journal: Brain Res Bull
Title: Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice.
Volume: 97
Pages: 104-11
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Publication
17614943 | J:125930
First Author: Dong S
Year: 2007
Journal: Eur J Neurosci
Title: Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.
Volume: 26
Issue: 1
Pages: 101-12
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Publication
19584449 | J:274528
First Author: Jiang X
Year: 2009
Journal: J Alzheimers Dis
Title: Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.
Volume: 18
Issue: 3
Pages: 515-23
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Publication
17980611 | J:141456
First Author: Chen Q
Year: 2008
Journal: Neurobiol Dis
Title: Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Volume: 29
Issue: 2
Pages: 316-26
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Publication
21910732 | J:178371
First Author: Kim J
Year: 2011
Journal: J Neurochem
Title: Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
Volume: 119
Issue: 5
Pages: 945-56
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Publication
15122901 | J:115485
First Author: Qyang Y
Year: 2004
Journal: Biochemistry
Title: Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.
Volume: 43
Issue: 18
Pages: 5352-9
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Publication
27889678 | J:239743
 
First Author: Fontana R
Year: 2017
Journal: Neurobiol Aging
Title: Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.
Volume: 50
Pages: 64-76
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Publication
18834536 | J:187802
 
First Author: Mirnics K
Year: 2008
Journal: Mol Neurodegener
Title: Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
Volume: 3
Pages: 14
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Publication
17222949 | J:137701
First Author: Zhang H
Year: 2008
Journal: Neurobiol Aging
Title: Presenilins regulate the cellular level of the tumor suppressor PTEN.
Volume: 29
Issue: 5
Pages: 653-60
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Publication
10518543 | J:58118
First Author: Herreman A
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Volume: 96
Issue: 21
Pages: 11872-7
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Publication
11715026 | J:92211
First Author: Armogida M
Year: 2001
Journal: Nat Cell Biol
Title: Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.
Volume: 3
Issue: 11
Pages: 1030-3
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Publication
15128703 | J:91235
First Author: Tournoy J
Year: 2004
Journal: Hum Mol Genet
Title: Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Volume: 13
Issue: 13
Pages: 1321-31
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Publication
16103124 | J:128865
First Author: Hass MR
Year: 2005
Journal: J Biol Chem
Title: A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
Volume: 280
Issue: 44
Pages: 36895-904
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Publication
18297084 | J:133658
First Author: Engin F
Year: 2008
Journal: Nat Med
Title: Dimorphic effects of Notch signaling in bone homeostasis.
Volume: 14
Issue: 3
Pages: 299-305
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Publication
9153393 | J:40308
First Author: Wong PC
Year: 1997
Journal: Nature
Title: Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Volume: 387
Issue: 6630
Pages: 288-92
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Publication
10557208 | J:58465
First Author: Donoviel DB
Year: 1999
Journal: Genes Dev
Title: Mice lacking both presenilin genes exhibit early embryonic patterning defects.
Volume: 13
Issue: 21
Pages: 2801-10
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Publication
17556541 | J:122380
First Author: Zhang YW
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.
Volume: 104
Issue: 25
Pages: 10613-8
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Publication
18195359 | J:131284
First Author: Yagi T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Defective signal transduction in B lymphocytes lacking presenilin proteins.
Volume: 105
Issue: 3
Pages: 979-84
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Publication
17097608 | J:116653
First Author: Kim JS
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.
Volume: 351
Issue: 4
Pages: 903-8
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Publication
30429473 | J:268351
First Author: Barthet G
Year: 2018
Journal: Nat Commun
Title: Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.
Volume: 9
Issue: 1
Pages: 4780
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Publication
18971484 | J:143253
First Author: Kallhoff-Munoz V
Year: 2008
Journal: J Neurosci
Title: Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.
Volume: 28
Issue: 44
Pages: 11421-31
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Publication
15886206 | J:100835
First Author: Vetrivel KS
Year: 2005
Journal: J Biol Chem
Title: Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Volume: 280
Issue: 27
Pages: 25892-900
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Publication
11937492 | J:75878
First Author: Hitoshi S
Year: 2002
Journal: Genes Dev
Title: Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Volume: 16
Issue: 7
Pages: 846-58
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Publication
31433986 | J:280229
First Author: Wu T
Year: 2019
Journal: Cell Rep
Title: Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Volume: 28
Issue: 8
Pages: 2111-2123.e6
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Publication
23365231 | J:193889
First Author: Kaufmann MR
Year: 2013
Journal: J Neurosci
Title: Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Volume: 33
Issue: 5
Pages: 1915-26
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Publication
20130175 | J:157933
First Author: Zhao G
Year: 2010
Journal: J Neurosci
Title: Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Volume: 30
Issue: 5
Pages: 1648-56
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Publication
27349870 | J:238594
First Author: Biswas S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
Volume: 477
Issue: 4
Pages: 661-666
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Publication
17920016 | J:126954
First Author: Liu Q
Year: 2007
Journal: Neuron
Title: Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Volume: 56
Issue: 1
Pages: 66-78
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Publication
18665263 | J:139496
First Author: Ong CT
Year: 2008
Journal: PLoS One
Title: Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.
Volume: 3
Issue: 7
Pages: e2823
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Publication
19779553 | J:154114
First Author: Ferjentsik Z
Year: 2009
Journal: PLoS Genet
Title: Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
Volume: 5
Issue: 9
Pages: e1000662
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Publication
19723764 | J:152074
First Author: Cras-Méneur C
Year: 2009
Journal: Genes Dev
Title: Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Volume: 23
Issue: 17
Pages: 2088-101
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Publication
15866159 | J:98438
First Author: Huppert SS
Year: 2005
Journal: Dev Cell
Title: Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
Volume: 8
Issue: 5
Pages: 677-88
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Publication
27240887 | J:254080
 
First Author: Cras-Méneur C
Year: 2016
Journal: Sci Rep
Title: Early pancreatic islet fate and maturation is controlled through RBP-Jκ.
Volume: 6
Pages: 26874
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Publication
25995356 | J:239367
First Author: Stasiulewicz M
Year: 2015
Journal: Development
Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
Volume: 142
Issue: 13
Pages: 2291-303
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Protein Coding Gene
MGP_CAROLIEiJ_G0014975 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016210 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016783 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028206 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015774 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10497236 | J:83860
First Author: Steiner H
Year: 1999
Journal: J Biol Chem
Title: A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
Volume: 274
Issue: 40
Pages: 28669-73
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Publication
23370287 | J:199553
 
First Author: Kishimoto Y
Year: 2013
Journal: Neurosci Lett
Title: Presenilin 2 mutation accelerates the onset of impairment in trace eyeblink conditioning in a mouse model of Alzheimer's disease overexpressing human mutant amyloid precursor protein.
Volume: 538
Pages: 15-9
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Publication
9353287 | J:43976
First Author: Vito P
Year: 1997
Journal: J Biol Chem
Title: Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.
Volume: 272
Issue: 45
Pages: 28315-20
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Publication
10846187 | J:64511
First Author: Sawamura N
Year: 2000
Journal: J Biol Chem
Title: Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.
Volume: 275
Issue: 36
Pages: 27901-8
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Publication
9203550 | J:40990
First Author: Blanchard V
Year: 1997
Journal: Brain Res
Title: Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein.
Volume: 758
Issue: 1-2
Pages: 209-17
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Publication
9648880 | J:48145
First Author: Oyama F
Year: 1998
Journal: J Neurochem
Title: Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Volume: 71
Issue: 1
Pages: 313-22
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