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Search results 1 to 90 out of 90 for Pstpip2

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
9050 | PSTPIP2
Type: gene
Organism: human
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Gene
100135727 | pstpip2
Type: gene
Organism: frog, western clawed
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Gene
307248 | Pstpip2
Type: gene
Organism: rat
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Gene
480150 | PSTPIP2
Type: gene
Organism: dog, domestic
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Gene
737635 | PSTPIP2
Type: gene
Organism: chimpanzee
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Gene
523223 | PSTPIP2
Type: gene
Organism: cattle
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Gene
770399 | PSTPIP2
Type: gene
Organism: chicken
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Gene
100537857 | pstpip2
Type: gene
Organism: zebrafish
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Gene
701032 | PSTPIP2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1335088 | Pstpip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030106 | PSTPIP2
Type: Family
Description: Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2), also known as MAYP, belongs to the PCH (Pombe Cdc15 homology) family of proteins involved in the regulation of actin-related functions, including cell adhesion and motility []. In mice, it regulates F-actin bundling and enhances filopodia formation and motility in macrophages []. It may play an anti-inflammatory role in macrophages [].Pombe Cdc15 homology (PCH) family proteins were initially identified as adaptor proteins involved in the regulation of cytokinesis and actin dynamics []. They share a similar domain architecture, consisting of an N-terminal FCH domain followed by a coiled coil (CC) region and by one or two C-terminal SH3 domains. However, in some family members the SH3 domain is absent (FCHO1, FCHO2 and PSTPIP2) or there are tissue-specific alternatively spliced isoforms with and without an SH3 domain (CIP4b, CIP4c, CIP4V, Fbp17b). PCH family proteins interact with receptors, adaptors, enzymes and structural proteins to regulate their localisation and activity. Through these interactions, PCH proteins regulate cell morphology and motility, organelle integrity, protein trafficking and the organisation of the actin cytoskeleton [].
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Publication
15788569 | J:100748
First Author: Chitu V
Year: 2005
Journal: Mol Biol Cell
Title: The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.
Volume: 16
Issue: 6
Pages: 2947-59
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Publication
16397132 | J:125785
First Author: Grosse J
Year: 2006
Journal: Blood
Title: Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.
Volume: 107
Issue: 8
Pages: 3350-8
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Protein
Q4FJU4
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Publication
36605205 | J:332442
 
First Author: Pavliuchenko N
Year: 2022
Journal: Front Immunol
Title: Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.
Volume: 13
Pages: 1035226
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Publication
22923495 | J:192940
First Author: Chitu V
Year: 2012
Journal: Blood
Title: PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.
Volume: 120
Issue: 15
Pages: 3126-35
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Publication
16122996 | J:104476
First Author: Ferguson PJ
Year: 2006
Journal: Bone
Title: A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis.
Volume: 38
Issue: 1
Pages: 41-7
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Protein
Q99M15
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q3U4E4
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
A0A494BAM6
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Publication
10816256 | -
First Author: Lippincott J
Year: 2000
Journal: Microsc Res Tech
Title: Involvement of PCH family proteins in cytokinesis and actin distribution.
Volume: 49
Issue: 2
Pages: 168-72
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Publication
17296299 | -
First Author: Chitu V
Year: 2007
Journal: Trends Cell Biol
Title: Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions.
Volume: 17
Issue: 3
Pages: 145-56
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Publication
19608749 | J:152809
First Author: Chitu V
Year: 2009
Journal: Blood
Title: Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice.
Volume: 114
Issue: 12
Pages: 2497-505
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Publication
39120532 | J:356796
     
First Author: Pavliuchenko N
Year: 2024
Journal: J Leukoc Biol
Title: Genetic background affects neutrophil activity and determines the severity of autoinflammatory osteomyelitis in mice.
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Publication
22646813 | J:196534
 
First Author: Chen TC
Year: 2012
Journal: J Biomed Sci
Title: Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis.
Volume: 19
Pages: 55
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Publication
32024700 | J:287607
First Author: Kralova J
Year: 2020
Journal: J Immunol
Title: Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
Volume: 204
Issue: 6
Pages: 1607-1620
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Publication
34461100 | J:313586
First Author: Kralova J
Year: 2021
Journal: J Biol Chem
Title: The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis.
Volume: 297
Issue: 4
Pages: 101131
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Publication
24395792 | J:206471
First Author: Lukens JR
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Critical role for inflammasome-independent IL-1β production in osteomyelitis.
Volume: 111
Issue: 3
Pages: 1066-71
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Publication
25274309 | J:217490
First Author: Lukens JR
Year: 2014
Journal: Nature
Title: Dietary modulation of the microbiome affects autoinflammatory disease.
Volume: 516
Issue: 7530
Pages: 246-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0022423 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1335088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024414 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023851 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019152 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023336 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9804836 | J:50391
First Author: Yeung YG
Year: 1998
Journal: J Biol Chem
Title: A novel macrophage actin-associated protein (MAYP) is tyrosine-phosphorylated following colony stimulating factor-1 stimulation.
Volume: 273
Issue: 46
Pages: 30638-42
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Publication
10678414 | J:105410
First Author: Hentunen TA
Year: 2000
Journal: Bone
Title: A murine model of inflammatory bone disease.
Volume: 26
Issue: 2
Pages: 183-8
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Publication
31416928 | J:279253
 
First Author: Young S
Year: 2019
Journal: Dis Model Mech
Title: Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.
Volume: 12
Issue: 8
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Publication
36341527 | J:332583
First Author: Grusanovic S
Year: 2023
Journal: EMBO Rep
Title: Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway.
Volume: 24
Issue: 1
Pages: e54729
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Publication
37709251 | J:341368
     
First Author: Burocziova M
Year: 2023
Journal: Exp Hematol
Title: Chronic Inflammation Promotes Cancer Progression as a Second hit.
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Publication
9804817 | J:50845
First Author: Wu Y
Year: 1998
Journal: J Biol Chem
Title: PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase.
Volume: 273
Issue: 46
Pages: 30487-96
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Publication
1686018 | J:1534
First Author: Byrd L
Year: 1991
Journal: Genomics
Title: Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse.
Volume: 11
Issue: 4
Pages: 794-8
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Publication
24395802 | J:206468
First Author: Cassel SL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.
Volume: 111
Issue: 3
Pages: 1072-7
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Publication
16081819 | J:107496
First Author: Végvári A
Year: 2005
Journal: J Immunol
Title: Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.
Volume: 175
Issue: 4
Pages: 2475-83
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Publication
31719149 | J:286548
First Author: Dasari TK
Year: 2020
Journal: J Biol Chem
Title: The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
Volume: 295
Issue: 11
Pages: 3394-3400
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Publication
27071119 | J:232215
First Author: Gurung P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis.
Volume: 113
Issue: 16
Pages: 4452-7
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Publication
15226265 | J:91118
First Author: Rogers MS
Year: 2004
Journal: FASEB J
Title: Genetic loci that control the angiogenic response to basic fibroblast growth factor.
Volume: 18
Issue: 10
Pages: 1050-9
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
- | J:200814
     
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24407241 | -
 
First Author: Liu L
Year: 2014
Journal: Cell Death Dis
Title: PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.
Volume: 5
Pages: e988
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HT Experiment
E-MTAB-13610 | Effects of mouse genetic background on neutrophil gene expression in autoinflammatory osteomyelitis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR042694 | PSTPIP2_F-BAR
Type: Domain
Description: F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization []. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2) is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involvedin regulating cell adhesion and motility []. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease []. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules [].
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Publication
17540576 | J:247401
First Author: Henne WM
Year: 2007
Journal: Structure
Title: Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.
Volume: 15
Issue: 7
Pages: 839-52
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Publication
25701138 | J:221966
 
First Author: Martin A
Year: 2015
Journal: Bone
Title: Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association.
Volume: 75
Pages: 96-104
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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