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Search results 1 to 95 out of 95 for Ptcd2

0.049s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Pentatricopeptide repeat (PPR) proteins constitute a large family of RNA-binding proteins that contain a canonical 35 residue repeat motif. Seven examples have been identified in human mitochondria, and are known to affect mitochondrial translation [, ]. One of these is PTCD2, a pentatricopeptide domain (PTCD)-containing protein that affects mitochondrial translation. PTCD2 appears to have a role in processing RNA transcripts involving cytochrome b encoded by mitochondrial DNA []. Disruption in PTCD2 resulted in elevated levels of the unprocessed precursor encoding cytochrome b. PTCD2 has been identified as a target for autoantibodies in neurodegenerative disease and is used as a biomarker for Alzheimer disease [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xu F
Year: 2008
Journal: Biochem J
Title: Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria.
Volume: 416
Issue: 1
Pages: 15-26
Publication
First Author: Rackham O
Year: 2012
Journal: Biochim Biophys Acta
Title: The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression.
Volume: 1819
Issue: 9-10
Pages: 1008-16
Publication
First Author: Nagele E
Year: 2011
Journal: PLoS One
Title: Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera.
Volume: 6
Issue: 8
Pages: e23112
Publication
First Author: Lightowlers RN
Year: 2013
Journal: RNA Biol
Title: Human pentatricopeptide proteins: only a few and what do they do?
Volume: 10
Issue: 9
Pages: 1433-8
Protein
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3615133
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616854
Age: embryonic day 13.5
Specimen Label: RT-PCR E13.5 brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3615133
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616854
Age: postnatal day 0
Specimen Label: RT-PCR P0 brain
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Note: Expression was detected in precortical tissue.
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1697427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
Publication
First Author: Davies SM
Year: 2012
Journal: FEBS Lett
Title: MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.
Volume: 586
Issue: 20
Pages: 3555-61
Publication
First Author: Rackham O
Year: 2012
Journal: Wiley Interdiscip Rev RNA
Title: The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression.
Volume: 3
Issue: 5
Pages: 675-95
Protein Domain
Type: Family
Description: Mammalian pentatricopeptide repeat domain (PPR) proteins are involved in regulation of mitochondrial RNA metabolism and translation and are required for mitochondrial function. The supernumerary mitochondrial ribosomal protein of the small subunit 27 (MRPS27) is not required for mitochondrial RNA processing or the stability of the small ribosomal subunit. However, MRPS27 is required for mitochondrial protein synthesis [].Pentatricopeptide repeat-containing protein 2 (PTCD2) is a related mitochondrial PPR protein, although despite their similarity, they may not have the same function [, ]. PTCD2 has a role in mitochondrial RNA metabolism and downstream effects on mitochondrial translation [, ]. PTCD2 has been identified as a target for autoantibodies in neurodegenerative disease and is used as a biomarker for Alzheimer disease [].
Protein
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: true