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Search results 1 to 95 out of 95 for Ptcd2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
79810 | PTCD2
Type: gene
Organism: human
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Gene
100489047 | ptcd2
Type: gene
Organism: frog, western clawed
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Gene
310025 | Ptcd2
Type: gene
Organism: rat
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Gene
610392 | PTCD2
Type: gene
Organism: dog, domestic
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Gene
461820 | PTCD2
Type: gene
Organism: chimpanzee
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Gene
514705 | PTCD2
Type: gene
Organism: cattle
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Gene
427217 | PTCD2
Type: gene
Organism: chicken
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Gene
550275 | ptcd2
Type: gene
Organism: zebrafish
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Gene
706020 | PTCD2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR034629 | PTCD2
Type: Family
Description: Pentatricopeptide repeat (PPR) proteins constitute a large family of RNA-binding proteins that contain a canonical 35 residue repeat motif. Seven examples have been identified in human mitochondria, and are known to affect mitochondrial translation [, ]. One of these is PTCD2, a pentatricopeptide domain (PTCD)-containing protein that affects mitochondrial translation. PTCD2 appears to have a role in processing RNA transcripts involving cytochrome b encoded by mitochondrial DNA []. Disruption in PTCD2 resulted in elevated levels of the unprocessed precursor encoding cytochrome b. PTCD2 has been identified as a target for autoantibodies in neurodegenerative disease and is used as a biomarker for Alzheimer disease [].
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Protein Coding Gene
MGI:1916177 | Ptcd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18729827 | J:143946
First Author: Xu F
Year: 2008
Journal: Biochem J
Title: Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria.
Volume: 416
Issue: 1
Pages: 15-26
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Publication
22051507 | -
First Author: Rackham O
Year: 2012
Journal: Biochim Biophys Acta
Title: The role of mammalian PPR domain proteins in the regulation of mitochondrial gene expression.
Volume: 1819
Issue: 9-10
Pages: 1008-16
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Publication
21826230 | -
First Author: Nagele E
Year: 2011
Journal: PLoS One
Title: Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera.
Volume: 6
Issue: 8
Pages: e23112
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Publication
23635806 | -
First Author: Lightowlers RN
Year: 2013
Journal: RNA Biol
Title: Human pentatricopeptide proteins: only a few and what do they do?
Volume: 10
Issue: 9
Pages: 1433-8
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Protein
Q8R3K3
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0018829 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916177 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015904 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019711 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3615133
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616854
Age: embryonic day 13.5
Specimen Label: RT-PCR E13.5 brain
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3615133
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616854
Age: postnatal day 0
Specimen Label: RT-PCR P0 brain
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1697427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Note: Expression was detected in precortical tissue.
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617537
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3615831
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617537
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
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Publication
16033648 | J:103446
 
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q6A096
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q80ZI4
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Publication
22841715 | -
First Author: Davies SM
Year: 2012
Journal: FEBS Lett
Title: MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.
Volume: 586
Issue: 20
Pages: 3555-61
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Publication
22777840 | -
First Author: Rackham O
Year: 2012
Journal: Wiley Interdiscip Rev RNA
Title: The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression.
Volume: 3
Issue: 5
Pages: 675-95
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Protein Domain
IPR034913 | MRPS27/PTCD2
Type: Family
Description: Mammalian pentatricopeptide repeat domain (PPR) proteins are involved in regulation of mitochondrial RNA metabolism and translation and are required for mitochondrial function. The supernumerary mitochondrial ribosomal protein of the small subunit 27 (MRPS27) is not required for mitochondrial RNA processing or the stability of the small ribosomal subunit. However, MRPS27 is required for mitochondrial protein synthesis [].Pentatricopeptide repeat-containing protein 2 (PTCD2) is a related mitochondrial PPR protein, although despite their similarity, they may not have the same function [, ]. PTCD2 has a role in mitochondrial RNA metabolism and downstream effects on mitochondrial translation [, ]. PTCD2 has been identified as a target for autoantibodies in neurodegenerative disease and is used as a biomarker for Alzheimer disease [].
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Protein
Q8BK72
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A338P7I7
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: true
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