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Search results 1 to 100 out of 132 for Ptcra

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Hits by Strain

Hits by Category

Type Details Score
Gene
171558 | PTCRA
Type: gene
Organism: human
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Gene
513669 | PTCRA
Type: gene
Organism: cattle
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Gene
100858958 | PTCRA
Type: gene
Organism: chicken
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Gene
697470 | PTCRA
Type: gene
Organism: macaque, rhesus
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Gene
116462 | Ptcra
Type: gene
Organism: rat
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Gene
481804 | PTCRA
Type: gene
Organism: dog, domestic
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Gene
462701 | PTCRA
Type: gene
Organism: chimpanzee
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Protein Domain
IPR027834 | PTCRA
Type: Family
Description: The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation []. This protein contains an immunoglobulin domain [].
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Protein Coding Gene
MGI:104857 | Ptcra
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P0C6B2
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
A0A0R4J0F4
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Publication
20944746 | -
First Author: Pang SS
Year: 2010
Journal: Nature
Title: The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
Volume: 467
Issue: 7317
Pages: 844-8
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Publication
38422122 | J:346607
First Author: Materna M
Year: 2024
Journal: Science
Title: The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.
Volume: 383
Issue: 6686
Pages: eadh4059
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Publication
17171761 | J:117041
First Author: Luche H
Year: 2007
Journal: Eur J Immunol
Title: Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.
Volume: 37
Issue: 1
Pages: 43-53
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Publication
33535043 | J:304284
First Author: Fahl SP
Year: 2021
Journal: Cell Rep
Title: The E protein-TCF1 axis controls γδ T cell development and effector fate.
Volume: 34
Issue: 5
Pages: 108716
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Publication
24591366 | J:209876
First Author: Korthals M
Year: 2014
Journal: J Immunol
Title: αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.
Volume: 192
Issue: 7
Pages: 3228-38
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Publication
35046107 | J:322243
First Author: Fahl SP
Year: 2022
Journal: J Immunol
Title: Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.
Volume: 208
Issue: 4
Pages: 870-880
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Publication
30765463 | J:275319
First Author: Klein F
Year: 2019
Journal: J Exp Med
Title: The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.
Volume: 216
Issue: 3
Pages: 638-655
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Publication
26223192 | J:253752
 
First Author: Almeida FF
Year: 2015
Journal: Sci Rep
Title: Identification of a novel lymphoid population in the murine epidermis.
Volume: 5
Pages: 12554
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Publication
23509324 | J:197923
First Author: Luche H
Year: 2013
Journal: J Exp Med
Title: In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.
Volume: 210
Issue: 4
Pages: 699-714
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Publication
36674959 | J:333105
 
First Author: Beckmann D
Year: 2023
Journal: Int J Mol Sci
Title: Ca(2+) Homeostasis by Plasma Membrane Ca(2+) ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes.
Volume: 24
Issue: 2
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Protein Coding Gene
MGP_CAROLIEiJ_G0021687 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023761 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023660 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023656 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022783 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020678 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022599 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7973703 | J:22696
First Author: Saint-Ruf C
Year: 1994
Journal: Science
Title: Analysis and expression of a cloned pre-T cell receptor gene.
Volume: 266
Issue: 5188
Pages: 1208-12
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Publication
7672822 | J:28707
First Author: Fehling HJ
Year: 1995
Journal: Immunogenetics
Title: Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene.
Volume: 42
Issue: 4
Pages: 275-81
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Publication
17056529 | J:140526
First Author: Ferrero I
Year: 2006
Journal: J Immunol
Title: TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.
Volume: 177
Issue: 9
Pages: 6038-43
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Publication
18203137 | J:131357
First Author: Croxford AL
Year: 2008
Journal: Eur J Immunol
Title: MHC-restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor.
Volume: 38
Issue: 2
Pages: 391-9
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Publication
17918204 | J:126317
First Author: Ferrero I
Year: 2007
Journal: Eur J Immunol
Title: A critical lineage-nonspecific role for pTalpha in mediating allelic and isotypic exclusion in TCRbeta-transgenic mice.
Volume: 37
Issue: 11
Pages: 3220-8
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Publication
21030681 | J:166147
First Author: Ishikawa E
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
Volume: 107
Issue: 46
Pages: 19979-84
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Publication
11891328 | J:75270
First Author: Bellavia D
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.
Volume: 99
Issue: 6
Pages: 3788-93
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Publication
7596413 | J:26493
First Author: Fehling HJ
Year: 1995
Journal: Nature
Title: Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells.
Volume: 375
Issue: 6534
Pages: 795-8
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Publication
16754723 | J:124418
First Author: Garbe AI
Year: 2006
Journal: J Exp Med
Title: Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.
Volume: 203
Issue: 6
Pages: 1579-90
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Publication
14993248 | J:123992
First Author: Borowski C
Year: 2004
Journal: J Exp Med
Title: Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.
Volume: 199
Issue: 5
Pages: 607-15
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Publication
9390684 | J:44364
First Author: Aifantis I
Year: 1997
Journal: Immunity
Title: Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.
Volume: 7
Issue: 5
Pages: 601-7
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Publication
10570293 | J:58653
First Author: Mancini S
Year: 1999
Journal: J Immunol
Title: TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement.
Volume: 163
Issue: 11
Pages: 6053-9
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Publication
17015684 | J:139457
First Author: Bosco N
Year: 2006
Journal: J Immunol
Title: Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse.
Volume: 177
Issue: 8
Pages: 5014-23
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Publication
10382759 | J:56063
First Author: Eberl G
Year: 1999
Journal: Eur J Immunol
Title: Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development.
Volume: 29
Issue: 6
Pages: 1966-71
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Publication
19461123 | J:149531
First Author: Campese AF
Year: 2009
Journal: Int Immunol
Title: Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.
Volume: 21
Issue: 6
Pages: 727-43
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Publication
11535637 | J:71362
First Author: Gibbons D
Year: 2001
Journal: J Exp Med
Title: The biological activity of natural and mutant pTalpha alleles.
Volume: 194
Issue: 5
Pages: 695-703
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Publication
15770699 | J:97804
First Author: Balciunaite G
Year: 2005
Journal: Eur J Immunol
Title: The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.
Volume: 35
Issue: 4
Pages: 1292-300
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Publication
9846486 | J:51338
First Author: Aifantis I
Year: 1998
Journal: Immunity
Title: On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment.
Volume: 9
Issue: 5
Pages: 649-55
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Publication
11169403 | J:71767
First Author: Alonso-C LM
Year: 2000
Journal: Eur J Immunol
Title: Early T cell development can be traced in rat fetal liver.
Volume: 30
Issue: 12
Pages: 3604-13
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Publication
1703490 | J:39556
First Author: Kishi H
Year: 1991
Journal: EMBO J
Title: Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.
Volume: 10
Issue: 1
Pages: 93-100
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Publication
8618853 | J:31085
First Author: Del Porto P
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene.
Volume: 92
Issue: 26
Pages: 12105-9
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Publication
8700903 | J:77632
First Author: Xu Y
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.
Volume: 93
Issue: 5
Pages: 2169-73
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Publication
11927911 | J:76266
First Author: Aifantis I
Year: 2002
Journal: Nat Immunol
Title: A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.
Volume: 3
Issue: 5
Pages: 483-8
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752320
Stage: TS20
Assay Id: MGI:5478765
Age: embryonic day 12.5
Specimen Label: 12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752321
Stage: TS21
Assay Id: MGI:5478765
Age: embryonic day 13.5
Specimen Label: 13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752322
Stage: TS22
Assay Id: MGI:5478765
Age: embryonic day 14.5
Specimen Label: 14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876824
Stage: TS24
Assay Id: MGI:5478765
Age: embryonic day 16.5
Specimen Label: 16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876826
Stage: TS26
Assay Id: MGI:5478765
Age: embryonic day 18.5
Specimen Label: 18
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5478618
Assay Type: RT-PCR
Annotation Date: 2013-05-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5478765
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 6
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Publication
14502287 | J:125582
First Author: Pennington DJ
Year: 2003
Journal: Nat Immunol
Title: The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.
Volume: 4
Issue: 10
Pages: 991-8
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Publication
11994445 | J:125675
First Author: Renno T
Year: 2002
Journal: J Immunol
Title: A role for CD147 in thymic development.
Volume: 168
Issue: 10
Pages: 4946-50
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Publication
17190001 | J:117487
First Author: Pennington DJ
Year: 2006
Journal: Nature
Title: Early events in the thymus affect the balance of effector and regulatory T cells.
Volume: 444
Issue: 7122
Pages: 1073-7
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Publication
16754716 | J:124376
First Author: Aifantis I
Year: 2006
Journal: J Exp Med
Title: The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.
Volume: 203
Issue: 6
Pages: 1543-50
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Publication
18606674 | J:137464
First Author: Kirberg J
Year: 2008
Journal: J Immunol
Title: Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.
Volume: 181
Issue: 2
Pages: 1207-14
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Publication
12370354 | J:120173
First Author: Rizzitelli A
Year: 2002
Journal: J Immunol
Title: T lymphocytes potentiate murine dendritic cells to produce IL-12.
Volume: 169
Issue: 8
Pages: 4237-45
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Publication
15592506 | J:96010
First Author: Felli MP
Year: 2005
Journal: Oncogene
Title: PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Volume: 24
Issue: 6
Pages: 992-1000
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Publication
25408420 | J:222612
First Author: Gehre N
Year: 2015
Journal: Eur J Immunol
Title: A stromal cell free culture system generates mouse pro-T cells that can reconstitute T-cell compartments in vivo.
Volume: 45
Issue: 3
Pages: 932-42
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Publication
11927910 | J:76234
First Author: Gounari F
Year: 2002
Journal: Nat Immunol
Title: Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Volume: 3
Issue: 5
Pages: 489-96
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Publication
21775286 | J:259835
First Author: Mahtani-Patching J
Year: 2011
Journal: Sci Signal
Title: PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.
Volume: 4
Issue: 182
Pages: ra47
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Publication
15197172 | J:91542
First Author: Laurent J
Year: 2004
Journal: Int Immunol
Title: New insights into the proliferation and differentiation of early mouse thymocytes.
Volume: 16
Issue: 8
Pages: 1069-80
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Publication
9208843 | J:111526
First Author: Fehling HJ
Year: 1997
Journal: Immunity
Title: Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
Volume: 6
Issue: 6
Pages: 703-14
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Publication
16641111 | J:109138
First Author: Schnell S
Year: 2006
Journal: Int Immunol
Title: Constitutive expression of the pre-TCR enables development of mature T cells.
Volume: 18
Issue: 6
Pages: 911-20
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Publication
15018807 | J:75720
First Author: Yamanaka H
Year: 2002
Journal: Brain Res Gene Expr Patterns
Title: Expression of Apc2 during mouse development.
Volume: 1
Issue: 2
Pages: 107-14
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Publication
25752506 | J:229717
First Author: Barthlott T
Year: 2015
Journal: Eur J Immunol
Title: A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage.
Volume: 45
Issue: 6
Pages: 1760-71
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Publication
15210747 | J:120401
First Author: Erman B
Year: 2004
Journal: J Exp Med
Title: Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation.
Volume: 199
Issue: 12
Pages: 1719-24
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Publication
9927518 | J:52569
First Author: Di Santo JP
Year: 1999
Journal: J Exp Med
Title: The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
Volume: 189
Issue: 3
Pages: 563-74
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Publication
12021779 | J:76772
First Author: Erman B
Year: 2002
Journal: Nat Immunol
Title: Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development.
Volume: 3
Issue: 6
Pages: 564-9
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Publication
15894276 | J:99104
First Author: Hayes SM
Year: 2005
Journal: Immunity
Title: TCR signal strength influences alphabeta/gammadelta lineage fate.
Volume: 22
Issue: 5
Pages: 583-93
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Publication
21673984 | J:174140
First Author: Hathcock KS
Year: 2011
Journal: PLoS One
Title: The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
Volume: 6
Issue: 6
Pages: e20639
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Publication
17890450 | J:129993
First Author: Bessette K
Year: 2008
Journal: Blood
Title: A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling.
Volume: 111
Issue: 1
Pages: 344-50
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Publication
17555992 | J:123569
First Author: Anderson SJ
Year: 2007
Journal: Immunity
Title: Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.
Volume: 26
Issue: 6
Pages: 759-72
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Publication
19966856 | J:168183
First Author: Checquolo S
Year: 2010
Journal: Oncogene
Title: Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.
Volume: 29
Issue: 10
Pages: 1463-74
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Publication
12626535 | J:126301
First Author: Haks MC
Year: 2003
Journal: J Immunol
Title: Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.
Volume: 170
Issue: 6
Pages: 2853-61
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Publication
11591775 | J:106739
First Author: Mancini SJ
Year: 2001
Journal: J Immunol
Title: TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling.
Volume: 167
Issue: 8
Pages: 4485-93
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Publication
11854357 | J:124458
First Author: Lambolez F
Year: 2002
Journal: J Exp Med
Title: Characterization of T cell differentiation in the murine gut.
Volume: 195
Issue: 4
Pages: 437-49
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Publication
17317856 | J:145430
First Author: Guo Z
Year: 2007
Journal: Blood
Title: Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.
Volume: 109
Issue: 12
Pages: 5463-72
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17192390 | J:121496
First Author: dos Santos NR
Year: 2007
Journal: Blood
Title: Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia.
Volume: 109
Issue: 9
Pages: 3972-81
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Publication
17507663 | J:125789
First Author: Fasseu M
Year: 2007
Journal: Blood
Title: p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Volume: 110
Issue: 7
Pages: 2610-9
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Publication
16498412 | J:106690
First Author: Vacca A
Year: 2006
Journal: EMBO J
Title: Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
Volume: 25
Issue: 5
Pages: 1000-8
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Publication
15894277 | J:99103
First Author: Haks MC
Year: 2005
Journal: Immunity
Title: Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.
Volume: 22
Issue: 5
Pages: 595-606
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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