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Search results 1 to 100 out of 4544 for Pten

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5728 | PTEN
Type: gene
Organism: human
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Gene
100144716 | pten
Type: gene
Organism: frog, western clawed
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Gene
50557 | Pten
Type: gene
Organism: rat
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Gene
403832 | PTEN
Type: gene
Organism: dog, domestic
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Gene
466142 | PTEN
Type: gene
Organism: chimpanzee
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Gene
540786 | PTEN
Type: gene
Organism: cattle
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Gene
423675 | PTEN
Type: gene
Organism: chicken
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Gene
705121 | PTEN
Type: gene
Organism: macaque, rhesus
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Protein
A0A6G7SEK5
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
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Protein
A0A6G7SF19
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
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Protein Coding Gene
MGI:109583 | Pten
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:7341820
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160398
Stage: TS08
Assay Id: MGI:7343549
Age: embryonic day 5.5
Image: 1A Pten (-)
Specimen Label: 1A Pten (-)
Detected: false
Specimen Num: 2
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Gene
65018 | PINK1
Type: gene
Organism: human
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Protein
A0A1V0DNR6
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
A0A024QYR9
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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GXD Expression
GXD Expression
 
Probe: MGI:3584409
Assay Type: Immunohistochemistry
Annotation Date: 2019-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6363485
Age: embryonic day 13.5
Image: 3B Pten KO
Specimen Label: 3B Pten KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6363456
Assay Type: Immunohistochemistry
Annotation Date: 2019-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6363496
Age: embryonic day 13.5
Image: 3B beta-catenin Pten KO
Note: Expression localized in plasma membrane and cytoplasm, not in the nucleus.
Specimen Label: 3B beta-catenin Pten KO
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3617793
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160518
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:7343555
Age: embryonic day 5.5
Image: 1A Pten (-)
Note: Expression in this mutant is the same as in wild-type.
Specimen Label: 1A Pten (-)
Detected: true
Specimen Num: 2
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Publication
20940307 | J:178436
First Author: Xu D
Year: 2010
Journal: J Biol Chem
Title: Regulation of PTEN stability and activity by Plk3.
Volume: 285
Issue: 51
Pages: 39935-42
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Publication
10339565 | J:71874
First Author: Sun H
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
Volume: 96
Issue: 11
Pages: 6199-204
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Publication
26399523 | J:227225
 
First Author: Shnitsar I
Year: 2015
Journal: Nat Commun
Title: PTEN regulates cilia through Dishevelled.
Volume: 6
Pages: 8388
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Publication
20554973 | J:165893
First Author: Weng Z
Year: 2010
Journal: Blood
Title: PTEN regulates collagen-induced platelet activation.
Volume: 116
Issue: 14
Pages: 2579-81
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Publication
20008297 | J:157776
First Author: Vemula S
Year: 2010
Journal: Blood
Title: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Volume: 115
Issue: 9
Pages: 1785-96
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Publication
19473982 | J:153190
First Author: Van Themsche C
Year: 2009
Journal: J Biol Chem
Title: X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.
Volume: 284
Issue: 31
Pages: 20462-6
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Publication
21524277 | J:329567
First Author: Huang Y
Year: 2011
Journal: Cell Biol Int
Title: Dispensable role of PTEN in mouse spermatogenesis.
Volume: 35
Issue: 9
Pages: 905-8
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Publication
20807812 | J:164210
First Author: Hill R
Year: 2010
Journal: Cancer Res
Title: PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Volume: 70
Issue: 18
Pages: 7114-24
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Publication
17921358 | J:146355
First Author: Davé V
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: Conditional deletion of Pten causes bronchiolar hyperplasia.
Volume: 38
Issue: 3
Pages: 337-45
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GXD Expression
GXD Expression
   
Probe: MGI:666662
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354755
Age: embryonic day 14.5
Specimen Label: Table S5 - Pten
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7764055
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7764448
Age: embryonic day 14.5
Specimen Label: 1C Pten Pax6-aCre
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7764055
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:7764448
Age: embryonic day 14.5
Note: Expression eliminated in distal retinal progenitor cells.
Specimen Label: 1C Pten Pten-cko
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7764055
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7764448
Age: embryonic day 14.5
Specimen Label: S1 Pten Pax6-aCre
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7764055
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:7764448
Age: embryonic day 14.5
Note: Expression eliminated in distal retinal progenitor cells.
Specimen Label: S1 Pten Pten-cko
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:666662
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354755
Age: embryonic day 14.5
Note: Expression is present in the upper and lower cortical plate.
Specimen Label: Table S5 - Pten
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:666662
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354755
Age: embryonic day 14.5
Specimen Label: Table S5 - Pten
Detected: true
Specimen Num: 1
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Publication
26076167 | J:233809
First Author: Lokody IB
Year: 2015
Journal: PLoS One
Title: Pten Regulates Epithelial Cytodifferentiation during Prostate Development.
Volume: 10
Issue: 6
Pages: e0129470
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Publication
16598206 | J:109085
First Author: Yilmaz OH
Year: 2006
Journal: Nature
Title: Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.
Volume: 441
Issue: 7092
Pages: 475-82
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Publication
26477312 | J:226088
First Author: Manda KR
Year: 2016
Journal: Oncogene
Title: NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence.
Volume: 35
Issue: 25
Pages: 3282-92
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Publication
22405073 | J:182671
First Author: Ortega-Molina A
Year: 2012
Journal: Cell Metab
Title: Pten positively regulates brown adipose function, energy expenditure, and longevity.
Volume: 15
Issue: 3
Pages: 382-94
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Publication
21771908 | J:174190
First Author: Ming M
Year: 2011
Journal: Cancer Res
Title: PTEN positively regulates UVB-induced DNA damage repair.
Volume: 71
Issue: 15
Pages: 5287-95
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Publication
32673396 | J:313432
 
First Author: Qi Y
Year: 2020
Journal: J Cell Biol
Title: PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
Volume: 219
Issue: 9
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Publication
36759189 | J:350824
 
First Author: Dusing M
Year: 2023
Journal: eNeuro
Title: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
Volume: 10
Issue: 2
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Publication
22401813 | J:186096
First Author: Garcia-Cao I
Year: 2012
Journal: Cell
Title: Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Volume: 149
Issue: 1
Pages: 49-62
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Publication
19211894 | J:146630
First Author: Gregorian C
Year: 2009
Journal: J Neurosci
Title: Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.
Volume: 29
Issue: 6
Pages: 1874-86
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Publication
38055645 | J:354052
 
First Author: Athavale D
Year: 2023
Journal: Hepatol Commun
Title: Overexpression of HMGB1 in hepatocytes accelerates PTEN inactivation-induced liver cancer.
Volume: 7
Issue: 12
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Publication
25641678 | J:220713
First Author: Lin J
Year: 2015
Journal: J Pathol
Title: Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy.
Volume: 236
Issue: 1
Pages: 30-40
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Publication
16489020 | J:106650
First Author: Zhong C
Year: 2006
Journal: Cancer Res
Title: Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.
Volume: 66
Issue: 4
Pages: 2188-94
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Publication
19261747 | J:146760
First Author: Puzio-Kuter AM
Year: 2009
Journal: Genes Dev
Title: Inactivation of p53 and Pten promotes invasive bladder cancer.
Volume: 23
Issue: 6
Pages: 675-80
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Publication
26460096 | J:228517
First Author: Xing Y
Year: 2015
Journal: Dev Biol
Title: PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway.
Volume: 408
Issue: 1
Pages: 56-65
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Publication
24582960 | J:211713
First Author: Hertzler-Schaefer K
Year: 2014
Journal: Cell Rep
Title: Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.
Volume: 6
Issue: 5
Pages: 818-26
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Publication
28323888 | J:247150
First Author: Yu EJ
Year: 2017
Journal: PLoS One
Title: LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.
Volume: 12
Issue: 3
Pages: e0174357
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GO Term
GO:1990455 | PTEN phosphatase complex
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Publication
19470765 | J:149666
First Author: Guha M
Year: 2009
Journal: Cancer Res
Title: Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Volume: 69
Issue: 12
Pages: 4954-8
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Publication
29018045 | J:251492
First Author: Kim HS
Year: 2017
Journal: J Exp Med
Title: PTEN drives Th17 cell differentiation by preventing IL-2 production.
Volume: 214
Issue: 11
Pages: 3381-3398
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Publication
35101965 | J:353529
First Author: Getz SA
Year: 2022
Journal: J Neurosci
Title: PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate.
Volume: 42
Issue: 10
Pages: 1945-1957
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Publication
21654839 | J:182199
First Author: Parapuram SK
Year: 2011
Journal: J Invest Dermatol
Title: Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
Volume: 131
Issue: 10
Pages: 1996-2003
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Publication
19038262 | J:149180
First Author: Ruan H
Year: 2009
Journal: J Mol Cell Cardiol
Title: Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Volume: 46
Issue: 2
Pages: 193-200
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Publication
30814515 | J:293994
First Author: Huang H
Year: 2019
Journal: Cell Death Dis
Title: AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration.
Volume: 10
Issue: 3
Pages: 203
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Publication
24482365 | J:209151
First Author: Cui M
Year: 2014
Journal: Mol Cancer Res
Title: PTEN is a potent suppressor of small cell lung cancer.
Volume: 12
Issue: 5
Pages: 654-9
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Publication
37225693 | J:335810
First Author: van Ree JH
Year: 2023
Journal: Nat Commun
Title: Hyperphosphorylated PTEN exerts oncogenic properties.
Volume: 14
Issue: 1
Pages: 2983
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Publication
25646418 | J:220011
First Author: Leong JW
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: PTEN regulates natural killer cell trafficking in vivo.
Volume: 112
Issue: 7
Pages: E700-9
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Publication
33214645 | J:300231
First Author: de Mello NP
Year: 2020
Journal: Sci Rep
Title: Inverse sex-based expression profiles of PTEN and Klotho in mice.
Volume: 10
Issue: 1
Pages: 20189
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Publication
18451155 | J:134611
First Author: Kwon CH
Year: 2008
Journal: Cancer Res
Title: Pten haploinsufficiency accelerates formation of high-grade astrocytomas.
Volume: 68
Issue: 9
Pages: 3286-94
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Publication
37418003 | J:349261
 
First Author: Zhang KK
Year: 2023
Journal: J Cell Biol
Title: PTEN is both an activator and a substrate of chaperone-mediated autophagy.
Volume: 222
Issue: 9
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Publication
20694004 | J:165283
First Author: Liu K
Year: 2010
Journal: Nat Neurosci
Title: PTEN deletion enhances the regenerative ability of adult corticospinal neurons.
Volume: 13
Issue: 9
Pages: 1075-81
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Publication
22900024 | J:189934
First Author: Napoli E
Year: 2012
Journal: PLoS One
Title: Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.
Volume: 7
Issue: 8
Pages: e42504
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Publication
39547478 | J:358944
 
First Author: Yonan JM
Year: 2024
Journal: Neurobiol Dis
Title: PTEN deletion in the adult dentate gyrus induces epilepsy.
Volume: 203
Pages: 106736
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Publication
21836055 | J:178019
First Author: Byun DS
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Intestinal epithelial-specific PTEN inactivation results in tumor formation.
Volume: 301
Issue: 5
Pages: G856-64
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Publication
19846776 | J:154673
First Author: Gregorian C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: PTEN dosage is essential for neurofibroma development and malignant transformation.
Volume: 106
Issue: 46
Pages: 19479-84
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Publication
32728066 | J:308615
First Author: Qi Y
Year: 2020
Journal: Sci Rep
Title: PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
Volume: 10
Issue: 1
Pages: 12685
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Publication
14691534 | J:86212
First Author: Trotman LC
Year: 2003
Journal: PLoS Biol
Title: Pten dose dictates cancer progression in the prostate.
Volume: 1
Issue: 3
Pages: E59
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Publication
29056325 | J:251968
First Author: Malek M
Year: 2017
Journal: Mol Cell
Title: PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Volume: 68
Issue: 3
Pages: 566-580.e10
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Publication
19057511 | J:144234
First Author: Yu J
Year: 2009
Journal: EMBO J
Title: PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Volume: 28
Issue: 1
Pages: 21-33
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Publication
18928559 | J:241768
 
First Author: Ohtoshi A
Year: 2008
Journal: Cerebrospinal Fluid Res
Title: Hydrocephalus caused by conditional ablation of the Pten or beta-catenin gene.
Volume: 5
Pages: 16
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Publication
22209699 | J:181962
First Author: Conley-LaComb MK
Year: 2012
Journal: Am J Pathol
Title: PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer.
Volume: 180
Issue: 3
Pages: 1017-27
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Publication
25609613 | J:218890
First Author: Williams MR
Year: 2015
Journal: J Neurosci
Title: Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive.
Volume: 35
Issue: 3
Pages: 943-59
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Publication
36171333 | J:329202
First Author: Arai N
Year: 2022
Journal: Sci Rep
Title: Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice.
Volume: 12
Issue: 1
Pages: 16206
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Publication
16633340 | J:109084
First Author: Zhang J
Year: 2006
Journal: Nature
Title: PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.
Volume: 441
Issue: 7092
Pages: 518-22
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Publication
24632614 | J:219257
First Author: Miyagawa S
Year: 2015
Journal: Oncogene
Title: Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina.
Volume: 34
Issue: 8
Pages: 1035-43
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Publication
20200318 | J:169364
First Author: Hu Z
Year: 2010
Journal: Diabetes
Title: PTEN inhibition improves muscle regeneration in mice fed a high-fat diet.
Volume: 59
Issue: 6
Pages: 1312-20
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Publication
16488991 | J:106662
First Author: Yoo LI
Year: 2006
Journal: Cancer Res
Title: Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.
Volume: 66
Issue: 4
Pages: 1929-39
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Publication
26692175 | J:260236
First Author: Li S
Year: 2016
Journal: Nat Immunol
Title: The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Volume: 17
Issue: 3
Pages: 241-9
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Publication
26307673 | J:224977
 
First Author: Conde-Perez A
Year: 2015
Journal: Nat Commun
Title: A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.
Volume: 6
Pages: 8093
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Publication
12563260 | J:83213
First Author: Anzelon AN
Year: 2003
Journal: Nat Immunol
Title: Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.
Volume: 4
Issue: 3
Pages: 287-94
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Publication
18239123 | J:131827
First Author: Reddy P
Year: 2008
Journal: Science
Title: Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.
Volume: 319
Issue: 5863
Pages: 611-3
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Publication
36339257 | J:330731
First Author: Geoffroy CG
Year: 2022
Journal: iScience
Title: Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting.
Volume: 25
Issue: 11
Pages: 105383
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Publication
14522255 | J:93902
First Author: Wang S
Year: 2003
Journal: Cancer Cell
Title: Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
Volume: 4
Issue: 3
Pages: 209-21
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Publication
11691952 | J:73255
First Author: Groszer M
Year: 2001
Journal: Science
Title: Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Volume: 294
Issue: 5549
Pages: 2186-9
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Publication
16432235 | J:105995
First Author: Wang S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
Volume: 103
Issue: 5
Pages: 1480-5
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Publication
19454716 | J:148853
First Author: Sarraj B
Year: 2009
Journal: J Immunol
Title: Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.
Volume: 182
Issue: 11
Pages: 7190-200
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Publication
25829446 | J:260282
First Author: Mense SM
Year: 2015
Journal: Sci Signal
Title: PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Volume: 8
Issue: 370
Pages: ra32
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Publication
33771972 | J:319431
First Author: Wang XQ
Year: 2021
Journal: Transl Psychiatry
Title: PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice.
Volume: 11
Issue: 1
Pages: 185
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Publication
17202315 | J:145331
First Author: Subramanian KK
Year: 2007
Journal: Blood
Title: Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.
Volume: 109
Issue: 9
Pages: 4028-37
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Publication
24561254 | J:211716
First Author: Sun Z
Year: 2014
Journal: Cell Rep
Title: PTEN C-terminal deletion causes genomic instability and tumor development.
Volume: 6
Issue: 5
Pages: 844-54
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Publication
22056987 | J:179396
First Author: Sun F
Year: 2011
Journal: Nature
Title: Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
Volume: 480
Issue: 7377
Pages: 372-5
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Publication
39092178 | J:353087
First Author: Tsai PJ
Year: 2024
Journal: iScience
Title: PTEN acts as a crucial inflammatory checkpoint controlling TLR9/IL-6 axis in B cells.
Volume: 27
Issue: 7
Pages: 110388
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Publication
26992888 | J:259025
 
First Author: Getz SA
Year: 2016
Journal: Neurobiol Dis
Title: Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
Volume: 93
Pages: 12-20
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Publication
35394871 | J:336695
First Author: Sathyanarayana SH
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Pten heterozygosity restores neuronal morphology in fragile X syndrome mice.
Volume: 119
Issue: 15
Pages: e2109448119
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Publication
26914657 | J:249209
First Author: Garfin PM
Year: 2016
Journal: PLoS One
Title: Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function.
Volume: 11
Issue: 2
Pages: e0149430
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Publication
26974310 | J:234820
First Author: Shojaee S
Year: 2016
Journal: Nat Med
Title: PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
Volume: 22
Issue: 4
Pages: 379-87
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Publication
26233892 | J:316240
First Author: Sun X
Year: 2015
Journal: J Genet Genomics
Title: Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.
Volume: 42
Issue: 7
Pages: 373-82
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