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Search results 1 to 100 out of 1076 for Pth

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. It stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells []. Defects in PTH are a cause of familial isolated hypoparathyroidism [].
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: false
GXD Expression    
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752321
Stage: TS21
Assay Id: MGI:7514268
Age: embryonic day 13.0
Image: 2A II Pth
Specimen Label: 2A II Pth
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7514268
Age: embryonic day 12.0
Image: 2A I Pth
Note: Expression specifically marked anterior-dorsal parathyroid domain, with clear interface at Foxn1-positive posterior/ventral thymus domain.
Specimen Label: 2A I Pth
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842526
Pattern: Clusters
Stage: TS26
Assay Id: MGI:7514268
Age: embryonic day 18.5
Image: 2A III Pth
Note: Expression in small clusters of cells located between parathyroid and thymus, or directly assocated with thymus, in some cases under thymic capsule.
Specimen Label: 2A III Pth
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876826
Stage: TS26
Assay Id: MGI:7514268
Age: embryonic day 18.5
Image: 2A III Pth
Specimen Label: 2A III Pth
Detected: false
Specimen Num: 3
GXD Expression
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3281221
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7514268
Age: embryonic day 13.0
Image: 2A II Pth
Note: Expression in domain starting to separate from thymus domain.
Specimen Label: 2A II Pth
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3281226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7514268
Age: embryonic day 18.5
Image: 2A III Pth
Specimen Label: 2A III Pth
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7514262
Assay Type: RNA in situ
Annotation Date: 2023-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3813021
Pattern: Single cells
Stage: TS21
Assay Id: MGI:7514268
Age: embryonic day 13.0
Image: 2A II Pth
Note: Expression in some cells located outside major parathyroid domain.
Specimen Label: 2A II Pth
Detected: true
Specimen Num: 2
Gene
Type: gene
Organism: human
Publication
First Author: Zoidis E
Year: 2011
Journal: Mol Cell Biochem
Title: Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
Volume: 348
Issue: 1-2
Pages: 33-42
Publication
First Author: Sunthornthepvarakul T
Year: 1999
Journal: J Clin Endocrinol Metab
Title: A novel mutation of the signal peptide of the preproparathyroid hormone gene associated with autosomal recessive familial isolated hypoparathyroidism.
Volume: 84
Issue: 10
Pages: 3792-6
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
Publication
First Author: Bai X
Year: 2007
Journal: Endocrinology
Title: Early lethality in Hyp mice with targeted deletion of Pth gene.
Volume: 148
Issue: 10
Pages: 4974-83
Publication
First Author: Ren Y
Year: 2011
Journal: PLoS One
Title: Endogenous PTH deficiency impairs fracture healing and impedes the fracture-healing efficacy of exogenous PTH(1-34).
Volume: 6
Issue: 7
Pages: e23060
Publication
First Author: Kovacs CS
Year: 2001
Journal: Endocrinology
Title: PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP.
Volume: 142
Issue: 11
Pages: 4983-93
Publication
First Author: Qiu T
Year: 2010
Journal: Nat Cell Biol
Title: TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.
Volume: 12
Issue: 3
Pages: 224-34
Publication  
First Author: Ma C
Year: 2021
Journal: Front Cell Dev Biol
Title: Exogenous PTH 1-34 Attenuates Impaired Fracture Healing in Endogenous PTH Deficiency Mice via Activating Indian Hedgehog Signaling Pathway and Accelerating Endochondral Ossification.
Volume: 9
Pages: 750878
Publication
First Author: Yuan Q
Year: 2012
Journal: PLoS Genet
Title: Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.
Volume: 8
Issue: 5
Pages: e1002726
Publication
First Author: Yuan Q
Year: 2011
Journal: Endocrinology
Title: PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels.
Volume: 152
Issue: 11
Pages: 4053-61
Publication
First Author: Kazmers NH
Year: 2009
Journal: Bone
Title: Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells.
Volume: 45
Issue: 1
Pages: 52-60
Publication
First Author: Babey M
Year: 2015
Journal: J Bone Miner Res
Title: Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts.
Volume: 30
Issue: 6
Pages: 1064-76
Publication
First Author: Murray RD
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability.
Volume: 304
Issue: 8
Pages: F1076-85
Publication
First Author: Okumura K
Year: 2017
Journal: Sci Rep
Title: The parathyroid hormone regulates skin tumour susceptibility in mice.
Volume: 7
Issue: 1
Pages: 11208
Publication
First Author: Zhang L
Year: 2023
Journal: Neuron
Title: Bidirectional control of parathyroid hormone and bone mass by subfornical organ.
Volume: 111
Issue: 12
Pages: 1914-1932.e6
Publication
First Author: Miao D
Year: 2004
Journal: Endocrinology
Title: Skeletal abnormalities in Pth-null mice are influenced by dietary calcium.
Volume: 145
Issue: 4
Pages: 2046-53
Publication
First Author: Hollnagel A
Year: 1997
Journal: J Bone Miner Res
Title: Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2).
Volume: 12
Issue: 12
Pages: 1993-2004
Publication
First Author: Huang H
Year: 2010
Journal: J Bone Miner Res
Title: Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.
Volume: 25
Issue: 4
Pages: 819-29
Publication
First Author: Miao D
Year: 2002
Journal: J Clin Invest
Title: Parathyroid hormone is essential for normal fetal bone formation.
Volume: 109
Issue: 9
Pages: 1173-82
Publication
First Author: Kirby BJ
Year: 2013
Journal: J Bone Miner Res
Title: Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone.
Volume: 28
Issue: 9
Pages: 1987-2000
Publication
First Author: Heinrich G
Year: 1984
Journal: J Biol Chem
Title: Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone.
Volume: 259
Issue: 5
Pages: 3320-9
Publication
First Author: Guo J
Year: 2010
Journal: Endocrinology
Title: Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH.
Volume: 151
Issue: 8
Pages: 3502-13
Publication
First Author: Kir S
Year: 2016
Journal: Cell Metab
Title: PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Volume: 23
Issue: 2
Pages: 315-23
Publication
First Author: Swarthout JT
Year: 2002
Journal: Gene
Title: Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.
Volume: 282
Issue: 1-2
Pages: 1-17
Publication
First Author: Cao G
Year: 2009
Journal: Endocrinology
Title: Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium.
Volume: 150
Issue: 2
Pages: 561-9
Publication
First Author: Xue Y
Year: 2005
Journal: Hum Mol Genet
Title: Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development.
Volume: 14
Issue: 11
Pages: 1515-28
Publication  
First Author: Jay FF
Year: 2015
Journal: Mol Cell Endocrinol
Title: Amphiregulin lacks an essential role for the bone anabolic action of parathyroid hormone.
Volume: 417
Pages: 158-65
Publication
First Author: Goltzman D
Year: 2008
Journal: Arch Biochem Biophys
Title: Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone.
Volume: 473
Issue: 2
Pages: 218-24
Publication
First Author: Atkinson EG
Year: 2023
Journal: J Bone Miner Res
Title: Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
Volume: 38
Issue: 1
Pages: 70-85
Publication
First Author: He Q
Year: 2015
Journal: Sci Signal
Title: The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.
Volume: 8
Issue: 391
Pages: ra84
Publication
First Author: Datta NS
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Parathyroid hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice.
Volume: 302
Issue: 10
Pages: E1183-8
Publication  
First Author: Gardinier JD
Year: 2020
Journal: Bone
Title: Osteocytes' expression of the PTH/PTHrP receptor has differing effects on endocortical and periosteal bone formation during adenine-induced CKD.
Volume: 133
Pages: 115186
Publication
First Author: Quinn SJ
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: CaSR-mediated interactions between calcium and magnesium homeostasis in mice.
Volume: 304
Issue: 7
Pages: E724-33
Publication
First Author: Shinoda Y
Year: 2010
Journal: J Cell Biochem
Title: Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells.
Volume: 109
Issue: 4
Pages: 755-63
Publication
First Author: Ding Q
Year: 2018
Journal: Int J Mol Med
Title: Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor‑mediated angiogenesis.
Volume: 42
Issue: 1
Pages: 171-181
Publication
First Author: Li YC
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia.
Volume: 94
Issue: 18
Pages: 9831-5
Publication
First Author: Xue Y
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice.
Volume: 302
Issue: 7
Pages: E841-51
Publication
First Author: Sun P
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Endogenous parathyroid hormone (PTH) signals through osteoblasts via RANKL during fracture healing to affect osteoclasts.
Volume: 525
Issue: 4
Pages: 850-856
Publication
First Author: Shu L
Year: 2011
Journal: J Bone Miner Res
Title: The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates.
Volume: 26
Issue: 5
Pages: 1057-71
Publication
First Author: Kantham L
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion.
Volume: 297
Issue: 4
Pages: E915-23
Publication
First Author: Onal M
Year: 2016
Journal: J Bone Miner Res
Title: Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice.
Volume: 31
Issue: 2
Pages: 416-29
Publication
First Author: Bonnet N
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin.
Volume: 109
Issue: 37
Pages: 15048-53
Publication
First Author: Shimizu E
Year: 2010
Journal: J Biol Chem
Title: HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression.
Volume: 285
Issue: 13
Pages: 9616-26
Publication
First Author: Goltzman D
Year: 2007
Journal: J Steroid Biochem Mol Biol
Title: Use of genetically modified mice to examine the skeletal anabolic activity of vitamin D.
Volume: 103
Issue: 3-5
Pages: 587-91
Publication
First Author: Quinn SJ
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo.
Volume: 304
Issue: 3
Pages: E310-20
Publication
First Author: Ogata N
Year: 2011
Journal: J Biol Chem
Title: G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone.
Volume: 286
Issue: 15
Pages: 13733-40
Publication
First Author: Chen HL
Year: 2002
Journal: J Biol Chem
Title: Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells.
Volume: 277
Issue: 22
Pages: 19374-81
Publication
First Author: Seldin MF
Year: 1992
Journal: Cytogenet Cell Genet
Title: Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization.
Volume: 60
Issue: 3-4
Pages: 252-4
Publication
First Author: Egbuna O
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone.
Volume: 297
Issue: 3
Pages: F720-8
Publication
First Author: Liu Z
Year: 2010
Journal: PLoS Genet
Title: Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.
Volume: 6
Issue: 12
Pages: e1001251
Publication
First Author: Liu J
Year: 2011
Journal: PLoS Genet
Title: The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH.
Volume: 7
Issue: 9
Pages: e1002294
Publication
First Author: Kong XF
Year: 1994
Journal: Biochem Biophys Res Commun
Title: The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous.
Volume: 200
Issue: 3
Pages: 1290-9
Publication
First Author: Ma Y
Year: 2017
Journal: Endocrinology
Title: FGF23 Is Not Required to Regulate Fetal Phosphorus Metabolism but Exerts Effects Within 12 Hours After Birth.
Volume: 158
Issue: 2
Pages: 252-263
Publication  
First Author: Andrukhova O
Year: 2016
Journal: Mol Cell Endocrinol
Title: Fgf23 and parathyroid hormone signaling interact in kidney and bone.
Volume: 436
Pages: 224-39
Publication
First Author: Pirih FQ
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo.
Volume: 332
Issue: 2
Pages: 494-503
Publication
First Author: Yamada T
Year: 2019
Journal: PLoS One
Title: Gcm2 regulates the maintenance of parathyroid cells in adult mice.
Volume: 14
Issue: 1
Pages: e0210662
Publication
First Author: Guo J
Year: 2010
Journal: Cell Metab
Title: Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation.
Volume: 11
Issue: 2
Pages: 161-71
Publication
First Author: Hirai T
Year: 2015
Journal: Endocrinology
Title: Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis.
Volume: 156
Issue: 8
Pages: 2774-80
Publication
First Author: Pirih FQ
Year: 2010
Journal: PLoS One
Title: Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6.
Volume: 5
Issue: 10
Pages: e13657
Publication
First Author: Liu Z
Year: 2016
Journal: FASEB J
Title: DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.
Volume: 30
Issue: 2
Pages: 635-52
Publication
First Author: Ide N
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.
Volume: 315
Issue: 5
Pages: F1261-F1270
Publication
First Author: Chojnowski JL
Year: 2014
Journal: Development
Title: Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Volume: 141
Issue: 19
Pages: 3697-708
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory